ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Cottage cheese | Osteoporosis (bbj-a-137) | rs566351 | -6.86026445781833 | 3.48095453803083 | 0.0487467812325961 |
| Cottage cheese | Osteoporosis (bbj-a-137) | rs80187236 | -7.15836444330508 | 2.03931472609873 | 0.0004478012331049 |
| Cottage cheese | Osteoporosis (bbj-a-137) | All - Inverse variance weighted | -3.89078481772344 | 1.42612508178454 | 0.0063676873916747 |
| Cottage cheese | Osteoporosis (bbj-a-137) | All - MR Egger | -8.67452632720719 | 2.75935772915406 | 0.0347246277164627 |
| Cottage cheese | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | rs73211402 | -4.76685556016717 | 1.80400826802878 | 0.0082328301521494 |
| Cottage cheese | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | All - MR Egger | -1.55724723658812 | 0.735059981686577 | 0.0456594770593437 |
| Cottage cheese | Heel bone mineral density (ebi-a-GCST006288) | rs59802640 | -1.13011737107081 | 0.536719398597031 | 0.0352389498140228 |
| Cottage cheese | Heel bone mineral density (ebi-a-GCST006288) | rs6795655 | -1.23342295718271 | 0.602290799067373 | 0.0405711608999539 |
| Cottage cheese | Heel bone mineral density (ebi-a-GCST006288) | All - Inverse variance weighted | -0.259955200135903 | 0.117248962683579 | 0.0266147875696429 |
| Cottage cheese | Bone disorder (ebi-a-GCST90038652) | rs117735622 | 0.141738275641167 | 0.0544558086107491 | 0.0092462425508948 |
| Cottage cheese | Bone disorder (ebi-a-GCST90038652) | All - Inverse variance weighted | 0.022689630579303 | 0.0111524372209788 | 0.041901235215052 |
| Cottage cheese | Rheumatoid arthritis (ebi-a-GCST90038685) | rs1230362 | 0.0845169394674953 | 0.0375967710960202 | 0.0245772108763593 |
| Cottage cheese | Rheumatoid arthritis (ebi-a-GCST90038685) | rs142022662 | -0.0815112929711686 | 0.0346134950332463 | 0.0185277290957818 |
| Cottage cheese | Rheumatoid arthritis (ebi-a-GCST90038685) | rs77834980 | 0.0801177468101692 | 0.0384922664551509 | 0.0373974431369755 |
| Cottage cheese | Rheumatoid arthritis (ebi-a-GCST90038685) | All - MR Egger | -0.0374971464893474 | 0.0156984287565778 | 0.0274481354327135 |
| Cottage cheese | Pain in joint (finn-b-JOINTPAIN) | rs118183251 | -3.92344019667146 | 1.81188574853357 | 0.0303577925474953 |
| Cottage cheese | Pain in joint (finn-b-JOINTPAIN) | All - Inverse variance weighted | -0.966704651305238 | 0.414890602300378 | 0.0198049348368631 |
| Cottage cheese | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs73211402 | -8.1406386764579 | 3.9121090459303 | 0.0374446757902628 |
| Cottage cheese | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs77834980 | -6.62582224471097 | 2.83084665563503 | 0.01925382792368 |
| Cottage cheese | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | All - Inverse variance weighted | -1.62710234100653 | 0.675056949707502 | 0.015938593934337 |
| Cottage cheese | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | All - MR Egger | -2.98622495398233 | 1.18227678177474 | 0.0192481739068741 |
| Cottage cheese | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | rs59802640 | -16.2232563807667 | 6.13513287075472 | 0.00818551580162 |
| Cottage cheese | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | All - Inverse variance weighted | -5.47785337901302 | 2.73926282628065 | 0.0455267714715802 |
| Cottage cheese | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs117312069 | -10.0282176222233 | 4.8054822808891 | 0.0369036353579781 |
| Cottage cheese | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs73271717 | -6.20853960936068 | 3.14167064570059 | 0.0481332081474505 |
| Cottage cheese | Cervical disc disorders (finn-b-M13_CERVICDISC) | All - Inverse variance weighted | -1.18339885545503 | 0.542376095992928 | 0.0291184856661557 |
| Cottage cheese | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | rs117607702 | 14.6030015445482 | 6.39294298386897 | 0.0223575635127692 |
| Cottage cheese | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | All - MR Egger | 6.14059967589685 | 2.73786383719848 | 0.0353085741687359 |
| Cottage cheese | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | rs118183251 | -3.50723366944323 | 1.65372726818684 | 0.0339381846895479 |
| Cottage cheese | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | rs142022662 | -2.38242657549735 | 1.21476835276065 | 0.0498535004391763 |
| Cottage cheese | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | All - Inverse variance weighted | -0.991134329216561 | 0.385185603801396 | 0.0100782061279888 |
| Cottage cheese | Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) | All - MR Egger | -4.69165182239787 | 2.22403823882246 | 0.0465070250660568 |
| Cottage cheese | Other joint disorders (finn-b-M13_OTHERJOINT) | rs115637887 | -2.01564730460781 | 0.741317093791929 | 0.0065477972079284 |
| Cottage cheese | Other joint disorders (finn-b-M13_OTHERJOINT) | rs73271717 | 3.49074516188954 | 1.50850058781655 | 0.0206650022879531 |
| Cottage cheese | Other joint disorders (finn-b-M13_OTHERJOINT) | All - Inverse variance weighted | -0.650210176352327 | 0.275823808564814 | 0.01840644303128 |
| Cottage cheese | Other joint disorders (finn-b-M13_OTHERJOINT) | All - MR Egger | -1.26962999048719 | 0.467007658968628 | 0.0125419571629539 |
| Cottage cheese | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs117607702 | -2.49853391811416 | 0.859000090855779 | 0.003629885276793 |
| Cottage cheese | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | All - Inverse variance weighted | -0.458697732753679 | 0.210259325544956 | 0.0291404763513817 |
| Cottage cheese | Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) | rs6795655 | 85.5301284383887 | 27.0893138721546 | 0.0015921650857524 |
| Cottage cheese | Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) | All - MR Egger | -16.6456523008873 | 7.52656699023105 | 0.0376881586402317 |
| Cottage cheese | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs550048 | -12.910110600094 | 5.66049772942125 | 0.022563972589555 |
| Cottage cheese | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs115637887 | -3.81380075111963 | 1.76139392119983 | 0.0303710411054834 |
| Cottage cheese | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs73211402 | -7.55300044792005 | 3.58336038660842 | 0.035048451644519 |
| Cottage cheese | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs77834980 | -5.12150759678897 | 2.59152387073835 | 0.0481260961231947 |
| Cottage cheese | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | -1.56156122363632 | 0.624530491694044 | 0.0124061459770496 |
| Cottage cheese | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | All - MR Egger | -2.94660530452919 | 1.08376759866472 | 0.0125361953948992 |
| Cottage cheese | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | All - MR Egger | -9.14750005406205 | 3.60303441818337 | 0.0187066055660066 |
| Cottage cheese | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs114902125 | 7.47560975609756 | 2.80487804878049 | 0.0076938568790868 |
| Cottage cheese | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs73271717 | 7.46770125704227 | 2.38118687828894 | 0.0017119583702781 |
| Cottage cheese | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | All - Inverse variance weighted | 1.04967091382683 | 0.47999734776739 | 0.0287551930957819 |
| Cottage cheese | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | rs76281158 | 12.6635941605594 | 6.18698634161903 | 0.040676606159111 |
| Cottage cheese | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | rs874603 | -9.07396090383767 | 3.92972901888281 | 0.0209405228703142 |
| Cottage cheese | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | rs141882920 | 45.758145762928 | 16.8693808582542 | 0.0066778376371222 |
| Cottage cheese | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | rs142022662 | 19.9444100465717 | 8.75911917516892 | 0.0227869368069029 |
| Cottage cheese | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | All - Inverse variance weighted | 5.49845693718752 | 2.70196560281576 | 0.0418524767115044 |
| Cottage cheese | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | rs115637887 | 26.2891871856295 | 12.4216562616788 | 0.0343108439935923 |
| Cottage cheese | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | rs117312069 | 74.5539281900411 | 35.8448667265437 | 0.0375342200494458 |
| Cottage cheese | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | rs550048 | 71.3999872406814 | 26.1508035470906 | 0.0063273423598138 |
| Cottage cheese | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | All - Inverse variance weighted | 9.55098766653195 | 4.72046734158494 | 0.0430407842279139 |
| Cottage cheese | Bone sialoprotein 2 (prot-a-1395) | rs117607702 | 7.97878930544887 | 3.97700522833709 | 0.0448316580264767 |
| Cottage cheese | Bone sialoprotein 2 (prot-a-1395) | All - Inverse variance weighted | 2.44398219897642 | 0.882625644127663 | 0.0056230240484092 |
| Cottage cheese | Bone sialoprotein 2 (prot-a-1395) | All - MR Egger | 3.37342934450489 | 1.60482932330759 | 0.0484187328267795 |
| Cottage cheese | Bone morphogenetic protein 7 (prot-a-257) | rs117607702 | -8.08616431680584 | 3.97700522833709 | 0.0420293428724737 |
| Cottage cheese | Bone morphogenetic protein 7 (prot-a-257) | rs566351 | -9.84552236736279 | 4.00600284118048 | 0.0139832922186655 |
| Cottage cheese | Bone morphogenetic protein 7 (prot-a-257) | rs73211402 | -8.89676059289821 | 3.59568846133299 | 0.0133502882193922 |
| Cottage cheese | Bone morphogenetic protein 7 (prot-a-257) | rs77834980 | 12.0892195342095 | 4.33516130355702 | 0.0052929287516202 |
| Cottage cheese | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | rs117735622 | 0.131507212441185 | 0.0551999160573461 | 0.0172011063305724 |
| Cottage cheese | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | rs139756730 | 0.125687152923608 | 0.0520311260441458 | 0.0157086740668075 |
| Cottage cheese | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | All - Inverse variance weighted | 0.0293573553257048 | 0.0107518867447454 | 0.0063250314970557 |
| Cottage cheese | Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) | rs566351 | -0.0398464776449634 | 0.0188477811366571 | 0.0345049895432554 |
| Cottage cheese | Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) | All - Inverse variance weighted | -0.0299446857830405 | 0.0116073766930272 | 0.0098858157256877 |
| Cottage cheese | Fractured bone site(s): Arm (ukb-b-19255) | All - Inverse variance weighted | -0.0322145145716656 | 0.0143536761156652 | 0.0248106004293882 |
| Cottage cheese | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | All - Inverse variance weighted | 0.032255070188815 | 0.0157426589427123 | 0.0404722902177654 |
| Cottage cheese | Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) | rs80187236 | -5.81609600563985 | 2.64167721468284 | 0.0276887736413694 |
| Cottage cheese | Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) | All - MR Egger | -5.47338046794208 | 2.02026500731894 | 0.0266895246241622 |
| Cottage cheese | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) | rs80187236 | -5.40352170220948 | 2.59921811161136 | 0.0376262891329622 |
| Cottage cheese | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) | All - MR Egger | -5.2534118644838 | 1.98628725752165 | 0.0294909833701959 |