ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Sweetened cereal | Rheumatoid Arthritis (bbj-a-74) | rs7258015 | -6.61797743460028 | 1.70363775544166 | 0.0001024920092943 |
| Sweetened cereal | Rheumatoid Arthritis (bbj-a-74) | All - MR Egger | 3.28354801259562 | 1.41332160828043 | 0.0425341245592513 |
| Sweetened cereal | Rheumatoid arthritis (ebi-a-GCST000679) | rs76927558 | -8.974266352642 | 3.68327337003376 | 0.0148304946870625 |
| Sweetened cereal | Rheumatoid arthritis (ebi-a-GCST000679) | All - Inverse variance weighted | -7.47526813311314 | 2.56660092024167 | 0.0035852898819664 |
| Sweetened cereal | Ankylosing spondylitis (ebi-a-GCST005529) | rs7258015 | -1.63046869799641 | 0.508533789855555 | 0.0013449342833087 |
| Sweetened cereal | Rheumatoid arthritis (ebi-a-GCST005569) | rs7258015 | -10.3187196299008 | 2.28661885109499 | 6.4021427252165e-06 |
| Sweetened cereal | Heel bone mineral density (ebi-a-GCST006979) | rs148188839 | -0.546312464243962 | 0.213511180757655 | 0.0105062375406507 |
| Sweetened cereal | Heel bone mineral density (ebi-a-GCST006979) | rs7258015 | -0.601030503228383 | 0.230454969047461 | 0.00910684012192 |
| Sweetened cereal | Ultradistal forearm bone mineral density (ebi-a-GCST90013422) | rs75544795 | 3.07492162151062 | 1.43492874060485 | 0.0321204112596415 |
| Sweetened cereal | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | rs77517441 | -7.66158876300315 | 2.99306227684199 | 0.0104737658086281 |
| Sweetened cereal | Compression fracture (ebi-a-GCST90018828) | rs143267594 | -8.30036441201023 | 4.06977981568934 | 0.0413989636229602 |
| Sweetened cereal | Compression fracture (ebi-a-GCST90018828) | rs144837725 | -7.98903754346673 | 4.0578770554606 | 0.0489791992415558 |
| Sweetened cereal | Compression fracture (ebi-a-GCST90018828) | All - MR Egger | -4.76467121779119 | 1.79257627976535 | 0.0187340507672401 |
| Sweetened cereal | Other joint disorder (ebi-a-GCST90038688) | All - MR Egger | 0.031692482528857 | 0.014068601666079 | 0.0421957257558708 |
| Sweetened cereal | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | rs112071479 | -16.7177536751891 | 8.10899473069116 | 0.0392428948945567 |
| Sweetened cereal | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | rs55646860 | -29.3629834214816 | 12.4214317746631 | 0.018083846937687 |
| Sweetened cereal | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | rs61873036 | -18.1641917163949 | 7.82769891853298 | 0.0203137318803792 |
| Sweetened cereal | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | All - Inverse variance weighted | -6.24180889805825 | 2.49745629548386 | 0.0124450676447164 |
| Sweetened cereal | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | rs184935820 | -12.3816586652095 | 3.75352909798207 | 0.0009714359290034 |
| Sweetened cereal | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | rs7258015 | -18.3884710111163 | 7.50931904413233 | 0.0143351530625582 |
| Sweetened cereal | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | All - Inverse variance weighted | -5.10961677885863 | 1.74000293844283 | 0.0033187845638683 |
| Sweetened cereal | Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) | rs112071479 | 8.65745391917659 | 3.56754761855945 | 0.0152358358595713 |
| Sweetened cereal | Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) | rs7258015 | 9.93268654729415 | 4.90913931970978 | 0.0430417029845977 |
| Sweetened cereal | Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) | rs74474667 | 10.0632218646366 | 4.66676468506145 | 0.0310556128630053 |
| Sweetened cereal | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | rs74474667 | -21.5150376554 | 9.74738481477246 | 0.0272957206808012 |
| Sweetened cereal | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | All - Inverse variance weighted | -5.58752206492227 | 2.28030217748692 | 0.0142720259515857 |
| Sweetened cereal | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | rs112071479 | -8.78303569597933 | 4.01092817747524 | 0.0285404601600654 |
| Sweetened cereal | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | All - MR Egger | -6.86535703601406 | 2.60568590312643 | 0.0196036008908658 |
| Sweetened cereal | Osteoporosis with pathological fracture (FG) (finn-b-OSTEOPOROSIS_FRACTURE_FG) | rs7258015 | -13.4169273780204 | 6.73966584570325 | 0.0465093972454767 |
| Sweetened cereal | Osteoporosis with pathological fracture (FG) (finn-b-OSTEOPOROSIS_FRACTURE_FG) | All - MR Egger | 7.05021830830431 | 3.1580120567338 | 0.0424308745772043 |
| Sweetened cereal | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs184935820 | -3.56270843904364 | 1.68485968176318 | 0.0344689064011745 |
| Sweetened cereal | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs61873036 | -5.27960278521973 | 2.39088711737618 | 0.027228998138118 |
| Sweetened cereal | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs7258015 | -7.94614923783532 | 3.45303867403315 | 0.0213800566244946 |
| Sweetened cereal | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | All - Inverse variance weighted | -2.16063193044736 | 0.856476185056419 | 0.0116457914843929 |
| Sweetened cereal | Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) | All - Inverse variance weighted | 1.7999704467308 | 0.880538624519447 | 0.0409367774593073 |
| Sweetened cereal | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | All - Inverse variance weighted | 4.39796645789158 | 2.13017100637297 | 0.0389601787510282 |
| Sweetened cereal | Rheumatoid arthritis (ieu-a-834) | rs76927558 | -8.974266352642 | 3.70646399553045 | 0.0154673461154589 |
| Sweetened cereal | Rheumatoid arthritis (ieu-a-834) | All - Inverse variance weighted | -7.43780288657351 | 2.54833638359232 | 0.00351506047765 |
| Sweetened cereal | Bone morphogenetic protein receptor type-1A (prot-a-259) | rs77517441 | -6.8279233190458 | 3.39566168636286 | 0.0443488640727565 |
| Sweetened cereal | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | rs7258015 | 0.0941809017839313 | 0.0373360846701724 | 0.0116518375829155 |
| Sweetened cereal | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | All - MR Egger | -0.0445794499746174 | 0.0202195685425079 | 0.0446989362736571 |
| Sweetened cereal | Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) | All - Inverse variance weighted | 0.0283176186745256 | 0.0127062054143099 | 0.0258375474732871 |
| Sweetened cereal | Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) | All - Inverse variance weighted | 0.0245196514321922 | 0.0124730006138168 | 0.0493196163836308 |
| Sweetened cereal | Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) | rs7258015 | -0.0375740531185516 | 0.0152583746588564 | 0.0137964469132167 |
| Sweetened cereal | Fractured heel (right) (ukb-b-3499) | rs7258015 | 0.104368093922652 | 0.0514510042934168 | 0.0425097749582599 |
| Sweetened cereal | Fractured heel (right) (ukb-b-3499) | All - MR Egger | -0.0552153302012755 | 0.025891160329065 | 0.0498919524203055 |
| Sweetened cereal | Non-cancer illness code, self-reported: sciatica (ukb-b-8194) | All - Inverse variance weighted | -0.022028167873563 | 0.0109454328108404 | 0.0441625969646764 |
| Sweetened cereal | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | rs55646860 | -0.0461887203433867 | 0.0201078422300207 | 0.0216159137673535 |
| Sweetened cereal | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | rs72929235 | 0.0425095075513651 | 0.0198365308676476 | 0.0321138193107762 |
| Sweetened cereal | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | All - MR Egger | 0.0242454561187104 | 0.0112899775515965 | 0.0497461964976299 |
| Sweetened cereal | Ankle spacing width (right) (ukb-e-4119_EAS) | rs55646860 | -29.7117800730337 | 12.2078828043251 | 0.014940454002613 |
| Sweetened cereal | Ankle spacing width (right) (ukb-e-4119_EAS) | All - Inverse variance weighted | -4.40131811671623 | 1.90572811542838 | 0.0209147164215603 |
| Sweetened cereal | Internal derangement of knee (ukb-e-835_CSA) | All - Inverse variance weighted | 5.88469185237845 | 2.82398971903322 | 0.0371763630811086 |