ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Sweetcorn | Bone mineral density (ebi-a-GCST90014022) | rs1872627 | 0.766561694409335 | 0.146759784913987 | 1.75818524025921e-07 |
| Sweetcorn | Bone mineral density (ebi-a-GCST90014022) | rs4236146 | 0.413099798714369 | 0.13751704434777 | 0.0026646425712787 |
| Sweetcorn | Bone mineral density (ebi-a-GCST90014022) | rs73265619 | 0.306266092824808 | 0.152429749300514 | 0.0445129786905467 |
| Sweetcorn | Bone mineral density (ebi-a-GCST90014022) | rs79332506 | 0.353176516313629 | 0.145719920778324 | 0.0153647006762597 |
| Sweetcorn | Bone mineral density (ebi-a-GCST90014022) | All - Inverse variance weighted | 0.111296568454023 | 0.0535625686851757 | 0.0377204504800707 |
| Sweetcorn | Shoulder impingement (ebi-a-GCST90014054) | All - MR Egger | 2.25355580756576 | 0.879879762782151 | 0.0217099099035428 |
| Sweetcorn | Joint disorder (ebi-a-GCST90038654) | rs76166697 | -0.108417298156196 | 0.0451041747321149 | 0.0162296991775918 |
| Sweetcorn | Joint disorder (ebi-a-GCST90038654) | rs866596 | -0.0903181656376201 | 0.0449583880589687 | 0.0445447675525952 |
| Sweetcorn | Joint disorder (ebi-a-GCST90038654) | All - Inverse variance weighted | -0.0257096478521058 | 0.0104844819495734 | 0.0142000730004955 |
| Sweetcorn | Osteoporosis (ebi-a-GCST90038656) | rs866596 | -0.0420906011022868 | 0.0172631249462973 | 0.0147614331694534 |
| Sweetcorn | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | All - Inverse variance weighted | -4.57272536439528 | 2.1527663308116 | 0.0336604465896089 |
| Sweetcorn | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | All - Inverse variance weighted | -4.57250471178981 | 2.15247245015567 | 0.0336447751075268 |
| Sweetcorn | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | rs116917456 | 16.739539625897 | 7.95753107721266 | 0.0354125064200652 |
| Sweetcorn | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | rs149477690 | 32.7952913034549 | 13.3500898315352 | 0.0140274532768006 |
| Sweetcorn | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | All - MR Egger | 9.85813859080943 | 4.59785537387999 | 0.0459315034965353 |
| Sweetcorn | Chondromalacia (finn-b-M13_CHONDROMALACIA) | All - MR Egger | -4.71920347321584 | 2.2386631658277 | 0.0493065464103745 |
| Sweetcorn | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | All - Inverse variance weighted | -0.405276330557626 | 0.182514699067969 | 0.0263839387351291 |
| Sweetcorn | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs2540716 | -2.23855799555786 | 1.03766490419088 | 0.0309820345467385 |
| Sweetcorn | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | All - Inverse variance weighted | -0.610719687264961 | 0.225062607066537 | 0.0066565584698331 |
| Sweetcorn | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs76166697 | -3.94379378486378 | 1.32469727216722 | 0.0029096218689991 |
| Sweetcorn | Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) | All - MR Egger | -3.10578559324451 | 1.22941475466539 | 0.0211224574816997 |
| Sweetcorn | Recurrent dislocation and subluxation of joint (finn-b-M13_RECUDISLOCATIO) | rs149477690 | -6.70862679808377 | 3.3284811818756 | 0.0438499911803002 |
| Sweetcorn | Recurrent dislocation and subluxation of joint (finn-b-M13_RECUDISLOCATIO) | All - MR Egger | -3.55298540310533 | 1.32051781101194 | 0.0149469569233766 |
| Sweetcorn | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | rs76166697 | 22.3363822130356 | 7.60985561304701 | 0.0033334207781984 |
| Sweetcorn | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | All - Inverse variance weighted | 4.69288231995321 | 2.07096752640879 | 0.0234493166251408 |
| Sweetcorn | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | rs1841715 | -10.8007380299993 | 5.3145515732176 | 0.0421237729274338 |
| Sweetcorn | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | rs4710195 | -13.2056170371059 | 5.48064106140922 | 0.0159742970209517 |
| Sweetcorn | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | All - Inverse variance weighted | -3.7875889706856 | 1.24540935575475 | 0.0023560580988677 |
| Sweetcorn | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs10445348 | -2.72439697491032 | 1.3092241018319 | 0.0374407846866585 |
| Sweetcorn | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs10497125 | -2.49268778080429 | 1.23629272999568 | 0.0437727782854923 |
| Sweetcorn | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs1841715 | 2.44579709078872 | 1.1953143676787 | 0.040741236636499 |
| Sweetcorn | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs866596 | -3.33877520959407 | 1.26431561245658 | 0.00827162176144 |
| Sweetcorn | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | -0.764866293170642 | 0.327870835151644 | 0.0196571699043955 |
| Sweetcorn | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | rs79332506 | -15.761640335245 | 6.6982836681786 | 0.0186183064657262 |
| Sweetcorn | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | rs866596 | -11.4340776019738 | 4.66446536634465 | 0.0142335019749387 |
| Sweetcorn | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | All - Inverse variance weighted | -2.47413027690229 | 1.03524479840568 | 0.016853016967083 |
| Sweetcorn | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | rs7647832 | -3.34928229665072 | 1.68831168831169 | 0.047277508036904 |
| Sweetcorn | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | All - Inverse variance weighted | -0.905531809071543 | 0.355592274819038 | 0.0108795113589773 |
| Sweetcorn | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs10497125 | -1.7639786513353 | 0.879476535566031 | 0.0448867401552406 |
| Sweetcorn | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs866596 | -2.61455558692477 | 0.902205801121927 | 0.003755994673044 |
| Sweetcorn | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | -0.504143820390831 | 0.200685556107604 | 0.0120012304309103 |
| Sweetcorn | Osteomyelitis (ieu-b-4975) | rs1872627 | -3.1148267957754 | 1.50830137749309 | 0.0389114308097273 |
| Sweetcorn | Osteomyelitis (ieu-b-4975) | All - Inverse variance weighted | -0.927599837361692 | 0.329137243513444 | 0.0048282175848595 |
| Sweetcorn | Bone sialoprotein 2 (prot-a-1396) | rs11264034 | -4.34484335696318 | 1.82940772924766 | 0.0175489501914767 |
| Sweetcorn | Bone sialoprotein 2 (prot-a-1396) | rs1872627 | -4.54165684783307 | 1.75667859208638 | 0.0097275717607516 |
| Sweetcorn | Bone sialoprotein 2 (prot-a-1396) | All - Inverse variance weighted | -0.779879965937105 | 0.376631208041439 | 0.038389391765901 |
| Sweetcorn | Bone morphogenetic protein 6 (prot-a-255) | rs1841715 | -3.53690456487492 | 1.52632450026665 | 0.0204890787326415 |
| Sweetcorn | Bone morphogenetic protein 6 (prot-a-255) | rs9638882 | -4.08516959643476 | 1.552570768342 | 0.0085076629168594 |
| Sweetcorn | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs1872627 | 1.01117561787242 | 0.222331955126145 | 5.41466969969377e-06 |
| Sweetcorn | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs4236146 | 0.527513906023418 | 0.207032551998788 | 0.0108350026429414 |
| Sweetcorn | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | All - Inverse variance weighted | 0.153617827403498 | 0.0580475162969602 | 0.0081349907255077 |
| Sweetcorn | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | rs4236146 | -0.0272476354349285 | 0.0117548644027444 | 0.0204499695048913 |
| Sweetcorn | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | rs866596 | -0.0257727055126616 | 0.0120550038665963 | 0.0325227542710118 |
| Sweetcorn | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | All - Inverse variance weighted | -0.00589492936586 | 0.0026094292404647 | 0.0238779333278122 |
| Sweetcorn | Operative procedures - secondary OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-12747) | rs4710195 | -0.0143616355125701 | 0.0070199944201618 | 0.0407742163492336 |
| Sweetcorn | Operative procedures - secondary OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-12747) | All - Inverse variance weighted | -0.0053623513094178 | 0.0025516400028945 | 0.0355943541615107 |
| Sweetcorn | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - Inverse variance weighted | -0.0078538775703798 | 0.0039476325129797 | 0.0466442908644148 |
| Sweetcorn | Operative procedures - secondary OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-19546) | All - Inverse variance weighted | -0.0050476589204615 | 0.0024725508302519 | 0.0412033064367876 |
| Sweetcorn | Diagnoses - main ICD10: M51.3 Other specified intervertebral disk degeneration (ukb-b-19807) | All - Inverse variance weighted | 0.0070104775694517 | 0.0027292978433834 | 0.0102109908317979 |
| Sweetcorn | Operation code: ankle surgery (ukb-b-4274) | rs866596 | -0.0183292621552285 | 0.0071379208759375 | 0.0102325138931527 |
| Sweetcorn | Operation code: ankle surgery (ukb-b-4274) | All - Inverse variance weighted | -0.0058298915891799 | 0.0029518797097658 | 0.0482708713730324 |
| Sweetcorn | Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) | All - Inverse variance weighted | -0.0052525616415185 | 0.0026000444967429 | 0.043364570488911 |
| Sweetcorn | Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) | rs9638882 | 0.0325791243707188 | 0.0139753032928943 | 0.0197432033404833 |
| Sweetcorn | Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) | All - Inverse variance weighted | 0.0086149868423036 | 0.0040316329763421 | 0.032610356987339 |
| Sweetcorn | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | rs149477690 | 0.0342028888168457 | 0.0146923318354953 | 0.0199152109174964 |
| Sweetcorn | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | All - Inverse variance weighted | 0.0065402253856585 | 0.0032446397565128 | 0.0438311934720375 |
| Sweetcorn | Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) | rs2540716 | 0.0193302397705478 | 0.0090060569316598 | 0.0318442732189458 |
| Sweetcorn | Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) | All - Inverse variance weighted | 0.0048395102889922 | 0.0023076071392947 | 0.0359760050166351 |
| Sweetcorn | Ankle spacing width (left) (ukb-e-4100_AFR) | rs73265619 | -1.74104611494808 | 0.835293133418232 | 0.0371280298029782 |
| Sweetcorn | Ankle spacing width (left) (ukb-e-4100_AFR) | All - MR Egger | -2.59844303841875 | 1.1812065345005 | 0.0465128054148179 |