ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Satsuma | Osteoprotegerin levels (ebi-a-GCST90012002) | rs78356316 | 0.927015836363841 | 0.353507053217854 | 0.0087328152699235 |
| Satsuma | Osteoprotegerin levels (ebi-a-GCST90012002) | All - Inverse variance weighted | 0.250869941511315 | 0.108509059698872 | 0.0207792092454328 |
| Satsuma | Achilles tendinitis (finn-b-M13_ACHILLESTEND) | rs117352891 | 2.24516671110142 | 1.02038343149373 | 0.0277844328027088 |
| Satsuma | Achilles tendinitis (finn-b-M13_ACHILLESTEND) | rs77643000 | 2.78006564916103 | 1.28979587893309 | 0.031128145237667 |
| Satsuma | Achilles tendinitis (finn-b-M13_ACHILLESTEND) | All - MR Egger | 1.71607271776972 | 0.803169087762227 | 0.0484214737799446 |
| Satsuma | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | All - Inverse variance weighted | -0.689204295154057 | 0.310788404454959 | 0.0265821333948769 |
| Satsuma | Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) | All - MR Egger | -2.09103863356583 | 0.967971164348836 | 0.0462714168555939 |
| Satsuma | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs117352891 | -1.1674220574097 | 0.443539591361885 | 0.0084869301134861 |
| Satsuma | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs55776785 | 1.96949493850005 | 0.952432785457712 | 0.038653458450555 |
| Satsuma | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | All - MR Egger | -0.811674267528433 | 0.361050945163443 | 0.0390189637513295 |
| Satsuma | Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) | rs7390284 | 6.61492962885959 | 2.91073875907484 | 0.0230506121774943 |
| Satsuma | Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) | rs77643000 | 6.46588683128069 | 2.26318115835264 | 0.0042767877995904 |
| Satsuma | Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) | All - Inverse variance weighted | 1.68117625751584 | 0.816894613356015 | 0.0395892940039989 |
| Satsuma | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | rs117352891 | -3.63072299377106 | 1.23447813406368 | 0.0032704948630778 |
| Satsuma | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | rs4344518 | -3.8500994884435 | 1.85069159959516 | 0.0374927871231613 |
| Satsuma | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | All - MR Egger | -2.4775714032773 | 0.989916164013056 | 0.0235407781058289 |
| Satsuma | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs117352891 | -5.71511670181051 | 2.60953165773932 | 0.0285175015554858 |
| Satsuma | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs117438562 | -16.249072225159 | 4.29649318009445 | 0.0001556119208944 |
| Satsuma | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | All - Inverse variance weighted | -2.71122324177846 | 1.11291323286705 | 0.0148445395682238 |
| Satsuma | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | All - MR Egger | -6.10612651670292 | 2.04191543258901 | 0.0086511348117328 |
| Satsuma | Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) | rs12191461 | 14.927235168508 | 6.99215486027295 | 0.0327728747027152 |
| Satsuma | Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) | All - Inverse variance weighted | 3.30462029718007 | 1.61112051858066 | 0.0402541272763472 |
| Satsuma | Fracture of neck (finn-b-ST19_FRACT_NECK) | rs12191461 | -5.77650635966948 | 2.73303314455482 | 0.0345504622255578 |
| Satsuma | Fracture of neck (finn-b-ST19_FRACT_NECK) | rs55776785 | -8.1058833133776 | 3.41855339066072 | 0.0177331072969479 |
| Satsuma | Fracture of neck (finn-b-ST19_FRACT_NECK) | All - Inverse variance weighted | -2.09093018710336 | 0.627756924710996 | 0.0008659807313846 |
| Satsuma | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs76469063 | 7.33970375843885 | 2.75585261814396 | 0.0077374932956607 |
| Satsuma | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs10513870 | -1.33581734580625 | 0.57872205485968 | 0.0209869490216277 |
| Satsuma | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs76469063 | -4.34118160749673 | 1.9010512880798 | 0.0223968790096652 |
| Satsuma | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | -0.340705394843897 | 0.167327822710872 | 0.0417347861393406 |
| Satsuma | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs117352891 | 0.811944060689789 | 0.3829467510119 | 0.0339847010962408 |
| Satsuma | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs148481633 | 8.90555334298231 | 4.22450387092387 | 0.0350248639602894 |
| Satsuma | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs1589066 | 2.4688901750832 | 0.651135870351613 | 0.0001496396735209 |
| Satsuma | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs77643000 | 1.09415268381403 | 0.475823573314268 | 0.0214769952505083 |
| Satsuma | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | All - Inverse variance weighted | 0.390248807478999 | 0.193295577084791 | 0.0434952656949036 |
| Satsuma | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | All - Inverse variance weighted | -2.04478536760028 | 1.0124918899036 | 0.0434293301177071 |
| Satsuma | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs117438562 | -6.29602540582122 | 2.59303773424202 | 0.0151802481337151 |
| Satsuma | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs147852969 | -4.59533479897157 | 2.24410329023363 | 0.0405857125581823 |
| Satsuma | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs4344518 | -6.0230097147539 | 2.66174617709631 | 0.0236477784449501 |
| Satsuma | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs55776785 | -8.58890279743115 | 3.73829868292152 | 0.0215878004242745 |
| Satsuma | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -2.22871777535612 | 0.728755937428644 | 0.002226338282742 |
| Satsuma | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | All - MR Egger | -4.24641898423045 | 1.36252024761397 | 0.0066448162623458 |
| Satsuma | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | rs117352891 | 3.68404469327904 | 1.64489363936757 | 0.0251113372975722 |
| Satsuma | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | rs117438562 | -5.00491433376641 | 2.50921691071595 | 0.0460852062508043 |
| Satsuma | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | rs1589066 | 6.31692229778614 | 2.84871943278831 | 0.0265916518671694 |
| Satsuma | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | rs4344518 | 5.36342543186246 | 2.54883195747816 | 0.0353550789845142 |
| Satsuma | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | All - Inverse variance weighted | 1.95664261394429 | 0.821108893411076 | 0.0171755963777811 |
| Satsuma | Osteoclast-associated immunoglobulin-like receptor (prot-a-2153) | rs117352891 | -1.87757014631151 | 0.862034142045776 | 0.029400873817466 |
| Satsuma | Bone morphogenetic protein 7 (prot-a-257) | rs4344518 | 3.35850953230104 | 1.15392824439044 | 0.0036084958877364 |
| Satsuma | Bone morphogenetic protein 7 (prot-a-257) | rs76469063 | 2.06982836798442 | 1.01602122728647 | 0.041630997293608 |
| Satsuma | Bone morphogenetic protein 7 (prot-a-257) | All - Inverse variance weighted | 0.808179267478131 | 0.25851480036847 | 0.001770570882249 |
| Satsuma | Fracture resulting from simple fall (ukb-a-332) | rs114628454 | -0.500590056623923 | 0.182028626965895 | 0.0059583943000321 |
| Satsuma | Fracture resulting from simple fall (ukb-a-332) | rs117352891 | -0.281673493460013 | 0.142575761248051 | 0.048199447117882 |
| Satsuma | Fracture resulting from simple fall (ukb-a-332) | rs78356316 | 0.355865020477084 | 0.170796556690873 | 0.0372001303991624 |
| Satsuma | Fracture resulting from simple fall (ukb-a-332) | All - Inverse variance weighted | -0.108296017315169 | 0.046195333091846 | 0.0190625015982795 |
| Satsuma | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | rs117614521 | 0.0172583132249464 | 0.0071781877384837 | 0.0162047269396454 |
| Satsuma | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | All - Inverse variance weighted | 0.0054033926220153 | 0.0018467109719671 | 0.0034340095235566 |
| Satsuma | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | All - MR Egger | 0.0090154784366756 | 0.0035343161393469 | 0.0213668945264689 |
| Satsuma | Diagnoses - secondary ICD10: M47.82 Other spondylosis (Cervical region) (ukb-b-2625) | rs1589066 | 0.0094282213138474 | 0.0045539267110403 | 0.0384195979960131 |
| Satsuma | Non-cancer illness code, self-reported: joint pain (ukb-b-4122) | rs7390284 | 0.0141473784257401 | 0.0054973502093949 | 0.0100678416788654 |
| Satsuma | Non-cancer illness code, self-reported: joint pain (ukb-b-4122) | All - Inverse variance weighted | 0.0092560976212616 | 0.0032366951207364 | 0.0042399213118524 |
| Satsuma | Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) | rs12191461 | -0.0177801504038622 | 0.0087197973725745 | 0.0414444932059704 |
| Satsuma | Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) | rs77643000 | -0.0147873889845635 | 0.0070562703644035 | 0.0361143071761846 |
| Satsuma | Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) | All - Inverse variance weighted | -0.0069995378001006 | 0.0035305887499939 | 0.0474186964288979 |
| Satsuma | Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) | All - MR Egger | -0.0410017667766253 | 0.0139146679080421 | 0.0320089364799579 |
| Satsuma | Fractured heel (left) (ukb-b-8221) | rs117352891 | -0.0294267917302891 | 0.0134044289326773 | 0.0281418234319886 |
| Satsuma | Fractured heel (left) (ukb-b-8221) | rs7390284 | 0.039210621226329 | 0.016255372773985 | 0.0158581567070944 |
| Satsuma | Fractured heel (left) (ukb-b-8221) | All - Inverse variance weighted | -0.0076822049622451 | 0.0036973835209203 | 0.0377332298562964 |
| Satsuma | Fractured heel (left) (ukb-b-8221) | All - MR Egger | -0.0183389717093992 | 0.0070672688189677 | 0.019541501349922 |
| Satsuma | Operative procedures - main OPCS: W90.1 Aspiration of joint (ukb-b-9333) | rs1589066 | 0.0130886901316741 | 0.0049184723628997 | 0.0077879080916646 |
| Satsuma | Operative procedures - main OPCS: W90.1 Aspiration of joint (ukb-b-9333) | All - Inverse variance weighted | 0.0090526058360839 | 0.0039441265822902 | 0.0217209898029249 |
| Satsuma | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs188460089 | 0.0155289491861639 | 0.0073284833779068 | 0.0340917019366406 |
| Satsuma | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | All - Inverse variance weighted | 0.0034909523347523 | 0.001677820761474 | 0.0374662503459133 |
| Satsuma | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | rs76469063 | -0.0176249454203473 | 0.0083150925335035 | 0.0340369982443415 |
| Satsuma | Fractured/broken bones in last 5 years (ukb-e-2463_AFR) | All - Inverse variance weighted | 1.23790279801572 | 0.554691364192476 | 0.0256350261156589 |
| Satsuma | Fractured/broken bones in last 5 years (ukb-e-2463_CSA) | rs117352891 | -3.44086542734111 | 1.70871809786956 | 0.0440398231142079 |
| Satsuma | Fractured/broken bones in last 5 years (ukb-e-2463_CSA) | rs76469063 | -4.2026332583213 | 1.64998488563464 | 0.0108630459800763 |
| Satsuma | Fractured/broken bones in last 5 years (ukb-e-2463_CSA) | All - Inverse variance weighted | -1.44163658100544 | 0.59282797457359 | 0.0150241747334321 |
| Satsuma | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | rs114628454 | 2.2903109321819 | 1.16321058414069 | 0.0489580972492821 |
| Satsuma | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | All - Inverse variance weighted | 1.4207746059539 | 0.534311569562083 | 0.0078355488110711 |
| Satsuma | Knee pain for 3+ months (ukb-e-3773_CSA) | rs114628454 | 3.06476025108139 | 1.29996849958127 | 0.0183952339637658 |
| Satsuma | Knee pain for 3+ months (ukb-e-3773_CSA) | All - Inverse variance weighted | 1.216677650348 | 0.610435038913109 | 0.0462469875292001 |
| Satsuma | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | rs13408253 | 1.12028806654822 | 0.486125470682986 | 0.0211932175981977 |
| Satsuma | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | All - MR Egger | 1.10712224740852 | 0.447821109229884 | 0.0385753659894187 |
| Satsuma | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | All - MR Egger | 0.695289478062151 | 0.306403469029648 | 0.0443701524525222 |
| Satsuma | M51 Other intervertebral disk disorders (ukb-e-M51_CSA) | rs114628454 | 4.29173997556797 | 1.9153791190639 | 0.0250472067838765 |
| Satsuma | M51 Other intervertebral disk disorders (ukb-e-M51_CSA) | All - MR Egger | 3.69792806732556 | 1.55926100636909 | 0.0370476408702098 |