ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Pineapple (ukb-b-1164)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pineapple (👉 📊) Rheumatoid Arthritis (bbj-a-73) Weighted median 13 1.677794927 0.84186225 0.0462662
Pineapple (👉 📊) Total body bone mineral density (age 30-45) (ebi-a-GCST005346) Weighted median 16 1.075140101 0.531609758 0.043132613
Pineapple (👉 📊) Total body bone mineral density (age 30-45) (ebi-a-GCST005346) Inverse variance weighted 16 0.793518599 0.381894678 0.03772348
Pineapple (👉 📊) Osteoarthritis (hip) (ebi-a-GCST007091) Inverse variance weighted 16 -0.59163694 0.2890738 0.040691086
Pineapple (👉 📊) Osteoprotegerin levels (ebi-a-GCST90010243) MR Egger 15 -6.418492897 2.810011602 0.039811633
Pineapple (👉 📊) Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) Weighted median 16 9.533649412 4.781562893 0.046170044
Pineapple (👉 📊) Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) Weighted median 16 -3.958878242 1.267535585 0.001788429
Pineapple (👉 📊) Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) Inverse variance weighted 16 -2.977311373 0.900435744 0.000944616
Pineapple (👉 📊) Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) Weighted mode 16 -4.696192854 2.143710902 0.044682497
Pineapple (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) Inverse variance weighted 16 -3.94380188 1.382669233 0.004340269
Pineapple (👉 📊) Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) Weighted median 16 -3.07203046 1.38341904 0.026377569
Pineapple (👉 📊) Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) MR Egger 16 7.649746315 3.55211414 0.049188253
Pineapple (👉 📊) Peroneal tendinitis (finn-b-M13_PERONEALTEND) Inverse variance weighted 16 -6.129018983 3.124760613 0.049828146
Pineapple (👉 📊) Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) MR Egger 16 5.072860088 2.023504647 0.025126075
Pineapple (👉 📊) Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) Weighted median 16 -2.108998663 0.905983376 0.019919762
Pineapple (👉 📊) Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) Inverse variance weighted 16 -2.322357121 0.648446428 0.000341736
Pineapple (👉 📊) Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) Weighted median 16 -5.421994485 2.743291585 0.04810318
Pineapple (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) Weighted median 16 -1.379913934 0.64241994 0.031714262
Pineapple (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) Inverse variance weighted 16 -1.247566271 0.464346616 0.007215884
Pineapple (👉 📊) Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) Inverse variance weighted 16 0.740023628 0.352172769 0.035613895
Pineapple (👉 📊) Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) MR Egger 16 3.329779905 1.0865658 0.008404438
Pineapple (👉 📊) Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) Weighted median 16 1.3862385 0.695096999 0.046118249
Pineapple (👉 📊) Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) Inverse variance weighted 16 1.566733458 0.474987875 0.000972131
Pineapple (👉 📊) Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) Simple mode 16 2.867881598 1.250651662 0.036709728
Pineapple (👉 📊) Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) MR Egger 16 1.756487498 0.673748013 0.020691837
Pineapple (👉 📊) Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) MR Egger 16 2.678167812 1.107280267 0.029782553
Pineapple (👉 📊) Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) MR Egger 16 -15.68917849 7.14735869 0.045516171
Pineapple (👉 📊) Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) Inverse variance weighted 16 -4.233504072 2.04442755 0.038381903
Pineapple (👉 📊) Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) MR Egger 16 4.856225702 1.627263609 0.009853558
Pineapple (👉 📊) Knee osteoarthritis (ieu-a-1171) Inverse variance weighted 5 3.168222319 1.209478011 0.008805991
Pineapple (👉 📊) Rheumatoid arthritis (ieu-a-833) Inverse variance weighted 6 1.458436648 0.728186148 0.04519501
Pineapple (👉 📊) Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) Inverse variance weighted 16 -0.066273436 0.025443819 0.009195556
Pineapple (👉 📊) Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) Inverse variance weighted 16 -0.014548458 0.005932246 0.014189231
Pineapple (👉 📊) Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) Inverse variance weighted 16 -0.002594471 0.001291484 0.044547085
Pineapple (👉 📊) Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) MR Egger 16 0.01990003 0.00718691 0.015073967
Pineapple (👉 📊) Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) Weighted median 16 0.009037272 0.004321343 0.036500195
Pineapple (👉 📊) Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) Inverse variance weighted 16 0.006404288 0.00323428 0.047689179
Pineapple (👉 📊) Heel bone mineral density (BMD) (left) (ukb-b-1096) MR Egger 16 0.4991795 0.190340889 0.020075728
Pineapple (👉 📊) Non-cancer illness code, self-reported: fracture lower leg / ankle (ukb-b-13979) Inverse variance weighted 2 -0.01886364 0.009279727 0.042074802
Pineapple (👉 📊) Fracture resulting from simple fall (ukb-b-15251) Weighted median 16 0.288547301 0.114048577 0.011404998
Pineapple (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) MR Egger 16 0.510351767 0.19039601 0.017928863
Pineapple (👉 📊) Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) Inverse variance weighted 2 0.020566288 0.008282081 0.013019803
Pineapple (👉 📊) Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) Inverse variance weighted 16 -0.054077275 0.021713207 0.012755469
Pineapple (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) MR Egger 16 0.522980008 0.189498111 0.015346245
Pineapple (👉 📊) Heel bone mineral density (BMD) (right) (ukb-b-4657) MR Egger 16 0.591077098 0.189540772 0.007550224
Pineapple (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) Weighted median 3 -0.02197135 0.010510367 0.036577796
Pineapple (👉 📊) Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) Wald ratio 1 0.028437772 0.009765249 0.003589616
Pineapple (👉 📊) Knee pain for 3+ months (ukb-b-8906) MR Egger 16 0.227790872 0.102186844 0.042697196
Pineapple (👉 📊) Fractured/broken bones in last 5 years (ukb-e-2463_AFR) Inverse variance weighted 9 -3.100257904 1.549187526 0.045369184
Pineapple (👉 📊) Ankle spacing width (ukb-e-3143_CSA) Inverse variance weighted 16 -1.088711592 0.552091941 0.048612443
Pineapple (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_CSA) MR Egger 16 -3.103816534 1.316773908 0.033504386
Pineapple (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_CSA) Inverse variance weighted 16 -1.381384353 0.613098797 0.024251667
Pineapple (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) MR Egger 16 -2.936325932 1.311973727 0.041985005
Pineapple (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) Inverse variance weighted 16 -1.356521956 0.610855289 0.026371774
Pineapple (👉 📊) M51 Other intervertebral disk disorders (ukb-e-M51_CSA) MR Egger 16 -9.751099721 4.526441447 0.049126205

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pineapple Total body bone mineral density (age 30-45) (ebi-a-GCST005346) All - Inverse variance weighted 0.793518599271715 0.381894677570004 0.0377234800874282
Pineapple Osteoarthritis (hip) (ebi-a-GCST007091) All - Inverse variance weighted -0.59163694037534 0.289073800376445 0.0406910863144059
Pineapple Osteoprotegerin levels (ebi-a-GCST90010243) rs149078766 -8.70192952794998 4.43649196253656 0.0498272781359294
Pineapple Osteoprotegerin levels (ebi-a-GCST90010243) rs62007226 11.0014055086621 4.18387314701931 0.0085515877710397
Pineapple Osteoprotegerin levels (ebi-a-GCST90010243) All - MR Egger -6.41849289673058 2.81001160195567 0.039811632928458
Pineapple Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) rs3917551 27.8142438988185 12.4041507981055 0.0249398208501201
Pineapple Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) rs75055053 -26.2089222992601 12.9171913661257 0.0424587554040465
Pineapple Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) rs111799849 -6.2250906733965 2.95119495814544 0.0349147446737157
Pineapple Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) rs2454222 -8.06512756359225 3.52553167292164 0.0221588203549654
Pineapple Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) All - Inverse variance weighted -2.97731137283532 0.900435744089271 0.0009446164209724
Pineapple Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs79943840 -12.2245061871248 5.05860411930465 0.0156672136665792
Pineapple Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) All - Inverse variance weighted -3.94380187951344 1.38266923261174 0.0043402691150995
Pineapple Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) rs2454222 -12.7089730467417 5.36411539482164 0.0178238175207767
Pineapple Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) All - MR Egger 7.6497463149573 3.55211414048169 0.0491882525460254
Pineapple Peroneal tendinitis (finn-b-M13_PERONEALTEND) rs114311510 -20.1907713165158 9.05091615884237 0.025694471117886
Pineapple Peroneal tendinitis (finn-b-M13_PERONEALTEND) All - Inverse variance weighted -6.12901898329378 3.12476061321951 0.0498281457039567
Pineapple Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) rs3917551 6.84222977831175 3.47909988727716 0.0492216521753002
Pineapple Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) All - MR Egger 5.07286008835511 2.02350464681922 0.0251260745177209
Pineapple Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) rs111799849 -4.24751423882614 2.13754775005861 0.0469116736592972
Pineapple Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) rs72771953 -5.77277645933281 2.05274915126718 0.0049201268107723
Pineapple Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) rs75055053 -5.64168654872111 2.76628436105614 0.0414055724122113
Pineapple Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) All - Inverse variance weighted -2.32235712111976 0.648446428473445 0.0003417355883741
Pineapple Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) rs3096085 27.5104254205845 12.2568062536667 0.0248001242097552
Pineapple Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) rs3096085 -5.63686238444828 2.7272583125882 0.0387473039736894
Pineapple Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) All - Inverse variance weighted -1.24756627131207 0.464346616081435 0.0072158840021015
Pineapple Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) rs75055053 2.99041827517157 1.49520913758578 0.0455002638963584
Pineapple Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) All - Inverse variance weighted 0.740023628296966 0.352172768835627 0.03561389516628
Pineapple Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) rs111799849 3.88895784204212 1.53627625391309 0.0113602275305362
Pineapple Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) rs114311510 3.54842949139177 1.4767830339418 0.016269624647684
Pineapple Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) All - Inverse variance weighted 1.5667334584221 0.474987875201994 0.0009721312024863
Pineapple Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) All - MR Egger 3.3297799050178 1.08656580000561 0.0084044380462227
Pineapple Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) rs111799849 2.39681160619475 0.863293478410768 0.0054971671140143
Pineapple Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) rs77093146 1.86084711087763 0.928573806819653 0.0450717675515872
Pineapple Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) rs79943840 2.05012319797438 0.96108033052451 0.032912876258789
Pineapple Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) All - MR Egger 1.75648749845708 0.673748012820697 0.0206918365536874
Pineapple Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) rs111799849 3.38422076041537 1.56661564133328 0.0307563182894716
Pineapple Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) All - MR Egger 2.67816781223054 1.10728026674387 0.0297825529070722
Pineapple Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) rs2454222 26.7163273816293 12.1877250843474 0.0283745659584152
Pineapple Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) All - MR Egger -15.6891784922373 7.14735869039291 0.0455161709711741
Pineapple Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) rs77093146 -15.545287395443 7.15112816168283 0.0297184250497379
Pineapple Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) All - Inverse variance weighted -4.23350407230617 2.04442755001492 0.0383819032591728
Pineapple Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) rs116956726 6.59669495310406 2.86065207682001 0.0211100216699635
Pineapple Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) rs1701827 -7.66649813853013 3.12543089580365 0.0141693507382457
Pineapple Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) All - MR Egger 4.85622570209072 1.62726360892097 0.0098535580261111
Pineapple Knee osteoarthritis (ieu-a-1171) All - Inverse variance weighted 3.16822231941771 1.20947801144207 0.0088059910802096
Pineapple Rheumatoid arthritis (ieu-a-833) All - Inverse variance weighted 1.45843664840079 0.728186147553731 0.045195009788123
Pineapple Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs72771953 -0.362472773208373 0.101925961703689 0.0003762061722186
Pineapple Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) All - Inverse variance weighted -0.0662734363175315 0.0254438185559999 0.0091955556943494
Pineapple Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) All - Inverse variance weighted -0.0145484575661535 0.0059322456928446 0.0141892307735339
Pineapple Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) rs75055053 -0.0122041800974983 0.004763347027129 0.0104040811118834
Pineapple Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) All - Inverse variance weighted -0.0025944705301451 0.0012914841721066 0.0445470847866367
Pineapple Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) All - Inverse variance weighted 0.0064042877318951 0.0032342801289661 0.0476891792743045
Pineapple Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) All - MR Egger 0.0199000301708811 0.0071869100205427 0.0150739665702684
Pineapple Heel bone mineral density (BMD) (left) (ukb-b-1096) All - MR Egger 0.499179500493005 0.190340888822586 0.0200757280548032
Pineapple Non-cancer illness code, self-reported: fracture lower leg / ankle (ukb-b-13979) All - Inverse variance weighted -0.0188636396271829 0.0092797272714523 0.0420748022763762
Pineapple Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) All - MR Egger 0.510351766759268 0.190396010054267 0.017928863223266
Pineapple Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) rs1701827 0.0289177735901089 0.0123015121570069 0.0187356420782943
Pineapple Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) All - Inverse variance weighted 0.0205662880605225 0.0082820808171877 0.0130198029564182
Pineapple Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) rs72771953 -0.247159821847381 0.0862247528109195 0.004150903545206
Pineapple Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) All - Inverse variance weighted -0.0540772752802483 0.0217132072255162 0.0127554689408835
Pineapple Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) All - MR Egger 0.522980008054497 0.189498110520078 0.0153462451348647
Pineapple Heel bone mineral density (BMD) (right) (ukb-b-4657) rs149078766 0.677081823793039 0.336639562032043 0.0442941947286342
Pineapple Heel bone mineral density (BMD) (right) (ukb-b-4657) All - MR Egger 0.59107709834704 0.189540771633446 0.007550224129748
Pineapple Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) rs62007226 -0.0330256485917735 0.0136817338230612 0.015784973828575
Pineapple Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) rs2454222 0.0284377724705258 0.0097652488722089 0.0035896163639721
Pineapple Knee pain for 3+ months (ukb-b-8906) All - MR Egger 0.227790871609286 0.102186844040515 0.0426971964397685
Pineapple Fractured/broken bones in last 5 years (ukb-e-2463_AFR) All - Inverse variance weighted -3.10025790406983 1.54918752562638 0.0453691841338879
Pineapple Ankle spacing width (ukb-e-3143_CSA) All - Inverse variance weighted -1.08871159168385 0.552091940699704 0.0486124425320199
Pineapple Heel bone mineral density (BMD) (ukb-e-3148_CSA) All - Inverse variance weighted -1.38138435268592 0.613098796500951 0.0242516667942754
Pineapple Heel bone mineral density (BMD) (ukb-e-3148_CSA) All - MR Egger -3.10381653443073 1.31677390824236 0.0335043857011033
Pineapple Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) All - Inverse variance weighted -1.35652195557243 0.610855288904452 0.0263717739277436
Pineapple Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) All - MR Egger -2.93632593180795 1.31197372655632 0.0419850046979015
Pineapple M51 Other intervertebral disk disorders (ukb-e-M51_CSA) rs2454222 20.6982827248948 8.97778535956632 0.0211385956117385
Pineapple M51 Other intervertebral disk disorders (ukb-e-M51_CSA) All - MR Egger -9.75109972121811 4.52644144676764 0.0491262052832517