ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Chocolate bar | Rheumatoid arthritis (ebi-a-GCST005569) | rs79174915 | -3.3635098077036 | 1.30614794998449 | 0.0100200412693424 |
| Chocolate bar | Osteoarthritis (Firth correction) (ebi-a-GCST90013881) | rs2011009 | -1.06804958313643 | 0.404645265032855 | 0.008303544193242 |
| Chocolate bar | Osteoarthritis (Firth correction) (ebi-a-GCST90013881) | rs79174915 | -0.770508122070059 | 0.382222855848981 | 0.0438145199641588 |
| Chocolate bar | Osteoarthritis (Firth correction) (ebi-a-GCST90013881) | All - MR Egger | -0.644801344659509 | 0.255779136373653 | 0.0327186755202468 |
| Chocolate bar | Osteoarthritis (SPA correction) (ebi-a-GCST90013931) | rs2011009 | -1.05795889740174 | 0.397836885422926 | 0.0078308306461778 |
| Chocolate bar | Osteoarthritis (SPA correction) (ebi-a-GCST90013931) | rs79174915 | -0.758339692896019 | 0.370202863061144 | 0.0405165511532263 |
| Chocolate bar | Osteoarthritis (SPA correction) (ebi-a-GCST90013931) | All - MR Egger | -0.6481156138371 | 0.254175631339391 | 0.0312012390558213 |
| Chocolate bar | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs12476436 | 4.33316819898474 | 1.49585984597469 | 0.0037702101590779 |
| Chocolate bar | Osteoarthritis (ebi-a-GCST90038686) | rs4656997 | 0.0519838879190175 | 0.0250594308882312 | 0.038039938971595 |
| Chocolate bar | Osteoarthritis (ebi-a-GCST90038686) | rs79174915 | -0.0423041184807494 | 0.0199760153635853 | 0.0341966194038111 |
| Chocolate bar | Osteoarthritis (ebi-a-GCST90038686) | All - MR Egger | -0.0387229671229892 | 0.0152801525171775 | 0.0320139777991857 |
| Chocolate bar | Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) | rs4656997 | -12.1808035812442 | 3.75538132071572 | 0.0011804606166662 |
| Chocolate bar | Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) | rs5757057 | -8.3987240962697 | 3.81266121244299 | 0.0276052608638398 |
| Chocolate bar | Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) | All - Inverse variance weighted | -2.51694011698784 | 1.0216247684128 | 0.0137524981707471 |
| Chocolate bar | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | rs13376315 | 14.9302012311087 | 4.27090642292444 | 0.0004726566843815 |
| Chocolate bar | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | All - Inverse variance weighted | 3.23918035235811 | 1.49953681441542 | 0.0307633352536203 |
| Chocolate bar | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | All - Inverse variance weighted | 0.78399714036649 | 0.32498574934289 | 0.0158476810170479 |
| Chocolate bar | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs12584633 | 2.19749971326987 | 1.0505791948618 | 0.0364650869064799 |
| Chocolate bar | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs13376315 | 2.25343836877316 | 0.796985830842102 | 0.0046920198342861 |
| Chocolate bar | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | All - Inverse variance weighted | 0.899719155905243 | 0.267957163657416 | 0.0007859451259726 |
| Chocolate bar | Cervicalgia (finn-b-M13_CERVICALGIA) | rs13376315 | 2.04715968314344 | 0.909501477549222 | 0.0243944625068537 |
| Chocolate bar | Cervicalgia (finn-b-M13_CERVICALGIA) | All - Inverse variance weighted | 0.627297963120053 | 0.304002259403421 | 0.0390684882812357 |
| Chocolate bar | Chondromalacia (finn-b-M13_CHONDROMALACIA) | rs12584633 | -8.02844362885652 | 3.2389035439844 | 0.0131842371187114 |
| Chocolate bar | Chondromalacia (finn-b-M13_CHONDROMALACIA) | All - Inverse variance weighted | -1.67980739503948 | 0.836639022001447 | 0.0446640956563442 |
| Chocolate bar | Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) | rs77853158 | -1.99951926072983 | 0.948124671717397 | 0.0349514713413465 |
| Chocolate bar | Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) | All - MR Egger | -1.76378902096571 | 0.746803254437218 | 0.0398317289057866 |
| Chocolate bar | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs141291681 | 2.14295236540826 | 0.988000712656252 | 0.0300843114913802 |
| Chocolate bar | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs4656997 | 1.78094781603029 | 0.545277849846311 | 0.0010902855699508 |
| Chocolate bar | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs13376315 | 2.6191142205713 | 0.729788986280905 | 0.0003321206368367 |
| Chocolate bar | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | 0.624014277090612 | 0.292425461009296 | 0.0328488436088754 |
| Chocolate bar | Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) | All - Inverse variance weighted | -0.654949599014237 | 0.260174843460316 | 0.0118243296006787 |
| Chocolate bar | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | All - MR Egger | -5.42958588425961 | 1.59858453339952 | 0.0068110599057727 |
| Chocolate bar | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs17567502 | -8.28563785926353 | 4.18261121390785 | 0.0475943558518444 |
| Chocolate bar | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -3.19115994612838 | 1.18367624210299 | 0.007018322058054 |
| Chocolate bar | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | All - MR Egger | 0.843015534579547 | 0.363317068844635 | 0.0427487176918385 |
| Chocolate bar | Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) | rs13376315 | 9.13877086032276 | 3.05511235156139 | 0.0027778848308674 |
| Chocolate bar | Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) | rs5757057 | 9.03416763167686 | 4.09275803397115 | 0.0272893064722951 |
| Chocolate bar | Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) | All - Inverse variance weighted | 2.48404462259912 | 1.12140998360365 | 0.0267526281951976 |
| Chocolate bar | Four-jointed box protein 1 (prot-a-1112) | rs2011009 | 2.81615450574029 | 1.21242187149183 | 0.0201925154274593 |
| Chocolate bar | Neck/shoulder pain for 3+ months (ukb-a-341) | rs17567502 | 0.226538579724947 | 0.106963207611822 | 0.0341825854633901 |
| Chocolate bar | Neck/shoulder pain for 3+ months (ukb-a-341) | rs77853158 | 0.217792694543609 | 0.0920428748208356 | 0.01797128768772 |
| Chocolate bar | Neck/shoulder pain for 3+ months (ukb-a-341) | All - Inverse variance weighted | 0.0798476436366648 | 0.0313267360204101 | 0.0108073903328281 |
| Chocolate bar | Neck/shoulder pain for 3+ months (ukb-a-341) | All - MR Egger | 0.150271266812677 | 0.0582579521763058 | 0.0274439706562896 |
| Chocolate bar | Fractured bone site(s): Ankle (ukb-a-438) | rs141291681 | 0.0334065093424002 | 0.0135179179473507 | 0.0134631778624449 |
| Chocolate bar | Fractured bone site(s): Ankle (ukb-a-438) | All - Inverse variance weighted | 0.0080391909690446 | 0.0039207100969429 | 0.0403212606007936 |
| Chocolate bar | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | rs73158385 | 0.0097583698841942 | 0.0046289167271465 | 0.0350195282092434 |
| Chocolate bar | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | All - Inverse variance weighted | 0.0029383101475639 | 0.0013015693428285 | 0.0239760172071068 |
| Chocolate bar | Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) | rs4656997 | 0.0149845431319177 | 0.0060041247630899 | 0.0125705977710475 |
| Chocolate bar | Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) | All - MR Egger | -0.0080881678568229 | 0.0032017076672057 | 0.0300658909066359 |
| Chocolate bar | Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) | All - Inverse variance weighted | -0.0098767252860142 | 0.0038625955899091 | 0.0105573845882268 |
| Chocolate bar | Operative procedures - secondary OPCS: Z48.2 Skin of neck (ukb-b-14873) | rs73158385 | 0.0187595058533969 | 0.0082175538796503 | 0.0224387539708004 |
| Chocolate bar | Operative procedures - secondary OPCS: Z48.2 Skin of neck (ukb-b-14873) | All - Inverse variance weighted | 0.0079515685915394 | 0.0036785535615778 | 0.0306488702009417 |
| Chocolate bar | Neck/shoulder pain for 3+ months (ukb-b-16118) | All - Inverse variance weighted | 0.0579459877540613 | 0.0264795171837031 | 0.0286453919595386 |
| Chocolate bar | Ankle spacing width (ukb-b-4080) | rs2011009 | 0.246634834355802 | 0.109630093722135 | 0.024467988281567 |
| Chocolate bar | Ankle spacing width (ukb-b-4080) | rs4656997 | 0.280167716912848 | 0.103531993298359 | 0.0068078958295814 |
| Chocolate bar | Ankle spacing width (ukb-b-4080) | rs77853158 | 0.170290313103706 | 0.0866570815565269 | 0.0494020208028645 |
| Chocolate bar | Ankle spacing width (ukb-b-4080) | All - Inverse variance weighted | 0.11638569752127 | 0.0330992540778522 | 0.0004376664574142 |
| Chocolate bar | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | rs12584633 | 2.03463699965592 | 0.925794242458998 | 0.0279690286651083 |
| Chocolate bar | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | All - Inverse variance weighted | 0.588184351069775 | 0.29630438795795 | 0.0471369093682071 |