ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Plum | Achilles tendon injury (ebi-a-GCST90018787) | rs7259991 | 2.02695525946207 | 0.973646631182656 | 0.0373590803565513 |
| Plum | Achilles tendon injury (ebi-a-GCST90018787) | All - Inverse variance weighted | 0.695392489924333 | 0.253722567184843 | 0.006129739072777 |
| Plum | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | All - Inverse variance weighted | 0.326729316586787 | 0.153240611820865 | 0.0329959406325069 |
| Plum | Heel bone mineral density T score (ebi-a-GCST90025982) | rs118089775 | -0.228370311069157 | 0.0900386507577152 | 0.0112011950352996 |
| Plum | Heel bone mineral density T score (ebi-a-GCST90025982) | All - Inverse variance weighted | -0.141823069060773 | 0.0575173034157185 | 0.0136728197406163 |
| Plum | Other joint disorder (ebi-a-GCST90038688) | rs60122509 | 0.0177771241475931 | 0.0085343633168979 | 0.0372507391112351 |
| Plum | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | rs62187193 | 0.019493488022613 | 0.0093800203946544 | 0.0376916327208233 |
| Plum | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | All - Inverse variance weighted | 0.0065739858729219 | 0.0029176512587625 | 0.0242479658769143 |
| Plum | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | rs62187193 | -14.2494230459595 | 6.84294327065853 | 0.0373102434947492 |
| Plum | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | All - Inverse variance weighted | -3.79254981036368 | 1.75235586032263 | 0.0304445707699709 |
| Plum | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | rs62187193 | -14.1018301518865 | 6.82952573483371 | 0.0389388037256262 |
| Plum | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | All - Inverse variance weighted | -3.77626120234968 | 1.75001367501332 | 0.0309397540347997 |
| Plum | Patellar tendinitis (finn-b-M13_PATELLARTEND) | rs60122509 | 5.178299133854 | 2.34223216428135 | 0.0270469609230761 |
| Plum | Patellar tendinitis (finn-b-M13_PATELLARTEND) | All - MR Egger | 5.43055876736511 | 2.3605400276096 | 0.0469565109735595 |
| Plum | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs60122509 | -0.979155217387939 | 0.469065661452246 | 0.0368466864542594 |
| Plum | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | All - Inverse variance weighted | -0.657661014328453 | 0.289719935253389 | 0.0232082613088872 |
| Plum | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | All - MR Egger | -1.22786359823271 | 0.476668652425341 | 0.0298957059110994 |
| Plum | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | rs111701790 | -2.00244504775612 | 0.956757817610886 | 0.0363537326306786 |
| Plum | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | rs60122509 | -0.986121539092675 | 0.455133018042773 | 0.0302602800204716 |
| Plum | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | All - Inverse variance weighted | -0.718375446783108 | 0.280141894722779 | 0.0103376075981428 |
| Plum | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | All - MR Egger | -1.20567534157763 | 0.472431877010822 | 0.0310894006298567 |
| Plum | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | All - Inverse variance weighted | -0.62327458349342 | 0.312387637931589 | 0.0460215009181249 |
| Plum | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | rs60122509 | -1.06507318507969 | 0.534858699774756 | 0.0464460551326469 |
| Plum | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | All - Inverse variance weighted | -0.610897039568248 | 0.31147767924433 | 0.0498455841785984 |
| Plum | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | rs60122509 | -1.04649632720039 | 0.531762556794873 | 0.0490707174757949 |
| Plum | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | All - Inverse variance weighted | -0.646893829133624 | 0.309546995556533 | 0.0366350384051129 |
| Plum | Injuries to the neck (finn-b-ST19_INJURI_NECK) | All - Inverse variance weighted | 0.771164289883144 | 0.349625242548556 | 0.0274058350882077 |
| Plum | Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) | All - MR Egger | -0.615972829758547 | 0.266178216719517 | 0.0459244794865637 |
| Plum | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | All - MR Egger | 5.03928773542315 | 2.12759079563091 | 0.0420092316281244 |
| Plum | Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) | rs117853141 | -3.24581616189336 | 1.47623125730427 | 0.0278979838948124 |
| Plum | Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -1.23553008690308 | 0.428494324528093 | 0.0039337969212999 |
| Plum | Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) | All - MR Egger | -1.69388496198057 | 0.74455078723519 | 0.0489577383519488 |
| Plum | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs118089775 | -7.63078646331453 | 3.38292930513322 | 0.0240910404719199 |
| Plum | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -1.72668074620978 | 0.846128890957498 | 0.0412823576336512 |
| Plum | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | rs76261861 | 5.66609442865318 | 2.62041232406808 | 0.0305957399570235 |
| Plum | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | rs62187193 | 0.132520081578618 | 0.0524777716156502 | 0.011561231788389 |
| Plum | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | All - Inverse variance weighted | 0.0374935739369356 | 0.0164168111422821 | 0.0223802054315342 |
| Plum | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs111701790 | -0.391128933337695 | 0.186205923721052 | 0.0356832805612724 |
| Plum | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | All - MR Egger | -0.265092635986379 | 0.107243507029388 | 0.0329987066903715 |
| Plum | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | rs111701790 | 0.0449907186314275 | 0.0214623470822975 | 0.0360588895488254 |
| Plum | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | All - MR Egger | 0.0280341713066071 | 0.0124004109443445 | 0.0473085728817491 |
| Plum | Heel bone mineral density (BMD) (left) (ukb-b-1096) | All - MR Egger | -0.272651679683627 | 0.11879588899316 | 0.0446227703723519 |
| Plum | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | All - MR Egger | -0.283688642250728 | 0.118812891198723 | 0.0381085047709877 |
| Plum | Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) | All - Inverse variance weighted | 0.0110726120110834 | 0.0054836325845993 | 0.0434652787957449 |
| Plum | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | All - MR Egger | -0.289127222277979 | 0.11824143885394 | 0.0345386837600196 |
| Plum | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs4747673 | 0.409399713190711 | 0.20572989609453 | 0.0465924240878424 |
| Plum | Heel bone mineral density (BMD) (right) (ukb-b-4657) | All - MR Egger | -0.289875668797787 | 0.11826370390816 | 0.0341936006581278 |
| Plum | Operation code: shoulder surgery (ukb-b-5935) | rs76261861 | 0.0311635818972661 | 0.0155728165054707 | 0.0453759496560891 |
| Plum | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | All - Inverse variance weighted | 0.0050289410589418 | 0.0025005014685939 | 0.0443071858226415 |
| Plum | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | All - Inverse variance weighted | 0.0088201156414138 | 0.0043475167966305 | 0.0424816287512647 |
| Plum | Spondylosis and allied disorders (ukb-e-721_CSA) | rs60122509 | 6.81461069872207 | 2.78033639593476 | 0.014245907184338 |
| Plum | Spondylosis and allied disorders (ukb-e-721_CSA) | All - MR Egger | 7.52615717105567 | 3.16869257801158 | 0.049231097486229 |
| Plum | Pain in joint (ukb-e-745_CSA) | All - Inverse variance weighted | -2.63246450059101 | 1.19487287994203 | 0.0275853388574243 |
| Plum | Open wounds of head; neck; and trunk (ukb-e-870_CSA) | rs118089775 | -8.95753610735042 | 4.40819626409883 | 0.0421517889288991 |
| Plum | Open wounds of head; neck; and trunk (ukb-e-870_CSA) | All - Inverse variance weighted | -2.30438672822874 | 1.14401167587115 | 0.0439776782330496 |