ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Battered fish (ukb-b-14166)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Battered fish (👉 📊) Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) Inverse variance weighted 3 2.151098164 1.070193763 0.044430328
Battered fish (👉 📊) Rheumatoid arthritis (ebi-a-GCST005569) Wald ratio 1 5.064677627 2.411638493 0.035720205
Battered fish (👉 📊) Osteoprotegerin levels (ebi-a-GCST90012002) MR Egger 16 1.358994054 0.594095426 0.038245401
Battered fish (👉 📊) Ulcerative colitis vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016625) MR Egger 9 -0.683060099 0.2275004 0.019872952
Battered fish (👉 📊) Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) Inverse variance weighted 15 4.611729102 1.911048905 0.01581346
Battered fish (👉 📊) Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) Inverse variance weighted 15 3.038960889 1.368953026 0.026424462
Battered fish (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) MR Egger 15 -12.86560414 5.232899059 0.028744557
Battered fish (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) Inverse variance weighted 15 -6.681174208 3.05648911 0.02882305
Battered fish (👉 📊) Contracture of joint (finn-b-M13_CONTRACTUREJOINT) MR Egger 15 -12.39365826 5.17613732 0.032424024
Battered fish (👉 📊) Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) MR Egger 15 6.706825864 2.415402307 0.015715192
Battered fish (👉 📊) Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) Inverse variance weighted 15 3.575599211 1.363246115 0.008719594
Battered fish (👉 📊) Osteomyelitis (ieu-b-4975) Inverse variance weighted 15 -1.80941246 0.691636416 0.008893206
Battered fish (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) Inverse variance weighted 4 -0.020454038 0.010282777 0.046684098
Battered fish (👉 📊) Fractured heel (ukb-b-18389) MR Egger 16 0.021726856 0.008214723 0.019220741
Battered fish (👉 📊) Fractured heel (right) (ukb-b-3499) MR Egger 16 -0.050877064 0.023021963 0.044267617
Battered fish (👉 📊) Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) MR Egger 15 0.016977872 0.007596517 0.043601027
Battered fish (👉 📊) Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) Weighted median 15 0.012374195 0.006032069 0.040227857
Battered fish (👉 📊) Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) Inverse variance weighted 16 0.013794519 0.006758501 0.041244689
Battered fish (👉 📊) Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) Inverse variance weighted 16 0.013873945 0.005334558 0.009301545
Battered fish (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_AFR) Inverse variance weighted 6 -3.504096382 1.626108281 0.03116987
Battered fish (👉 📊) Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) Inverse variance weighted 8 1.57167437 0.761153409 0.038936355
Battered fish (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) Inverse variance weighted 6 -3.441578569 1.628818392 0.034606795

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Battered fish Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) rs1432197 3.4756242568371 1.77112757750645 0.0497183303356367
Battered fish Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) All - Inverse variance weighted 2.1510981642736 1.07019376268553 0.0444303283398755
Battered fish Rheumatoid arthritis (ebi-a-GCST005569) rs4143128 5.0646776266829 2.41163849343269 0.0357202048205614
Battered fish Osteoprotegerin levels (ebi-a-GCST90012002) rs117035563 3.6509353226156 1.59407035212794 0.0220026237732584
Battered fish Osteoprotegerin levels (ebi-a-GCST90012002) rs182505167 2.72879270639452 1.38016972144232 0.0480254845874028
Battered fish Osteoprotegerin levels (ebi-a-GCST90012002) All - MR Egger 1.35899405401179 0.594095426391012 0.0382454006271865
Battered fish Ulcerative colitis vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016625) All - MR Egger -0.683060098730243 0.227500399613473 0.0198729517566668
Battered fish Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) rs1432197 17.3646355964154 7.92465415736203 0.0284361049460985
Battered fish Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) All - Inverse variance weighted 4.61172910214773 1.91104890547543 0.015813460261596
Battered fish Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) All - Inverse variance weighted 3.03896088918287 1.36895302576533 0.026424462058834
Battered fish Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) rs186654512 49.1197011243333 22.9192733984683 0.0321001438715892
Battered fish Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) All - Inverse variance weighted -6.68117420822736 3.05648910972433 0.0288230500227875
Battered fish Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) All - MR Egger -12.8656041411896 5.23289905873928 0.0287445572354532
Battered fish Contracture of joint (finn-b-M13_CONTRACTUREJOINT) rs138104392 -26.9572589841729 13.1156599679828 0.0398453048593312
Battered fish Contracture of joint (finn-b-M13_CONTRACTUREJOINT) All - MR Egger -12.3936582561227 5.17613731951261 0.0324240244877231
Battered fish Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) rs115669273 9.25378204414874 4.35747711445991 0.0336989263668256
Battered fish Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) rs78466056 8.81391258319043 3.67774769658306 0.0165501574272793
Battered fish Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) All - Inverse variance weighted 3.57559921102126 1.36324611526862 0.0087195938122223
Battered fish Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) All - MR Egger 6.70682586410588 2.41540230653707 0.0157151917792203
Battered fish Osteomyelitis (ieu-b-4975) All - Inverse variance weighted -1.80941246046264 0.691636416389358 0.0088932057352347
Battered fish Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) All - Inverse variance weighted -0.0204540377155262 0.0102827772692641 0.046684098251202
Battered fish Fractured heel (ukb-b-18389) All - MR Egger 0.0217268560372362 0.0082147229047716 0.0192207409992208
Battered fish Fractured heel (right) (ukb-b-3499) rs62062462 0.139368999317077 0.0524950538303941 0.0079332455787754
Battered fish Fractured heel (right) (ukb-b-3499) All - MR Egger -0.0508770637201695 0.0230219631569525 0.0442676174537524
Battered fish Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) rs78146210 0.0345910369220831 0.0171290658011864 0.0434420151543527
Battered fish Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) All - MR Egger 0.0169778719066802 0.0075965169568874 0.0436010274061766
Battered fish Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) rs115669273 0.0595334453939007 0.0223186288003467 0.0076433143366122
Battered fish Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) rs76018473 0.0537409837798443 0.0213342197718441 0.0117687337951491
Battered fish Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) rs78466056 -0.0453879279448172 0.0200873947541092 0.0238508790323507
Battered fish Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) All - Inverse variance weighted 0.0137945187807242 0.0067585014069479 0.0412446886551339
Battered fish Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) rs4810026 0.0509302322884816 0.0207595148066079 0.0141534892226916
Battered fish Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) All - Inverse variance weighted 0.0138739451469672 0.0053345579100505 0.0093015454173081
Battered fish Heel bone mineral density (BMD) (ukb-e-3148_AFR) All - Inverse variance weighted -3.50409638176798 1.62610828148247 0.0311698699687549
Battered fish Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) All - Inverse variance weighted 1.57167436982824 0.761153408768108 0.0389363554416212
Battered fish Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) All - Inverse variance weighted -3.4415785686767 1.62881839243836 0.0346067952836768