ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Crisp | Rheumatoid arthritis (bbj-a-151) | rs72610845 | 1.33787518579409 | 0.590397451516119 | 0.0234477993896987 |
| Crisp | Rheumatoid arthritis (bbj-a-151) | All - Inverse variance weighted | 1.095004123844 | 0.454149539810978 | 0.0159040867611004 |
| Crisp | Rheumatoid arthritis (ebi-a-GCST000679) | rs12959170 | -2.83261318438545 | 0.945428713060653 | 0.0027344325534528 |
| Crisp | Rheumatoid arthritis (ebi-a-GCST000679) | All - Inverse variance weighted | -2.09055693225657 | 0.728003892133952 | 0.0040836235089806 |
| Crisp | Osteoprotegerin levels (ebi-a-GCST90000490) | rs10153975 | -5.2169807724451 | 2.03917060826166 | 0.0105159999629148 |
| Crisp | Osteoprotegerin levels (ebi-a-GCST90000490) | rs7377083 | -4.6800071761403 | 2.33079097551869 | 0.0446533730631112 |
| Crisp | Rheumatoid arthritis (ebi-a-GCST90018690) | rs543197 | 2.18276753777476 | 0.990481987976255 | 0.0275424381565444 |
| Crisp | Rheumatoid arthritis (ebi-a-GCST90018690) | rs72610845 | 1.08959382223957 | 0.526309495178881 | 0.0384286564632637 |
| Crisp | Rheumatoid arthritis (ebi-a-GCST90018690) | All - Inverse variance weighted | 1.0016071960212 | 0.381572972570167 | 0.0086663545495871 |
| Crisp | Rheumatoid arthritis (ebi-a-GCST90018910) | All - Inverse variance weighted | 0.514159457241503 | 0.225358139037041 | 0.0225176012737797 |
| Crisp | Joint disorder (ebi-a-GCST90038654) | rs114906375 | 0.0636860474250637 | 0.0278992021007979 | 0.0224469074769822 |
| Crisp | Joint disorder (ebi-a-GCST90038654) | rs12959170 | 0.0687677841660909 | 0.0274164022217278 | 0.0121323359778593 |
| Crisp | Joint disorder (ebi-a-GCST90038654) | rs7377083 | -0.175780041602219 | 0.0326426136666683 | 7.24499911682805e-08 |
| Crisp | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | rs12959170 | 10.5699910615659 | 5.01957478034481 | 0.035225702418199 |
| Crisp | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | All - Inverse variance weighted | 4.79284153471572 | 2.06251902340308 | 0.0201372601529503 |
| Crisp | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | rs12959170 | 10.5114423666163 | 5.02347802667479 | 0.0363971099799572 |
| Crisp | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | All - Inverse variance weighted | 4.76742197995966 | 2.06475367472264 | 0.0209461145191452 |
| Crisp | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | rs150252324 | -6.53250709829848 | 3.15572043411881 | 0.0384474246558177 |
| Crisp | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | rs543197 | 6.62532914295422 | 2.85021282218258 | 0.020098534302167 |
| Crisp | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | rs72610845 | -8.74727140591098 | 3.97937767684772 | 0.027938376066343 |
| Crisp | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | All - MR Egger | -8.80313983395291 | 2.74063939675118 | 0.0148153552463262 |
| Crisp | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | rs543197 | 9.80586464320432 | 4.53013958492596 | 0.0304196084949432 |
| Crisp | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | All - Inverse variance weighted | 3.99575672165346 | 1.47232734779189 | 0.0066495208821578 |
| Crisp | Pyogenic arthritis (finn-b-M13_PYOGARTH) | rs12959170 | -4.21940928270042 | 1.70962189252802 | 0.0135856454717123 |
| Crisp | Pyogenic arthritis (finn-b-M13_PYOGARTH) | All - Inverse variance weighted | -1.48638735234767 | 0.704907865059242 | 0.0349768400007823 |
| Crisp | Postmenopausal osteoporosis with pathological fracture (finn-b-OSTPOPATFRCTURE_POSTEMENO) | rs543197 | -5.99771605462593 | 2.90212067159319 | 0.0387655741776372 |
| Crisp | Postmenopausal osteoporosis with pathological fracture (finn-b-OSTPOPATFRCTURE_POSTEMENO) | rs57871178 | 5.61078517594933 | 2.81281426148782 | 0.0460731043361826 |
| Crisp | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | All - Inverse variance weighted | 0.222482986060338 | 0.112201845068932 | 0.0473806444714921 |
| Crisp | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs114906375 | -2.17710893400218 | 0.857376920400857 | 0.011108500577018 |
| Crisp | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | All - MR Egger | -1.8574809770667 | 0.645724807976638 | 0.0237673322562041 |
| Crisp | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | All - MR Egger | -4.73048092632562 | 1.83898588547984 | 0.0368823051793197 |
| Crisp | Ankle and foot (finn-b-Z21_ANKLE_FOOT) | rs10153975 | -11.0843613736397 | 5.00262447180672 | 0.0267114202115543 |
| Crisp | Ankle and foot (finn-b-Z21_ANKLE_FOOT) | All - Inverse variance weighted | -4.90574147740948 | 2.08294472252802 | 0.0185129763095511 |
| Crisp | Rheumatoid arthritis (ieu-a-834) | rs12959170 | -2.83261318438545 | 0.959195462866466 | 0.0031458615260371 |
| Crisp | Rheumatoid arthritis (ieu-a-834) | All - Inverse variance weighted | -2.08694788698436 | 0.726829374837109 | 0.0040878255821857 |
| Crisp | Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) | rs114906375 | 0.0217505526938918 | 0.0095169848163485 | 0.0222867028175993 |
| Crisp | Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) | All - MR Egger | 0.0197365161041148 | 0.0080814362460681 | 0.0446144771312722 |
| Crisp | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs72721656 | 0.460951974946302 | 0.198653445703324 | 0.0203201958160407 |
| Crisp | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs7377083 | -0.639054688977352 | 0.203814506470648 | 0.0017157777566439 |
| Crisp | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs150252324 | 0.0055461786629638 | 0.0025049843526559 | 0.0268248437868431 |
| Crisp | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs57871178 | 0.0072366883008449 | 0.0025491222015652 | 0.0045270160403076 |
| Crisp | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | All - Inverse variance weighted | 0.0027362995833816 | 0.0009052486675267 | 0.0025052641543648 |
| Crisp | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | rs12959170 | -0.0179105532071023 | 0.007567106562528 | 0.0179379793789744 |
| Crisp | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | All - Inverse variance weighted | -0.0117573145354537 | 0.0034905497133748 | 0.0007562570887718 |
| Crisp | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | rs150252324 | 0.056493060592872 | 0.0278529633237308 | 0.0425336854057756 |
| Crisp | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | rs57871178 | -0.0658595596721105 | 0.0280306960416504 | 0.0187960514079112 |
| Crisp | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | rs7377083 | -0.166102434554085 | 0.0282440760476922 | 4.07880382419526e-09 |
| Crisp | Operative procedures - secondary OPCS: Z48.2 Skin of neck (ukb-b-14873) | All - Inverse variance weighted | 0.0074092495567394 | 0.0033464620354493 | 0.0268250253892969 |
| Crisp | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | rs7377083 | -0.0198086685835366 | 0.0079331746177978 | 0.0125269814161198 |
| Crisp | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | All - Inverse variance weighted | -0.0097482514348886 | 0.0037459222352717 | 0.0092583653060832 |
| Crisp | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | rs12959170 | -0.0086746527086577 | 0.0042830712303422 | 0.0428330095444209 |
| Crisp | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | rs7377083 | 0.0116875566696891 | 0.0050931686053559 | 0.021747365358558 |
| Crisp | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | rs72721656 | -0.0164431290888521 | 0.0077033973339454 | 0.0327994590591948 |
| Crisp | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | All - Inverse variance weighted | -0.0089953861679976 | 0.0033581949537117 | 0.0073922424834735 |
| Crisp | Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) | rs7377083 | -0.0226413045059373 | 0.0113016936660864 | 0.0451391980011518 |
| Crisp | Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) | All - Inverse variance weighted | -0.0088963248335012 | 0.0043840883186496 | 0.0424348392246224 |
| Crisp | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | rs72721656 | -0.0139821525193068 | 0.006518962435849 | 0.0319653826000551 |
| Crisp | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | rs7377083 | -0.0191007035526743 | 0.0066476757548281 | 0.0040622040657375 |
| Crisp | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | All - Inverse variance weighted | -0.0095932976853078 | 0.0040619765002827 | 0.0181898130845312 |
| Crisp | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | rs72610845 | 0.0163234650549399 | 0.0064027109181875 | 0.0107889419288528 |
| Crisp | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | All - MR Egger | 0.0136861660163817 | 0.0056456352652728 | 0.0458086538726668 |
| Crisp | Shoulder lesions (ukb-d-M13_SHOULDER) | All - MR Egger | 0.0304043317304397 | 0.012520352789705 | 0.0455278223798446 |
| Crisp | Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) | All - MR Egger | 0.0303369693004977 | 0.0125212087690815 | 0.0458999497808404 |
| Crisp | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | All - Inverse variance weighted | 1.93216699495374 | 0.936674322927346 | 0.039132120965659 |