ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Muesli (ukb-b-11004)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Muesli (👉 📊) Neck circumference (ebi-a-GCST90017135) Inverse variance weighted 10 -1.693663346 0.750756534 0.024074251
Muesli (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017136) MR Egger 10 -4.949457319 1.741014997 0.021716301
Muesli (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017138) Inverse variance weighted 10 -1.224700438 0.579977284 0.034717753
Muesli (👉 📊) Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) MR Egger 10 16.83668111 6.834337875 0.039102175
Muesli (👉 📊) Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) MR Egger 10 16.87892615 6.832869171 0.038695091
Muesli (👉 📊) Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) Inverse variance weighted 10 -2.042738357 1.026448156 0.046579504
Muesli (👉 📊) Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) Weighted median 10 -4.599711658 1.953871845 0.018565009
Muesli (👉 📊) Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) Inverse variance weighted 10 -3.806212419 1.589997755 0.016672672
Muesli (👉 📊) Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) Weighted median 10 -0.582680689 0.284803223 0.040765597
Muesli (👉 📊) Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) Weighted median 10 -2.811145884 1.216924677 0.020885885
Muesli (👉 📊) Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) Inverse variance weighted 10 -2.738748141 0.882898818 0.001922209
Muesli (👉 📊) Otherdisorders of bone (finn-b-M13_OTHERBONE) Weighted median 10 -1.195034901 0.604026815 0.047878328
Muesli (👉 📊) Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) Inverse variance weighted 10 -1.499775941 0.663177607 0.023728333
Muesli (👉 📊) Shoulder lesions (finn-b-M13_SHOULDER) MR Egger 10 -2.299335827 0.819748254 0.023022257
Muesli (👉 📊) Shoulder lesions (finn-b-M13_SHOULDER) Inverse variance weighted 10 -0.521814942 0.257718667 0.042893412
Muesli (👉 📊) Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) Weighted median 10 -3.529368177 1.789279612 0.048551655
Muesli (👉 📊) Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) Inverse variance weighted 10 2.664781377 0.987528853 0.006966656
Muesli (👉 📊) Injuries to the neck (finn-b-ST19_INJURI_NECK) Inverse variance weighted 10 0.87216292 0.437700703 0.04630514
Muesli (👉 📊) Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) MR Egger 10 -8.744320489 2.969315809 0.018570111
Muesli (👉 📊) Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) Inverse variance weighted 10 6.90896637 2.69945318 0.010485459
Muesli (👉 📊) Osteomodulin (prot-a-2147) Weighted median 10 -1.543303809 0.655989261 0.018640883
Muesli (👉 📊) Non-cancer illness code self-reported: bone disorder (ukb-a-84) Inverse variance weighted 10 0.004149603 0.002069321 0.044931362
Muesli (👉 📊) Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) Weighted median 6 -0.009513315 0.003642794 0.009013447
Muesli (👉 📊) Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) Inverse variance weighted 6 -0.008187562 0.002653913 0.002034898
Muesli (👉 📊) Non-cancer illness code, self-reported: bone disorder (ukb-b-14356) Inverse variance weighted 5 0.005341645 0.002504225 0.032920335
Muesli (👉 📊) Operation code: reduction or fixation of bone fracture (ukb-b-847) Inverse variance weighted 10 0.019326242 0.007752813 0.012673892
Muesli (👉 📊) Fractured bone site(s): Spine (ukb-b-873) Inverse variance weighted 5 0.007365055 0.00304791 0.015673627
Muesli (👉 📊) Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) MR Egger 8 -0.083136366 0.029654389 0.031020178
Muesli (👉 📊) Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) Inverse variance weighted 10 0.008352103 0.002989496 0.005209006
Muesli (👉 📊) Osteoarthrosis (ukb-e-740_CSA) Weighted median 9 3.449819801 1.630554625 0.03436744
Muesli (👉 📊) Osteoarthrosis (ukb-e-740_CSA) Inverse variance weighted 9 2.863778592 1.278367691 0.025078993

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Muesli Neck circumference (ebi-a-GCST90017135) rs56025738 -5.7502984753293 2.52480770359932 0.0227552286844147
Muesli Neck circumference (ebi-a-GCST90017135) All - Inverse variance weighted -1.69366334569753 0.750756533515077 0.0240742512219052
Muesli Neck circumference (BMI adjusted) (ebi-a-GCST90017136) rs72751802 -3.55767318228668 1.5369871435546 0.0206290336339445
Muesli Neck circumference (BMI adjusted) (ebi-a-GCST90017136) All - MR Egger -4.9494573192856 1.74101499651051 0.0217163014555673
Muesli Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs56025738 -4.36850449180905 1.96112970465622 0.025910877809208
Muesli Neck circumference (BMI adjusted) (ebi-a-GCST90017138) All - Inverse variance weighted -1.22470043801167 0.579977284460237 0.0347177525928183
Muesli Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) rs72751802 14.3256242880133 5.51055096468546 0.0093312940227284
Muesli Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) All - MR Egger 16.8366811065272 6.83433787526946 0.0391021751610558
Muesli Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) rs72751802 14.2058297018245 5.50150986384102 0.0098181416653726
Muesli Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) All - MR Egger 16.8789261490793 6.83286917051993 0.0386950908687997
Muesli Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) All - Inverse variance weighted -2.04273835675133 1.02644815597083 0.0465795043343822
Muesli Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) All - Inverse variance weighted -3.8062124192161 1.58999775450933 0.0166726716249733
Muesli Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs10020462 -1.59186922182085 0.740274847909698 0.0315254899239897
Muesli Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) rs10020462 -6.48436238958494 2.99449524943923 0.0303549612508394
Muesli Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) rs12662137 -5.94162177640174 2.70952270164826 0.028316993308871
Muesli Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) rs2239578 -5.25463984698489 2.67461168211531 0.0494563193865917
Muesli Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) All - Inverse variance weighted -2.73874814132506 0.882898818358736 0.0019222089520517
Muesli Otherdisorders of bone (finn-b-M13_OTHERBONE) rs56025738 -3.09631456363885 1.22130233104339 0.011236504547866
Muesli Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) All - Inverse variance weighted -1.49977594066854 0.663177607141995 0.0237283330161797
Muesli Shoulder lesions (finn-b-M13_SHOULDER) rs12662137 -1.38876460797824 0.644272240814646 0.0311183861605023
Muesli Shoulder lesions (finn-b-M13_SHOULDER) rs72751802 -1.74267218776558 0.646438710377376 0.0070218929642714
Muesli Shoulder lesions (finn-b-M13_SHOULDER) All - Inverse variance weighted -0.521814942267669 0.257718667405894 0.0428934121584603
Muesli Shoulder lesions (finn-b-M13_SHOULDER) All - MR Egger -2.29933582724178 0.819748254499413 0.0230222570245997
Muesli Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) rs56025738 8.23987630399468 2.51697884250289 0.001061428747684
Muesli Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) All - Inverse variance weighted 2.66478137667431 0.987528853371411 0.0069666562719227
Muesli Injuries to the neck (finn-b-ST19_INJURI_NECK) All - Inverse variance weighted 0.872162919780257 0.437700702528241 0.0463051400291903
Muesli Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) rs78220500 -7.47255197012763 3.00730089728585 0.0129622941367386
Muesli Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) All - MR Egger -8.7443204893296 2.96931580922832 0.0185701108326628
Muesli Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) All - Inverse variance weighted 6.90896636971812 2.69945317960575 0.0104854592952061
Muesli Osteomodulin (prot-a-2147) rs72751802 2.92479612317596 1.43075420863244 0.0409304548580216
Muesli Non-cancer illness code self-reported: bone disorder (ukb-a-84) All - Inverse variance weighted 0.004149603002167 0.0020693214489694 0.0449313617148221
Muesli Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) rs218011 -0.0150747266739645 0.0059130944583633 0.0107914541809476
Muesli Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) All - Inverse variance weighted -0.0081875624767008 0.0026539126742504 0.002034897872666
Muesli Non-cancer illness code, self-reported: bone disorder (ukb-b-14356) rs2239578 0.0122438363074595 0.00518715450743 0.0182545105964462
Muesli Non-cancer illness code, self-reported: bone disorder (ukb-b-14356) All - Inverse variance weighted 0.0053416449666805 0.0025042245192807 0.032920334712597
Muesli Operation code: reduction or fixation of bone fracture (ukb-b-847) rs490737 0.0640652218175237 0.0246848630183472 0.0094501739352462
Muesli Operation code: reduction or fixation of bone fracture (ukb-b-847) All - Inverse variance weighted 0.0193262415782965 0.0077528134637878 0.0126738916125045
Muesli Fractured bone site(s): Spine (ukb-b-873) rs2239578 0.0169952392962986 0.0051850211236521 0.0010463542951939
Muesli Fractured bone site(s): Spine (ukb-b-873) All - Inverse variance weighted 0.0073650550748057 0.0030479100444744 0.0156736270731702
Muesli Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) All - MR Egger -0.0831363661426298 0.0296543888227117 0.0310201783079899
Muesli Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) rs1835512 0.0232196739210791 0.0099559844637668 0.0196884454361034
Muesli Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) All - Inverse variance weighted 0.0083521032523606 0.0029894962234679 0.0052090061169886
Muesli Osteoarthrosis (ukb-e-740_CSA) All - Inverse variance weighted 2.86377859167008 1.27836769070262 0.0250789929082015