ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Homemade soup | Rheumatoid Arthritis (bbj-a-72) | All - Inverse variance weighted | 1.26093536383618 | 0.545267107040615 | 0.0207496225267674 |
| Homemade soup | Osteoarthritis (hip) (ebi-a-GCST007091) | All - Inverse variance weighted | 0.419010617643578 | 0.194767020482248 | 0.0314491562648265 |
| Homemade soup | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | All - Inverse variance weighted | 0.478208885990512 | 0.238259352917083 | 0.0447396691454408 |
| Homemade soup | Bone disorder (ebi-a-GCST90038652) | rs10110298 | 0.0496773458215865 | 0.0218069974891638 | 0.0227238304472308 |
| Homemade soup | Bone disorder (ebi-a-GCST90038652) | All - Inverse variance weighted | 0.0116081847540679 | 0.0052266598590428 | 0.0263539004852013 |
| Homemade soup | Osteoporosis (ebi-a-GCST90038656) | rs10110298 | 0.0420657242371114 | 0.0185990942217246 | 0.0237154366996067 |
| Homemade soup | Osteoporosis (ebi-a-GCST90038656) | All - Inverse variance weighted | 0.0115674365332721 | 0.0044577451396553 | 0.0094616364376131 |
| Homemade soup | Fractures (ebi-a-GCST90038703) | rs10110298 | -0.0441186428746225 | 0.0196716805170512 | 0.0249130014074169 |
| Homemade soup | Fractures (ebi-a-GCST90038703) | All - MR Egger | -0.0264370191227084 | 0.0106940634422953 | 0.0268742781093875 |
| Homemade soup | Fracture of lower leg or ankle (ebi-a-GCST90038707) | rs57169211 | 0.0240230801109375 | 0.0108194250838262 | 0.0263939549127047 |
| Homemade soup | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs182666209 | 3.63085100409874 | 1.79340699990202 | 0.0429130849715379 |
| Homemade soup | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs57169211 | -8.79849532978418 | 3.93555884645814 | 0.0253753197208804 |
| Homemade soup | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs2319386 | 1.73000300285495 | 0.699172198045007 | 0.0133475505995448 |
| Homemade soup | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs71371995 | 1.73428186887137 | 0.64987502403384 | 0.007615924600983 |
| Homemade soup | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | All - MR Egger | 1.04174411788371 | 0.466396616197786 | 0.0423419218074644 |
| Homemade soup | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs1896796 | 4.86728208667644 | 2.40128835590832 | 0.0426679244398311 |
| Homemade soup | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs4660057 | 5.55212831585441 | 2.24390045488133 | 0.013348997919813 |
| Homemade soup | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs57169211 | 7.56971996093422 | 3.43999142175686 | 0.0277710518519988 |
| Homemade soup | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs6593964 | 4.52624339432985 | 2.18082636272257 | 0.0379428392351341 |
| Homemade soup | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | All - Inverse variance weighted | 1.35663529303396 | 0.642960531420693 | 0.0348598869025359 |
| Homemade soup | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | rs2319386 | 19.9039982789607 | 8.86066304830115 | 0.0246826973770627 |
| Homemade soup | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs143428752 | 8.80572034634335 | 3.64163231774979 | 0.0156030926868591 |
| Homemade soup | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | All - MR Egger | 7.93000393481769 | 2.81053282122155 | 0.0135916906252501 |
| Homemade soup | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | rs71371995 | 2.72255335512401 | 1.09594308786772 | 0.0129839022585131 |
| Homemade soup | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | All - MR Egger | 2.15298827771367 | 0.643203691473263 | 0.0047897366329331 |
| Homemade soup | Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) | rs71371995 | 1.56123822341857 | 0.634493366660258 | 0.0138702569063494 |
| Homemade soup | Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) | rs182666209 | -4.2770940421236 | 2.12698730743444 | 0.0443392358133194 |
| Homemade soup | Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) | All - Inverse variance weighted | -1.92673636510507 | 0.748536750335365 | 0.0100529198096552 |
| Homemade soup | Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) | rs143428752 | 11.2763900838066 | 3.82555314187857 | 0.0032019980853235 |
| Homemade soup | Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) | rs1896796 | 14.7528254680355 | 6.20452650044575 | 0.0174185351569247 |
| Homemade soup | Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) | All - Inverse variance weighted | 4.91782865173336 | 1.42420285616423 | 0.0005543079251941 |
| Homemade soup | Rheumatoid arthritis (ieu-a-831) | All - Inverse variance weighted | 1.48093837590112 | 0.589620205159159 | 0.0120157355695313 |
| Homemade soup | Psoriatic arthritis (ieu-b-5116) | rs71371995 | -3.498600269179 | 1.69998077292828 | 0.0395878838751535 |
| Homemade soup | Bone morphogenetic protein 7 (prot-a-257) | rs2319386 | 5.20793650082242 | 1.79723109882082 | 0.0037584333193828 |
| Homemade soup | Bone morphogenetic protein 7 (prot-a-257) | All - Inverse variance weighted | 0.950115581422589 | 0.427914663070748 | 0.0263957697708814 |
| Homemade soup | Fractured bone site(s): Wrist (ukb-a-439) | rs2319386 | -0.0578385718959668 | 0.0250596313211217 | 0.0209970440388487 |
| Homemade soup | Fractured bone site(s): Wrist (ukb-a-439) | All - Inverse variance weighted | -0.0122719186573274 | 0.0057193016892476 | 0.0318967394137061 |
| Homemade soup | Fractured bone site(s): Other bones (ukb-a-441) | rs1896796 | 0.0967898944583441 | 0.0394951542863716 | 0.0142587556393059 |
| Homemade soup | Fractured bone site(s): Other bones (ukb-a-441) | All - MR Egger | -0.0416250979647264 | 0.0194687903423156 | 0.0482899861015867 |
| Homemade soup | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | rs1896796 | 0.0413295516636471 | 0.0180773876283323 | 0.0222392354652172 |
| Homemade soup | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | rs71371995 | 0.0347532782157277 | 0.0177167083253221 | 0.0498078676912186 |
| Homemade soup | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | All - Inverse variance weighted | 0.0129529997564093 | 0.0063660407453655 | 0.0418808048532424 |
| Homemade soup | Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC (ukb-b-10298) | All - Inverse variance weighted | 0.0110654208754654 | 0.0046554041025464 | 0.0174589134116787 |
| Homemade soup | Operation code: knee replacement/revision (ukb-b-11120) | rs1023349 | -0.0341860529986053 | 0.0160575313807531 | 0.0332564827588322 |
| Homemade soup | Operation code: knee replacement/revision (ukb-b-11120) | rs6593964 | -0.038478770742833 | 0.0157737818820943 | 0.0147111389215481 |
| Homemade soup | Operation code: knee replacement/revision (ukb-b-11120) | All - Inverse variance weighted | -0.0136748274259457 | 0.0058101428208493 | 0.0185919581685857 |
| Homemade soup | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | All - Inverse variance weighted | 0.0178318531451019 | 0.0059709825450052 | 0.0028226600211897 |
| Homemade soup | Operation code: bone surgery/joint surgery (ukb-b-12974) | rs1023349 | -0.0267889121338912 | 0.0132011854951185 | 0.0424296987623569 |
| Homemade soup | Operation code: bone surgery/joint surgery (ukb-b-12974) | All - Inverse variance weighted | -0.0148756473681028 | 0.0051102876612933 | 0.0036036428489518 |
| Homemade soup | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | rs1174972 | 0.0321250266461878 | 0.0134920444048471 | 0.0172640830359605 |
| Homemade soup | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | rs4660057 | 0.0333291754513223 | 0.0127711831660012 | 0.009061711921467 |
| Homemade soup | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | All - Inverse variance weighted | 0.0181338869142115 | 0.0049619354850111 | 0.0002575837606522 |
| Homemade soup | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | All - Inverse variance weighted | -0.0101557048960691 | 0.0047052825585159 | 0.0308996676662599 |
| Homemade soup | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | All - Inverse variance weighted | -0.0112701508001043 | 0.0042357528976922 | 0.0077973859616273 |
| Homemade soup | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | rs1174972 | 0.0253662962618815 | 0.0117782709220401 | 0.0312674761473205 |
| Homemade soup | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | rs4660057 | 0.0313623390797974 | 0.0111490668492519 | 0.0049081459043142 |
| Homemade soup | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | All - Inverse variance weighted | 0.0154891343805597 | 0.0046805927514614 | 0.0009355463287915 |
| Homemade soup | Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) | All - Inverse variance weighted | -0.0087003981277728 | 0.004336306906847 | 0.04481280285748 |
| Homemade soup | Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) | rs2319386 | 0.0366893300047956 | 0.0142754379910452 | 0.0101668610778606 |
| Homemade soup | Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) | All - MR Egger | 0.100950275789656 | 0.0373006221336434 | 0.0424584245431039 |
| Homemade soup | Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) | rs6593964 | 0.0248799369852868 | 0.0098033729330645 | 0.0111521248568816 |
| Homemade soup | Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) | All - Inverse variance weighted | 0.0091855671134296 | 0.0041552554384869 | 0.0270642252963676 |
| Homemade soup | Knee pain for 3+ months (ukb-b-8906) | rs137972883 | -0.27385833261968 | 0.137154234820587 | 0.0458558231224053 |
| Homemade soup | Knee pain for 3+ months (ukb-b-8906) | All - Inverse variance weighted | -0.0620456887105698 | 0.0310360337708012 | 0.045592120324359 |
| Homemade soup | Cervicalgia (ukb-d-M13_CERVICALGIA) | rs112195932 | -0.0222716511413218 | 0.0093436487791689 | 0.0171435781938146 |
| Homemade soup | Cervicalgia (ukb-d-M13_CERVICALGIA) | rs1896796 | 0.0187062519771087 | 0.0094364161849711 | 0.0474404092306652 |
| Homemade soup | Cervicalgia (ukb-d-M13_CERVICALGIA) | All - MR Egger | -0.0156937493605198 | 0.0054014106842473 | 0.0115164009252938 |
| Homemade soup | Internal derangement of knee (ukb-e-835_CSA) | All - Inverse variance weighted | 2.52412778246602 | 1.13746433259387 | 0.0264810772379402 |