ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Beef | Rheumatoid arthritis (bbj-a-151) | All - Inverse variance weighted | -1.48108236716384 | 0.55904609406732 | 0.0080658035186782 |
| Beef | Osteoarthritis (Firth correction) (ebi-a-GCST90013881) | rs6739502 | 0.944796023817726 | 0.398729885340288 | 0.0178114833721095 |
| Beef | Osteoarthritis (Firth correction) (ebi-a-GCST90013881) | All - Inverse variance weighted | 0.469976596540055 | 0.214325876503826 | 0.0283208454034138 |
| Beef | Osteoarthritis (SPA correction) (ebi-a-GCST90013931) | rs6739502 | 0.944855076029723 | 0.39870183553959 | 0.0177963255456501 |
| Beef | Osteoarthritis (SPA correction) (ebi-a-GCST90013931) | All - Inverse variance weighted | 0.469997667582647 | 0.214330210720103 | 0.0283169557457614 |
| Beef | Rheumatoid arthritis (ebi-a-GCST90018690) | rs7699859 | -1.99292012335491 | 0.996568648742562 | 0.0455238006526386 |
| Beef | Rheumatoid arthritis (ebi-a-GCST90018690) | All - Inverse variance weighted | -1.33203594607952 | 0.509431323554783 | 0.0089292585072521 |
| Beef | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | rs143363049 | 1.88622726464283 | 0.75261871998652 | 0.0122030043620267 |
| Beef | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | All - MR Egger | 2.03461318315457 | 0.70085059375242 | 0.0336704161924095 |
| Beef | Osteoarthritis (ebi-a-GCST90038686) | rs2602248 | 0.0754261201143947 | 0.0276712106768351 | 0.006414631684179 |
| Beef | Osteoarthritis (ebi-a-GCST90038686) | All - Inverse variance weighted | 0.0265640195944607 | 0.0135475721675953 | 0.0499028741473517 |
| Beef | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | All - Inverse variance weighted | 5.44018990623741 | 2.59989786276733 | 0.0363971242717374 |
| Beef | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | All - Inverse variance weighted | 5.40891261030805 | 2.59796893497608 | 0.037344534019167 |
| Beef | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | All - Inverse variance weighted | 4.02487609950865 | 1.7020055772173 | 0.0180405738434433 |
| Beef | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | All - Inverse variance weighted | 0.910519159987524 | 0.44718986605513 | 0.0417412411172094 |
| Beef | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs143363049 | 12.0503243562021 | 5.10170649742106 | 0.0181757425810115 |
| Beef | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | All - Inverse variance weighted | 2.51921189796872 | 1.00088713837916 | 0.0118365887493096 |
| Beef | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | rs7697997 | -13.5267377230152 | 4.91224010682556 | 0.0058929341058557 |
| Beef | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | All - Inverse variance weighted | -4.61188407057199 | 2.00541027561687 | 0.0214640331259205 |
| Beef | Infective bursitis (finn-b-M13_INFBURSA) | rs6739502 | -8.96117317061168 | 3.50868559618129 | 0.0106494114462265 |
| Beef | Infective bursitis (finn-b-M13_INFBURSA) | All - Inverse variance weighted | -3.24751376096302 | 1.46779702288975 | 0.0269315320743804 |
| Beef | Shoulder lesions (finn-b-M13_SHOULDER) | All - Inverse variance weighted | 0.47411055332552 | 0.240031605971764 | 0.0482453967545732 |
| Beef | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | All - Inverse variance weighted | -5.11899712086382 | 2.1318518028074 | 0.0163415160230559 |
| Beef | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | rs2602248 | -3.15538608198284 | 1.56339370829361 | 0.0435607883214252 |
| Beef | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | rs7697997 | -3.89990406910881 | 1.52814535217242 | 0.0107091003573958 |
| Beef | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | All - Inverse variance weighted | -1.74984073424327 | 0.621470504772142 | 0.0048679323059028 |
| Beef | Injuries to the neck (finn-b-ST19_INJURI_NECK) | rs117540843 | -4.03648590278895 | 1.65660227147612 | 0.0148258514715735 |
| Beef | Injuries to the neck (finn-b-ST19_INJURI_NECK) | rs2602248 | -3.13155386081983 | 1.25357483317445 | 0.0124861367757913 |
| Beef | Injuries to the neck (finn-b-ST19_INJURI_NECK) | All - Inverse variance weighted | -1.37703000907414 | 0.593309218252148 | 0.0202905452217357 |
| Beef | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | rs7697997 | -15.3393012953081 | 7.11045550301049 | 0.0309832208645857 |
| Beef | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | All - Inverse variance weighted | -7.35917236617709 | 2.91840362612323 | 0.0116808154349299 |
| Beef | Forearm bone mineral density (ieu-a-977) | rs6739502 | -2.37153683381723 | 0.835736430293785 | 0.004544539378306 |
| Beef | Bone sialoprotein 2 (prot-a-1396) | rs117540843 | 2.4925258103038 | 1.06374869783947 | 0.0191215467836472 |
| Beef | Bone sialoprotein 2 (prot-a-1396) | All - MR Egger | 1.97526708758941 | 0.804304315713407 | 0.0493955269237578 |
| Beef | Osteocrin (prot-a-2157) | All - Inverse variance weighted | 1.00622674862958 | 0.415641755307451 | 0.0154821742292812 |
| Beef | Bone morphogenetic protein receptor type-1A (prot-a-259) | rs117540843 | 2.51962768795576 | 1.06374869783947 | 0.017854076965251 |
| Beef | Bone morphogenetic protein receptor type-1A (prot-a-259) | rs328328 | -3.01842551925668 | 1.18112302927435 | 0.0106018435684866 |
| Beef | Bone proteoglycan II (prot-c-2666_53_2) | rs2602248 | 4.52621544327931 | 2.19399904671115 | 0.0391128269502144 |
| Beef | Bone proteoglycan II (prot-c-2666_53_2) | rs7699859 | 4.43710878493487 | 2.24777637821116 | 0.0483818332748312 |
| Beef | Bone proteoglycan II (prot-c-2666_53_2) | All - Inverse variance weighted | 3.14178462768609 | 1.32218538888479 | 0.0174917025382293 |
| Beef | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | rs2602248 | 0.0759737845567207 | 0.0340825071496663 | 0.0258063387654582 |
| Beef | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | rs6739502 | 0.0759076817085773 | 0.033192313370405 | 0.0222013435690021 |
| Beef | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | rs7699859 | 0.0663611750568272 | 0.0333563537911364 | 0.0466503090607225 |
| Beef | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | All - Inverse variance weighted | 0.0325784436455087 | 0.0141589417712881 | 0.0213967469685656 |
| Beef | Fractured/broken bones in last 5 years (ukb-a-308) | rs143363049 | 0.0701655012309622 | 0.0327887144635719 | 0.0323605536704773 |
| Beef | Fractured/broken bones in last 5 years (ukb-a-308) | All - Inverse variance weighted | 0.0287934193299135 | 0.0134283535564946 | 0.0320148155969738 |
| Beef | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | rs7699859 | 0.0356640460988287 | 0.0166603927473493 | 0.0323023879371318 |
| Beef | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | All - Inverse variance weighted | 0.0146195251989843 | 0.0058023418057321 | 0.0117491438217372 |
| Beef | Operation code: knee replacement/revision (ukb-b-11120) | All - Inverse variance weighted | 0.012265647491183 | 0.0050306770118666 | 0.0147618160357448 |
| Beef | Fractured/broken bones in last 5 years (ukb-b-13346) | rs143363049 | 0.0666530933191047 | 0.0284253044642272 | 0.0190347031451031 |
| Beef | Fractured/broken bones in last 5 years (ukb-b-13346) | All - Inverse variance weighted | 0.0259418265627224 | 0.0123235014095179 | 0.035285261456438 |
| Beef | Heel bone ultrasound T-score, manual entry (ukb-b-17612) | rs143363049 | -0.98681045054153 | 0.314504760032576 | 0.001702996279278 |
| Beef | Heel bone ultrasound T-score, manual entry (ukb-b-17612) | All - Inverse variance weighted | -0.266560124879884 | 0.126759259209772 | 0.0354758370990734 |
| Beef | Heel bone ultrasound T-score, manual entry (ukb-b-17612) | All - MR Egger | -0.60708475698742 | 0.229483810678219 | 0.038261303382416 |
| Beef | Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) | rs7697997 | 0.0139880737173461 | 0.0066870580068549 | 0.0364552624244147 |
| Beef | Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) | All - Inverse variance weighted | 0.0084524162462252 | 0.0029342797156508 | 0.0039694901524789 |
| Beef | Diagnoses - main ICD10: M54.56 Low back pain (Lumbar region) (ukb-b-19813) | rs7697997 | -0.0141202076735072 | 0.0057765822571237 | 0.0145098171903571 |
| Beef | Diagnoses - main ICD10: M54.56 Low back pain (Lumbar region) (ukb-b-19813) | All - Inverse variance weighted | -0.0062886427735331 | 0.0025921784344776 | 0.0152659799417738 |
| Beef | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | rs6739502 | 0.0204642980168299 | 0.0066346636484425 | 0.0020392787977462 |
| Beef | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | All - Inverse variance weighted | 0.0079471045658471 | 0.0039303336053773 | 0.043177140001193 |
| Beef | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | All - Inverse variance weighted | -0.0062391774509656 | 0.0025088533490234 | 0.0128874600840222 |
| Beef | Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) | All - Inverse variance weighted | -0.0051562601031198 | 0.0025908586746636 | 0.0465717487858829 |
| Beef | Other joint disorders (ukb-d-M13_OTHERJOINT) | All - Inverse variance weighted | 0.023142704701009 | 0.0107131791624718 | 0.0307565034636835 |
| Beef | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | -0.0062391774509656 | 0.0025088533490234 | 0.0128874600840222 |
| Beef | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | All - Inverse variance weighted | 0.0061972820068591 | 0.002931397824694 | 0.0345063232910162 |
| Beef | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | rs6739502 | -9.98474484523399 | 4.80832636189164 | 0.0378428286093255 |
| Beef | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | All - Inverse variance weighted | -4.55415439308396 | 1.84654127929452 | 0.0136510825203634 |