ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
Intake (exposure) | Outcome | SNP | b | se | P-value |
---|---|---|---|---|---|
Avocado | Rheumatoid Arthritis (bbj-a-73) | rs28482137 | 4.57758532674302 | 1.90682674001694 | 0.0163668795856406 |
Avocado | Rheumatoid Arthritis (bbj-a-73) | All - Inverse variance weighted | 0.849714400604326 | 0.411695574700194 | 0.0390235354441538 |
Avocado | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | rs56293519 | 2.38687079825999 | 1.16518840743461 | 0.0405125152170631 |
Avocado | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | rs73614552 | 2.12114621731219 | 0.902966851756518 | 0.0188195915655052 |
Avocado | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | rs77419563 | 3.52600470811388 | 1.70034040679459 | 0.0381066999239493 |
Avocado | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | All - Inverse variance weighted | 0.511488677011848 | 0.251615483205147 | 0.0420708361059514 |
Avocado | Heel bone mineral density (ebi-a-GCST006979) | rs145012853 | 0.573431305486293 | 0.163599765612167 | 0.0004564592078912 |
Avocado | Heel bone mineral density (ebi-a-GCST006979) | rs4713874 | -0.425797086348653 | 0.188304900920699 | 0.023746203136 |
Avocado | Heel bone mineral density (ebi-a-GCST006979) | rs6767991 | -0.472494335854998 | 0.178458968549595 | 0.0081056821315511 |
Avocado | Bone mineral density (ebi-a-GCST90014022) | rs4713874 | -0.489907361800477 | 0.213137716439965 | 0.0215305952553458 |
Avocado | Bone mineral density (ebi-a-GCST90014022) | rs6767991 | -0.449844476018586 | 0.198411159325679 | 0.0233759503645937 |
Avocado | Bone mineral density (ebi-a-GCST90014022) | All - Inverse variance weighted | -0.137097601279147 | 0.0415124732680934 | 0.0009580521014851 |
Avocado | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | rs10882792 | 30.0519955534837 | 12.3936780578764 | 0.0153174861100775 |
Avocado | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | rs8009320 | 6.07348651122959 | 2.17891682658271 | 0.0053134825723033 |
Avocado | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | All - Inverse variance weighted | 4.94668809241037 | 1.9252222565789 | 0.0101871426038585 |
Avocado | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | rs7557244 | -10.1840569486308 | 5.19463861989354 | 0.0499380987719455 |
Avocado | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | rs8009320 | 6.47150998834944 | 2.16855347894559 | 0.0028427257092989 |
Avocado | Rheumatoid arthritis (ebi-a-GCST90018910) | rs28482137 | 2.87075017867117 | 1.33928303314575 | 0.0320731509324273 |
Avocado | Rheumatoid arthritis (ebi-a-GCST90018910) | rs4713874 | 1.64816428598492 | 0.693839275565491 | 0.0175286772725086 |
Avocado | Rheumatoid arthritis (ebi-a-GCST90018910) | rs76118425 | 4.83668930961985 | 1.73546923887672 | 0.0053204482110901 |
Avocado | Rheumatoid arthritis (ebi-a-GCST90018910) | All - MR Egger | 0.89563463094317 | 0.336361559027476 | 0.0136198837034382 |
Avocado | Heel bone mineral density T score (ebi-a-GCST90025982) | rs6767991 | -0.523716447141047 | 0.180094850428171 | 0.0036374431973376 |
Avocado | Heel bone mineral density T score (ebi-a-GCST90025982) | All - Inverse variance weighted | -0.211818566060387 | 0.0659350708667239 | 0.0013157020583679 |
Avocado | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs2142667 | 0.0519040327973352 | 0.017552261378763 | 0.0031053357447727 |
Avocado | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs74494362 | 0.0398878354630855 | 0.0172404522740257 | 0.0206886384557907 |
Avocado | Spine arthritis or spondylitis (ebi-a-GCST90038657) | All - Inverse variance weighted | 0.0107799630560581 | 0.003796373574355 | 0.0045178315811266 |
Avocado | Fracture of forearm or wrist (ebi-a-GCST90038705) | rs7103110 | -0.0406381687127592 | 0.0132922150253723 | 0.002233473700606 |
Avocado | Fracture of forearm or wrist (ebi-a-GCST90038705) | All - Inverse variance weighted | -0.0077647120004834 | 0.0027078399187676 | 0.0041373796242534 |
Avocado | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs62434602 | -8.40963539102753 | 3.47051294673624 | 0.0153858159587789 |
Avocado | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs9288373 | -5.89859948998297 | 2.02051474242511 | 0.0035075671172534 |
Avocado | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | All - Inverse variance weighted | -3.4235194974928 | 1.52280999304786 | 0.024566031824971 |
Avocado | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs62196418 | 2.55401044756682 | 1.15038997496636 | 0.0264102302498245 |
Avocado | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs73614552 | 3.84999738469967 | 1.91054571682629 | 0.0438910628222094 |
Avocado | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | All - Inverse variance weighted | 0.454270996094051 | 0.229544298872454 | 0.0478146188716406 |
Avocado | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs76118425 | -3.85445234771188 | 1.95067846086779 | 0.0481599037166043 |
Avocado | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | All - Inverse variance weighted | -0.664526733209192 | 0.307629205596706 | 0.0307606808547427 |
Avocado | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | All - MR Egger | -1.64636467286115 | 0.584992010979527 | 0.010101036912362 |
Avocado | Osteomalacia (finn-b-M13_OSTEOMALACIA) | rs28482137 | 32.1788273165693 | 11.1226555039728 | 0.0038147372876904 |
Avocado | Osteomalacia (finn-b-M13_OSTEOMALACIA) | rs62196418 | -27.8806777895148 | 13.3271593326291 | 0.0364367674344147 |
Avocado | Osteomalacia (finn-b-M13_OSTEOMALACIA) | rs9288373 | 34.2835727263099 | 11.7971989799659 | 0.003659909658545 |
Avocado | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs145012853 | -6.36720924017643 | 2.42968977936652 | 0.0087778975787953 |
Avocado | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs2196281 | 8.73140857392826 | 3.40624088655585 | 0.0103665644292634 |
Avocado | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | All - MR Egger | -2.53127315543157 | 1.13718920517711 | 0.036580662621553 |
Avocado | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | rs141678669 | 36.9197846985698 | 14.7280553445558 | 0.0121841428971086 |
Avocado | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | All - MR Egger | 8.77932912511555 | 4.00902912220665 | 0.0394247342298054 |
Avocado | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs574491624 | 5.5230799472502 | 2.41229200183975 | 0.0220470122912974 |
Avocado | Spondylosis (finn-b-M13_SPONDYLOSIS) | All - Inverse variance weighted | 0.674916565886126 | 0.320554807806845 | 0.0352509492318363 |
Avocado | Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) | rs183191848 | 6.53213019381898 | 3.25369051331423 | 0.0446851242717855 |
Avocado | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs2142667 | -14.4050795872835 | 4.44338897464581 | 0.001187303455732 |
Avocado | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs62196418 | 9.63722922424646 | 4.116804375823 | 0.0192347926832745 |
Avocado | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs183191848 | -3.28173956946349 | 1.25560774879925 | 0.0089576497105422 |
Avocado | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | -1.07498744765835 | 0.383862160831865 | 0.0051031140825502 |
Avocado | Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) | rs77419563 | -2.48954222907176 | 0.877267261672905 | 0.0045420251844249 |
Avocado | Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) | All - Inverse variance weighted | -0.812490468456134 | 0.29161181034893 | 0.0053329029828633 |
Avocado | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | rs574491624 | 7.95254807884989 | 3.89134762005638 | 0.0409882499427227 |
Avocado | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | rs62196418 | -5.41913264936982 | 2.76021242421173 | 0.0496110058457148 |
Avocado | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | rs7103110 | -5.51649349041981 | 2.35158216098024 | 0.0189829989602552 |
Avocado | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | rs77419563 | 3.27874405134893 | 1.62243636425221 | 0.0432925173050161 |
Avocado | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | rs10882792 | -5.31609710617851 | 2.34876465736723 | 0.0236135816359887 |
Avocado | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | All - MR Egger | 1.9640036199408 | 0.930444937358985 | 0.046383646240899 |
Avocado | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | rs2196281 | 23.5695538057743 | 10.7203266258384 | 0.0279074146996751 |
Avocado | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | rs7103110 | 17.0504440895134 | 7.09010862069982 | 0.0161803765979453 |
Avocado | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | 3.68535386374155 | 1.6297764681002 | 0.023742951730954 |
Avocado | Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) | rs10882792 | -6.5084089360634 | 2.94043819700936 | 0.0268690726572608 |
Avocado | Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -1.5144860482411 | 0.61232751458077 | 0.0133861674491553 |
Avocado | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | All - Inverse variance weighted | -5.4129113937289 | 2.49252263646368 | 0.0298813272765517 |
Avocado | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | All - Inverse variance weighted | -5.52673541255663 | 2.56085826228892 | 0.0309155900552349 |
Avocado | Psoriatic arthritis (ieu-b-5116) | rs112335607 | -6.09146499051557 | 1.96332525490923 | 0.0019181154308908 |
Avocado | Psoriatic arthritis (ieu-b-5116) | rs56293519 | -5.58420428224394 | 2.01535223998644 | 0.0055913113271827 |
Avocado | Psoriatic arthritis (ieu-b-5116) | rs71446071 | 5.66995788704361 | 2.87432457842696 | 0.0485385657165864 |
Avocado | Psoriatic arthritis (ieu-b-5116) | rs76118425 | -4.37037507104663 | 2.00690876784443 | 0.0294309831491651 |
Avocado | Psoriatic arthritis (ieu-b-5116) | rs9288373 | -5.64793345336929 | 2.23991983118925 | 0.0116859293791663 |
Avocado | Psoriatic arthritis (ieu-b-5116) | All - Inverse variance weighted | -1.57364629813731 | 0.739166177857396 | 0.0332585693425162 |
Avocado | Bone sialoprotein 2 (prot-a-1395) | rs116888107 | -6.42296078777251 | 1.91962479117595 | 0.0008200237983287 |
Avocado | Bone sialoprotein 2 (prot-a-1395) | rs574491624 | 4.96199304175899 | 2.45809501453291 | 0.0435253222559154 |
Avocado | Osteocrin (prot-a-2157) | rs76118425 | 6.33487658578847 | 2.23762409018922 | 0.0046392167783032 |
Avocado | Osteocrin (prot-a-2157) | All - MR Egger | 2.51520131288318 | 0.85749419568542 | 0.0076950697469083 |
Avocado | Bone morphogenetic protein 7 (prot-a-257) | rs574491624 | 5.45628388707267 | 2.45809501453291 | 0.0264377465992883 |
Avocado | Bone morphogenetic protein 7 (prot-a-257) | rs62434602 | 6.02417052279216 | 2.11471563125595 | 0.0043899550461053 |
Avocado | Bone morphogenetic protein 7 (prot-a-257) | rs6767991 | -5.46253984101993 | 2.36166045850774 | 0.0207221921494193 |
Avocado | Bone morphogenetic protein 7 (prot-a-257) | All - MR Egger | 2.36977801191625 | 0.944330365375918 | 0.0199495376673179 |
Avocado | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs111384672 | 0.0134039226975493 | 0.0042722258539793 | 0.001704205707726 |
Avocado | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs574491624 | 0.0114030798709118 | 0.0049137472017221 | 0.020305824553964 |
Avocado | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs76118425 | 0.0131370055016306 | 0.0050300189273751 | 0.0090087769762141 |
Avocado | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | All - Inverse variance weighted | 0.003305085087368 | 0.0011859108713129 | 0.0053205194677606 |
Avocado | Fractured bone site(s): Ankle (ukb-b-15582) | rs6767991 | -0.0481275680657425 | 0.023736319649783 | 0.0426019223803274 |
Avocado | Fractured bone site(s): Ankle (ukb-b-15582) | All - Inverse variance weighted | -0.0162136049185055 | 0.007717486443057 | 0.0356504547848664 |
Avocado | Fractured bone site(s): Leg (ukb-b-3798) | All - Inverse variance weighted | -0.0165010358372282 | 0.0070990758646211 | 0.0201044887399123 |
Avocado | Non-cancer illness code, self-reported: other joint disorder (ukb-b-5316) | All - Inverse variance weighted | -0.0160858022012833 | 0.0069329490553786 | 0.0203302649226205 |
Avocado | Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) | rs76315615 | -0.0254871096092004 | 0.010276702821533 | 0.0131350597073979 |
Avocado | Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) | All - Inverse variance weighted | -0.0060906240422992 | 0.0028040506335366 | 0.0298495823848604 |
Avocado | Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) | All - Inverse variance weighted | -0.963491050576975 | 0.337992476559271 | 0.0043632889726726 |
Avocado | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) | All - Inverse variance weighted | -0.91246459914425 | 0.332300569956938 | 0.0060344897406079 |
Avocado | Spondylosis and allied disorders (ukb-e-721_CSA) | rs10882792 | 19.0680245275576 | 8.84731236776993 | 0.0311435619979206 |
Avocado | Spondylosis and allied disorders (ukb-e-721_CSA) | All - Inverse variance weighted | 2.77955579829628 | 1.39466789333425 | 0.0462628064300919 |