ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Naan bread | Total body bone mineral density (age 30-45) (ebi-a-GCST005346) | rs151165951 | -5.25456982458867 | 2.46702538899357 | 0.0331781146258253 |
| Naan bread | Ultradistal forearm bone mineral density (ebi-a-GCST90013422) | All - MR Egger | 2.23331563978318 | 0.896822465736001 | 0.0270818062611835 |
| Naan bread | Compression fracture (ebi-a-GCST90018828) | rs116586337 | -12.35563276383 | 5.51909865804446 | 0.0251751287592108 |
| Naan bread | Compression fracture (ebi-a-GCST90018828) | All - Inverse variance weighted | -1.90844551336727 | 0.912164706221367 | 0.0364192056614729 |
| Naan bread | Joint disorder (ebi-a-GCST90038654) | All - MR Egger | -0.106793942539232 | 0.0463084399644074 | 0.0348221489863056 |
| Naan bread | Rheumatoid arthritis (ebi-a-GCST90038685) | rs76569571 | -0.100430426619832 | 0.0352953721568051 | 0.0044351838503711 |
| Naan bread | Rheumatoid arthritis (ebi-a-GCST90038685) | All - Inverse variance weighted | -0.0163847059589182 | 0.0079503301416824 | 0.0393141347858534 |
| Naan bread | Other joint disorder (ebi-a-GCST90038688) | rs74494383 | 0.0642360252995396 | 0.0321337562127578 | 0.0456061766306114 |
| Naan bread | Other joint disorder (ebi-a-GCST90038688) | All - Inverse variance weighted | 0.0159076554289152 | 0.00729282562177 | 0.0291631105507215 |
| Naan bread | Fracture of pelvis or lower limb (ebi-a-GCST90038706) | All - MR Egger | 0.0275145432820045 | 0.012958479901527 | 0.0496772155310499 |
| Naan bread | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | rs115110335 | -46.0569984797551 | 21.6046078410381 | 0.0330221668386991 |
| Naan bread | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | All - Inverse variance weighted | -10.9648635545223 | 4.64709106897288 | 0.0182990271048812 |
| Naan bread | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs145066826 | -18.8683453397863 | 8.49744630550661 | 0.0263867144151883 |
| Naan bread | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs418458 | 39.802168946038 | 14.8840534340088 | 0.0074919271638492 |
| Naan bread | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | All - Inverse variance weighted | -3.89484615098387 | 1.97948016491621 | 0.0491128593967509 |
| Naan bread | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs11240656 | -34.628752786683 | 17.5392384244239 | 0.0483409394676693 |
| Naan bread | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs166722 | -42.6707831108481 | 16.3564670031273 | 0.0090859810000203 |
| Naan bread | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | All - Inverse variance weighted | -10.7233300274357 | 4.77120182935735 | 0.024607369210797 |
| Naan bread | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | All - Inverse variance weighted | 9.79898446053668 | 4.25305717504102 | 0.021223425896241 |
| Naan bread | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs76569571 | 8.65611724907642 | 2.9805421212462 | 0.0036818229202313 |
| Naan bread | Spondylosis (finn-b-M13_SPONDYLOSIS) | All - MR Egger | 3.87122957217214 | 1.37778263539118 | 0.0125855009619698 |
| Naan bread | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs2231640 | -16.9578727869925 | 8.33753560574053 | 0.0419597544162453 |
| Naan bread | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | All - Inverse variance weighted | -7.83476014060444 | 3.82984608432559 | 0.0407847645836936 |
| Naan bread | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | All - MR Egger | -16.3050306994872 | 7.64985853233075 | 0.0489084087511865 |
| Naan bread | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | All - MR Egger | -6.51220832909924 | 2.83516807209979 | 0.035458200215828 |
| Naan bread | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | rs2231640 | 16.1196898041514 | 7.0700393877857 | 0.0226076884771056 |
| Naan bread | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | rs76569571 | 42.6446795809072 | 14.7686078402533 | 0.0038828948999404 |
| Naan bread | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | All - Inverse variance weighted | 11.4736530698845 | 3.30331798029439 | 0.0005139619348536 |
| Naan bread | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs11240656 | 14.2305542527835 | 6.50493732773962 | 0.0286947917732972 |
| Naan bread | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs2231640 | -8.82477205511564 | 3.67642048164856 | 0.0163784753187847 |
| Naan bread | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | All - MR Egger | -12.1500865341516 | 3.35611213136498 | 0.0022985628756106 |
| Naan bread | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | All - Inverse variance weighted | -6.3465622029156 | 3.17112721852136 | 0.0453537767348959 |
| Naan bread | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs166722 | 12.5039658100517 | 4.29240617359984 | 0.0035792476263179 |
| Naan bread | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | All - MR Egger | -6.22363910656151 | 2.39166893331924 | 0.0192539437788802 |
| Naan bread | Osteoclast-associated immunoglobulin-like receptor (prot-a-2153) | rs145066826 | 8.60450074715079 | 3.76920846622209 | 0.0224397808733475 |
| Naan bread | Osteoclast-associated immunoglobulin-like receptor (prot-a-2153) | All - Inverse variance weighted | 2.2602615131752 | 1.01333882987552 | 0.0257136619287556 |
| Naan bread | Osteoclast-associated immunoglobulin-like receptor (prot-a-2153) | All - MR Egger | 4.74620459677129 | 1.94020071222832 | 0.0272415890982434 |
| Naan bread | Bone morphogenetic protein 6 (prot-a-256) | rs117917175 | 9.95780857168793 | 3.74157848829178 | 0.0077818207366488 |
| Naan bread | Bone morphogenetic protein 6 (prot-a-256) | All - Inverse variance weighted | 2.02380857134457 | 0.962290175086757 | 0.0354555664117934 |
| Naan bread | Knee pain for 3+ months (ukb-a-353) | All - Inverse variance weighted | 0.172120232090271 | 0.0831314822602065 | 0.0384094869594654 |
| Naan bread | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | rs166722 | 0.140932225306001 | 0.0494797123821255 | 0.0043955813488028 |
| Naan bread | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | All - MR Egger | -0.0743045512752176 | 0.0245454340439589 | 0.0080110725709973 |
| Naan bread | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | rs74494383 | 0.06196739617944 | 0.0279575015331667 | 0.0266582712845069 |
| Naan bread | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | rs76569571 | -0.059903272972669 | 0.027182241333068 | 0.0275408728815349 |
| Naan bread | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | All - Inverse variance weighted | 0.0148361909479615 | 0.0064852940206559 | 0.0221569403534921 |
| Naan bread | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | rs117825653 | 2.81153748658775 | 1.09541188195137 | 0.0102686585371652 |
| Naan bread | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | rs192941551 | 2.78915331636872 | 1.08810929906268 | 0.0103681662147026 |
| Naan bread | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | rs62083930 | -2.57937314291191 | 1.06848269912777 | 0.0157761966210322 |
| Naan bread | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | All - MR Egger | 1.37545312723114 | 0.625354299492163 | 0.0439393110199012 |
| Naan bread | Operative procedures - main OPCS: T67.6 Primary simple repair of tendon (ukb-b-16193) | All - Inverse variance weighted | -0.0256642836524933 | 0.0124375407001949 | 0.0390695861139535 |
| Naan bread | Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) | rs166722 | 0.0381264313574935 | 0.0180978242033054 | 0.0351448138342985 |
| Naan bread | Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) | All - Inverse variance weighted | 0.0286582090905643 | 0.0133804581288176 | 0.0322099171481878 |
| Naan bread | Ankle spacing width (ukb-b-4080) | rs11240656 | -1.0831475544648 | 0.364339130490649 | 0.0029499064496092 |
| Naan bread | Ankle spacing width (ukb-b-4080) | rs3931612 | 0.798468896229012 | 0.360248933388384 | 0.0266616201385726 |
| Naan bread | Ankle spacing width (ukb-b-4080) | rs7121517 | 0.66810360963856 | 0.327294013279622 | 0.0412215208047499 |
| Naan bread | Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) | rs7121517 | -0.0456835556624439 | 0.0205726369000149 | 0.0263782036789622 |
| Naan bread | Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) | All - Inverse variance weighted | -0.027809864679787 | 0.012356463578623 | 0.0244087915844206 |
| Naan bread | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | rs7121517 | 0.0540959114056592 | 0.0262541959680136 | 0.0393538920132348 |
| Naan bread | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | All - Inverse variance weighted | 0.0290106663415294 | 0.0139385083538731 | 0.0374035092385036 |
| Naan bread | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | rs166722 | 0.0528280558066124 | 0.026720228430659 | 0.0480324756650949 |
| Naan bread | Knee pain for 3+ months (ukb-e-3773_AFR) | All - Inverse variance weighted | 3.93705749129383 | 1.79862287133729 | 0.0286020118782505 |
| Naan bread | Ankle spacing width (left) (ukb-e-4100_EAS) | rs418458 | 2.84785137907028 | 1.11601198013279 | 0.0107164707968341 |
| Naan bread | Ankle spacing width (left) (ukb-e-4100_EAS) | All - Inverse variance weighted | 2.08412934664207 | 0.912478164086399 | 0.0223696490405555 |
| Naan bread | Ankle spacing width (right) (ukb-e-4119_EAS) | rs418458 | 2.87354979184286 | 1.13657071035085 | 0.0114628414682345 |
| Naan bread | Ankle spacing width (right) (ukb-e-4119_EAS) | All - Inverse variance weighted | 2.3428231106638 | 0.930550432991024 | 0.0118132430999443 |
| Naan bread | Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) | rs418458 | -1.83276407455343 | 0.82468542806547 | 0.0262576625669165 |
| Naan bread | Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) | All - Inverse variance weighted | -1.6573527166293 | 0.727490811536789 | 0.0227160436974062 |
| Naan bread | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) | rs418458 | -1.88602987557296 | 0.811135355876292 | 0.0200627215658512 |
| Naan bread | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) | All - Inverse variance weighted | -1.66928607956048 | 0.715469919707117 | 0.0196411953288149 |
| Naan bread | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | rs2231640 | -15.9391056655718 | 7.29151050113802 | 0.028816972856078 |
| Naan bread | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | rs3931612 | -26.398637489678 | 13.1778144783925 | 0.0451489907685487 |
| Naan bread | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | All - Inverse variance weighted | -8.06517906606842 | 3.43886963610536 | 0.0190118034550521 |