ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Orange | Achilles tendon injury (ebi-a-GCST90018567) | All - Inverse variance weighted | 4.21929090360872 | 1.78007268495655 | 0.0177740724816545 |
| Orange | Chondromalacia (finn-b-M13_CHONDROMALACIA) | All - Inverse variance weighted | 3.22104623034332 | 1.49735586634648 | 0.031463879458696 |
| Orange | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | rs4782961 | -8.76797640021305 | 3.46504808339528 | 0.0113930801386303 |
| Orange | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | All - Inverse variance weighted | -3.47525822886223 | 1.43922443725397 | 0.0157492865704652 |
| Orange | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs1188537 | 10.3343942787536 | 4.61427055792257 | 0.0251130453598966 |
| Orange | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | All - MR Egger | -19.8039370435119 | 6.58126087946777 | 0.0297849804011283 |
| Orange | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | rs72758819 | -7.98784006660212 | 3.74636952195946 | 0.0329941161166202 |
| Orange | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | All - Inverse variance weighted | -4.12945688589385 | 1.66998883711289 | 0.0134079698919739 |
| Orange | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs2760994 | -4.03691209679668 | 1.27686860520226 | 0.0015691999136724 |
| Orange | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs72758819 | -2.27052698300574 | 1.00596959385949 | 0.0240047450037588 |
| Orange | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -1.09626880050913 | 0.53599242208648 | 0.0408246474153477 |
| Orange | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -0.6467316254301 | 0.259783136732233 | 0.012792083159128 |
| Orange | Osteomyelitis (ieu-b-4975) | All - Inverse variance weighted | 0.963623900791895 | 0.45716934075281 | 0.03504784532904 |
| Orange | Osteocalcin (prot-a-246) | rs2760994 | -3.99788117873373 | 1.41068889570381 | 0.0045970469164008 |
| Orange | Osteocalcin (prot-a-246) | rs66957934 | 2.81896280721283 | 1.3759836737218 | 0.0404925219549813 |
| Orange | Bone morphogenetic protein 10 (prot-a-254) | rs2225962 | 2.81151549889757 | 1.42249296075175 | 0.0481015036941473 |
| Orange | Bone morphogenetic protein 10 (prot-a-254) | rs2760994 | 2.92731885472135 | 1.41626474114138 | 0.0387408320350763 |
| Orange | Bone morphogenetic protein 10 (prot-a-254) | rs72758819 | 2.97375964579779 | 1.49476359714544 | 0.0466513926000084 |
| Orange | Bone morphogenetic protein 10 (prot-a-254) | All - Inverse variance weighted | 1.29703740498956 | 0.59434243317789 | 0.0290869134298867 |
| Orange | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | rs72758819 | -0.0495621351783467 | 0.0214722790729943 | 0.0209884796096357 |
| Orange | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | All - Inverse variance weighted | -0.0260427488468229 | 0.0077883880804962 | 0.000826417079191 |
| Orange | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | All - Inverse variance weighted | -0.0102442109694566 | 0.004618990849594 | 0.0265653257552632 |
| Orange | Operation code: knee surgery (not replacement) (ukb-b-1508) | rs2760994 | -0.0533897237168586 | 0.0208522679751317 | 0.0104557854749799 |
| Orange | Operation code: knee surgery (not replacement) (ukb-b-1508) | All - Inverse variance weighted | -0.0187447018897732 | 0.0088973213792508 | 0.0351366231564362 |
| Orange | Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) | All - Inverse variance weighted | -0.0078481048657993 | 0.0036990154561987 | 0.0338651246492557 |
| Orange | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | rs2760994 | -0.0138872564052524 | 0.0058180601633722 | 0.0169900907740149 |
| Orange | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | All - Inverse variance weighted | -0.0073567734544586 | 0.0033423626761998 | 0.0277310848165232 |
| Orange | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | All - Inverse variance weighted | -0.0094594891827794 | 0.0044821946052109 | 0.0348188153493678 |
| Orange | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | rs2225962 | -0.0194823380763711 | 0.0074024023395825 | 0.0084910357700489 |
| Orange | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | All - Inverse variance weighted | -0.0097338121112482 | 0.0040654257765362 | 0.0166525336189839 |
| Orange | Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) | rs2760994 | -0.0342704285037219 | 0.010452424098804 | 0.0010428411708659 |
| Orange | Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) | rs2760994 | -0.0129332850093395 | 0.0056622710418467 | 0.0223647028104317 |
| Orange | Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) | All - Inverse variance weighted | -0.0075209886976629 | 0.0037553324461175 | 0.0452042251214638 |
| Orange | Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) | All - Inverse variance weighted | 0.0069715335200947 | 0.003329694301511 | 0.0362826290312821 |
| Orange | Fractured bone site(s): Spine (ukb-b-873) | All - Inverse variance weighted | 0.0064128521530687 | 0.0032479845892135 | 0.0483351803602877 |
| Orange | Shoulder lesions (ukb-d-M13_SHOULDER) | All - Inverse variance weighted | -0.0148154988318815 | 0.0071604440242864 | 0.0385390085190334 |
| Orange | Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) | All - Inverse variance weighted | -0.0147967706532795 | 0.0071609321987872 | 0.038798363355063 |