ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Red wine | Osteoarthritis (self-reported) (ebi-a-GCST005811) | All - Inverse variance weighted | 0.264403727288075 | 0.134849846544771 | 0.0499108844141948 |
| Red wine | Menstruation quality of life impact (joint pain) (ebi-a-GCST006647) | rs1229984 | -1.42156208277704 | 0.66683270001027 | 0.0330222886045443 |
| Red wine | Menstruation quality of life impact (joint pain) (ebi-a-GCST006647) | All - Inverse variance weighted | -1.36221643699837 | 0.586618886766699 | 0.0202249162418006 |
| Red wine | Osteoprotegerin levels (ebi-a-GCST90010243) | rs1229984 | 1.05429461504228 | 0.501438670363904 | 0.0355060426356564 |
| Red wine | Osteoprotegerin levels (ebi-a-GCST90010243) | All - Inverse variance weighted | 0.626177126661905 | 0.312939013067075 | 0.0453971556313865 |
| Red wine | Neck circumference (ebi-a-GCST90017135) | All - Inverse variance weighted | 1.033510208611 | 0.402771482170222 | 0.0102879869911568 |
| Red wine | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | All - Inverse variance weighted | 0.574434316410695 | 0.239143693501454 | 0.016303627550932 |
| Red wine | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | All - Inverse variance weighted | 0.635782407954472 | 0.310464786810747 | 0.0405756167222909 |
| Red wine | Compression fracture (ebi-a-GCST90018608) | rs1229984 | 0.707329430693917 | 0.282635822121803 | 0.0123278602978084 |
| Red wine | Compression fracture (ebi-a-GCST90018608) | All - Inverse variance weighted | 0.536620196209188 | 0.204912115372041 | 0.0088244274136912 |
| Red wine | Compression fracture (ebi-a-GCST90018828) | rs1229984 | 0.653007428708363 | 0.271301906815925 | 0.0160868097841989 |
| Red wine | Compression fracture (ebi-a-GCST90018828) | All - Inverse variance weighted | 0.415378076114121 | 0.186791237712008 | 0.0261648866719326 |
| Red wine | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | rs4860371 | -6.76299769774481 | 2.75325299401492 | 0.0140350041074095 |
| Red wine | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | rs7820063 | -6.53713327271271 | 2.85984857408044 | 0.0222640911456551 |
| Red wine | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | All - Inverse variance weighted | -2.12908270862478 | 1.01687666844546 | 0.0362825031397912 |
| Red wine | Bone disorder (ebi-a-GCST90038652) | rs17478663 | 0.0260619703441987 | 0.00940233457211 | 0.0055736725132957 |
| Red wine | Bone disorder (ebi-a-GCST90038652) | rs3751395 | 0.0194853922303694 | 0.0094716358922875 | 0.0396635109952724 |
| Red wine | Bone disorder (ebi-a-GCST90038652) | All - MR Egger | -0.0199224534806993 | 0.0079927776107949 | 0.0342778974234378 |
| Red wine | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | All - Inverse variance weighted | -3.20591429940966 | 1.54073633078625 | 0.0374551794329533 |
| Red wine | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | All - Inverse variance weighted | -3.1839678060626 | 1.53940599165304 | 0.0386109431089632 |
| Red wine | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | rs3751395 | 9.21325183311941 | 4.24762679340712 | 0.0300800151595558 |
| Red wine | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | All - MR Egger | -10.5358325502058 | 4.09293356290209 | 0.0329143186663072 |
| Red wine | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | rs3751395 | 9.26726055076184 | 4.25715774357932 | 0.0294905913941194 |
| Red wine | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | All - MR Egger | -10.5834981146626 | 4.10125700594758 | 0.0325884426240087 |
| Red wine | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | All - Inverse variance weighted | 3.92243404772901 | 1.50260181672852 | 0.0090428971555087 |
| Red wine | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | All - Inverse variance weighted | -1.65680362648436 | 0.679490329931314 | 0.014756380337606 |
| Red wine | Loose body in joint (finn-b-M13_LOOSEJOINT) | All - Inverse variance weighted | 2.44643488344542 | 0.893718561123715 | 0.00619333287954 |
| Red wine | Patellar tendinitis (finn-b-M13_PATELLARTEND) | All - Inverse variance weighted | -2.54647959610283 | 1.15352330783419 | 0.0272744953813883 |
| Red wine | Spondylosis (finn-b-M13_SPONDYLOSIS) | All - Inverse variance weighted | 0.564999787540091 | 0.190876294827844 | 0.0030760789066214 |
| Red wine | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | rs1229984 | 4.26551641504913 | 1.44808462565472 | 0.0032230134953958 |
| Red wine | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | All - MR Egger | 2.09537526783027 | 0.901133651769676 | 0.0485189434536072 |
| Red wine | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | All - Inverse variance weighted | 0.464633063645207 | 0.230644211195837 | 0.0439569283609281 |
| Red wine | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs116478398 | 7.69639825433817 | 3.02493006355667 | 0.0109489877712395 |
| Red wine | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | All - Inverse variance weighted | 1.46039360673552 | 0.71856021563936 | 0.0421143290040563 |
| Red wine | Ankle and foot (finn-b-Z21_ANKLE_FOOT) | rs114966038 | 12.3974445855347 | 5.61020060398313 | 0.027118757487099 |
| Red wine | Ankle and foot (finn-b-Z21_ANKLE_FOOT) | rs3751395 | 9.28632245110622 | 4.25715774357932 | 0.0291580352332098 |
| Red wine | Ankle and foot (finn-b-Z21_ANKLE_FOOT) | All - Inverse variance weighted | 4.21797340158835 | 1.50895245885346 | 0.0051851723232392 |
| Red wine | Knee and hip osteoarthritis (ieu-a-1170) | rs566577 | -1.32663931600359 | 0.608906777908019 | 0.029352238148413 |
| Red wine | Knee and hip osteoarthritis (ieu-a-1170) | All - Inverse variance weighted | -0.591279953035294 | 0.298350187656229 | 0.0474980451944576 |
| Red wine | Forearm bone mineral density (ieu-a-977) | All - Inverse variance weighted | -0.339626990735529 | 0.171221302498967 | 0.0473053917392844 |
| Red wine | Bone sialoprotein 2 (prot-a-1395) | rs116478398 | -1.99452559967581 | 0.888799172060975 | 0.0248280395787343 |
| Red wine | Bone sialoprotein 2 (prot-a-1395) | rs61808187 | -2.03500173458617 | 0.815624561740196 | 0.0125949099375227 |
| Red wine | Bone sialoprotein 2 (prot-a-1395) | All - MR Egger | -1.5191909748373 | 0.670643448259067 | 0.0497459396902179 |
| Red wine | Bone sialoprotein 2 (prot-a-1396) | rs17478663 | 1.96352994235454 | 0.801561370650249 | 0.0143002502022571 |
| Red wine | Bone sialoprotein 2 (prot-a-1396) | rs7820063 | 1.88693468520464 | 0.83863763786873 | 0.0244489453100894 |
| Red wine | Bone sialoprotein 2 (prot-a-1396) | All - Inverse variance weighted | 0.666093664980284 | 0.235795923931505 | 0.0047299280695904 |
| Red wine | Fractured bone site(s): Wrist (ukb-a-439) | All - Inverse variance weighted | 0.0066167345349367 | 0.0032439520800132 | 0.0413788177885285 |
| Red wine | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | All - Inverse variance weighted | 0.0050987460541728 | 0.0023421459458732 | 0.0294839338495482 |
| Red wine | Fractured heel (ukb-b-18389) | rs116478398 | -0.0145049012001802 | 0.0049726505949681 | 0.0035348882862454 |
| Red wine | Fractured heel (ukb-b-18389) | rs1229984 | -0.007748450926021 | 0.0038926260655232 | 0.0465308310008445 |
| Red wine | Fractured heel (ukb-b-18389) | All - MR Egger | -0.0082820929947105 | 0.0034152268750303 | 0.0382922276833286 |
| Red wine | Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint (ukb-b-19054) | rs3751395 | 0.0087751140537037 | 0.0041665501772756 | 0.035196860671338 |
| Red wine | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | All - Inverse variance weighted | 0.005858440285976 | 0.0029720314156162 | 0.0487020826856528 |
| Red wine | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | rs3751395 | 0.0086191559390527 | 0.0043746425893685 | 0.048809296877121 |
| Red wine | Operation code: reduction or fixation of bone fracture (ukb-b-847) | rs3751395 | 0.0363853553773621 | 0.0138263587957962 | 0.0084985488941487 |
| Red wine | Operation code: reduction or fixation of bone fracture (ukb-b-847) | All - Inverse variance weighted | 0.0088062272358099 | 0.0042543391663905 | 0.0384579542360214 |
| Red wine | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | rs402236 | 0.0098176134984219 | 0.0043771126300259 | 0.0249004997699869 |
| Red wine | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | rs402236 | 0.0098176134984219 | 0.0043771126300259 | 0.0249004997699869 |
| Red wine | Ankle spacing width (left) (ukb-e-4100_EAS) | rs1229984 | -1.07151415562631 | 0.339170175618774 | 0.0015819050010933 |
| Red wine | Ankle spacing width (left) (ukb-e-4100_EAS) | All - Inverse variance weighted | -0.75698126594931 | 0.249242756752276 | 0.0023884683694695 |
| Red wine | Ankle spacing width (left) (ukb-e-4100_EAS) | All - MR Egger | -1.45929216756059 | 0.567963714757473 | 0.0423725890254455 |
| Red wine | Ankle spacing width (right) (ukb-e-4119_AFR) | rs17478663 | 1.7455131272907 | 0.803924696558801 | 0.0299130662453381 |
| Red wine | Ankle spacing width (right) (ukb-e-4119_AFR) | rs7820063 | 1.3547767009503 | 0.643112570612818 | 0.0351528387610568 |
| Red wine | Ankle spacing width (right) (ukb-e-4119_AFR) | All - Inverse variance weighted | 0.6944144635212 | 0.244265880418031 | 0.0044710267351179 |
| Red wine | Ankle spacing width (right) (ukb-e-4119_EAS) | rs1229984 | -0.884940604566773 | 0.345246653657869 | 0.0103708494992043 |
| Red wine | Ankle spacing width (right) (ukb-e-4119_EAS) | All - Inverse variance weighted | -0.722631195000491 | 0.253461092955169 | 0.0043574605304905 |
| Red wine | Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) | rs1229984 | 0.922597651569614 | 0.371777754955325 | 0.013079995305863 |
| Red wine | Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) | rs402236 | 1.96696360206921 | 0.92162025883803 | 0.0328227155174898 |
| Red wine | Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) | All - Inverse variance weighted | 0.6985103015508 | 0.32694056530325 | 0.0326382367396732 |
| Red wine | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) | rs1229984 | 0.874670500838725 | 0.373147102119065 | 0.01907629435152 |
| Red wine | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) | rs402236 | 1.9429193045362 | 0.925588735129886 | 0.0358065638683047 |
| Red wine | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) | All - Inverse variance weighted | 0.688817796295343 | 0.31290949623495 | 0.0277125044004951 |