ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Salted peanuts | Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) | All - Inverse variance weighted | -1.15566904789032 | 0.56284277955563 | 0.0400462516739485 |
| Salted peanuts | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs7190023 | 9.03043732388837 | 2.95586631655166 | 0.0022499307081682 |
| Salted peanuts | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | All - Inverse variance weighted | 1.84070903924638 | 0.78450940626922 | 0.0189598910702683 |
| Salted peanuts | Heel bone mineral density (ebi-a-GCST006979) | rs142627973 | -0.540681577342219 | 0.170844073161065 | 0.0015520752170687 |
| Salted peanuts | Heel bone mineral density (ebi-a-GCST006979) | rs28868570 | 0.3533858143396 | 0.173979469746122 | 0.0422354591126888 |
| Salted peanuts | Heel bone mineral density (ebi-a-GCST006979) | rs9421416 | 0.363924831969274 | 0.176359105665036 | 0.0390609408624656 |
| Salted peanuts | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs181745116 | -8.51177455299833 | 3.65817337811053 | 0.0199768332952946 |
| Salted peanuts | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | All - MR Egger | -5.82348356453178 | 2.36613708822925 | 0.0360888599425969 |
| Salted peanuts | Bone disorder (ebi-a-GCST90038652) | rs9421416 | -0.0594154359654337 | 0.0277327663725176 | 0.0321591124847119 |
| Salted peanuts | Bone disorder (ebi-a-GCST90038652) | All - Inverse variance weighted | -0.0264209673163632 | 0.0082525782130477 | 0.0013669463141139 |
| Salted peanuts | Osteoporosis (ebi-a-GCST90038656) | rs9421416 | -0.0486919512901407 | 0.0236528584274458 | 0.0395318555926436 |
| Salted peanuts | Osteoporosis (ebi-a-GCST90038656) | All - Inverse variance weighted | -0.0209986277493053 | 0.0070385209151476 | 0.0028507781738571 |
| Salted peanuts | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | rs11137480 | 24.6714358447745 | 11.6841987176721 | 0.0347275189526505 |
| Salted peanuts | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | All - Inverse variance weighted | 6.49227083372856 | 3.17339846559234 | 0.0407719502316944 |
| Salted peanuts | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | rs11137480 | 24.6369182710147 | 11.6928281111121 | 0.0351166200102655 |
| Salted peanuts | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | All - Inverse variance weighted | 6.45244866027578 | 3.17256029891225 | 0.0419687276101857 |
| Salted peanuts | Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) | All - Inverse variance weighted | 3.13549882350504 | 1.46069237410268 | 0.0318264178582266 |
| Salted peanuts | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | rs6975809 | -15.2642068931992 | 6.98625665812482 | 0.0288968647902405 |
| Salted peanuts | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | All - MR Egger | 8.69199627743168 | 3.8008460398129 | 0.0430145913476774 |
| Salted peanuts | Pain in joint (finn-b-JOINTPAIN) | rs138462855 | 2.79363536985303 | 1.42017584019285 | 0.0491710766228247 |
| Salted peanuts | Pain in joint (finn-b-JOINTPAIN) | rs28868570 | 2.03773007724132 | 0.917718630428293 | 0.0263895851944561 |
| Salted peanuts | Pain in joint (finn-b-JOINTPAIN) | All - MR Egger | 1.71730563386706 | 0.654460711865687 | 0.0236591329246374 |
| Salted peanuts | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs117611360 | -8.61790113747986 | 4.22289026123755 | 0.0412747916847708 |
| Salted peanuts | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | All - Inverse variance weighted | 1.31456363064615 | 0.557805397729271 | 0.0184395911186982 |
| Salted peanuts | Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) | All - MR Egger | 18.593258316058 | 7.46269591933514 | 0.0299558137895056 |
| Salted peanuts | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | rs28868570 | -6.87055480038386 | 3.40444008062109 | 0.0435791877412711 |
| Salted peanuts | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | rs922863 | -10.8518906405027 | 3.92735089846764 | 0.0057245066810824 |
| Salted peanuts | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | All - Inverse variance weighted | -2.93359459102707 | 1.35778499716033 | 0.0307282827850873 |
| Salted peanuts | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs144387937 | -3.76642140838967 | 1.84668019555159 | 0.0413938267577404 |
| Salted peanuts | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | All - Inverse variance weighted | -0.903784441529828 | 0.385158841784955 | 0.018949449019115 |
| Salted peanuts | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs117611360 | -8.35081742454143 | 3.85787585355503 | 0.0304171518400152 |
| Salted peanuts | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | 1.06795760415929 | 0.510419089673487 | 0.0364103316042499 |
| Salted peanuts | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs11137480 | -22.4364229438313 | 5.96291086699516 | 0.0001681137975674 |
| Salted peanuts | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs28639739 | -15.8495261958615 | 5.52421151760264 | 0.0041163905552427 |
| Salted peanuts | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | -5.23841998178667 | 2.15457761229618 | 0.01504483981246 |
| Salted peanuts | Forearm bone mineral density (ieu-a-977) | rs138462855 | -3.67850457975564 | 1.3873498459919 | 0.0080144270702065 |
| Salted peanuts | Forearm bone mineral density (ieu-a-977) | rs181745116 | -3.07387209744174 | 1.41880025880396 | 0.0302707759721156 |
| Salted peanuts | Forearm bone mineral density (ieu-a-977) | All - MR Egger | -1.90758080588621 | 0.84072299015408 | 0.0425164819598414 |
| Salted peanuts | Bone proteoglycan II (prot-c-2666_53_2) | rs28868570 | -8.14598633783394 | 3.58855121338685 | 0.0232080043271615 |
| Salted peanuts | Fractured bone site(s): Arm (ukb-a-440) | rs1209910 | -0.0504212935341104 | 0.0224334577059049 | 0.0246021229662733 |
| Salted peanuts | Fractured bone site(s): Arm (ukb-a-440) | All - Inverse variance weighted | -0.012439836167559 | 0.0059319416182362 | 0.0359852999107202 |
| Salted peanuts | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs138462855 | 0.531142649811422 | 0.264730431316123 | 0.0448186172874441 |
| Salted peanuts | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | rs11137480 | -0.0560438545774618 | 0.0214531898552851 | 0.0089914613625768 |
| Salted peanuts | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | rs1209910 | -0.0478214912241645 | 0.0219573096342734 | 0.0294112219907259 |
| Salted peanuts | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | All - MR Egger | 0.0305027994079636 | 0.0109643459268153 | 0.0165888066838666 |
| Salted peanuts | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | rs117611360 | 0.0630270080985717 | 0.0284648918459342 | 0.026814916204575 |
| Salted peanuts | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | rs181745116 | -0.0562259810415832 | 0.0272368569697343 | 0.0389860206899549 |
| Salted peanuts | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | rs922863 | -0.0625913625840591 | 0.0290145794289494 | 0.0309871001211212 |
| Salted peanuts | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | All - Inverse variance weighted | -0.021307332518004 | 0.0083431677015483 | 0.0106534240230214 |
| Salted peanuts | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | rs9421416 | -0.0578151433404966 | 0.0251982457744654 | 0.0217668767328466 |
| Salted peanuts | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | All - Inverse variance weighted | -0.0303501826130917 | 0.0085618151620569 | 0.0003928657932026 |
| Salted peanuts | Operative procedures - secondary OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-12747) | rs11137480 | -0.0222703071201125 | 0.0096357533029003 | 0.0208209275229488 |
| Salted peanuts | Operative procedures - secondary OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-12747) | All - Inverse variance weighted | -0.0112931794930194 | 0.0050673761070296 | 0.0258402011859909 |
| Salted peanuts | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | rs28639739 | 0.0340013957672936 | 0.0137887514609311 | 0.0136677410289292 |
| Salted peanuts | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | rs6975809 | 0.0336907018896227 | 0.0155189344222449 | 0.0299355795767617 |
| Salted peanuts | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs6975809 | -0.0616826044987048 | 0.0211385653867789 | 0.0035226988234233 |
| Salted peanuts | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - MR Egger | -0.237471248701039 | 0.082374710466106 | 0.0448857362617603 |
| Salted peanuts | Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) | All - Inverse variance weighted | 0.0122719636201429 | 0.0052783996550958 | 0.0200751573142307 |
| Salted peanuts | Fractured bone site(s): Other bones (ukb-b-17738) | rs28868570 | 0.0847643905435509 | 0.0430530919963587 | 0.0489721586534745 |
| Salted peanuts | Fractured bone site(s): Other bones (ukb-b-17738) | rs922863 | 0.137234731562121 | 0.0446488810494984 | 0.002114621426672 |
| Salted peanuts | Fractured bone site(s): Other bones (ukb-b-17738) | All - Inverse variance weighted | 0.0344001211742825 | 0.0153024238843942 | 0.0245750553363367 |
| Salted peanuts | Fractured bone site(s): Arm (ukb-b-19255) | rs1209910 | -0.0451367356207201 | 0.0192902748960346 | 0.0192904529543287 |
| Salted peanuts | Fractured bone site(s): Arm (ukb-b-19255) | All - Inverse variance weighted | -0.0198741721832129 | 0.007851946972697 | 0.0113700917442435 |
| Salted peanuts | Ankle spacing width (left) (ukb-b-2122) | rs117611360 | 0.657827184967342 | 0.295617749790043 | 0.0260636004225274 |
| Salted peanuts | Ankle spacing width (left) (ukb-b-2122) | rs142627973 | 0.791689973381155 | 0.278120546543626 | 0.0044192827661882 |
| Salted peanuts | Ankle spacing width (left) (ukb-b-2122) | rs28639739 | -0.704714498322557 | 0.265491755723907 | 0.00794556321121 |
| Salted peanuts | Ankle spacing width (left) (ukb-b-2122) | All - MR Egger | 0.64728763553307 | 0.139601321796867 | 0.0005734491155628 |
| Salted peanuts | Ankle spacing width (right) (ukb-b-8607) | rs117611360 | 0.798028328679152 | 0.29888151276215 | 0.0075840144943 |
| Salted peanuts | Ankle spacing width (right) (ukb-b-8607) | rs142627973 | 0.689790675252907 | 0.281801367764495 | 0.0143735254100771 |
| Salted peanuts | Ankle spacing width (right) (ukb-b-8607) | rs28639739 | -0.701536184846676 | 0.268741539211812 | 0.0090423352744279 |
| Salted peanuts | Ankle spacing width (right) (ukb-b-8607) | All - MR Egger | 0.607407490828517 | 0.141329398410613 | 0.0010358842292564 |
| Salted peanuts | Other joint disorders (ukb-d-M13_OTHERJOINT) | rs144387937 | -0.143088742682876 | 0.0490287293555388 | 0.0035175678289949 |
| Salted peanuts | Other joint disorders (ukb-d-M13_OTHERJOINT) | All - MR Egger | -0.0794565863046321 | 0.0303762992017015 | 0.0225613962384207 |
| Salted peanuts | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs1209910 | -0.0336079325360428 | 0.0153521465399788 | 0.0285869761983778 |
| Salted peanuts | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | All - Inverse variance weighted | -0.009105724934524 | 0.0041980287761763 | 0.0300790577616398 |
| Salted peanuts | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | rs11137480 | -0.0308401577453121 | 0.0151367327390558 | 0.0416061474909334 |
| Salted peanuts | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | rs1209910 | -0.0304247664674924 | 0.0154948039573631 | 0.0495827189785421 |
| Salted peanuts | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | rs922863 | -0.0322244653290707 | 0.0162737708080697 | 0.0476869657191232 |
| Salted peanuts | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | All - Inverse variance weighted | -0.0091876471272377 | 0.0042933132473989 | 0.0323555803453544 |
| Salted peanuts | Fractured/broken bones in last 5 years (ukb-e-2463_CSA) | rs9421416 | -13.888253852133 | 5.97823602030086 | 0.0201718607135407 |
| Salted peanuts | Fractured/broken bones in last 5 years (ukb-e-2463_CSA) | All - Inverse variance weighted | -3.43955359677881 | 1.42082276006365 | 0.0154856197025528 |
| Salted peanuts | Heel bone mineral density (BMD) (ukb-e-3148_EAS) | rs435571 | -4.3179166157644 | 2.2027693642763 | 0.0499698668851057 |