ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Other alcohol | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs1105335 | 9.76161040865569 | 3.87715603604833 | 0.0118115698121939 |
| Other alcohol | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs115331905 | 8.58259795801584 | 3.66888534168599 | 0.0193202724771307 |
| Other alcohol | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs117693960 | 9.59513880537345 | 4.1484946093265 | 0.0207270028176362 |
| Other alcohol | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs148063101 | -10.0277236850456 | 5.01020432021858 | 0.0453428371365036 |
| Other alcohol | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs73234113 | 8.05178894241493 | 3.98887383353364 | 0.0435327692122318 |
| Other alcohol | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | All - Inverse variance weighted | 1.94469039589579 | 0.772366209989144 | 0.01180787434469 |
| Other alcohol | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | All - MR Egger | 2.87606062099637 | 1.3359447396923 | 0.0372666269309922 |
| Other alcohol | Osteoprotegerin levels (ebi-a-GCST90012002) | rs117693960 | -3.94590149547716 | 1.67717065211385 | 0.0186370035107944 |
| Other alcohol | Osteoprotegerin levels (ebi-a-GCST90012002) | rs4880272 | 2.9419157298236 | 1.41383328763367 | 0.0374514762217347 |
| Other alcohol | Osteoprotegerin levels (ebi-a-GCST90012002) | rs73945065 | -3.08120911781131 | 1.49887985210196 | 0.0398138996865664 |
| Other alcohol | Osteoprotegerin levels (ebi-a-GCST90012002) | All - MR Egger | -0.819801017111823 | 0.401038533639052 | 0.0470887801639406 |
| Other alcohol | Rheumatoid arthritis (ebi-a-GCST90018690) | rs1105335 | -1.87655068336644 | 0.938822432722012 | 0.0456262618231725 |
| Other alcohol | Rheumatoid arthritis (ebi-a-GCST90018690) | rs4880272 | -11.3061106160314 | 3.6047179188374 | 0.0017099153200351 |
| Other alcohol | Rheumatoid arthritis (ebi-a-GCST90018690) | All - Inverse variance weighted | -1.43419381711876 | 0.560754611999559 | 0.0105393022475477 |
| Other alcohol | Rheumatoid arthritis (ebi-a-GCST90018910) | rs143127868 | 5.970358529985 | 2.22381132657497 | 0.0072585924974149 |
| Other alcohol | Rheumatoid arthritis (ebi-a-GCST90018910) | rs184144317 | -6.05472768421362 | 2.82896863886195 | 0.0323337816402294 |
| Other alcohol | Rheumatoid arthritis (ebi-a-GCST90018910) | All - Inverse variance weighted | -0.611720414732598 | 0.301987995085359 | 0.0428011961608895 |
| Other alcohol | Osteoarthritis (ebi-a-GCST90038686) | rs115331905 | -0.148737463482215 | 0.0677035207661958 | 0.028028012265429 |
| Other alcohol | Osteoarthritis (ebi-a-GCST90038686) | rs1321865 | -0.194275888295498 | 0.0777872389676097 | 0.0125062221127022 |
| Other alcohol | Osteoarthritis (ebi-a-GCST90038686) | rs358054 | -0.234270696751036 | 0.077860655481258 | 0.0026224228372369 |
| Other alcohol | Osteoarthritis (ebi-a-GCST90038686) | All - Inverse variance weighted | -0.0259206398648789 | 0.0127879359492879 | 0.0426664618779351 |
| Other alcohol | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | rs7695589 | -38.0611202685894 | 16.6857119742737 | 0.0225448608190302 |
| Other alcohol | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | rs9466782 | -32.0198016452506 | 16.136762160364 | 0.0472249988739691 |
| Other alcohol | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | All - Inverse variance weighted | -9.91774285342513 | 2.69110540897674 | 0.0002283627266284 |
| Other alcohol | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | rs7695589 | -38.3771375408294 | 16.6983526651633 | 0.0215470584694412 |
| Other alcohol | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | rs9466782 | -32.008525081896 | 16.1762301321049 | 0.0478454855922969 |
| Other alcohol | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | All - Inverse variance weighted | -9.94358662913344 | 2.69548147385414 | 0.0002251518360512 |
| Other alcohol | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs117197531 | 26.3872184117284 | 12.7994668920456 | 0.0392470440204806 |
| Other alcohol | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs117476691 | 33.610500745612 | 15.8053926450518 | 0.0334598953673669 |
| Other alcohol | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs145439530 | 25.3610140242265 | 10.5353436736937 | 0.0160739650355101 |
| Other alcohol | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs7091162 | -36.9927852580304 | 16.9773652150381 | 0.0293355783114538 |
| Other alcohol | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | All - MR Egger | 10.4187513812435 | 4.39693859692981 | 0.0225991875211356 |
| Other alcohol | Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) | rs141723674 | -10.0300394188154 | 3.71373405608203 | 0.0069173678180443 |
| Other alcohol | Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) | rs145772870 | -20.921630577175 | 6.90032014683321 | 0.0024295554598031 |
| Other alcohol | Transient synovitis (finn-b-M13_TRANSSYNOVITIS) | rs73945065 | -33.2257049870653 | 15.8618077710662 | 0.0361978024349321 |
| Other alcohol | Transient synovitis (finn-b-M13_TRANSSYNOVITIS) | rs74356299 | 37.5644294773566 | 18.2310436515387 | 0.0393540973944371 |
| Other alcohol | Transient synovitis (finn-b-M13_TRANSSYNOVITIS) | rs77641174 | -48.9649981181784 | 24.8149542090077 | 0.0484721816919881 |
| Other alcohol | Transient synovitis (finn-b-M13_TRANSSYNOVITIS) | All - MR Egger | -10.1799293626696 | 4.86856005984138 | 0.04277174619808 |
| Other alcohol | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | rs115592884 | 12.7610610009526 | 4.43288889168346 | 0.003992883622661 |
| Other alcohol | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | All - MR Egger | 2.32226847995559 | 1.11113732348391 | 0.0428625461914643 |
| Other alcohol | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs117481280 | -4.61126184692952 | 2.1823016174952 | 0.0345984724036933 |
| Other alcohol | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs145439530 | -3.21202040871555 | 1.27606513969062 | 0.0118315543346013 |
| Other alcohol | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | All - Inverse variance weighted | -0.67625971193206 | 0.317012167841614 | 0.0329059033353565 |
| Other alcohol | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs12280926 | 6.43849542527957 | 3.11032579755047 | 0.0384487008169289 |
| Other alcohol | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs180874328 | -4.72243816952815 | 1.92376108468502 | 0.014096513848601 |
| Other alcohol | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs80024463 | 9.02104600733464 | 4.16952126455845 | 0.0304974602639106 |
| Other alcohol | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs117481280 | -4.14302854968917 | 1.91473973335786 | 0.0304831222261785 |
| Other alcohol | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs145439530 | -2.93932133318623 | 1.12410305943383 | 0.0089275844833411 |
| Other alcohol | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs309494 | -4.59535145387172 | 1.85206588898466 | 0.0130939775771243 |
| Other alcohol | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs77658154 | -7.35440350998243 | 3.04809990949051 | 0.0158312438176641 |
| Other alcohol | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | All - Inverse variance weighted | -0.686453832817581 | 0.298766167408844 | 0.0215829093955825 |
| Other alcohol | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs117693960 | 1.95344876341168 | 0.955597232018358 | 0.040932046636374 |
| Other alcohol | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | All - MR Egger | 0.687119556877486 | 0.337721789867406 | 0.0483958072864911 |
| Other alcohol | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs115331905 | 17.1279703641237 | 7.72219377767069 | 0.0265535559981501 |
| Other alcohol | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs117476691 | 10.4517407272746 | 5.2403610553439 | 0.0461007608704124 |
| Other alcohol | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs117481280 | 16.8689406639715 | 5.74421920007358 | 0.0033174492401442 |
| Other alcohol | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs11869330 | -13.1563441692901 | 6.24568609956061 | 0.0351636329216882 |
| Other alcohol | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs145772870 | 18.8865615389465 | 6.44496907115386 | 0.0033848803668009 |
| Other alcohol | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs148063101 | 14.4497182538755 | 4.52263488574836 | 0.0013984157585042 |
| Other alcohol | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs358054 | 11.8746604700375 | 5.68846010540717 | 0.0368429610525064 |
| Other alcohol | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs73234113 | 32.4563126512703 | 14.9647271891948 | 0.0300937485617081 |
| Other alcohol | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | All - Inverse variance weighted | 2.24938125137721 | 1.04614960038465 | 0.0315431484990396 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs11869330 | 1.63385296543829 | 0.592648271914614 | 0.0058357931822371 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs141723674 | 1.61031142131658 | 0.519496047556076 | 0.0019367958133747 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs184144317 | -1.18044411133645 | 0.597114451988361 | 0.0480513157743329 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs4280024 | -1.35284161962759 | 0.5904607582876 | 0.0219540098473393 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs4880272 | -1.70732508454437 | 0.592581802394662 | 0.0039620999972354 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs7234196 | 1.6733108065353 | 0.57316089633186 | 0.0035065704450044 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs73234113 | 1.17213264840715 | 0.56040323198157 | 0.0364753911817032 |
| Other alcohol | Fractured bone site(s): Ankle (ukb-a-438) | rs117093907 | -0.117389830125343 | 0.0357438656373973 | 0.001022740774998 |
| Other alcohol | Fractured bone site(s): Ankle (ukb-a-438) | rs7234196 | -0.0900714115604582 | 0.0395791699599741 | 0.0228623151978107 |
| Other alcohol | Fractured bone site(s): Ankle (ukb-a-438) | rs73234113 | 0.0923218797961202 | 0.0388540248291291 | 0.0174957056122358 |
| Other alcohol | Fractured bone site(s): Ankle (ukb-a-438) | All - Inverse variance weighted | -0.0146353703347234 | 0.0061692504806346 | 0.0176772854131085 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs117481280 | 0.986630267102012 | 0.439512201239982 | 0.024779034581425 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs11869330 | 2.0479874076194 | 0.44559940068349 | 4.30620462222261e-06 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs145439530 | 0.843551915867131 | 0.409414987624458 | 0.0393618858578103 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs358054 | -0.897600607527539 | 0.444044040058136 | 0.0432360489039974 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs4280024 | -1.78180661378232 | 0.446068306687436 | 6.48390414552202e-05 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs4880272 | -2.06698142308747 | 0.446891280504524 | 3.74156828711374e-06 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs72658299 | 1.09328579916815 | 0.433364565717507 | 0.0116429429210518 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs77641174 | 0.975994229080416 | 0.445703174005771 | 0.0285398161347573 |
| Other alcohol | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | All - MR Egger | 0.362784747432036 | 0.17562422571688 | 0.0449176155835338 |
| Other alcohol | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | rs115331905 | -0.0905065807306569 | 0.0432731982049815 | 0.0364818454461038 |
| Other alcohol | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | rs117197531 | 0.107890972922017 | 0.0525176348210513 | 0.0399393060487647 |
| Other alcohol | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | All - Inverse variance weighted | -0.0152397857760865 | 0.007345526162778 | 0.0380140614834562 |
| Other alcohol | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | rs74356299 | -0.115408563139374 | 0.0342793892297535 | 0.0007607224276731 |
| Other alcohol | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | All - Inverse variance weighted | -0.0106039986615764 | 0.0051085256459083 | 0.0379175036629971 |
| Other alcohol | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | rs12280926 | 0.0774434816285037 | 0.0226457940004196 | 0.0006267334206369 |
| Other alcohol | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | rs140198022 | 0.0538330724475029 | 0.0231969638796184 | 0.0203033239151358 |
| Other alcohol | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | rs145772870 | 0.0512245441235192 | 0.0243196004119176 | 0.0351776953069249 |
| Other alcohol | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | rs180874328 | -0.0469666504157169 | 0.0236890358794619 | 0.0474085038578899 |
| Other alcohol | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | rs9466782 | 0.0458638129443671 | 0.0228039738609261 | 0.0443022027004091 |
| Other alcohol | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | All - Inverse variance weighted | 0.0081080631300052 | 0.0039156199767361 | 0.038387106655327 |
| Other alcohol | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | rs1321865 | -0.102086605710884 | 0.0373635246330804 | 0.0062902799520934 |
| Other alcohol | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | All - MR Egger | 0.0712988935336043 | 0.0303463020350987 | 0.0352583677677699 |
| Other alcohol | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | All - Inverse variance weighted | 0.0198022140924038 | 0.0086238867967818 | 0.0216641488155398 |
| Other alcohol | Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) | rs1321865 | 0.0613519121707644 | 0.0307447793521933 | 0.0459858758399843 |
| Other alcohol | Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) | rs309494 | 0.0654357159070179 | 0.0303163690596379 | 0.030894529539556 |
| Other alcohol | Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) | All - Inverse variance weighted | 0.026873524763566 | 0.0106574655830954 | 0.0116833073307622 |
| Other alcohol | Neck/shoulder pain for 3+ months (ukb-b-16118) | rs145439530 | -0.675854474450595 | 0.271248149913715 | 0.0127152555761249 |
| Other alcohol | Neck/shoulder pain for 3+ months (ukb-b-16118) | rs74356299 | -0.587457526513752 | 0.286867591745759 | 0.0405761587582833 |
| Other alcohol | Neck/shoulder pain for 3+ months (ukb-b-16118) | rs77658154 | -0.648222482882342 | 0.279733179643076 | 0.0204880208226902 |
| Other alcohol | Neck/shoulder pain for 3+ months (ukb-b-16118) | All - MR Egger | -0.151516157439163 | 0.0722719141906803 | 0.0419599822537722 |
| Other alcohol | Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) | rs7695589 | -0.05548112997664 | 0.0203736335413148 | 0.0064656256463056 |
| Other alcohol | Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) | All - Inverse variance weighted | -0.0212856030524621 | 0.0099627767380149 | 0.0326376140376689 |
| Other alcohol | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | rs115331905 | -0.0622208836550914 | 0.0274953468060115 | 0.0236381245683356 |
| Other alcohol | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | rs7234196 | 0.0727911255000362 | 0.0314794169724121 | 0.0207589357179876 |
| Other alcohol | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | All - MR Egger | -0.0177606803138225 | 0.0087214016729512 | 0.0478935212377401 |
| Other alcohol | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs2008984 | 0.0578656597488927 | 0.0240121892565128 | 0.0159592890475193 |
| Other alcohol | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs7091162 | -0.0496607079944243 | 0.023267798150616 | 0.032817364984693 |
| Other alcohol | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs73234113 | -0.0750743242568407 | 0.0225931092341855 | 0.0008909134555542 |
| Other alcohol | Ankle spacing width (right) (ukb-e-4119_EAS) | rs7695589 | -10.4791327474794 | 4.34586952784491 | 0.0158963936519931 |
| Other alcohol | Spondylosis and allied disorders (ukb-e-721_CSA) | All - MR Egger | 10.1845003163561 | 3.98323628853138 | 0.0167468987966572 |
| Other alcohol | Pain in joint (ukb-e-745_AFR) | rs309494 | 44.2128511092204 | 17.4344849098406 | 0.0112145148675987 |
| Other alcohol | Pain in joint (ukb-e-745_AFR) | rs358054 | -34.3725201869228 | 15.1739673311736 | 0.0234985926430183 |
| Other alcohol | Pain in joint (ukb-e-745_AFR) | rs878282 | -6.71580257745337 | 2.60685223167222 | 0.0099889538505678 |
| Other alcohol | Pain in joint (ukb-e-745_AFR) | All - Inverse variance weighted | -4.97793925376538 | 2.13295808094853 | 0.0196051730437225 |