ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Sweets | Total body bone mineral density (age 30-45) (ebi-a-GCST005346) | rs61913309 | -2.64049037678426 | 0.831583008272965 | 0.0014970347091163 |
| Sweets | Total body bone mineral density (age 30-45) (ebi-a-GCST005346) | rs62559005 | -1.43073183192439 | 0.602034685352928 | 0.0174780445136364 |
| Sweets | Total body bone mineral density (age 30-45) (ebi-a-GCST005346) | All - Inverse variance weighted | -0.549437675602976 | 0.199439872415812 | 0.005870938274333 |
| Sweets | Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) | All - Inverse variance weighted | -0.110794896119252 | 0.0518225494654475 | 0.0325194286994007 |
| Sweets | Rheumatoid arthritis (ebi-a-GCST90018690) | rs34413686 | -3.54329479699917 | 1.26141296361752 | 0.004969738649528 |
| Sweets | Rheumatoid arthritis (ebi-a-GCST90018690) | All - Inverse variance weighted | -0.603671943891307 | 0.273514174912581 | 0.0273073780823244 |
| Sweets | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | rs73112179 | 1.19567341353616 | 0.507575253373656 | 0.0184899606962464 |
| Sweets | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | All - Inverse variance weighted | 0.603031123906142 | 0.234123765538282 | 0.0100039202942219 |
| Sweets | Rheumatoid arthritis (ebi-a-GCST90018910) | rs116687379 | -1.61671657446413 | 0.799370654215094 | 0.0431260887527073 |
| Sweets | Rheumatoid arthritis (ebi-a-GCST90018910) | rs62559005 | -0.80471170093987 | 0.332198421997532 | 0.0154191040010579 |
| Sweets | Rheumatoid arthritis (ebi-a-GCST90018910) | All - Inverse variance weighted | -0.336744031622732 | 0.146311736006539 | 0.0213604639776054 |
| Sweets | Other joint disorder (ebi-a-GCST90038688) | rs62559005 | 0.0209806689300932 | 0.0091369676880069 | 0.0216621735874605 |
| Sweets | Other joint disorder (ebi-a-GCST90038688) | rs72859681 | 0.0213405067513311 | 0.0105055159548841 | 0.0422182780302988 |
| Sweets | Other joint disorder (ebi-a-GCST90038688) | All - MR Egger | 0.0119639686762444 | 0.0056578395621244 | 0.0495398290170778 |
| Sweets | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | All - Inverse variance weighted | -0.0048241454381884 | 0.0022307088773503 | 0.0305714606473631 |
| Sweets | Fracture of forearm or wrist (ebi-a-GCST90038705) | rs62559005 | -0.0133205570859602 | 0.0063726690644117 | 0.0365941425728853 |
| Sweets | Fracture of forearm or wrist (ebi-a-GCST90038705) | rs72698049 | -0.0134888386208673 | 0.0066666398332031 | 0.0430387302302103 |
| Sweets | Fracture of forearm or wrist (ebi-a-GCST90038705) | All - Inverse variance weighted | -0.0039806250281513 | 0.001632559473357 | 0.0147576405829133 |
| Sweets | Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) | rs116978350 | 6.88995309702652 | 2.98137197362386 | 0.0208328092072517 |
| Sweets | Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) | All - MR Egger | 2.50097082123369 | 1.00331203478247 | 0.0220767081695657 |
| Sweets | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | rs192934965 | -6.87478077867415 | 2.85712107117259 | 0.0161198070401561 |
| Sweets | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | rs62559005 | -5.55502920827642 | 2.52686669728809 | 0.0279215869209013 |
| Sweets | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | rs72791190 | -9.14826100055384 | 4.47220252817452 | 0.0407974256544389 |
| Sweets | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | All - Inverse variance weighted | -2.42546254184475 | 1.12009033470312 | 0.0303557728747221 |
| Sweets | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | All - MR Egger | -5.25796914331749 | 1.99592548890141 | 0.0163399965558977 |
| Sweets | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | rs111664160 | -7.02169435754559 | 3.12475606607382 | 0.024632512292983 |
| Sweets | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | All - MR Egger | -6.14595813406668 | 2.43073533865395 | 0.0204732775942045 |
| Sweets | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs111664160 | 4.86726992152083 | 2.3537747461586 | 0.038653458450555 |
| Sweets | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs62559005 | 5.13288536516042 | 2.48249362286964 | 0.0386745606123049 |
| Sweets | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | All - Inverse variance weighted | 2.55471874315963 | 0.98496587846089 | 0.009494572395024 |
| Sweets | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs192934965 | 2.91049669833621 | 1.29855275799491 | 0.0250041365894919 |
| Sweets | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | All - MR Egger | 1.8359710614101 | 0.850589757113352 | 0.0438948317043136 |
| Sweets | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | rs62559005 | 4.64598081883913 | 2.34697585505116 | 0.0477529293240851 |
| Sweets | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | All - Inverse variance weighted | 1.99785028102041 | 0.924035855991688 | 0.0306111064788813 |
| Sweets | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | rs9813850 | 12.6226312593871 | 2.85607004761448 | 9.88927162988294e-06 |
| Sweets | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | All - Inverse variance weighted | 1.14809413924361 | 0.569150745528851 | 0.0436740494414415 |
| Sweets | Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) | All - Inverse variance weighted | -1.96703073140829 | 0.987728224857193 | 0.0464292843010352 |
| Sweets | Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) | rs74543812 | -5.13579014897712 | 1.85187825219189 | 0.0055493130801023 |
| Sweets | Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) | All - Inverse variance weighted | 0.42936433476663 | 0.20550206797824 | 0.0366768461885627 |
| Sweets | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | rs142705784 | 11.5775419277015 | 4.91993851900852 | 0.0186132040496017 |
| Sweets | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | All - Inverse variance weighted | 2.51808872122078 | 0.968751031994419 | 0.0093410116188025 |
| Sweets | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | rs116687379 | 8.45048977313099 | 3.46499687018897 | 0.0147354694447072 |
| Sweets | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | rs142705784 | -6.16512315654306 | 3.12512160006226 | 0.048522610832708 |
| Sweets | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | rs146405287 | 7.9581732006884 | 3.49689186946505 | 0.0228588957260451 |
| Sweets | Crushing injury of wrist and hand (finn-b-ST19_CRUSHI_INJURY_WRIST_HAND) | All - Inverse variance weighted | -2.01307876423105 | 0.966123922015186 | 0.0371906347051777 |
| Sweets | Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) | rs61913309 | 5.06236872562047 | 2.44331090059583 | 0.0382719861058349 |
| Sweets | Four-jointed box protein 1 (prot-a-1112) | rs16964118 | -2.5555437008134 | 1.28285245418566 | 0.0463623678746279 |
| Sweets | Four-jointed box protein 1 (prot-a-1112) | All - Inverse variance weighted | -0.630863925585745 | 0.281920510142512 | 0.0252382180829348 |
| Sweets | Bone sialoprotein 2 (prot-a-1395) | rs111664160 | -3.02628181648963 | 1.40145669835056 | 0.0308204630770997 |
| Sweets | Bone sialoprotein 2 (prot-a-1395) | rs74543812 | -2.63240430536745 | 1.2652362962435 | 0.0374738886855093 |
| Sweets | Bone sialoprotein 2 (prot-a-1395) | All - MR Egger | -1.48696374980147 | 0.585507486303983 | 0.0205406882125268 |
| Sweets | Bone morphogenetic protein receptor type-1A (prot-a-259) | rs16964118 | -2.56570490837131 | 1.28285245418566 | 0.0455002638963584 |
| Sweets | Bone morphogenetic protein receptor type-1A (prot-a-259) | rs74543812 | -2.90683584004562 | 1.2652362962435 | 0.0215922695068411 |
| Sweets | Bone morphogenetic protein receptor type-1A (prot-a-259) | All - MR Egger | -1.37130138072159 | 0.585527841494095 | 0.0308802394192072 |
| Sweets | Fractured bone site(s): Wrist (ukb-a-439) | rs11038176 | -0.041229334152706 | 0.0176858837071721 | 0.0197428100291765 |
| Sweets | Fractured bone site(s): Wrist (ukb-a-439) | All - MR Egger | 0.0169060453381568 | 0.007855417004384 | 0.0452043070864775 |
| Sweets | Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) | All - Inverse variance weighted | 0.00741953457418 | 0.0031581448768086 | 0.0188070690134938 |
| Sweets | Operative procedures - secondary OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-12747) | rs61948777 | 0.0126142042984109 | 0.0055263145591487 | 0.0224556620336078 |
| Sweets | Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) | rs61913309 | -0.0157213339620215 | 0.0067317501821766 | 0.0195224988720644 |
| Sweets | Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) | All - Inverse variance weighted | -0.0111608733285554 | 0.0040115902231632 | 0.0053998931153179 |
| Sweets | Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) | All - Inverse variance weighted | 0.00631121480632 | 0.0031002024405488 | 0.0417761885775828 |
| Sweets | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | All - Inverse variance weighted | -0.0035596031317867 | 0.0016481532164478 | 0.0307918297818224 |
| Sweets | Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) | All - Inverse variance weighted | -0.003164125791004 | 0.0015575405404008 | 0.0422054587742524 |
| Sweets | Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) | rs79312248 | 0.0162044786794715 | 0.0070909904719564 | 0.0222998861441182 |
| Sweets | Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) | rs9813850 | 0.0154799396031061 | 0.0070085961716677 | 0.0271949857344881 |
| Sweets | Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) | All - Inverse variance weighted | 0.0035169530423806 | 0.0015989171495879 | 0.0278364028418229 |
| Sweets | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | -0.0035596031317867 | 0.0016481532164478 | 0.0307918297818224 |
| Sweets | Fractured/broken bones in last 5 years (ukb-e-2463_AFR) | All - Inverse variance weighted | 2.08596252113292 | 0.95010116938456 | 0.0281265892053436 |
| Sweets | Open wounds of head; neck; and trunk (ukb-e-870_CSA) | rs11038176 | -10.584582647338 | 4.07102860313777 | 0.0093229881175996 |
| Sweets | Open wounds of head; neck; and trunk (ukb-e-870_CSA) | rs73112179 | -8.01052096339227 | 3.06151515716222 | 0.008883070762591 |
| Sweets | Open wounds of head; neck; and trunk (ukb-e-870_CSA) | All - MR Egger | 4.91252337953348 | 2.13217271105961 | 0.037068087027557 |
| Sweets | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | rs72859681 | -4.48853364958965 | 1.81188514295362 | 0.0132390695402817 |
| Sweets | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | rs79312248 | 6.82583534827033 | 3.31160376887728 | 0.0392851828121091 |
| Sweets | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | rs11038176 | 6.30580638652071 | 3.05201029107602 | 0.0388175559037619 |
| Sweets | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | All - Inverse variance weighted | 1.52419612906381 | 0.759454855530651 | 0.0447538364376132 |
| Sweets | M75 Shoulder lesions (ukb-e-M75_CSA) | rs72791190 | 12.7599388792974 | 4.09155116333191 | 0.0018170833468937 |
| Sweets | M75 Shoulder lesions (ukb-e-M75_CSA) | All - Inverse variance weighted | 2.37551354136851 | 1.06019549287536 | 0.0250495800822891 |