ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Flavoured milk | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | rs138864146 | -5.78490665264265 | 2.22393560837341 | 0.0092897626057203 |
| Flavoured milk | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | rs77140717 | -3.03882997475933 | 1.48372766027395 | 0.0405497163879058 |
| Flavoured milk | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | rs996238 | -4.70584793040222 | 1.88233917216089 | 0.0124193306515523 |
| Flavoured milk | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | All - Inverse variance weighted | -1.26897693999425 | 0.444859017464678 | 0.0043371722205777 |
| Flavoured milk | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | All - MR Egger | -2.06488779913052 | 0.881935090678831 | 0.0302693322427672 |
| Flavoured milk | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | rs10880014 | 6.7820613347273 | 3.43954521693675 | 0.0486335687337412 |
| Flavoured milk | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | All - Inverse variance weighted | 1.51976381425264 | 0.747989837506333 | 0.0421741695590239 |
| Flavoured milk | Osteoarthritis (hip) (ebi-a-GCST007091) | All - MR Egger | -1.64809201866315 | 0.736995831356771 | 0.0375282313955152 |
| Flavoured milk | Bone mineral density (ebi-a-GCST90014022) | rs141474325 | 0.832261781474111 | 0.308176783082323 | 0.0069214822445825 |
| Flavoured milk | Bone mineral density (ebi-a-GCST90014022) | All - Inverse variance weighted | 0.139289261308284 | 0.068929370802999 | 0.0433052975909976 |
| Flavoured milk | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | rs9872037 | 5.88058053627622 | 2.49287461758827 | 0.0183264483646077 |
| Flavoured milk | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | All - Inverse variance weighted | 3.82339304674392 | 1.26304038098141 | 0.0024688412221273 |
| Flavoured milk | Heel bone mineral density (ebi-a-GCST90029004) | rs141474325 | 0.550930818632631 | 0.280587297603942 | 0.0495890726612021 |
| Flavoured milk | Heel bone mineral density (ebi-a-GCST90029004) | rs77166451 | 0.669103554458337 | 0.273077433569589 | 0.0142763486577694 |
| Flavoured milk | Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) | rs77166451 | -35.9693132648456 | 16.0600992806137 | 0.0251123921521348 |
| Flavoured milk | Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) | All - Inverse variance weighted | -5.81089890865224 | 2.63079850254159 | 0.0271887884506659 |
| Flavoured milk | Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) | rs77166451 | -36.149823471636 | 16.070717528072 | 0.0244856684875972 |
| Flavoured milk | Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) | All - Inverse variance weighted | -5.84415888488349 | 2.63248149703954 | 0.0264174793287517 |
| Flavoured milk | Disorders of synovium and tendon (finn-b-M13_SYNOTEND) | All - MR Egger | -1.58044475070633 | 0.718202400094547 | 0.0410630462494106 |
| Flavoured milk | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | rs77140717 | -10.0746405853587 | 4.7561474124525 | 0.0341551228596344 |
| Flavoured milk | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | rs9872037 | 21.7895653273542 | 11.0285355758428 | 0.0481837548156812 |
| Flavoured milk | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | All - MR Egger | -7.71158964255114 | 3.53783102630173 | 0.0427984635282119 |
| Flavoured milk | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs148140816 | 5.21818044316721 | 2.61506067975656 | 0.0459955886808101 |
| Flavoured milk | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | All - Inverse variance weighted | 0.879590188453205 | 0.350527775934451 | 0.0120960105888167 |
| Flavoured milk | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs9872037 | 3.8909938084561 | 1.53207881207959 | 0.0110953128987481 |
| Flavoured milk | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | All - Inverse variance weighted | 0.592738409815264 | 0.243429545839901 | 0.0148939089375782 |
| Flavoured milk | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | rs181673695 | -4.26255245219419 | 1.70559817146023 | 0.0124490207499816 |
| Flavoured milk | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | All - Inverse variance weighted | -0.902683826232034 | 0.455194228387332 | 0.0473591675208347 |
| Flavoured milk | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | All - MR Egger | -1.91759048000425 | 0.85457604172851 | 0.0376528681636444 |
| Flavoured milk | Knee and hip osteoarthritis (ieu-a-1170) | rs9872037 | 7.08512278517337 | 3.20666527239389 | 0.0271399719848267 |
| Flavoured milk | Knee osteoarthritis (ieu-a-1171) | rs9872037 | 11.5891061900848 | 4.21718068316124 | 0.00599472754713 |
| Flavoured milk | Femoral neck bone mineral density (ieu-a-980) | rs138864146 | -2.88884333064441 | 1.12293149476105 | 0.0100940448627158 |
| Flavoured milk | Femoral neck bone mineral density (ieu-a-980) | All - Inverse variance weighted | -0.425913910850685 | 0.217020666270958 | 0.0496984841753674 |
| Flavoured milk | Bone sialoprotein 2 (prot-a-1395) | rs146541987 | -7.90324512034487 | 3.46931172580795 | 0.0227239500359497 |
| Flavoured milk | Bone sialoprotein 2 (prot-a-1395) | rs148140816 | -7.68596982132409 | 3.42306268583051 | 0.0247457471420419 |
| Flavoured milk | Bone sialoprotein 2 (prot-a-1395) | rs77140717 | -5.14978944477008 | 2.62139639103794 | 0.049469651005598 |
| Flavoured milk | Bone sialoprotein 2 (prot-a-1395) | rs9544664 | -7.09640290260187 | 3.21934375581451 | 0.027503177387525 |
| Flavoured milk | Bone sialoprotein 2 (prot-a-1395) | rs996238 | 7.21725900206765 | 3.6671478172668 | 0.0490582462076129 |
| Flavoured milk | Bone sialoprotein 2 (prot-a-1395) | All - MR Egger | -4.02266281154628 | 1.73900755517634 | 0.0320726213758175 |
| Flavoured milk | Alkaline phosphatase, bone (prot-c-2795_23_3) | rs9872037 | -19.5522438874919 | 6.69827288512327 | 0.0035115868988518 |
| Flavoured milk | Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) | rs138864146 | 0.0624484684259082 | 0.029537073764245 | 0.0344947579049226 |
| Flavoured milk | Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) | All - MR Egger | 0.0331019553000311 | 0.0136547619964524 | 0.0254867667288377 |
| Flavoured milk | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs34654942 | 0.0942366317032332 | 0.0330553307785089 | 0.0043599040953577 |
| Flavoured milk | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - Inverse variance weighted | 0.0456028957205759 | 0.017454721479531 | 0.0089846003335518 |
| Flavoured milk | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs114155753 | -0.096787419525557 | 0.0398389638788245 | 0.0151210712605657 |
| Flavoured milk | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | rs34654942 | 7.21279855056975 | 3.4937986981592 | 0.0389743696850644 |
| Flavoured milk | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | All - MR Egger | -4.97054201154882 | 1.62127273582402 | 0.0107396326137077 |
| Flavoured milk | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | All - MR Egger | -4.95540305189551 | 1.63106842011096 | 0.0112841631096328 |
| Flavoured milk | Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) | rs10880014 | -25.5096706743335 | 11.7442063077191 | 0.0298476063145444 |
| Flavoured milk | Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) | All - Inverse variance weighted | -10.1822431083266 | 4.04277608214988 | 0.0117813544131202 |
| Flavoured milk | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | rs79169291 | -13.1964200759281 | 4.93947782662976 | 0.0075485515798993 |
| Flavoured milk | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | All - Inverse variance weighted | -7.87283308102191 | 3.05516941221293 | 0.0099693899734501 |