ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Scotch egg (ukb-b-13516)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Scotch egg (👉 📊) Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) Inverse variance weighted 109 -1.284415135 0.607544397 0.034505951
Scotch egg (👉 📊) Osteoarthritis of the hip or knee (ebi-a-GCST007092) Weighted median 109 -0.764595948 0.384091622 0.046518244
Scotch egg (👉 📊) Osteoprotegerin levels (ebi-a-GCST90000490) Inverse variance weighted 59 4.778662073 2.349811546 0.041988278
Scotch egg (👉 📊) Osteopontin levels (ebi-a-GCST90010244) Inverse variance weighted 98 -3.892959621 1.549770581 0.012006315
Scotch egg (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) Inverse variance weighted 37 -0.304776696 0.141333983 0.031050185
Scotch egg (👉 📊) Neck circumference (ebi-a-GCST90017134) Inverse variance weighted 42 8.698021275 4.057196603 0.032044901
Scotch egg (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017137) Inverse variance weighted 42 8.698021275 4.057196603 0.032044901
Scotch egg (👉 📊) Compression fracture (ebi-a-GCST90018828) Inverse variance weighted 104 1.794503473 0.79815817 0.024556711
Scotch egg (👉 📊) Heel bone mineral density T score (ebi-a-GCST90025982) MR Egger 30 -0.809114934 0.360293632 0.032799496
Scotch egg (👉 📊) Heel bone mineral density T score (ebi-a-GCST90025982) Inverse variance weighted 30 -0.304021466 0.145918488 0.037205486
Scotch egg (👉 📊) Bone disorder (ebi-a-GCST90038652) Inverse variance weighted 80 0.025287488 0.01227511 0.039392614
Scotch egg (👉 📊) Other joint disorder (ebi-a-GCST90038688) MR Egger 80 0.044008659 0.020412074 0.0341649
Scotch egg (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) Weighted median 106 -12.83126513 6.500605575 0.048398017
Scotch egg (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) Inverse variance weighted 106 10.59894796 4.405767959 0.016141594
Scotch egg (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) Inverse variance weighted 106 10.60628398 4.408874488 0.016142971
Scotch egg (👉 📊) Pain in joint (finn-b-JOINTPAIN) Inverse variance weighted 106 0.985154973 0.497853019 0.047837755
Scotch egg (👉 📊) Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) Inverse variance weighted 106 5.664146112 2.661128328 0.03329769
Scotch egg (👉 📊) Gluteal tendinitis (finn-b-M13_GLUTEALTEND) MR Egger 106 16.71799207 6.166415307 0.007846081
Scotch egg (👉 📊) Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) Inverse variance weighted 106 0.978028729 0.460923382 0.033846974
Scotch egg (👉 📊) Loose body in joint (finn-b-M13_LOOSEJOINT) Weighted median 106 -7.769960694 3.785912779 0.040137132
Scotch egg (👉 📊) Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) MR Egger 106 -2.425979278 0.91907336 0.009577617
Scotch egg (👉 📊) Patellar tendinitis (finn-b-M13_PATELLARTEND) MR Egger 106 -17.28167324 7.818067583 0.029262685
Scotch egg (👉 📊) Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) Inverse variance weighted 106 4.572224264 2.078674474 0.027836247
Scotch egg (👉 📊) Shoulder lesions (finn-b-M13_SHOULDER) MR Egger 106 2.33718241 1.0387936 0.026561283
Scotch egg (👉 📊) Disorders of synovium and tendon (finn-b-M13_SYNOTEND) Weighted mode 106 -3.090653627 1.523315244 0.044999142
Scotch egg (👉 📊) Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) Weighted median 106 -6.78126128 2.010882658 0.000745484
Scotch egg (👉 📊) Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) Weighted mode 106 -8.87500994 3.537682266 0.013646447
Scotch egg (👉 📊) Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) MR Egger 106 20.04084324 9.969706882 0.047001864
Scotch egg (👉 📊) Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) Weighted median 106 -11.67699613 4.594497012 0.011037231
Scotch egg (👉 📊) Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) Inverse variance weighted 106 -6.588547714 3.110777241 0.034177204
Scotch egg (👉 📊) Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) Weighted mode 106 -15.5067458 7.17117701 0.032859692
Scotch egg (👉 📊) Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) Inverse variance weighted 106 2.778493888 1.37956373 0.044005535
Scotch egg (👉 📊) Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) MR Egger 106 -5.596776949 2.411508119 0.022245659
Scotch egg (👉 📊) Osteocrin (prot-a-2157) MR Egger 96 -4.208781967 2.05955959 0.043797926
Scotch egg (👉 📊) Bone morphogenetic protein 6 (prot-a-256) Weighted median 96 -2.859134334 1.298285689 0.027648487
Scotch egg (👉 📊) Bone morphogenetic protein receptor type-1A (prot-a-259) Inverse variance weighted 96 -1.942273071 0.897445469 0.030447158
Scotch egg (👉 📊) Fractured bone site(s): Arm (ukb-a-440) Inverse variance weighted 104 -0.019933544 0.008817335 0.023776469
Scotch egg (👉 📊) Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) Inverse variance weighted 3 0.071340138 0.032135645 0.026420868
Scotch egg (👉 📊) Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) Weighted median 104 -0.049925609 0.021651752 0.021119232
Scotch egg (👉 📊) Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) Inverse variance weighted 104 -0.030976902 0.015094175 0.040146138
Scotch egg (👉 📊) Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) MR Egger 104 0.038266808 0.018571472 0.041894342
Scotch egg (👉 📊) Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) Inverse variance weighted 104 -0.031252178 0.010814926 0.003855773
Scotch egg (👉 📊) Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) Weighted median 104 -0.021802754 0.011081705 0.049130795
Scotch egg (👉 📊) Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) Inverse variance weighted 23 6.853887768 3.134199561 0.028756658
Scotch egg (👉 📊) Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) MR Egger 36 5.212016594 1.851042904 0.008041515
Scotch egg (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) MR Egger 37 5.012673134 1.861069574 0.010782849

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Scotch egg Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs111226842 -14.1981499599508 6.79459206466816 0.0366514921478763
Scotch egg Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs114833428 13.8232625777356 6.00192430622829 0.0212710551674373
Scotch egg Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs139964816 -16.6302977574972 6.23508105324834 0.0076482871027757
Scotch egg Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs144736558 -16.3488123223747 7.42285358408477 0.0276302248781373
Scotch egg Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs150706854 -16.7066625707006 6.49072082979454 0.0100550546880017
Scotch egg Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs181511320 -12.7826205393626 4.63795817064681 0.0058497268727552
Scotch egg Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs1917920 -14.0364669659462 6.13606355663181 0.0221645501735089
Scotch egg Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs77660610 13.0872718109531 5.9724843207526 0.0284329124406148
Scotch egg Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs79276437 13.7956601016749 6.20059652470023 0.0260884621477857
Scotch egg Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) All - Inverse variance weighted -1.28441513531736 0.607544397485194 0.0345059507080097
Scotch egg Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs139402847 7.21411896277768 2.94547759883746 0.0143166470165704
Scotch egg Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs150494806 -6.91111451289024 2.8477393676893 0.0152293983879634
Scotch egg Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs187550776 5.6816038269714 2.45221944723201 0.0205079224308294
Scotch egg Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs76118553 -6.20680042307913 3.02550773595271 0.0402192023930777
Scotch egg Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs7652799 7.85639755157156 2.97962804867842 0.008371581658549
Scotch egg Osteoprotegerin levels (ebi-a-GCST90000490) rs150976403 -56.7273519096021 18.3012279623912 0.0019375120760345
Scotch egg Osteoprotegerin levels (ebi-a-GCST90000490) rs17018017 45.6698693236296 17.0877918737677 0.0075252327622194
Scotch egg Osteoprotegerin levels (ebi-a-GCST90000490) rs72679605 40.2792892402253 18.893812628958 0.0330169392046807
Scotch egg Osteoprotegerin levels (ebi-a-GCST90000490) rs76843325 -34.9998501558379 16.0093502757133 0.0288000235009758
Scotch egg Osteoprotegerin levels (ebi-a-GCST90000490) rs77785297 65.1088029235595 26.1293127876413 0.0127100577180238
Scotch egg Osteoprotegerin levels (ebi-a-GCST90000490) All - Inverse variance weighted 4.77866207325078 2.34981154627166 0.0419882784291905
Scotch egg Osteopontin levels (ebi-a-GCST90010244) rs111714951 207.868088256138 78.9045151739452 0.0084279729492326
Scotch egg Osteopontin levels (ebi-a-GCST90010244) rs144736558 -39.7844812462721 18.2549735097014 0.0293036251517663
Scotch egg Osteopontin levels (ebi-a-GCST90010244) rs150494806 -57.5677829504831 25.0424346933446 0.021515767806858
Scotch egg Osteopontin levels (ebi-a-GCST90010244) rs150706854 -25.8535571658324 9.2428486239361 0.0051556918783392
Scotch egg Osteopontin levels (ebi-a-GCST90010244) rs150976403 -14.9920287431855 5.74216678202307 0.0090313240438563
Scotch egg Osteopontin levels (ebi-a-GCST90010244) rs193041511 52.7215605948418 26.5490730681134 0.0470538149395474
Scotch egg Osteopontin levels (ebi-a-GCST90010244) rs4857246 -32.2849972455163 14.2593839478212 0.0235665589998697
Scotch egg Osteopontin levels (ebi-a-GCST90010244) rs77660610 -34.0615550453578 15.2090099675216 0.0251192256143549
Scotch egg Osteopontin levels (ebi-a-GCST90010244) rs79276437 67.0891043676717 30.1095842440197 0.0258695526308122
Scotch egg Osteopontin levels (ebi-a-GCST90010244) All - Inverse variance weighted -3.89295962141619 1.54977058074336 0.0120063154654325
Scotch egg Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) rs150494806 -2.81397170720287 1.00177392776422 0.0049697381034436
Scotch egg Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) All - Inverse variance weighted -0.304776696197093 0.14133398331216 0.031050184512101
Scotch egg Neck circumference (ebi-a-GCST90017134) rs149736097 52.5125470553005 25.616776467492 0.0403714585051402
Scotch egg Neck circumference (ebi-a-GCST90017134) All - Inverse variance weighted 8.69802127532352 4.05719660309496 0.0320449008909377
Scotch egg Neck circumference (BMI adjusted) (ebi-a-GCST90017137) rs149736097 52.5125470553005 25.616776467492 0.0403714585051402
Scotch egg Neck circumference (BMI adjusted) (ebi-a-GCST90017137) All - Inverse variance weighted 8.69802127532352 4.05719660309496 0.0320449008909377
Scotch egg Compression fracture (ebi-a-GCST90018828) rs9813274 12.4837969887327 4.5601090171835 0.0061887545486585
Scotch egg Compression fracture (ebi-a-GCST90018828) All - Inverse variance weighted 1.79450347280981 0.7981581695003 0.0245567106285555
Scotch egg Heel bone mineral density T score (ebi-a-GCST90025982) rs13397475 -1.58019956156446 0.75438515318121 0.0361989685036875
Scotch egg Heel bone mineral density T score (ebi-a-GCST90025982) rs2228606 -1.73852037585796 0.701822725392363 0.0132436117994516
Scotch egg Heel bone mineral density T score (ebi-a-GCST90025982) rs34905593 -1.35912267210539 0.66887300079057 0.0421577828252489
Scotch egg Heel bone mineral density T score (ebi-a-GCST90025982) rs73170156 -1.75358482411595 0.748781391328507 0.0191849153495745
Scotch egg Heel bone mineral density T score (ebi-a-GCST90025982) All - Inverse variance weighted -0.30402146616733 0.145918487748406 0.0372054863987903
Scotch egg Heel bone mineral density T score (ebi-a-GCST90025982) All - MR Egger -0.809114933906356 0.360293632125273 0.0327994955099444
Scotch egg Bone disorder (ebi-a-GCST90038652) rs12162128 -0.192526278282558 0.0875419698776193 0.0278604747202446
Scotch egg Bone disorder (ebi-a-GCST90038652) rs7043 0.228559228360471 0.11647363710271 0.0497245600646239
Scotch egg Bone disorder (ebi-a-GCST90038652) All - Inverse variance weighted 0.0252874884318164 0.0122751103603847 0.039392613796249
Scotch egg Other joint disorder (ebi-a-GCST90038688) rs147477887 -0.151960157564704 0.0770163299457549 0.0484852988733766
Scotch egg Other joint disorder (ebi-a-GCST90038688) rs72718363 0.171476398267554 0.0778828730000081 0.0276849849720087
Scotch egg Other joint disorder (ebi-a-GCST90038688) rs72746231 -0.207587317992522 0.0649143538924522 0.0013844924296314
Scotch egg Other joint disorder (ebi-a-GCST90038688) rs7532469 0.192520408913731 0.0755099470471428 0.0107845561379915
Scotch egg Other joint disorder (ebi-a-GCST90038688) All - MR Egger 0.0440086592744327 0.0204120738163462 0.0341649003034222
Scotch egg Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) rs139110217 50.133505868947 24.0310564104545 0.0369608268065375
Scotch egg Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) rs148914642 359.462365591398 145.122887864823 0.0132509879391808
Scotch egg Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) rs193041511 179.276031250649 81.7734535565259 0.0283542436980919
Scotch egg Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) rs7532469 601.93425020225 298.852688092962 0.0439937492569025
Scotch egg Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) rs76631139 81.4378307266245 32.6589268431659 0.0126460076793293
Scotch egg Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) rs117785685 77.4701698700993 34.5911949685535 0.025117410630436
Scotch egg Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) rs181511320 84.1581161657435 37.5414913687864 0.0249784337526073
Scotch egg Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) rs1917920 73.3497019378255 35.8882589910272 0.0409697893218195
Scotch egg Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) rs79387749 102.203575822739 40.9401775718545 0.0125456574757419
Scotch egg Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) All - Inverse variance weighted 10.5989479606954 4.40576795864242 0.0161415942688842
Scotch egg Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) rs117785685 77.2252591155783 34.5520092478301 0.0254144637458382
Scotch egg Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) rs181511320 84.561679631143 37.6423822351362 0.0246752836550285
Scotch egg Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) rs1917920 73.4480259350612 35.916351561666 0.0408573643227634
Scotch egg Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) rs79387749 103.206712703814 41.1784918585189 0.0121993186023864
Scotch egg Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) All - Inverse variance weighted 10.6062839761359 4.40887448773194 0.0161429707226446
Scotch egg Pain in joint (finn-b-JOINTPAIN) rs111714951 -6.55936500937052 3.08676000440966 0.0335866128968976
Scotch egg Pain in joint (finn-b-JOINTPAIN) rs139402847 21.5963338008512 8.30716729047126 0.0093299039486055
Scotch egg Pain in joint (finn-b-JOINTPAIN) rs141315161 9.39482975728994 4.72210562702155 0.0466413574443355
Scotch egg Pain in joint (finn-b-JOINTPAIN) rs146174961 15.4589457476838 7.1941172826943 0.0316477603350474
Scotch egg Pain in joint (finn-b-JOINTPAIN) rs147993198 8.29296716361689 2.60737008763824 0.00146977046532
Scotch egg Pain in joint (finn-b-JOINTPAIN) rs150494806 12.7979433243586 6.089434774387 0.0355827555341096
Scotch egg Pain in joint (finn-b-JOINTPAIN) rs6073027 30.3102240031905 11.4612908433117 0.0081793983545275
Scotch egg Pain in joint (finn-b-JOINTPAIN) rs6075230 12.9085880726117 5.13646571930134 0.011966641970055
Scotch egg Pain in joint (finn-b-JOINTPAIN) All - Inverse variance weighted 0.985154972956116 0.497853018620918 0.047837754843022
Scotch egg Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs140220113 133.546827712744 60.7849642182517 0.028017789395384
Scotch egg Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs149736097 42.4527663781961 21.337065372587 0.0466322203817422
Scotch egg Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs149890841 188.581750437421 73.2537794393464 0.0100425122389028
Scotch egg Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs1917920 57.4493069562823 21.7857885303653 0.0083640764903979
Scotch egg Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs76118553 172.224363126522 69.7506620860425 0.013543706124162
Scotch egg Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) All - Inverse variance weighted 5.66414611229672 2.66112832766104 0.0332976896173962
Scotch egg Gluteal tendinitis (finn-b-M13_GLUTEALTEND) rs141157749 107.061974345722 45.9991542545694 0.0199398908172796
Scotch egg Gluteal tendinitis (finn-b-M13_GLUTEALTEND) rs149736097 -45.6871457401502 21.4231515153006 0.032957044314477
Scotch egg Gluteal tendinitis (finn-b-M13_GLUTEALTEND) rs17052129 32.4550204974903 13.598915258538 0.017005494327086
Scotch egg Gluteal tendinitis (finn-b-M13_GLUTEALTEND) rs6073027 133.518815698265 60.4210386379391 0.0271185808919104
Scotch egg Gluteal tendinitis (finn-b-M13_GLUTEALTEND) rs74969721 -52.1834078495082 25.0183529760974 0.0369962826490499
Scotch egg Gluteal tendinitis (finn-b-M13_GLUTEALTEND) rs79086705 -50.1073906138135 14.9277067783639 0.0007888710973732
Scotch egg Gluteal tendinitis (finn-b-M13_GLUTEALTEND) All - MR Egger 16.7179920736378 6.16641530721363 0.007846080799608
Scotch egg Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs116997434 10.6995533728575 5.32540412749286 0.0445208766501151
Scotch egg Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs139402847 22.0335531319286 7.66284406572557 0.0040354741773671
Scotch egg Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs146174961 13.8396056951216 6.56584873771116 0.0350468467450966
Scotch egg Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs147993198 10.5236517306934 2.36605592602838 8.67699176422718e-06
Scotch egg Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs150494806 13.1018522687366 5.52664043294643 0.0177557756074296
Scotch egg Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) All - Inverse variance weighted 0.978028729496517 0.460923381631744 0.0338469736188982
Scotch egg Loose body in joint (finn-b-M13_LOOSEJOINT) rs138418668 -64.5751618162155 31.6974157829322 0.0416262547877584
Scotch egg Loose body in joint (finn-b-M13_LOOSEJOINT) rs138938508 133.040583357878 50.6243250238752 0.0085889227950125
Scotch egg Loose body in joint (finn-b-M13_LOOSEJOINT) rs141157749 138.410938307569 52.2388760982944 0.008059254242411
Scotch egg Loose body in joint (finn-b-M13_LOOSEJOINT) rs142171882 -73.9885911581476 33.0255948359979 0.0250687993212682
Scotch egg Loose body in joint (finn-b-M13_LOOSEJOINT) rs146174961 91.7095098620464 39.9702678547726 0.0217650533098576
Scotch egg Loose body in joint (finn-b-M13_LOOSEJOINT) rs149833481 74.1789364870398 25.4852385752503 0.0036066299194255
Scotch egg Loose body in joint (finn-b-M13_LOOSEJOINT) rs72718363 134.776496591177 61.8707491284952 0.0293795682270277
Scotch egg Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs117206175 6.83344756682659 2.79643591501028 0.0145404327550453
Scotch egg Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs149833481 8.57464439095237 3.78239131592332 0.0233908188144105
Scotch egg Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs150706854 -16.6699795804044 8.20397911057301 0.042159899952226
Scotch egg Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs61754246 -7.40920869651121 2.94088591338445 0.0117561756880234
Scotch egg Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs6693625 14.0735199259363 5.66850108127991 0.0130369394548643
Scotch egg Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) All - MR Egger -2.42597927768886 0.919073360334825 0.0095776167159698
Scotch egg Patellar tendinitis (finn-b-M13_PATELLARTEND) rs118176537 112.41070594331 46.7344494559539 0.0161588776226641
Scotch egg Patellar tendinitis (finn-b-M13_PATELLARTEND) rs140201217 -79.431148109608 38.912317213429 0.0412224594929084
Scotch egg Patellar tendinitis (finn-b-M13_PATELLARTEND) rs145451778 150.309159901432 51.1134291804617 0.0032747361602184
Scotch egg Patellar tendinitis (finn-b-M13_PATELLARTEND) rs147993198 -46.7443188172075 18.5635333101829 0.0117999100191523
Scotch egg Patellar tendinitis (finn-b-M13_PATELLARTEND) rs6073027 165.519271491107 79.1560235872796 0.0365235046990975
Scotch egg Patellar tendinitis (finn-b-M13_PATELLARTEND) All - MR Egger -17.2816732383761 7.8180675825486 0.0292626848404082
Scotch egg Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) rs138462899 59.8295560845639 24.2247124323418 0.0135198573947558
Scotch egg Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) rs139841884 212.97601448528 94.480925040969 0.0241855101356804
Scotch egg Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) rs187550776 80.5686131001335 39.1600582496435 0.0396460244261802
Scotch egg Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) rs6073027 131.068929171691 48.8647909525121 0.0073122776386372
Scotch egg Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) rs7205695 53.8130381303813 24.9077490774908 0.0307344609572268
Scotch egg Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) rs73173637 50.451104990349 24.4258170856015 0.0388773416150806
Scotch egg Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) rs74769776 58.7127827235166 27.4055458533884 0.0321638272276431
Scotch egg Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) rs79086705 24.7039557600046 10.4921864070639 0.0185471544405592
Scotch egg Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) rs80124426 39.2197072620543 18.456332829202 0.0335866128968977
Scotch egg Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) All - Inverse variance weighted 4.57222426352604 2.07867447357342 0.0278362474492005
Scotch egg Shoulder lesions (finn-b-M13_SHOULDER) rs138462899 11.9801041243299 5.04493345461818 0.0175641553880035
Scotch egg Shoulder lesions (finn-b-M13_SHOULDER) rs138938508 21.0547924420525 7.73823868048304 0.0065109064198415
Scotch egg Shoulder lesions (finn-b-M13_SHOULDER) rs139841884 37.6170339556044 17.6424748742279 0.032991577434181
Scotch egg Shoulder lesions (finn-b-M13_SHOULDER) rs144736558 -9.10494368618645 4.55247184309323 0.0455002638963584
Scotch egg Shoulder lesions (finn-b-M13_SHOULDER) rs146016809 -6.78483890447941 2.78853326702426 0.014969296752714
Scotch egg Shoulder lesions (finn-b-M13_SHOULDER) rs147477887 -8.86066429128788 4.41858060149104 0.0449289389640742
Scotch egg Shoulder lesions (finn-b-M13_SHOULDER) rs147865041 12.4556522626917 5.1749661808622 0.0160883518699004
Scotch egg Shoulder lesions (finn-b-M13_SHOULDER) rs147993198 6.22119680052736 2.24834170085284 0.0056572029455425
Scotch egg Shoulder lesions (finn-b-M13_SHOULDER) rs191696194 6.5709886726053 3.22363356428022 0.0415119917334991
Scotch egg Shoulder lesions (finn-b-M13_SHOULDER) rs79387749 9.62678874269816 3.70772692508064 0.0094202880394687
Scotch egg Shoulder lesions (finn-b-M13_SHOULDER) All - MR Egger 2.33718240993001 1.03879359978485 0.0265612831655944
Scotch egg Disorders of synovium and tendon (finn-b-M13_SYNOTEND) rs139110217 -5.53820006083812 2.76668581940736 0.045312142347885
Scotch egg Disorders of synovium and tendon (finn-b-M13_SYNOTEND) rs150976403 19.1543468624355 9.27776524843102 0.0389662453315054
Scotch egg Disorders of synovium and tendon (finn-b-M13_SYNOTEND) rs7532469 68.2595425461499 28.6000588365081 0.0170007098698062
Scotch egg Disorders of synovium and tendon (finn-b-M13_SYNOTEND) rs76843325 11.088467993287 5.36442100215776 0.0387304692050263
Scotch egg Disorders of synovium and tendon (finn-b-M13_SYNOTEND) rs78908056 -10.2009491039793 4.94591471708089 0.0391601575567549
Scotch egg Disorders of synovium and tendon (finn-b-M13_SYNOTEND) rs80124426 10.1455864675146 4.84343822052889 0.0361970002613043
Scotch egg Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs118035561 43.8359529883859 22.1795818182025 0.048108330862645
Scotch egg Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs141315161 29.6288980519 13.9132367102047 0.0332089917331332
Scotch egg Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs148303914 29.9026907227205 13.8172247809676 0.0304520412242582
Scotch egg Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs4861592 48.5367742649296 22.3494592426631 0.0298767666220915
Scotch egg Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs76118553 -73.1041381402556 35.0188171822602 0.036836882995149
Scotch egg Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) rs147092370 160.976589165964 62.1692165602538 0.0096163018265308
Scotch egg Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) rs73173637 116.029408575332 53.3925047170834 0.0297697525374279
Scotch egg Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) All - MR Egger 20.0408432362202 9.96970688183872 0.0470018642360685
Scotch egg Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) rs186621522 140.163857717733 49.9315132592032 0.0049986280601642
Scotch egg Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) rs6693625 -94.3920932406234 44.637224815596 0.0344598159599604
Scotch egg Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) All - Inverse variance weighted -6.58854771445245 3.11077724084416 0.034177204391379
Scotch egg Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) rs139841884 161.710271484397 61.0582046962561 0.0080859187606125
Scotch egg Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) rs145451778 -47.3415272045595 18.2094426051068 0.0093268877623648
Scotch egg Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) rs149736097 24.0057357967088 10.7361717984256 0.025353872173595
Scotch egg Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) rs72840551 105.360152364249 40.7286628392913 0.0096849390008988
Scotch egg Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) rs79387749 34.0844851857189 11.9434252967844 0.0043195869558808
Scotch egg Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) All - Inverse variance weighted 2.77849388830088 1.37956373034383 0.0440055354986954
Scotch egg Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) rs111714951 -12.9927398144794 6.53574184607147 0.0468170201985902
Scotch egg Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) rs116997434 27.5897367154321 12.2350245858188 0.0241345791764233
Scotch egg Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) rs1917920 16.6729406741093 8.10470662928482 0.0396677247810534
Scotch egg Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) rs4861592 -39.7753989987 16.201974939839 0.0140895461240132
Scotch egg Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) rs61912378 37.5880875303302 11.052323840219 0.0006715907150522
Scotch egg Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) rs74969721 18.5782472841571 9.27587239579883 0.0451926243142152
Scotch egg Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) rs76631139 -16.6855902697766 7.09111400667843 0.0186212285886922
Scotch egg Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) rs79387749 -18.2726093751732 8.80100202844253 0.037875783307593
Scotch egg Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) rs9619461 -28.9110083986942 14.0903882981896 0.0401866905091225
Scotch egg Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) All - MR Egger -5.59677694854838 2.41150811878817 0.0222456587402775
Scotch egg Osteocrin (prot-a-2157) rs117206175 -19.2940370116518 8.12200137080192 0.0175238900467923
Scotch egg Osteocrin (prot-a-2157) rs138313407 -14.5412290095468 6.56656565426417 0.0267989092874236
Scotch egg Osteocrin (prot-a-2157) All - MR Egger -4.20878196740011 2.0595595895798 0.0437979255517872
Scotch egg Bone morphogenetic protein 6 (prot-a-256) rs114833428 -20.4622289001799 9.90710170046285 0.0388842043240258
Scotch egg Bone morphogenetic protein 6 (prot-a-256) rs147070466 -23.3408604943946 9.9218640714614 0.0186493308970444
Scotch egg Bone morphogenetic protein 6 (prot-a-256) rs149890841 19.787772365092 10.0701131628967 0.0494142375450078
Scotch egg Bone morphogenetic protein 6 (prot-a-256) rs149969774 -24.494084946273 9.69458662418223 0.0115181308315958
Scotch egg Bone morphogenetic protein 6 (prot-a-256) rs6075230 -24.0273814077103 10.0767895495602 0.0171056845212956
Scotch egg Bone morphogenetic protein 6 (prot-a-256) rs79086705 19.8898937614694 8.73114492383907 0.022724219208192
Scotch egg Bone morphogenetic protein receptor type-1A (prot-a-259) rs138462899 16.8314979323514 7.23838278271304 0.0200552861464115
Scotch egg Bone morphogenetic protein receptor type-1A (prot-a-259) rs17052129 -20.2675378430455 8.37344286473242 0.0155011171183118
Scotch egg Bone morphogenetic protein receptor type-1A (prot-a-259) rs1917920 20.0861880067197 9.43910373462634 0.033339057709729
Scotch egg Bone morphogenetic protein receptor type-1A (prot-a-259) rs7043 -25.3126899413474 10.2456125953073 0.0134891037280277
Scotch egg Bone morphogenetic protein receptor type-1A (prot-a-259) rs9813274 -23.099677601622 9.552298334829 0.0155961111170483
Scotch egg Bone morphogenetic protein receptor type-1A (prot-a-259) All - Inverse variance weighted -1.9422730714176 0.897445468765217 0.0304471580063236
Scotch egg Fractured bone site(s): Arm (ukb-a-440) rs116601894 0.269013128857796 0.0948755953439655 0.0045764013318
Scotch egg Fractured bone site(s): Arm (ukb-a-440) rs12162128 0.173758719456207 0.0800360427030657 0.0299307277742594
Scotch egg Fractured bone site(s): Arm (ukb-a-440) rs149833481 -0.25360566550808 0.0928911240495824 0.0063307657537257
Scotch egg Fractured bone site(s): Arm (ukb-a-440) rs149969774 -0.186490627436358 0.0929012575844887 0.0447063525023706
Scotch egg Fractured bone site(s): Arm (ukb-a-440) rs72718363 -0.188332805148582 0.0942566002779065 0.0457073237907903
Scotch egg Fractured bone site(s): Arm (ukb-a-440) rs78908056 -0.20719971688902 0.089500164153204 0.0206087518940499
Scotch egg Fractured bone site(s): Arm (ukb-a-440) All - Inverse variance weighted -0.0199335440606147 0.0088173348779901 0.023776469395071
Scotch egg Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) All - Inverse variance weighted 0.0713401383941663 0.0321356454583057 0.0264208684615906
Scotch egg Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs113705424 0.317363035929563 0.159582075403654 0.0467328293544379
Scotch egg Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs150494806 -0.329344997433658 0.156692074955202 0.0355654335766251
Scotch egg Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs1917920 -0.500891939117781 0.156895602388992 0.0014103845168239
Scotch egg Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs3817357 -0.364224360649958 0.169272292906512 0.0314204463446358
Scotch egg Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs4861592 0.382431610101513 0.185636738306641 0.0393882788255687
Scotch egg Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) All - Inverse variance weighted -0.0309769018164215 0.0150941750342031 0.0401461376453635
Scotch egg Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) rs139964816 0.170391150725307 0.0863073276397791 0.0483547596723506
Scotch egg Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) All - MR Egger 0.0382668084538849 0.0185714720959613 0.0418943424363098
Scotch egg Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) rs145451778 -0.303539087184604 0.115846523651866 0.0087882603540504
Scotch egg Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) rs61912378 -0.254810562150731 0.113583255067261 0.0248722300597402
Scotch egg Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) rs7205695 -0.256247232472325 0.118661131611316 0.0308123647411296
Scotch egg Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) rs7532469 -0.301517798043686 0.121141612120321 0.0128113895513607
Scotch egg Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) rs7652799 0.236939576044683 0.118371583052947 0.0453213901955753
Scotch egg Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) rs76828697 -0.24635874326163 0.119347069287944 0.0389967541561195
Scotch egg Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) rs78908056 -0.26627355172105 0.109520033086464 0.01504570154611
Scotch egg Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) All - Inverse variance weighted -0.0312521784414249 0.0108149264662048 0.0038557725839165
Scotch egg Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) rs12162128 -0.152906028587482 0.0691971933286738 0.0271249956973845
Scotch egg Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) rs146016809 -0.178445703527406 0.0824894319917587 0.030521546657854
Scotch egg Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) rs147070466 0.173784496712696 0.0819948642113467 0.0340519589942721
Scotch egg Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) rs147263345 -0.167198981334824 0.0792099133513463 0.0347865792397982
Scotch egg Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) rs4857246 0.167183557432685 0.0782035325403141 0.0325329317087217
Scotch egg Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) rs148303914 30.0873821149473 15.0927497085339 0.0462068281228686
Scotch egg Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) rs4861592 13.1178602052388 5.14687577794374 0.0108124189748321
Scotch egg Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) rs74969721 -89.3664049103818 33.2076231769598 0.0071208036190301
Scotch egg Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) All - Inverse variance weighted 6.85388776778687 3.13419956115241 0.028756657540686
Scotch egg Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) rs17018017 -13.6537318019 6.87096526392757 0.0469042744570041
Scotch egg Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) All - MR Egger 5.21201659352477 1.85104290408396 0.0080415153741602
Scotch egg Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) rs17018017 -14.0292876672575 6.91079694661701 0.0423510993937944
Scotch egg Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) All - MR Egger 5.01267313407871 1.86106957390272 0.010782849257279