ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Tinned tomato | Rheumatoid arthritis (ebi-a-GCST002318) | rs149714813 | -1.87883226027345 | 0.816288044482031 | 0.0213533359205186 |
| Tinned tomato | Rheumatoid arthritis (ebi-a-GCST002318) | rs58393161 | 2.31559349380258 | 0.979677074516069 | 0.0180969076246778 |
| Tinned tomato | Rheumatoid arthritis (ebi-a-GCST002318) | All - MR Egger | -2.43193425383266 | 0.841760769878007 | 0.0277259858877495 |
| Tinned tomato | Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) | All - Inverse variance weighted | 0.906932515107065 | 0.455210136503905 | 0.0463339700236585 |
| Tinned tomato | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | All - Inverse variance weighted | -0.349859704783902 | 0.173723952938493 | 0.0440218252643999 |
| Tinned tomato | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | All - MR Egger | -0.92621271039953 | 0.408724592610711 | 0.0468798377060366 |
| Tinned tomato | Osteoarthritis (hip) (ebi-a-GCST007091) | All - Inverse variance weighted | -0.40075667557678 | 0.167508325159728 | 0.0167359317424593 |
| Tinned tomato | Frozen shoulder (ebi-a-GCST90000512) | rs118020377 | -1.48804802996691 | 0.678554067025789 | 0.0283096130789159 |
| Tinned tomato | Frozen shoulder (ebi-a-GCST90000512) | All - Inverse variance weighted | -0.580549468950779 | 0.255509471307957 | 0.0230789588253245 |
| Tinned tomato | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | All - Inverse variance weighted | 0.655223007985937 | 0.222518665350669 | 0.0032339804313978 |
| Tinned tomato | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs74526388 | 0.0204192019175716 | 0.0097733315865575 | 0.0366827493389841 |
| Tinned tomato | Spine arthritis or spondylitis (ebi-a-GCST90038657) | All - Inverse variance weighted | 0.0089770344343785 | 0.0026322977748681 | 0.0006488157533853 |
| Tinned tomato | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | rs137930953 | 14.0984805902768 | 5.15956924778958 | 0.0062857238741441 |
| Tinned tomato | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | rs58393161 | -14.3142701589989 | 6.78755508927542 | 0.0349532748729803 |
| Tinned tomato | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | All - MR Egger | 11.5805528380668 | 4.03671072204899 | 0.0152740268552631 |
| Tinned tomato | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | rs137930953 | 13.9468072767503 | 5.13101897700811 | 0.0065650851874515 |
| Tinned tomato | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | rs58393161 | -14.2467125263773 | 6.78755508927542 | 0.035821649239708 |
| Tinned tomato | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | All - MR Egger | 11.5151031593268 | 4.02085995618148 | 0.0154103895128808 |
| Tinned tomato | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | rs10900329 | -14.0111301575412 | 7.13040722547932 | 0.0494161860720816 |
| Tinned tomato | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | All - MR Egger | 10.1694068364626 | 4.30321002712591 | 0.0375998589782781 |
| Tinned tomato | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | All - MR Egger | 10.0803661188664 | 4.3019870487014 | 0.0389526157532472 |
| Tinned tomato | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | rs10900329 | 11.0965461939951 | 3.86050330591608 | 0.0040482399587735 |
| Tinned tomato | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | All - MR Egger | -6.47754286944643 | 2.31363880512477 | 0.0172833959511687 |
| Tinned tomato | Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) | rs10900329 | -7.86985686367718 | 2.58327211266524 | 0.0023154681517371 |
| Tinned tomato | Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) | rs149714813 | -3.99845764518711 | 1.88474030006794 | 0.0338805910023816 |
| Tinned tomato | Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) | rs58393161 | -5.88546199485767 | 2.78575885104337 | 0.0346267831784657 |
| Tinned tomato | Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) | All - Inverse variance weighted | -2.46764069368408 | 0.942455088610859 | 0.0088366181559184 |
| Tinned tomato | Infective bursitis (finn-b-M13_INFBURSA) | rs60704180 | 16.0332560711027 | 5.11607065142054 | 0.0017249937235521 |
| Tinned tomato | Infective bursitis (finn-b-M13_INFBURSA) | All - Inverse variance weighted | 2.27827956663958 | 1.1016130015226 | 0.0386277432171796 |
| Tinned tomato | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs118020377 | 1.90254338711946 | 0.686001376938016 | 0.0055477076089672 |
| Tinned tomato | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | All - Inverse variance weighted | 0.375902965916589 | 0.184741108002248 | 0.0418754914180275 |
| Tinned tomato | Disorders of synovium and tendon (finn-b-M13_SYNOTEND) | rs142793391 | 2.13957288247045 | 0.787083854319745 | 0.0065607517731196 |
| Tinned tomato | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs74526388 | 7.43592729531185 | 3.38680407969179 | 0.0281235422468989 |
| Tinned tomato | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | All - Inverse variance weighted | 3.66835929802329 | 1.29851733999829 | 0.0047275183021253 |
| Tinned tomato | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs10900329 | 4.09578273625176 | 1.57973331796815 | 0.0095224364936937 |
| Tinned tomato | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs137930953 | -3.55718530017933 | 1.2446133668799 | 0.0042623372047607 |
| Tinned tomato | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs146219384 | 7.61032971578567 | 3.86690360626319 | 0.0490602002083548 |
| Tinned tomato | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs74526388 | -2.48187720166526 | 1.21303871049133 | 0.0407563706742845 |
| Tinned tomato | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | All - MR Egger | -3.1809616315218 | 1.28507651243664 | 0.0308294664916561 |
| Tinned tomato | Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) | rs142793391 | 4.93421871964372 | 1.43219372225903 | 0.0005706002880452 |
| Tinned tomato | Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) | All - Inverse variance weighted | 1.02197263580789 | 0.485892129241296 | 0.0354403229044712 |
| Tinned tomato | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | rs10900329 | -23.7824289480128 | 7.25044775116079 | 0.0010375836275766 |
| Tinned tomato | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -4.76453221415466 | 2.18945559778763 | 0.0295458074280378 |
| Tinned tomato | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs117521657 | 7.81201003449357 | 3.0299466917529 | 0.0099297385432279 |
| Tinned tomato | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs149714813 | 2.82981065110487 | 1.40950492354651 | 0.0446791324672602 |
| Tinned tomato | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | All - Inverse variance weighted | 1.19541300756092 | 0.56644602113977 | 0.0348261462321147 |
| Tinned tomato | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | rs58393161 | -4.59789299665788 | 1.48229393928556 | 0.0019229805121767 |
| Tinned tomato | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | All - Inverse variance weighted | -0.986909986942591 | 0.423315902477887 | 0.0197333612668341 |
| Tinned tomato | Lumbar spine bone mineral density (ieu-a-982) | rs137943755 | -0.977684868663507 | 0.464009014160874 | 0.0351142403286804 |
| Tinned tomato | Lumbar spine bone mineral density (ieu-a-982) | rs58393161 | 0.988209206118337 | 0.464995211356041 | 0.0335696799897613 |
| Tinned tomato | Lumbar spine bone mineral density (ieu-a-982) | All - MR Egger | -0.670327153735729 | 0.280069070029195 | 0.0356441627172492 |
| Tinned tomato | Bone sialoprotein 2 (prot-a-1395) | rs117521657 | -2.35183443085607 | 1.11516149263092 | 0.0349477674358229 |
| Tinned tomato | Bone sialoprotein 2 (prot-a-1395) | rs74526388 | -2.7414674857104 | 1.25428202664803 | 0.0288385379831239 |
| Tinned tomato | Bone sialoprotein 2 (prot-a-1395) | All - Inverse variance weighted | -1.00813800734534 | 0.353007411087585 | 0.004292109974766 |
| Tinned tomato | Bone sialoprotein 2 (prot-a-1396) | rs10900329 | 2.85216289019173 | 1.22921498297825 | 0.0203239784021019 |
| Tinned tomato | Bone sialoprotein 2 (prot-a-1396) | rs60704180 | -2.83527670946715 | 1.41522055196825 | 0.0451325636540891 |
| Tinned tomato | Bone sialoprotein 2 (prot-a-1396) | All - MR Egger | -2.08618517457535 | 0.729331246211045 | 0.0155053120470079 |
| Tinned tomato | Osteocalcin (prot-a-246) | rs10900329 | -3.08744232052741 | 1.22921498297825 | 0.0120144798313641 |
| Tinned tomato | Osteocalcin (prot-a-246) | rs142793391 | 3.85073303410863 | 1.35747057153247 | 0.0045582812570905 |
| Tinned tomato | Osteocalcin (prot-a-246) | rs149714813 | 4.62166403667089 | 1.40194436073821 | 0.0009785922599988 |
| Tinned tomato | Osteocalcin (prot-a-246) | All - MR Egger | 2.45171582509829 | 1.04814212602809 | 0.0392340836081267 |
| Tinned tomato | Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) | rs10900329 | 0.0396590368908544 | 0.0154272242309004 | 0.0101488046117207 |
| Tinned tomato | Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) | All - MR Egger | -0.0459876297225487 | 0.0176982408002382 | 0.048341193800923 |
| Tinned tomato | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | rs10900329 | -0.0168997373513298 | 0.0080610093967723 | 0.0360397161376417 |
| Tinned tomato | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | rs58393161 | -0.0216602884313515 | 0.0085301843528574 | 0.0111089745949112 |
| Tinned tomato | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | All - Inverse variance weighted | -0.0191454989617188 | 0.0058588398827387 | 0.0010838810537613 |
| Tinned tomato | Fracture resulting from simple fall (ukb-b-15251) | All - Inverse variance weighted | 0.129528222082342 | 0.0550571767558728 | 0.0186420316152256 |
| Tinned tomato | Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) | rs10900329 | -0.0122402443064779 | 0.0050367083927533 | 0.0150901990271141 |
| Tinned tomato | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | rs10900329 | -0.01606483148711 | 0.006797078693767 | 0.018103686732978 |
| Tinned tomato | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | rs137943755 | -0.0160658567477009 | 0.0072310048163068 | 0.0262967289282458 |
| Tinned tomato | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | rs74526388 | -0.0173531495337079 | 0.0070403068502722 | 0.0137078814544872 |
| Tinned tomato | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | All - Inverse variance weighted | -0.0060319464115553 | 0.0023612469413582 | 0.0106322177983642 |
| Tinned tomato | Cervicalgia (ukb-d-M13_CERVICALGIA) | rs149732595 | -0.0226920039850928 | 0.0068465960665658 | 0.0009185701037146 |
| Tinned tomato | Cervicalgia (ukb-d-M13_CERVICALGIA) | rs60704180 | -0.0137709986170168 | 0.0067671398038033 | 0.0418528191179111 |
| Tinned tomato | Shoulder lesions (ukb-d-M13_SHOULDER) | rs137930953 | -0.0388963535951036 | 0.0174259254302615 | 0.0256085613215284 |
| Tinned tomato | Shoulder lesions (ukb-d-M13_SHOULDER) | rs74526388 | -0.0579924694556853 | 0.0171607858549982 | 0.0007265486009018 |
| Tinned tomato | Shoulder lesions (ukb-d-M13_SHOULDER) | All - Inverse variance weighted | -0.0142090487842445 | 0.0059150844782531 | 0.0162980547038549 |
| Tinned tomato | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | rs76510800 | -0.0256842185024951 | 0.0102900869954283 | 0.0125597049111729 |
| Tinned tomato | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | All - Inverse variance weighted | -0.0069163163559788 | 0.0030852531790114 | 0.0249785815193304 |
| Tinned tomato | Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) | rs137930953 | -0.0389229410347689 | 0.017427085285012 | 0.0255177062227112 |
| Tinned tomato | Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) | rs74526388 | -0.0579165332324085 | 0.0171619503721603 | 0.0007389464504226 |
| Tinned tomato | Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) | All - Inverse variance weighted | -0.0142335281439608 | 0.0059172198269519 | 0.0161529229038521 |
| Tinned tomato | Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) | rs142793391 | 0.0224519654679413 | 0.0069844974369959 | 0.0013065246702197 |
| Tinned tomato | Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) | All - Inverse variance weighted | 0.0049593481281217 | 0.0023860846725666 | 0.0376683002347285 |
| Tinned tomato | Osteoarthrosis (ukb-e-740_AFR) | All - Inverse variance weighted | 1.26368229976211 | 0.614641536158298 | 0.0397857623088241 |