ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Other sweets | Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) | All - Inverse variance weighted | 0.759014078762512 | 0.368697102144356 | 0.0395288740609569 |
| Other sweets | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | rs720112 | -6.23709566414315 | 2.27259692590044 | 0.0060606940569954 |
| Other sweets | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | rs76694902 | 3.25501015674742 | 1.12300275899706 | 0.0037496651276254 |
| Other sweets | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | All - Inverse variance weighted | 1.03028829258131 | 0.402303828699174 | 0.0104380177721053 |
| Other sweets | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs10732346 | 5.35804069110072 | 2.16137585379239 | 0.0131753023778785 |
| Other sweets | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs117902110 | 4.99443682620378 | 2.51348428598504 | 0.0469160682364896 |
| Other sweets | Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) | rs10732346 | -17.9188955083743 | 6.75099347381924 | 0.0079482433390479 |
| Other sweets | Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) | All - Inverse variance weighted | -3.523680668617 | 1.32832026344439 | 0.007984270302742 |
| Other sweets | Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) | rs10732346 | -17.7469799057109 | 6.75760561238321 | 0.008633820957822 |
| Other sweets | Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) | All - Inverse variance weighted | -3.53379247719819 | 1.33010736322737 | 0.0078892695341363 |
| Other sweets | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | All - MR Egger | -5.43253051699403 | 2.48043229223792 | 0.0384664474543024 |
| Other sweets | Cervical root disorders (finn-b-G6_CERVROOT) | rs720112 | 21.9086946547373 | 9.83597155310851 | 0.02592020201579 |
| Other sweets | Cervical root disorders (finn-b-G6_CERVROOT) | All - MR Egger | -5.81291730346678 | 2.80073524574186 | 0.0488243792081009 |
| Other sweets | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | rs114773112 | 30.3971885292835 | 13.5530539022814 | 0.024907814124413 |
| Other sweets | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | rs4849108 | 23.9292721982904 | 11.2842719351662 | 0.0339566340736351 |
| Other sweets | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | rs78668444 | 23.7320169473385 | 10.1861544525921 | 0.0198150926445658 |
| Other sweets | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | All - Inverse variance weighted | 3.89489533351374 | 1.95912361210779 | 0.0468027942289698 |
| Other sweets | Chondromalacia (finn-b-M13_CHONDROMALACIA) | All - Inverse variance weighted | 1.90817508141915 | 0.908052392728057 | 0.0356064684282537 |
| Other sweets | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | rs117902110 | 42.6993098988818 | 16.7675619028507 | 0.0108795946082104 |
| Other sweets | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | rs146890637 | 26.8009814578208 | 8.56868615597806 | 0.0017613082656136 |
| Other sweets | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | rs76004663 | 34.0993127109345 | 13.733003451619 | 0.0130274026647806 |
| Other sweets | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | All - Inverse variance weighted | 3.43290652920409 | 1.61916199678919 | 0.0339913032934109 |
| Other sweets | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | rs117902110 | 18.4376289062064 | 9.06384828924044 | 0.0419320048064336 |
| Other sweets | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | rs137971383 | 10.269196446589 | 3.44249773165857 | 0.0028537685204508 |
| Other sweets | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | rs146890637 | 9.18686473807662 | 4.4416687325591 | 0.0386084092051415 |
| Other sweets | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | All - Inverse variance weighted | 1.6566375669827 | 0.815129298534994 | 0.0421170524192283 |
| Other sweets | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs78668444 | 2.80628294119336 | 1.05464028673685 | 0.0077934161261437 |
| Other sweets | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | All - Inverse variance weighted | 0.421604036690945 | 0.201529282225374 | 0.0364363947736404 |
| Other sweets | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | All - MR Egger | 0.873224469158234 | 0.348205324256981 | 0.0193162506943172 |
| Other sweets | Osteomalacia (finn-b-M13_OSTEOMALACIA) | rs76694902 | 12.4900706424522 | 5.72901191522906 | 0.029246793124817 |
| Other sweets | Osteomalacia (finn-b-M13_OSTEOMALACIA) | All - Inverse variance weighted | 3.37322305910187 | 1.69866014245439 | 0.0470539828191371 |
| Other sweets | Osteomalacia (finn-b-M13_OSTEOMALACIA) | All - MR Egger | 6.35531812602424 | 2.92469413478339 | 0.0398793239650942 |
| Other sweets | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | rs10978815 | 8.96418881133365 | 4.38681883142437 | 0.0410091776384474 |
| Other sweets | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | rs2796349 | -9.40664649051333 | 3.59387731346758 | 0.0088600133068704 |
| Other sweets | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | All - Inverse variance weighted | 1.28742597287622 | 0.643898439642545 | 0.0455625008361718 |
| Other sweets | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | All - MR Egger | 2.72190939253064 | 1.1120548131892 | 0.0220729610830172 |
| Other sweets | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs4849108 | -4.57084432816858 | 1.96215521324342 | 0.0198324916334416 |
| Other sweets | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | All - MR Egger | 1.61501378058845 | 0.586484273615504 | 0.0110524930252474 |
| Other sweets | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | rs116350919 | -6.13365624806977 | 3.08119265857369 | 0.0465165199211369 |
| Other sweets | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | rs76694902 | -4.94921626292332 | 1.95615923354455 | 0.0114040358831213 |
| Other sweets | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | All - MR Egger | -2.73617374558597 | 0.986832059301059 | 0.0105783999672044 |
| Other sweets | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs117902110 | 61.9218034047961 | 22.3976275683691 | 0.0056982323066436 |
| Other sweets | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs1817113 | 21.4622551086915 | 9.27807384119925 | 0.0207103739206383 |
| Other sweets | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | rs76694902 | -1.89794742746263 | 0.876815329108935 | 0.0304189458948785 |
| Other sweets | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | rs78668444 | -2.75407302600837 | 1.33135283721732 | 0.0385810599040076 |
| Other sweets | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -0.546436484743883 | 0.254403875747136 | 0.0317209508013968 |
| Other sweets | Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) | All - Inverse variance weighted | -0.303536970677349 | 0.143013499958278 | 0.0338011594438261 |
| Other sweets | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | rs7324017 | -19.3374168477903 | 8.12751103207535 | 0.0173476962190921 |
| Other sweets | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | All - Inverse variance weighted | -2.76767147938316 | 1.16407273144223 | 0.0174268476867931 |
| Other sweets | Lumbar spine bone mineral density (ieu-a-982) | rs12473699 | 1.32283072598297 | 0.65424118417874 | 0.0431834499882761 |
| Other sweets | Lumbar spine bone mineral density (ieu-a-982) | All - Inverse variance weighted | 0.429412337169836 | 0.141283734952662 | 0.0023708022560544 |
| Other sweets | Bone morphogenetic protein 6 (prot-a-255) | rs148513160 | 4.1621365634359 | 1.80092447456361 | 0.0208267184191033 |
| Other sweets | Bone morphogenetic protein 6 (prot-a-255) | rs76589137 | 3.91276653826322 | 1.68238850637468 | 0.0200334312342463 |
| Other sweets | Bone morphogenetic protein 6 (prot-a-255) | All - Inverse variance weighted | 0.882928120901801 | 0.384586369553226 | 0.0216881027761885 |
| Other sweets | Bone morphogenetic protein 6 (prot-a-255) | All - MR Egger | 1.88866861502968 | 0.769951885241669 | 0.0225620261777109 |
| Other sweets | Fractured bone site(s): Arm (ukb-a-440) | All - Inverse variance weighted | -0.0114047285823907 | 0.0036838597885647 | 0.0019624040299341 |
| Other sweets | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | rs2796349 | 0.0407941450355023 | 0.0178913979746246 | 0.0226018625887457 |
| Other sweets | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | rs76004663 | -0.0429144378620726 | 0.0176320072578236 | 0.0149373659586846 |
| Other sweets | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | All - MR Egger | -0.0173458585481612 | 0.0070948744206386 | 0.0222095616599718 |
| Other sweets | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs1817113 | -0.011311122186865 | 0.0041807307441628 | 0.0068194027787089 |
| Other sweets | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | All - MR Egger | 0.0041482189314455 | 0.0016389128366182 | 0.0183372400084019 |
| Other sweets | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | rs2796349 | -0.040497395530206 | 0.019651452101036 | 0.0393236639027322 |
| Other sweets | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | rs9604094 | -0.0471831818287856 | 0.0205502375601677 | 0.0216763365929317 |
| Other sweets | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | All - Inverse variance weighted | -0.0154227860178268 | 0.0064519723077385 | 0.0168300926786977 |
| Other sweets | Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) | rs963422 | 0.0327412044882586 | 0.0144538028026281 | 0.0234984979313208 |
| Other sweets | Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) | All - Inverse variance weighted | 0.0122423266560198 | 0.0043065377016212 | 0.0044728855670682 |
| Other sweets | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - MR Egger | 0.0648971025577799 | 0.027953814379553 | 0.0426575753576563 |
| Other sweets | Fractured bone site(s): Other bones (ukb-b-17738) | rs78668444 | 0.0718943584576147 | 0.0355559964392838 | 0.0431759635173772 |
| Other sweets | Fractured bone site(s): Other bones (ukb-b-17738) | All - MR Egger | 0.042732981377782 | 0.0201883207397634 | 0.0493349439600133 |
| Other sweets | Diagnoses - secondary ICD10: M81.99 Osteoporosis, unspecified (Site unspecified) (ukb-b-17796) | rs12473699 | -0.0272194932687169 | 0.0102356498122269 | 0.0078307071464544 |
| Other sweets | Diagnoses - secondary ICD10: M81.99 Osteoporosis, unspecified (Site unspecified) (ukb-b-17796) | All - Inverse variance weighted | -0.0111226932567348 | 0.00363777992197 | 0.0022315456149132 |
| Other sweets | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs11679650 | -0.182179524182575 | 0.0707495762868186 | 0.010024268683139 |
| Other sweets | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs2796349 | 0.15956888022349 | 0.0655874607147014 | 0.0149777135710476 |
| Other sweets | Fractured bone site(s): Arm (ukb-b-19255) | All - Inverse variance weighted | -0.0096366582527581 | 0.0046781975047347 | 0.0394073002460988 |
| Other sweets | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | rs1817113 | -0.0274427788214546 | 0.0110130736495035 | 0.0127084525346587 |
| Other sweets | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | All - MR Egger | 0.189253740988901 | 0.0629351536214138 | 0.0237885986730334 |
| Other sweets | Ankle spacing width (left) (ukb-b-2122) | rs12473699 | -0.477082158988587 | 0.232611767117371 | 0.0402688622869316 |
| Other sweets | Ankle spacing width (left) (ukb-b-2122) | rs2796349 | 0.611440024444186 | 0.230815679199162 | 0.0080720717445245 |
| Other sweets | Ankle spacing width (left) (ukb-b-2122) | rs4552452 | -0.523749094796372 | 0.240055978941803 | 0.0291258468230541 |
| Other sweets | Ankle spacing width (left) (ukb-b-2122) | All - MR Egger | -0.215123181747399 | 0.1012603012271 | 0.0441291978065809 |
| Other sweets | Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) | rs1817113 | -0.0195925315339493 | 0.0080594256795614 | 0.0150568654387741 |
| Other sweets | Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) | All - MR Egger | 0.156923596384218 | 0.0560137098266688 | 0.0487359313723737 |
| Other sweets | Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) | rs1817113 | 0.041851244105356 | 0.0155035080320515 | 0.006945016138274 |
| Other sweets | Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) | All - Inverse variance weighted | 0.012943879241143 | 0.0047021580644189 | 0.0059096482626458 |
| Other sweets | Non-cancer illness code, self-reported: sciatica (ukb-b-8194) | rs1817113 | 0.0329311045508569 | 0.0161758233332055 | 0.0417681856271749 |
| Other sweets | Non-cancer illness code, self-reported: sciatica (ukb-b-8194) | All - Inverse variance weighted | 0.0098182099873421 | 0.0044869580485502 | 0.0286574974631198 |
| Other sweets | Operation code: reduction or fixation of bone fracture (ukb-b-847) | rs148513160 | -0.0804352901155927 | 0.0330445184083385 | 0.0149268382958656 |
| Other sweets | Operation code: reduction or fixation of bone fracture (ukb-b-847) | rs9604094 | -0.0739984758823941 | 0.033993887977356 | 0.0294942183396211 |
| Other sweets | Operation code: reduction or fixation of bone fracture (ukb-b-847) | All - Inverse variance weighted | -0.0262166338062604 | 0.0076816547023844 | 0.0006427814901065 |
| Other sweets | Knee pain for 3+ months (ukb-b-8906) | rs2796349 | -0.306610842742405 | 0.13869965661739 | 0.0270628582578611 |
| Other sweets | Knee pain for 3+ months (ukb-b-8906) | rs76694902 | -0.326942970621229 | 0.149798380984143 | 0.0290687122898395 |
| Other sweets | Knee pain for 3+ months (ukb-b-8906) | All - Inverse variance weighted | -0.0628799337382332 | 0.0278419937715125 | 0.0239172093287269 |
| Other sweets | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs10978815 | -0.0587928998985108 | 0.0275125618773431 | 0.0326022632131445 |
| Other sweets | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs1817113 | -0.0574443123873788 | 0.0277282521182379 | 0.0382944623047962 |
| Other sweets | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs76589137 | -0.0606792239174174 | 0.0243133448593123 | 0.01257029042366 |
| Other sweets | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | All - Inverse variance weighted | -0.0128983361743912 | 0.0052036691749896 | 0.0131862062874193 |
| Other sweets | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | rs10978815 | -0.0677459041859116 | 0.0269343634141795 | 0.0118957442254575 |
| Other sweets | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | rs76589137 | -0.0514448926769592 | 0.0238025620026894 | 0.0306708256651598 |
| Other sweets | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | All - Inverse variance weighted | -0.0127306545106828 | 0.0050943204853405 | 0.0124547924790872 |
| Other sweets | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | rs78668444 | 0.0348676087075697 | 0.0141452584260277 | 0.013702550641076 |
| Other sweets | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | All - Inverse variance weighted | 0.0056364319196912 | 0.002767401578787 | 0.0416777549227549 |
| Other sweets | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | All - MR Egger | 0.0111040294935343 | 0.0053182595737873 | 0.0475938858840769 |
| Other sweets | Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) | rs76694902 | -3.39326319619198 | 1.56565503441167 | 0.0302110598375244 |
| Other sweets | Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) | rs963422 | 12.7182339727169 | 5.91715976331361 | 0.0316041674452451 |
| Other sweets | Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) | All - MR Egger | -3.88585809893866 | 1.76282720894321 | 0.0447353899338502 |
| Other sweets | Pain in joint (ukb-e-745_AFR) | rs4849108 | 21.5912251817437 | 7.87117436117188 | 0.0060866697697391 |
| Other sweets | Pain in joint (ukb-e-745_AFR) | All - MR Egger | -3.93945608994855 | 1.83413563566843 | 0.0497152707313266 |
| Other sweets | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | rs10978815 | 10.0577867069862 | 4.71821213313726 | 0.0330319718286607 |
| Other sweets | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | All - MR Egger | 1.85870836131219 | 0.748158814251399 | 0.0273833571238488 |