ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Grape | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | All - Inverse variance weighted | 0.233571946658742 | 0.119012346135146 | 0.0496943160667957 |
| Grape | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | All - Inverse variance weighted | 0.233571946658742 | 0.119012346135146 | 0.0496943160667957 |
| Grape | Bone mineral density (ebi-a-GCST90014022) | rs139190506 | 0.224420451549428 | 0.0956280343902925 | 0.0189351073296385 |
| Grape | Bone mineral density (ebi-a-GCST90014022) | rs9320216 | 0.462682045519642 | 0.0995620992795294 | 3.36519098029407e-06 |
| Grape | Bone mineral density (ebi-a-GCST90014022) | All - Inverse variance weighted | 0.116398021529885 | 0.0592007248755072 | 0.0492802790289803 |
| Grape | Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) | rs10497191 | 0.663269920709096 | 0.283397147939341 | 0.0192617792731853 |
| Grape | Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) | All - Inverse variance weighted | 0.332021000220432 | 0.157118431615715 | 0.0345845623867471 |
| Grape | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | All - MR Egger | 2.86493184787398 | 1.10482244639005 | 0.0410398523706115 |
| Grape | Compression fracture (ebi-a-GCST90018608) | All - Inverse variance weighted | 1.23012905922792 | 0.537890709116929 | 0.0221987523295038 |
| Grape | Compression fracture (ebi-a-GCST90018828) | All - Inverse variance weighted | 0.786762802475915 | 0.370915571646458 | 0.0339102615455302 |
| Grape | Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) | rs139190506 | -5.29229819495978 | 1.88542142255432 | 0.0050011807177176 |
| Grape | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | All - Inverse variance weighted | -2.66803784424948 | 1.26811652496232 | 0.0353839038933215 |
| Grape | Loose body in joint (finn-b-M13_LOOSEJOINT) | All - Inverse variance weighted | 2.20796281834902 | 1.09279663586727 | 0.0433346589596178 |
| Grape | Osteomalacia (finn-b-M13_OSTEOMALACIA) | rs117720571 | -18.434505413338 | 6.6923241394056 | 0.0058768508889471 |
| Grape | Osteomalacia (finn-b-M13_OSTEOMALACIA) | All - Inverse variance weighted | -4.16411535302677 | 2.0006276245846 | 0.037396896569604 |
| Grape | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | rs9320216 | -6.5905435477119 | 2.8256989886972 | 0.0196818302095598 |
| Grape | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | All - Inverse variance weighted | -1.85467366545847 | 0.848819068218134 | 0.0288885009498411 |
| Grape | Otherdisorders of bone (finn-b-M13_OTHERBONE) | All - Inverse variance weighted | 0.746790659582401 | 0.357089543347102 | 0.0364988473376589 |
| Grape | Peroneal tendinitis (finn-b-M13_PERONEALTEND) | All - Inverse variance weighted | -4.83268949972496 | 1.71732293395515 | 0.0048916576536758 |
| Grape | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs139190506 | -1.26552160968175 | 0.455279115678192 | 0.0054415668853465 |
| Grape | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs62355507 | -2.12377743075532 | 1.03558806608038 | 0.0402870461398839 |
| Grape | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -0.790772481851648 | 0.278124726747771 | 0.0044658872796799 |
| Grape | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs117720571 | 1.37617353781562 | 0.693918012712112 | 0.0473458445416492 |
| Grape | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs139167288 | 4.20949972909518 | 2.01625428932635 | 0.0368174898261118 |
| Grape | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | 0.441531613495829 | 0.22087651851076 | 0.045608621821649 |
| Grape | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs139190506 | -0.811528593200393 | 0.284227922499662 | 0.0043009244662265 |
| Grape | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -0.437486828391672 | 0.173938633406149 | 0.0118971903570771 |
| Grape | Rheumatoid arthritis (ieu-a-832) | rs10497191 | -2.0398142844222 | 1.01754047453948 | 0.0450002910059625 |
| Grape | Rheumatoid arthritis (ieu-a-832) | All - Inverse variance weighted | -1.46044811697788 | 0.624694660239849 | 0.019394556842712 |
| Grape | Lumbar spine bone mineral density (ieu-a-982) | rs139167288 | 1.3434350731443 | 0.430355788333032 | 0.0017981942091437 |
| Grape | Lumbar spine bone mineral density (ieu-a-982) | All - Inverse variance weighted | 0.384490429332304 | 0.142236799649402 | 0.006868134829773 |
| Grape | Bone morphogenetic protein 6 (prot-a-256) | All - Inverse variance weighted | 0.976463991765039 | 0.394827706608869 | 0.0133931857020053 |
| Grape | Fractured/broken bones in last 5 years (ukb-a-308) | All - Inverse variance weighted | 0.022381934747793 | 0.0110173091352005 | 0.0422018047056091 |
| Grape | Fractured bone site(s): Other bones (ukb-a-441) | rs10915419 | 0.0510317774892367 | 0.0230386113578897 | 0.0267563307279675 |
| Grape | Fractured bone site(s): Other bones (ukb-a-441) | All - Inverse variance weighted | 0.0209954140546591 | 0.0082951497569682 | 0.0113722603158599 |
| Grape | Non-cancer illness code, self-reported: sciatica (ukb-b-8194) | All - Inverse variance weighted | -0.0129843845121379 | 0.0053568765448893 | 0.0153560054512462 |
| Grape | Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) | rs10497191 | -0.0156479845639 | 0.0071625312792064 | 0.0289108248116583 |
| Grape | Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) | All - Inverse variance weighted | -0.0147211247009021 | 0.0050423826263017 | 0.0035061824055053 |
| Grape | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | rs10497191 | 0.0172335614579879 | 0.0076182580119991 | 0.0236887932056469 |
| Grape | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | All - Inverse variance weighted | 0.0064759540875145 | 0.00285295326223 | 0.0232128964600362 |
| Grape | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | rs10497191 | -9.6777111158009 | 4.21176399650276 | 0.0215742590099806 |
| Grape | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | All - Inverse variance weighted | -6.46320760842736 | 2.2509076890959 | 0.0040868604800264 |