ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Sweet pepper (ukb-b-10932)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sweet pepper (👉 📊) Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) MR Egger 10 3.514263028 1.318373196 0.028556153
Sweet pepper (👉 📊) Achilles tendon injury (ebi-a-GCST90018567) Inverse variance weighted 5 -3.088766101 1.56356251 0.048215179
Sweet pepper (👉 📊) Fracture of forearm or wrist (ebi-a-GCST90038705) Inverse variance weighted 10 -0.00454272 0.002101653 0.030656829
Sweet pepper (👉 📊) Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) Inverse variance weighted 9 -2.405217156 1.041327725 0.020901443
Sweet pepper (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) Inverse variance weighted 9 -2.393019723 1.042840714 0.0217496
Sweet pepper (👉 📊) Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) Weighted median 9 5.25632617 2.645738675 0.046954095
Sweet pepper (👉 📊) Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) Inverse variance weighted 9 -3.531199164 1.178831682 0.002739885
Sweet pepper (👉 📊) Cervical disc disorders (finn-b-M13_CERVICDISC) Weighted median 9 0.861244314 0.402484845 0.032369478
Sweet pepper (👉 📊) Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) MR Egger 9 -1.289938253 0.505404171 0.037976437
Sweet pepper (👉 📊) Loose body in joint (finn-b-M13_LOOSEJOINT) Weighted median 9 3.13310893 1.5670767 0.045572283
Sweet pepper (👉 📊) Loose body in joint (finn-b-M13_LOOSEJOINT) Inverse variance weighted 9 3.602155768 1.159694998 0.001895576
Sweet pepper (👉 📊) Osteoporosis (finn-b-M13_OSTEOPOROSIS) MR Egger 9 -3.858640408 1.125110365 0.010991682
Sweet pepper (👉 📊) Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) Inverse variance weighted 9 2.086196111 0.972082597 0.031864209
Sweet pepper (👉 📊) Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) Weighted median 9 -5.764663781 2.440667563 0.01818052
Sweet pepper (👉 📊) Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) Inverse variance weighted 9 -6.050036346 1.867549043 0.001197145
Sweet pepper (👉 📊) Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) MR Egger 9 2.929092357 1.187074687 0.042990942
Sweet pepper (👉 📊) Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) Inverse variance weighted 9 2.053893387 0.929465256 0.027121954
Sweet pepper (👉 📊) Bone morphogenetic protein 10 (prot-a-254) MR Egger 10 2.099441999 0.85816138 0.040158965
Sweet pepper (👉 📊) Bone morphogenetic protein receptor type-1A (prot-a-259) Weighted median 10 -1.106178168 0.511154682 0.030458429
Sweet pepper (👉 📊) Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) Wald ratio 1 -0.012471121 0.005531701 0.024165843
Sweet pepper (👉 📊) Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) Weighted median 3 0.009417195 0.00446634 0.034989361
Sweet pepper (👉 📊) Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) Inverse variance weighted 3 0.008937089 0.0035621 0.012109472
Sweet pepper (👉 📊) Fractured heel (ukb-b-18389) MR Egger 10 0.01481822 0.005180355 0.021136332
Sweet pepper (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) Weighted median 10 0.143699181 0.069515232 0.038718979
Sweet pepper (👉 📊) Fractured heel (right) (ukb-b-3499) MR Egger 10 -0.039659427 0.0145364 0.025914486
Sweet pepper (👉 📊) Fractured heel (right) (ukb-b-3499) Weighted median 10 -0.018668426 0.008518063 0.02840637
Sweet pepper (👉 📊) Fractured heel (right) (ukb-b-3499) Inverse variance weighted 10 -0.017709918 0.006192232 0.004236116
Sweet pepper (👉 📊) Heel bone mineral density (BMD) (right) (ukb-b-4657) Weighted median 10 0.146436104 0.072027036 0.042045314
Sweet pepper (👉 📊) Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) Inverse variance weighted 4 -0.007973985 0.003955079 0.043785586
Sweet pepper (👉 📊) Ankle spacing width (right) (ukb-b-8607) Weighted median 10 -0.15700671 0.071930466 0.029053729
Sweet pepper (👉 📊) Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) Inverse variance weighted 6 -0.008580788 0.004202292 0.041158442
Sweet pepper (👉 📊) Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) Weighted median 10 -0.0102529 0.004874659 0.035439036
Sweet pepper (👉 📊) Ankle spacing width (left) (ukb-e-4100_CSA) MR Egger 7 -3.664977106 1.206768483 0.028848943

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Sweet pepper Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) rs186726688 11.4312534835284 5.1756480585135 0.0271982092834594
Sweet pepper Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) All - MR Egger 3.51426302782782 1.31837319623276 0.0285561530918063
Sweet pepper Achilles tendon injury (ebi-a-GCST90018567) All - Inverse variance weighted -3.08876610082009 1.56356251035116 0.048215178928348
Sweet pepper Fracture of forearm or wrist (ebi-a-GCST90038705) All - Inverse variance weighted -0.0045427200543209 0.0021016528160918 0.0306568290253071
Sweet pepper Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) All - Inverse variance weighted -2.4052171562311 1.04132772490409 0.0209014433450519
Sweet pepper Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) All - Inverse variance weighted -2.3930197230637 1.04284071383741 0.021749600385507
Sweet pepper Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs1267469 -6.39432544438602 3.02407832558808 0.0344750725746219
Sweet pepper Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) All - Inverse variance weighted -3.53119916358914 1.17883168162413 0.0027398854808323
Sweet pepper Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs28608590 1.60579944214713 0.566206739716618 0.0045673067430414
Sweet pepper Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs34710626 1.00681810152966 0.497521225609684 0.0430042574370729
Sweet pepper Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) All - MR Egger -1.28993825254492 0.505404170513224 0.0379764371828403
Sweet pepper Loose body in joint (finn-b-M13_LOOSEJOINT) rs78836938 11.4484460092366 5.2108927224047 0.028018874233668
Sweet pepper Loose body in joint (finn-b-M13_LOOSEJOINT) All - Inverse variance weighted 3.60215576819731 1.15969499751737 0.0018955759319351
Sweet pepper Osteoporosis (finn-b-M13_OSTEOPOROSIS) rs62188982 -3.02199789424615 1.01001170756276 0.0027711773521902
Sweet pepper Osteoporosis (finn-b-M13_OSTEOPOROSIS) rs78836938 -3.98182372249354 1.82392490197247 0.0290279109648509
Sweet pepper Osteoporosis (finn-b-M13_OSTEOPOROSIS) All - MR Egger -3.85864040758663 1.12511036498757 0.0109916823385005
Sweet pepper Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) rs34710626 5.93198384380777 2.68484827074575 0.0271447584789653
Sweet pepper Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) All - Inverse variance weighted 2.08619611119257 0.972082596650353 0.0318642094099889
Sweet pepper Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) rs62188982 -11.7129209163512 4.69508094828579 0.0126055908200906
Sweet pepper Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) All - Inverse variance weighted -6.05003634617148 1.86754904278309 0.0011971446329441
Sweet pepper Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) rs28608590 -3.72675419665938 1.29020880033787 0.0038709731110456
Sweet pepper Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) rs78836938 3.98519719641827 1.88127395869294 0.0341454142761238
Sweet pepper Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) All - MR Egger 2.92909235718177 1.18707468734402 0.0429909424772631
Sweet pepper Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) rs62286519 4.97354181784445 2.51162205058367 0.0476798151621827
Sweet pepper Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) All - Inverse variance weighted 2.05389338672629 0.929465255534278 0.0271219543749959
Sweet pepper Bone morphogenetic protein 10 (prot-a-254) rs79955297 2.5180245458536 1.19963199259175 0.0358171216662462
Sweet pepper Bone morphogenetic protein 10 (prot-a-254) All - MR Egger 2.09944199894552 0.858161380125943 0.0401589645151269
Sweet pepper Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) rs28608590 -0.012471121135755 0.0055317006158658 0.0241658428503147
Sweet pepper Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) rs1267469 0.0113122736431653 0.0057522803052816 0.0492325689401305
Sweet pepper Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) All - Inverse variance weighted 0.0089370890991905 0.0035621003577786 0.0121094722098127
Sweet pepper Fractured heel (ukb-b-18389) rs78836938 0.0191049948779421 0.0071975315166801 0.0079453928795829
Sweet pepper Fractured heel (ukb-b-18389) All - MR Egger 0.0148182202782025 0.0051803554470362 0.0211363317589166
Sweet pepper Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) rs186726688 0.320207887197239 0.157867151671605 0.0425257990141303
Sweet pepper Fractured heel (right) (ukb-b-3499) rs186726688 -0.0588078265716213 0.0190684189425719 0.0020420798395585
Sweet pepper Fractured heel (right) (ukb-b-3499) All - Inverse variance weighted -0.0177099184384364 0.0061922315304157 0.0042361161300173
Sweet pepper Fractured heel (right) (ukb-b-3499) All - MR Egger -0.0396594274683113 0.0145363999675631 0.0259144856043849
Sweet pepper Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) rs113397084 -0.0201953467869475 0.0073103856281682 0.0057350792177885
Sweet pepper Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) All - Inverse variance weighted -0.0079739845519138 0.003955079473791 0.0437855862443911
Sweet pepper Ankle spacing width (right) (ukb-b-8607) rs1267469 0.317565127086402 0.134932676701207 0.0185972102833029
Sweet pepper Ankle spacing width (right) (ukb-b-8607) rs62188982 -0.535592866156035 0.152289404521745 0.000436550638432
Sweet pepper Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) All - Inverse variance weighted -0.0085807877626288 0.0042022921231121 0.0411584422041677
Sweet pepper Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) rs1267469 0.0205716357128628 0.0098479143330209 0.0367137320753944
Sweet pepper Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) rs62188982 -0.0261654651010146 0.0112585763925168 0.0201229541632511
Sweet pepper Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) rs62286519 -0.0214783447151562 0.0107379132330673 0.0454749459759209
Sweet pepper Ankle spacing width (left) (ukb-e-4100_CSA) rs78836938 -2.98439993208073 1.04645161145227 0.004345555864467
Sweet pepper Ankle spacing width (left) (ukb-e-4100_CSA) All - MR Egger -3.66497710580011 1.20676848285222 0.0288489427758201