ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Beetroot (ukb-b-11880)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Beetroot (👉 📊) Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) Inverse variance weighted 3 1.205980097 0.485738395 0.013036268
Beetroot (👉 📊) Neck circumference (ebi-a-GCST90017134) Weighted median 8 4.194591177 2.032010674 0.038993406
Beetroot (👉 📊) Neck circumference (ebi-a-GCST90017134) Inverse variance weighted 8 3.800637272 1.539991805 0.013588573
Beetroot (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017137) Weighted median 8 4.194591177 2.01322652 0.037204147
Beetroot (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017137) Inverse variance weighted 8 3.800637272 1.539991805 0.013588573
Beetroot (👉 📊) Sciatica (ebi-a-GCST90038692) MR Egger 10 -0.020745581 0.008664759 0.043566051
Beetroot (👉 📊) Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) MR Egger 10 -5.018541218 1.848274553 0.026442059
Beetroot (👉 📊) Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) Inverse variance weighted 10 -2.700069315 1.118533494 0.015781194
Beetroot (👉 📊) Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) Weighted mode 10 -4.084368119 1.662149222 0.036320282
Beetroot (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) MR Egger 10 -5.019311071 1.852631675 0.026687532
Beetroot (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) Inverse variance weighted 10 -2.698224199 1.120605153 0.01604775
Beetroot (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) Weighted mode 10 -4.022655897 1.696817416 0.041860474
Beetroot (👉 📊) Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) Weighted median 10 4.362670361 1.998033035 0.029000289
Beetroot (👉 📊) Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) Inverse variance weighted 10 6.191244549 2.992276354 0.038539038
Beetroot (👉 📊) Cervical root disorders (finn-b-G6_CERVROOT) MR Egger 10 -8.369510645 3.400944546 0.039261347
Beetroot (👉 📊) Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) MR Egger 10 -3.151648173 1.172506373 0.027583749
Beetroot (👉 📊) Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) Weighted median 10 3.977072803 1.855321024 0.032064663
Beetroot (👉 📊) Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) Simple mode 10 -13.87096589 4.920968265 0.020088054
Beetroot (👉 📊) Osteomyelitis (finn-b-M13_OSTEOMYELITIS) Weighted median 10 -2.259713541 1.092924481 0.038679126
Beetroot (👉 📊) Osteomyelitis (finn-b-M13_OSTEOMYELITIS) Inverse variance weighted 10 -1.612734321 0.808509326 0.046075506
Beetroot (👉 📊) Osteoporosis (finn-b-M13_OSTEOPOROSIS) Inverse variance weighted 10 1.125443727 0.430236569 0.008899996
Beetroot (👉 📊) Postmenopausal osteoporosis with pathological fracture (finn-b-OSTPOPATFRCTURE_POSTEMENO) Inverse variance weighted 10 2.342449911 0.968254898 0.01555258
Beetroot (👉 📊) Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) MR Egger 10 -8.225041311 3.462980376 0.044885309
Beetroot (👉 📊) Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) Inverse variance weighted 10 -4.175954039 2.100686962 0.046822834
Beetroot (👉 📊) Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) Weighted median 10 2.952705189 1.313053395 0.024529552
Beetroot (👉 📊) Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) Inverse variance weighted 10 2.083106646 0.954838182 0.029136617
Beetroot (👉 📊) Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) Inverse variance weighted 10 1.08006489 0.462782881 0.019603684
Beetroot (👉 📊) Forearm bone mineral density (ieu-a-977) Weighted median 12 -0.767688544 0.389572505 0.048770538
Beetroot (👉 📊) Fractured bone site(s): Ankle (ukb-b-15582) Inverse variance weighted 4 0.017508319 0.007743673 0.023760256
Beetroot (👉 📊) Fractured bone site(s): Other bones (ukb-b-17738) Inverse variance weighted 9 -0.019413454 0.00964928 0.044229729
Beetroot (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint (ukb-b-7012) Inverse variance weighted 2 -0.009967597 0.004622086 0.031043475
Beetroot (👉 📊) Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) Inverse variance weighted 10 0.006624264 0.003034347 0.029028937
Beetroot (👉 📊) Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) Inverse variance weighted 10 0.00587708 0.002631149 0.025505768
Beetroot (👉 📊) Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) Weighted median 12 -0.010315005 0.004519672 0.022474786
Beetroot (👉 📊) Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) Inverse variance weighted 12 -0.012032796 0.003305 0.000271807
Beetroot (👉 📊) Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) Inverse variance weighted 10 0.006624264 0.003034347 0.029028937
Beetroot (👉 📊) Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) Weighted median 11 -0.008694731 0.004154982 0.036384561

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Beetroot Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) rs13101707 1.87319455771399 0.849521594003324 0.0274541405472447
Beetroot Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) All - Inverse variance weighted 1.20598009732245 0.485738395414397 0.013036268293083
Beetroot Neck circumference (ebi-a-GCST90017134) rs117786423 8.70541536716756 3.94896512616955 0.027490592060875
Beetroot Neck circumference (ebi-a-GCST90017134) All - Inverse variance weighted 3.80063727155509 1.53999180473565 0.0135885725708314
Beetroot Neck circumference (BMI adjusted) (ebi-a-GCST90017137) rs117786423 8.70541536716756 3.94896512616955 0.027490592060875
Beetroot Neck circumference (BMI adjusted) (ebi-a-GCST90017137) All - Inverse variance weighted 3.80063727155509 1.53999180473565 0.0135885725708314
Beetroot Sciatica (ebi-a-GCST90038692) rs2045966 -0.0260638715094533 0.0121914408071194 0.0325262572243137
Beetroot Sciatica (ebi-a-GCST90038692) All - MR Egger -0.0207455805128028 0.008664758646017 0.0435660513284455
Beetroot Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) rs189837126 -4.18927021903322 1.57072396646161 0.0076510015139094
Beetroot Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) All - Inverse variance weighted -2.70006931523567 1.1185334937013 0.0157811935247377
Beetroot Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) All - MR Egger -5.01854121817809 1.84827455304403 0.0264420590980582
Beetroot Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) rs189837126 -4.16807150226221 1.57476181727514 0.0081258626974944
Beetroot Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) All - Inverse variance weighted -2.69822419888013 1.12060515266834 0.0160477499443328
Beetroot Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) All - MR Egger -5.01931107090772 1.85263167503893 0.0266875323769281
Beetroot Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) rs189837126 4.82220333405342 2.01286863054271 0.0165892469514082
Beetroot Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) rs150382547 37.4489624271711 14.3425137247106 0.0090265763444755
Beetroot Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) rs28449718 19.1880980385924 7.31792605779318 0.008739805064268
Beetroot Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) rs75961109 54.4442704663483 16.222370103604 0.000790433875156
Beetroot Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) All - Inverse variance weighted 6.19124454852872 2.99227635438152 0.0385390383076334
Beetroot Cervical root disorders (finn-b-G6_CERVROOT) All - MR Egger -8.36951064478103 3.40094454569506 0.039261346503465
Beetroot Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) rs13101707 5.83802380665891 2.67390403358423 0.0290112715141918
Beetroot Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) rs189837126 -2.33185884481126 0.993311300127394 0.0188967798736299
Beetroot Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) All - MR Egger -3.15164817260061 1.17250637300863 0.0275837485442699
Beetroot Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs189837126 4.08024824706802 1.76454080551086 0.0207580190668226
Beetroot Osteomyelitis (finn-b-M13_OSTEOMYELITIS) rs189837126 -2.31570744155716 1.13362661589742 0.0410779200609813
Beetroot Osteomyelitis (finn-b-M13_OSTEOMYELITIS) All - Inverse variance weighted -1.61273432060977 0.808509326189351 0.0460755057817771
Beetroot Osteoporosis (finn-b-M13_OSTEOPOROSIS) rs28449718 3.70028928378421 1.65305019550498 0.0251909728677249
Beetroot Osteoporosis (finn-b-M13_OSTEOPOROSIS) All - Inverse variance weighted 1.12544372737595 0.430236569219894 0.0088999955292141
Beetroot Postmenopausal osteoporosis with pathological fracture (finn-b-OSTPOPATFRCTURE_POSTEMENO) All - Inverse variance weighted 2.34244991095855 0.96825489752307 0.0155525803531905
Beetroot Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) rs189837126 -5.96087726346775 2.93854592954354 0.0425079649114674
Beetroot Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) All - Inverse variance weighted -4.17595403925858 2.10068696229458 0.0468228335971381
Beetroot Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) All - MR Egger -8.22504131126187 3.46298037645903 0.0448853086236694
Beetroot Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) rs189837126 3.07280446909328 1.33551915657372 0.0214011603861975
Beetroot Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) All - Inverse variance weighted 2.08310664558279 0.954838182407401 0.0291366171871688
Beetroot Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) rs150382547 6.45634853883443 3.18229779945866 0.0424753749853001
Beetroot Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) All - Inverse variance weighted 1.08006488970909 0.462782880931067 0.0196036836828793
Beetroot Fractured bone site(s): Ankle (ukb-b-15582) rs12549181 0.0396123370287206 0.0148609821187148 0.0076867944363407
Beetroot Fractured bone site(s): Ankle (ukb-b-15582) All - Inverse variance weighted 0.0175083189141363 0.0077436726133607 0.0237602555842812
Beetroot Fractured bone site(s): Other bones (ukb-b-17738) rs13101707 -0.056822243316354 0.0283967717065301 0.0453912395151129
Beetroot Fractured bone site(s): Other bones (ukb-b-17738) All - Inverse variance weighted -0.0194134543806816 0.0096492796250547 0.0442297287205752
Beetroot Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint (ukb-b-7012) rs28449718 -0.0148031280796007 0.0067149442095559 0.0274888487590779
Beetroot Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint (ukb-b-7012) All - Inverse variance weighted -0.0099675966500366 0.0046220855181279 0.0310434754881025
Beetroot Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) rs117786423 0.0178947547490785 0.0080372894811454 0.0259829590593327
Beetroot Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) rs72685482 0.0224643272002409 0.0087011659089931 0.0098297750054353
Beetroot Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) rs72980032 0.0183737950934672 0.0088634259390744 0.0381731917879741
Beetroot Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) All - Inverse variance weighted 0.0066242636271053 0.0030343474086164 0.0290289367464261
Beetroot Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) rs117786423 0.0181474567621208 0.0075954182024383 0.0168821815037812
Beetroot Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) rs72685482 0.021742123302405 0.0082227990420329 0.0081901968698219
Beetroot Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) All - Inverse variance weighted 0.0058770801672812 0.0026311492214749 0.0255057682014635
Beetroot Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) rs13101707 -0.0233894407529714 0.0111810634116342 0.0364492690232137
Beetroot Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) All - Inverse variance weighted -0.0120327956386435 0.0033049996032934 0.0002718071971954
Beetroot Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) rs117786423 0.0178947547490785 0.0080372894811454 0.0259829590593327
Beetroot Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) rs72685482 0.0224643272002409 0.0087011659089931 0.0098297750054353
Beetroot Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) rs72980032 0.0183737950934672 0.0088634259390744 0.0381731917879741
Beetroot Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) All - Inverse variance weighted 0.0066242636271053 0.0030343474086164 0.0290289367464261