ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Other drink | Osteoporosis (bbj-a-137) | All - Inverse variance weighted | -1.0366424291464 | 0.497192011495612 | 0.0370698326939522 |
| Other drink | Rheumatoid arthritis (bbj-a-151) | All - Inverse variance weighted | -1.23958190892273 | 0.632299010109994 | 0.0499448207671088 |
| Other drink | Rheumatoid arthritis (ebi-a-GCST90018910) | All - Inverse variance weighted | -0.629323539316774 | 0.309159151662774 | 0.0417908075465433 |
| Other drink | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | rs16884231 | 19.5452412123607 | 9.88686609193983 | 0.0480541282716381 |
| Other drink | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | rs6496597 | 21.8691665190555 | 10.028477606246 | 0.0292051303637713 |
| Other drink | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | All - MR Egger | -11.3747483388139 | 4.17113034891552 | 0.0149221022619624 |
| Other drink | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | rs16884231 | 21.4225724378134 | 10.9243386112689 | 0.0498796163856166 |
| Other drink | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | All - Inverse variance weighted | 6.69821674702301 | 2.77819542690299 | 0.0159090435579744 |
| Other drink | Transient synovitis (finn-b-M13_TRANSSYNOVITIS) | rs72963585 | 28.0565739805773 | 13.9266327367358 | 0.0439467305729078 |
| Other drink | Transient synovitis (finn-b-M13_TRANSSYNOVITIS) | All - MR Egger | -14.1415966232326 | 5.03460828068773 | 0.0126082845162318 |
| Other drink | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | rs75805105 | -13.6823420389731 | 6.90969367111738 | 0.0476848535680486 |
| Other drink | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | All - MR Egger | -13.6220857793685 | 5.14789003949537 | 0.0176069304139596 |
| Other drink | Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) | All - Inverse variance weighted | 6.28188022604962 | 3.1123660715982 | 0.0435536134895965 |
| Other drink | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | rs138084634 | 39.3353701303072 | 15.9100335050931 | 0.0134223338161202 |
| Other drink | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | rs6496597 | -5.22543636140671 | 2.00297039146489 | 0.0090848770616382 |
| Other drink | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | All - Inverse variance weighted | -1.07452677916212 | 0.496792770602263 | 0.0305467510334996 |
| Other drink | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs149362721 | -3.53030788082175 | 1.49911135151843 | 0.0185260094884302 |
| Other drink | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs529703549 | -1.47538053790549 | 0.703467524516794 | 0.0359672659742603 |
| Other drink | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | All - MR Egger | -1.16116046242134 | 0.505486797512053 | 0.0354460593378068 |
| Other drink | Psoriatic arthritis (ieu-b-5116) | rs6496597 | -8.78377457726424 | 2.79564251747489 | 0.0016782555098876 |
| Other drink | Psoriatic arthritis (ieu-b-5116) | All - Inverse variance weighted | -1.26130881963133 | 0.598543815037269 | 0.035091954134533 |
| Other drink | Osteocrin (prot-a-2157) | All - Inverse variance weighted | -1.27704464985737 | 0.497092774576622 | 0.010198457594507 |
| Other drink | Osteocrin (prot-a-2157) | All - MR Egger | -1.85745722534488 | 0.862360359721659 | 0.0468371037723567 |
| Other drink | Bone proteoglycan II (prot-c-2666_53_2) | rs6594004 | 7.63395044316107 | 3.57563430675357 | 0.0327616680879824 |
| Other drink | Bone proteoglycan II (prot-c-2666_53_2) | All - Inverse variance weighted | 4.37949359020801 | 2.08385798550086 | 0.0355859045803796 |
| Other drink | Non-cancer illness code self-reported: bone disorder (ukb-a-84) | rs75805105 | 0.0252581019878095 | 0.0091982327681846 | 0.0060331665456846 |
| Other drink | Non-cancer illness code self-reported: bone disorder (ukb-a-84) | rs75940184 | 0.0329574658648486 | 0.0115848397887002 | 0.004442831543743 |
| Other drink | Non-cancer illness code self-reported: bone disorder (ukb-a-84) | All - Inverse variance weighted | 0.0061526774350138 | 0.0026613262349644 | 0.0207840788827988 |
| Other drink | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | rs529703549 | 0.557924529975955 | 0.281626569017769 | 0.0475823956960141 |
| Other drink | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | rs6496597 | -2.11070158466297 | 0.679951220176861 | 0.0019079714838929 |
| Other drink | Diagnoses - secondary ICD10: M06.99 Rheumatoid arthritis, unspecified (Site unspecified) (ukb-b-11874) | All - Inverse variance weighted | -0.0208215532641413 | 0.0081382333558805 | 0.0105129158698261 |
| Other drink | Fractured bone site(s): Leg (ukb-b-3798) | rs6496597 | 0.0417053862190187 | 0.016766633510921 | 0.0128679286446952 |
| Other drink | Fractured bone site(s): Leg (ukb-b-3798) | All - Inverse variance weighted | 0.0152926109057551 | 0.0061721221945128 | 0.0132235653455693 |
| Other drink | Non-cancer illness code, self-reported: sciatica (ukb-b-8194) | rs10046909 | -0.05370728336564 | 0.0201830712901141 | 0.0077907459171001 |
| Other drink | Non-cancer illness code, self-reported: sciatica (ukb-b-8194) | rs6496597 | 0.0620405090542437 | 0.0201910315978798 | 0.0021214830746208 |
| Other drink | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | rs62314642 | -0.0278159604107308 | 0.0136721888540738 | 0.0419020028609072 |
| Other drink | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | All - Inverse variance weighted | -0.0171649199630525 | 0.0066705599903976 | 0.0100752704189343 |
| Other drink | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | rs529703549 | 0.015096666577941 | 0.0062627115314171 | 0.0159278791893701 |
| Other drink | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | All - MR Egger | 0.0154949155687869 | 0.0058199203550163 | 0.0177462093329055 |
| Other drink | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs10046909 | -0.0351322779811903 | 0.015641198219542 | 0.0246952179252401 |
| Other drink | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs529703549 | 0.016796015965544 | 0.0065204214721103 | 0.0099976794405883 |
| Other drink | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | All - MR Egger | 0.0160552761198022 | 0.0060594162599652 | 0.0182044260626168 |
| Other drink | Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) | All - Inverse variance weighted | 0.0121299312135496 | 0.0059543338937447 | 0.0416340044659616 |
| Other drink | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | rs139266627 | 0.0435425518812735 | 0.021384475645052 | 0.0417327050338198 |
| Other drink | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | rs529703549 | 0.0146721777960299 | 0.0058282728034385 | 0.0118219697100578 |
| Other drink | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | All - MR Egger | 0.0145058905388587 | 0.0054161988067812 | 0.0171922148519943 |
| Other drink | Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) | rs8087800 | -0.0357587667401148 | 0.0157230182589026 | 0.0229483131865685 |
| Other drink | Ankle spacing width (left) (ukb-e-4100_EAS) | rs2184436 | -5.2657780011793 | 1.84000154662594 | 0.0042119815902405 |
| Other drink | Ankle spacing width (left) (ukb-e-4100_EAS) | All - Inverse variance weighted | -3.1401350388358 | 1.06444263579696 | 0.0031774565473061 |
| Other drink | Ankle spacing width (left) (ukb-e-4100_EAS) | All - MR Egger | -7.5507804950598 | 2.48755293723487 | 0.0141220994574973 |
| Other drink | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | rs2184436 | 5.78776425554127 | 2.06329566654745 | 0.0050299944086701 |
| Other drink | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | All - Inverse variance weighted | 2.9211772869379 | 1.194007531346 | 0.0144238108935215 |
| Other drink | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | All - MR Egger | 6.51795489525917 | 2.78961606425383 | 0.0442728987216054 |
| Other drink | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | rs2184436 | 5.68385032527477 | 2.04976268958251 | 0.0055553913643676 |
| Other drink | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | All - Inverse variance weighted | 2.67173172547251 | 1.18579734885647 | 0.0242522215096962 |
| Other drink | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | All - MR Egger | 6.46616643768319 | 2.77116869045164 | 0.0445007454465672 |
| Other drink | Ankle spacing width (right) (ukb-e-4119_EAS) | rs2184436 | -6.64807493402674 | 1.87939217600603 | 0.0004041579710982 |
| Other drink | Ankle spacing width (right) (ukb-e-4119_EAS) | All - Inverse variance weighted | -3.18610157801527 | 1.08323847368186 | 0.0032686485420205 |
| Other drink | Ankle spacing width (right) (ukb-e-4119_EAS) | All - MR Egger | -8.97195914117819 | 2.53708190359473 | 0.0063505547112399 |
| Other drink | Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) | rs2184436 | 5.51227151018357 | 2.02269673565263 | 0.0064260779518749 |
| Other drink | Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) | All - Inverse variance weighted | 2.34470973961346 | 1.1663543941373 | 0.0444005804114438 |