ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Pear | Total body bone mineral density (ebi-a-GCST005348) | rs59427628 | -0.594945827673583 | 0.301056924846873 | 0.0481332081474505 |
| Pear | Total body bone mineral density (ebi-a-GCST005348) | All - MR Egger | -0.402846418797545 | 0.184606196556193 | 0.046629297504968 |
| Pear | Heel bone mineral density (ebi-a-GCST006288) | rs115587374 | 0.49930942294802 | 0.210702302374233 | 0.0178006553802661 |
| Pear | Heel bone mineral density (ebi-a-GCST006288) | rs138721349 | 0.569460394528354 | 0.211855475280197 | 0.0071888634695911 |
| Pear | Heel bone mineral density (ebi-a-GCST006288) | All - MR Egger | 0.300698311570762 | 0.108202272976227 | 0.0147772889252236 |
| Pear | Osteoprotegerin levels (ebi-a-GCST90012002) | rs6985457 | 1.03271790347763 | 0.500605627787463 | 0.0391186082012988 |
| Pear | Osteoprotegerin levels (ebi-a-GCST90012002) | All - Inverse variance weighted | 0.298755954178522 | 0.152367691894385 | 0.0499074255564154 |
| Pear | Bone mineral density (ebi-a-GCST90014022) | rs115587374 | 0.523751021377947 | 0.125463266130045 | 2.98592954166681e-05 |
| Pear | Bone mineral density (ebi-a-GCST90014022) | rs142073328 | 0.26706629522983 | 0.123494464229253 | 0.0305737243233522 |
| Pear | Bone mineral density (ebi-a-GCST90014022) | All - MR Egger | 0.229768231754008 | 0.0848101672142178 | 0.0189832555531677 |
| Pear | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | rs4953674 | 19.8746608764236 | 7.34074851878424 | 0.0067803638364096 |
| Pear | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | All - MR Egger | -10.2771785401617 | 3.70667818308743 | 0.014965199770736 |
| Pear | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | rs4953674 | 19.8081427668683 | 7.33599722524457 | 0.0069312483540906 |
| Pear | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | All - MR Egger | -10.269550451434 | 3.70921542614291 | 0.0150819300137747 |
| Pear | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs1873849 | -8.60704269242755 | 4.18614313908798 | 0.0397748630802122 |
| Pear | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | All - MR Egger | -7.54625253731559 | 3.12281664271528 | 0.0299085672961761 |
| Pear | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | rs114476136 | -9.82786156513623 | 3.750652039526 | 0.0087850519456764 |
| Pear | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | All - MR Egger | -5.67448774541197 | 1.65786502123206 | 0.0041219297462802 |
| Pear | Shoulder lesions (finn-b-M13_SHOULDER) | All - Inverse variance weighted | 0.385598176174328 | 0.160288187030815 | 0.0161434751661423 |
| Pear | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs115587374 | -4.24777325119813 | 1.70954039441125 | 0.0129643986130496 |
| Pear | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs142073328 | -1.52235321977706 | 0.77028470607523 | 0.0481149973633045 |
| Pear | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | All - MR Egger | -1.42933547424401 | 0.599421290131077 | 0.0317968072655347 |
| Pear | Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) | All - Inverse variance weighted | 0.647716136775958 | 0.295804958440683 | 0.0285479591017018 |
| Pear | Fracture of neck (finn-b-ST19_FRACT_NECK) | All - Inverse variance weighted | -1.4691071796711 | 0.742130563732893 | 0.0477506878514816 |
| Pear | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | rs142073328 | 14.1930161720754 | 5.55463751728912 | 0.0106137428345011 |
| Pear | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | All - Inverse variance weighted | 4.92293407534352 | 1.94631660024098 | 0.0114270966394163 |
| Pear | Knee and hip osteoarthritis (ieu-a-1170) | rs1609494 | 2.49829772104056 | 1.1718108449051 | 0.0330070570432204 |
| Pear | Knee and hip osteoarthritis (ieu-a-1170) | rs4953674 | 2.31816562059021 | 1.15522000864735 | 0.044782941419622 |
| Pear | Knee and hip osteoarthritis (ieu-a-1170) | rs9512379 | 2.61587209676382 | 1.04258079735787 | 0.0121061361742675 |
| Pear | Knee and hip osteoarthritis (ieu-a-1170) | All - Inverse variance weighted | 1.68108494021743 | 0.52636070826161 | 0.0014041880119164 |
| Pear | Knee osteoarthritis (ieu-a-1171) | All - Inverse variance weighted | 1.70853557152 | 0.682897199251363 | 0.0123531330427117 |
| Pear | Lumbar spine bone mineral density (ieu-a-982) | rs59427628 | -1.45926592286491 | 0.496743925997341 | 0.0033069698597531 |
| Pear | Lumbar spine bone mineral density (ieu-a-982) | rs9512379 | -1.21834051770358 | 0.491593214523151 | 0.0131991240184852 |
| Pear | Lumbar spine bone mineral density (ieu-a-982) | All - Inverse variance weighted | -0.3746688821643 | 0.167450050132837 | 0.02525391520309 |
| Pear | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs111598442 | 0.565421643908318 | 0.262601174924456 | 0.03130631610519 |
| Pear | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - MR Egger | 0.300363723277692 | 0.133936815366357 | 0.0416322535258147 |
| Pear | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | rs142073328 | 0.181385133244941 | 0.0610613274139383 | 0.0029727640838059 |
| Pear | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | All - MR Egger | 0.0865563382013743 | 0.033958172675151 | 0.0231662937145557 |
| Pear | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs115587374 | 0.575425501706643 | 0.188785415012662 | 0.0023033924310025 |
| Pear | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs116740634 | -0.428035634359547 | 0.185939311579549 | 0.0213341594740072 |
| Pear | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs142073328 | 0.409743320837893 | 0.185716683560016 | 0.0273642816978148 |
| Pear | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs59427628 | 0.385976481719752 | 0.191158603239229 | 0.0434723988530164 |
| Pear | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | All - MR Egger | 0.352653435574843 | 0.135189560242685 | 0.0206296542559928 |
| Pear | Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) | rs4744 | 0.0132616497899517 | 0.0066850732133751 | 0.0472814508850475 |
| Pear | Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) | All - Inverse variance weighted | 0.0070802590792504 | 0.002695388281825 | 0.0086190742658471 |
| Pear | Operative procedures - secondary OPCS: Z48.2 Skin of neck (ukb-b-14873) | rs17484600 | -0.021388994619729 | 0.0097174071826103 | 0.0277288748627776 |
| Pear | Operative procedures - secondary OPCS: Z48.2 Skin of neck (ukb-b-14873) | All - Inverse variance weighted | -0.01013219841824 | 0.0040319387657032 | 0.0119714696004398 |
| Pear | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs142073328 | 0.166609198916917 | 0.0521632379021712 | 0.0014031782197959 |
| Pear | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | All - MR Egger | 0.0856650443784197 | 0.0279521866631896 | 0.0084011001759809 |
| Pear | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs115587374 | 0.454627638921888 | 0.154893052311936 | 0.0033343298677306 |
| Pear | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs138721349 | 0.335966914276577 | 0.155712411507319 | 0.0309580375845094 |
| Pear | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | All - MR Egger | 0.25575544123485 | 0.098755838585367 | 0.0213988058726864 |
| Pear | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs111598442 | 0.414302990383072 | 0.207259526988545 | 0.0456129501481609 |
| Pear | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs142073328 | 0.425085258286091 | 0.204587357702262 | 0.0377306454602455 |
| Pear | Heel bone mineral density (BMD) (right) (ukb-b-4657) | All - Inverse variance weighted | 0.0999138811546032 | 0.0505420770957378 | 0.0480590890023671 |
| Pear | Heel bone mineral density (BMD) (right) (ukb-b-4657) | All - MR Egger | 0.249369095710872 | 0.109336361039778 | 0.038737153780113 |
| Pear | Heel bone mineral density (BMD) (ukb-b-8875) | rs115587374 | 0.450760407430802 | 0.154864463387826 | 0.0036064681157675 |
| Pear | Heel bone mineral density (BMD) (ukb-b-8875) | rs138721349 | 0.318428282769548 | 0.155668801151313 | 0.0408006862338718 |
| Pear | Heel bone mineral density (BMD) (ukb-b-8875) | All - MR Egger | 0.244189744429165 | 0.0984763060784622 | 0.0264854246102808 |
| Pear | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | rs34798770 | 0.0218308140357497 | 0.0108929160967788 | 0.0450561945672525 |
| Pear | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | rs4744 | -0.0232498967970666 | 0.0105507879847502 | 0.0275512838279519 |
| Pear | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | rs4953674 | -0.0219203778228623 | 0.0100541172334168 | 0.0292397551063121 |
| Pear | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | All - MR Egger | -0.207341376564407 | 0.0567251840695126 | 0.0216719875965327 |
| Pear | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | rs59427628 | -0.0182300720027812 | 0.0083900622542712 | 0.0297940744046476 |
| Pear | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | All - Inverse variance weighted | 0.0043930519984099 | 0.0020759454470679 | 0.034330412264258 |
| Pear | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | rs142073328 | 0.0174751836907827 | 0.0080786340978495 | 0.0305307262418267 |
| Pear | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | All - Inverse variance weighted | 0.0042863961820576 | 0.0020638646128745 | 0.0378127682920322 |
| Pear | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | rs59427628 | -0.0182300720027812 | 0.0083900622542712 | 0.0297940744046476 |
| Pear | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | 0.0043930519984099 | 0.0020759454470679 | 0.034330412264258 |
| Pear | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | All - MR Egger | -2.97294694543467 | 1.33229191455935 | 0.0497198111378446 |
| Pear | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | rs1873849 | -2.22083722862782 | 0.844707593227381 | 0.0085606265746259 |
| Pear | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | rs59427628 | -4.10727661755377 | 2.01242218216094 | 0.0412546331911227 |
| Pear | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | All - Inverse variance weighted | -1.12220951456014 | 0.500137593433398 | 0.0248451717171639 |
| Pear | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | All - MR Egger | -2.84899391543099 | 1.03459419327294 | 0.024914889578133 |
| Pear | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | rs1873849 | -2.19175236314532 | 0.839098369170043 | 0.0090005649647452 |
| Pear | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | All - Inverse variance weighted | -1.07436915178643 | 0.520301852373879 | 0.0389328529317544 |
| Pear | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | All - MR Egger | -2.89310538323103 | 1.02751735727495 | 0.0226459014896544 |
| Pear | Ankle spacing width (right) (ukb-e-4119_EAS) | rs17484600 | -7.83379797751191 | 2.65670167786271 | 0.003191206793725 |