ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Shellfish | Rheumatoid Arthritis (bbj-a-73) | rs67500360 | 7.15194339986555 | 3.31118813680447 | 0.0307778829915948 |
| Shellfish | Rheumatoid Arthritis (bbj-a-73) | rs8021398 | 10.0944830124432 | 4.24653801094014 | 0.0174489390226339 |
| Shellfish | Rheumatoid Arthritis (bbj-a-73) | rs80356083 | -9.04202831423566 | 4.57286988742775 | 0.048005440019971 |
| Shellfish | Rheumatoid Arthritis (bbj-a-73) | All - Inverse variance weighted | 1.75442739662072 | 0.875265926771521 | 0.0450218033002964 |
| Shellfish | Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) | rs1991446 | 5.80914955360431 | 2.68711055814475 | 0.0306291778276595 |
| Shellfish | Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) | All - Inverse variance weighted | 2.85802990149511 | 1.38979208064858 | 0.0397397169549093 |
| Shellfish | Ankylosing spondylitis (ebi-a-GCST005529) | rs36102575 | -2.08023093925259 | 0.98271888494726 | 0.0342758228405128 |
| Shellfish | Ankylosing spondylitis (ebi-a-GCST005529) | All - Inverse variance weighted | -1.09129501502988 | 0.53618814292528 | 0.0418223301380206 |
| Shellfish | Rheumatoid arthritis (ebi-a-GCST005569) | rs80356083 | -8.84386894093481 | 4.2654963046499 | 0.0381396711106441 |
| Shellfish | Rheumatoid arthritis (ebi-a-GCST005569) | All - Inverse variance weighted | -6.180988541456 | 2.38853367383628 | 0.0096597959449405 |
| Shellfish | Heel bone mineral density (ebi-a-GCST006288) | rs146828945 | -1.60247971772642 | 0.647248078198296 | 0.0132924836816591 |
| Shellfish | Heel bone mineral density (ebi-a-GCST006288) | rs67500360 | -1.41939598131018 | 0.722001786034813 | 0.049308135615044 |
| Shellfish | Heel bone mineral density (ebi-a-GCST006288) | rs75694103 | -2.15971813646303 | 0.807473736834408 | 0.0074804952441652 |
| Shellfish | Heel bone mineral density (ebi-a-GCST006288) | All - MR Egger | -0.50752802851995 | 0.236101029157384 | 0.0376873608587191 |
| Shellfish | Osteoprotegerin levels (ebi-a-GCST90000490) | rs73696164 | -28.0173163759891 | 9.7601391938357 | 0.004097120699266 |
| Shellfish | Osteoprotegerin levels (ebi-a-GCST90000490) | All - Inverse variance weighted | -4.20422061805619 | 2.13218801923604 | 0.0486339269902805 |
| Shellfish | Frozen shoulder (ebi-a-GCST90000513) | rs145725821 | 4.26353096187372 | 2.1566257197816 | 0.0480478197786197 |
| Shellfish | Frozen shoulder (ebi-a-GCST90000513) | All - MR Egger | 2.56600309062831 | 1.03897761195157 | 0.0206994514859797 |
| Shellfish | Other joint disorder (ebi-a-GCST90038688) | rs62428873 | 0.114139353078195 | 0.0439819555156752 | 0.0094552264899663 |
| Shellfish | Other joint disorder (ebi-a-GCST90038688) | rs77497974 | -0.103333493761355 | 0.0440482607597069 | 0.0189804145040151 |
| Shellfish | Other joint disorder (ebi-a-GCST90038688) | rs8021398 | -0.116900462722336 | 0.0444504224062123 | 0.0085408310039753 |
| Shellfish | Other joint disorder (ebi-a-GCST90038688) | All - MR Egger | 0.0314903951712628 | 0.0149368898065749 | 0.0429325455844139 |
| Shellfish | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | rs146163137 | 90.0888459236754 | 42.1711243075695 | 0.0326575320607333 |
| Shellfish | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | rs182535176 | 30.8319095807596 | 12.1660439704861 | 0.0112685326094067 |
| Shellfish | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | rs62100374 | -77.3289692134226 | 27.1968322644988 | 0.00446479089796 |
| Shellfish | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | rs73696164 | 183.106176726459 | 80.2228758440698 | 0.0224617027852593 |
| Shellfish | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | All - MR Egger | 18.8727884347518 | 7.32330726731687 | 0.0139700583156912 |
| Shellfish | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | All - Inverse variance weighted | -10.5929584935833 | 4.50869995887108 | 0.0188012432488534 |
| Shellfish | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | rs117089761 | -35.8954403642793 | 14.9712249370225 | 0.0165015774859135 |
| Shellfish | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | rs62580288 | -32.4027396307756 | 12.8598855783086 | 0.0117463041395841 |
| Shellfish | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | All - Inverse variance weighted | -5.40145579331666 | 2.73062286659314 | 0.0479169845792526 |
| Shellfish | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | All - MR Egger | -10.923421915195 | 5.08906311777346 | 0.0382839597388949 |
| Shellfish | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | rs11050137 | 27.8455828261887 | 10.2850041240331 | 0.0067813238701243 |
| Shellfish | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | rs1991446 | -55.8292059153803 | 26.2659020320381 | 0.03354164192209 |
| Shellfish | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | rs36102575 | 90.7002902472214 | 37.3624472009628 | 0.01519997827694 |
| Shellfish | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | All - MR Egger | 15.3948260425983 | 7.25119845883195 | 0.0403196391239328 |
| Shellfish | Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) | rs12487739 | -32.2475473487655 | 14.0095043322762 | 0.021344559710797 |
| Shellfish | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs62428873 | 8.60431813851723 | 3.05453293917362 | 0.0048489407993542 |
| Shellfish | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs77497974 | 5.33623708053086 | 2.59291790497046 | 0.0395896879563969 |
| Shellfish | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | rs12487739 | -56.6505626525188 | 21.3402886866831 | 0.0079395527654185 |
| Shellfish | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | rs182535176 | 19.8599402962657 | 8.08441131742485 | 0.0140269602983845 |
| Shellfish | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | rs75715109 | -30.3348240632664 | 14.5706828942019 | 0.0373508564844185 |
| Shellfish | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | All - MR Egger | 10.077839955192 | 4.7827332050662 | 0.0417621771074297 |
| Shellfish | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | rs76829828 | 9.85065891326511 | 4.51232866367103 | 0.0290318046044162 |
| Shellfish | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | All - Inverse variance weighted | -2.43385700176053 | 0.933442152318307 | 0.009123273346475 |
| Shellfish | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | rs191200892 | 11.8179356608174 | 4.66865233607309 | 0.0113628390670825 |
| Shellfish | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | All - Inverse variance weighted | 1.67621800148294 | 0.731298906346497 | 0.021899259801071 |
| Shellfish | Fracture of neck (finn-b-ST19_FRACT_NECK) | rs12487739 | -30.4494304316469 | 13.7328709604118 | 0.0266049070536294 |
| Shellfish | Fracture of neck (finn-b-ST19_FRACT_NECK) | All - MR Egger | 6.6110762810245 | 3.08248123540792 | 0.0384310006623927 |
| Shellfish | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | rs145725821 | 5.09945649302826 | 2.35240010068397 | 0.0301763805220616 |
| Shellfish | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | All - Inverse variance weighted | 1.61275258115001 | 0.584006525162921 | 0.0057530916615915 |
| Shellfish | Injuries to the neck (finn-b-ST19_INJURI_NECK) | rs146828945 | 9.50053622156184 | 4.73594158050282 | 0.0448508998355486 |
| Shellfish | Injuries to the neck (finn-b-ST19_INJURI_NECK) | rs7604193 | -12.7534088107565 | 5.27204111433502 | 0.0155604701866232 |
| Shellfish | Injuries to the neck (finn-b-ST19_INJURI_NECK) | All - Inverse variance weighted | -1.54018671502154 | 0.766134513482894 | 0.0443957880034319 |
| Shellfish | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | rs12487739 | 12.8634517916951 | 4.92012211387415 | 0.0089369191648666 |
| Shellfish | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | All - MR Egger | -2.5703463414712 | 1.10963277645611 | 0.0260266397630972 |
| Shellfish | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs2272317 | 18.6464921502059 | 8.99925896565392 | 0.0382651554568714 |
| Shellfish | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs75715109 | 35.0889847735708 | 16.1707038780836 | 0.0300136050193502 |
| Shellfish | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs76829828 | 33.0023033644225 | 13.3765056828909 | 0.0136180287178567 |
| Shellfish | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | rs145725821 | 26.1747239736606 | 9.32258956677926 | 0.0049901850088878 |
| Shellfish | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | rs182535176 | 21.7561909768507 | 7.1982426825376 | 0.0025075333989302 |
| Shellfish | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | rs36102575 | 48.7835573769202 | 24.3917786884601 | 0.0455002638963584 |
| Shellfish | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | rs62428873 | 42.1242832295694 | 19.9067046076124 | 0.0343375610126379 |
| Shellfish | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | rs75021567 | -34.5322355875018 | 16.9291843919613 | 0.0413697479873914 |
| Shellfish | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | All - MR Egger | 11.8104574690717 | 4.50444690013976 | 0.0125075568707824 |
| Shellfish | Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) | rs140584763 | 17.7508139659943 | 7.65079147804492 | 0.0203339651099165 |
| Shellfish | Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) | rs75021567 | 23.3148745782602 | 8.72359542320669 | 0.007526096303761 |
| Shellfish | Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) | All - Inverse variance weighted | 2.42202451216449 | 1.21017477458253 | 0.0453510163751686 |
| Shellfish | Rheumatoid arthritis (ieu-a-832) | rs67500360 | 7.54310955127269 | 3.49692683835047 | 0.0310003538046234 |
| Shellfish | Rheumatoid arthritis (ieu-a-832) | rs8021398 | 9.50429429927206 | 3.98217943062958 | 0.0170000481616293 |
| Shellfish | Rheumatoid arthritis (ieu-a-832) | All - Inverse variance weighted | 4.70255958205506 | 1.54819908045864 | 0.0023859804080521 |
| Shellfish | Psoriatic arthritis (ieu-b-5116) | rs138970101 | -13.1343208812788 | 4.07155631477965 | 0.001255893623354 |
| Shellfish | Psoriatic arthritis (ieu-b-5116) | rs36102575 | -9.82372790699504 | 4.35103395656517 | 0.0239586553341175 |
| Shellfish | Psoriatic arthritis (ieu-b-5116) | rs67500360 | 14.2346528659615 | 5.35264153656968 | 0.0078286998991005 |
| Shellfish | Psoriatic arthritis (ieu-b-5116) | rs72811531 | -11.829861336248 | 5.10721662853491 | 0.0205417291876393 |
| Shellfish | Psoriatic arthritis (ieu-b-5116) | All - MR Egger | -7.84628935188613 | 3.25357035403942 | 0.0238950067938448 |
| Shellfish | Osteocrin (prot-a-2157) | rs11050137 | -10.4382621101674 | 4.46398715976727 | 0.0193702866941012 |
| Shellfish | Osteocrin (prot-a-2157) | rs62100374 | 16.1434951036824 | 5.68203677343174 | 0.0044951751089409 |
| Shellfish | Osteocrin (prot-a-2157) | rs62428873 | 11.0872785156322 | 5.35311507046322 | 0.038341739807485 |
| Shellfish | Osteocrin (prot-a-2157) | rs62580288 | -10.8047761978159 | 5.01415784939757 | 0.0311732906736151 |
| Shellfish | Osteocrin (prot-a-2157) | All - MR Egger | -4.6546188398328 | 1.75120814923805 | 0.0118941218092454 |
| Shellfish | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs112496522 | -1.51494073669093 | 0.729044645636541 | 0.0377111325476939 |
| Shellfish | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs67500360 | -1.9642480871478 | 0.886468612277707 | 0.0267043572121356 |
| Shellfish | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - MR Egger | -0.547932738502161 | 0.26208341292773 | 0.0429558086840376 |
| Shellfish | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | rs112496522 | -0.472657261619192 | 0.178709679107035 | 0.0081731236396328 |
| Shellfish | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | rs2272317 | -0.470977303668982 | 0.23519051476037 | 0.0452271924959312 |
| Shellfish | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | All - Inverse variance weighted | -0.0766506204949997 | 0.0335685177811319 | 0.022406349193553 |
| Shellfish | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | All - MR Egger | -0.190012722096014 | 0.0647283033863775 | 0.0054954006842742 |
| Shellfish | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs112496522 | 0.045246771320273 | 0.0212312537767116 | 0.0330776213024231 |
| Shellfish | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs116445357 | -0.0564275957207969 | 0.0235455240130378 | 0.0165510597825258 |
| Shellfish | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs140584763 | 0.054503945168513 | 0.0273774162323885 | 0.0464989227745615 |
| Shellfish | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs1458476 | 0.066856381529547 | 0.0235295603000884 | 0.0044918995903811 |
| Shellfish | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs191200892 | 0.0559334247556491 | 0.0274433778507604 | 0.0415360117433719 |
| Shellfish | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs4556085 | -0.0572304890799032 | 0.0272398640437344 | 0.0356424656647036 |
| Shellfish | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | All - Inverse variance weighted | 0.0103282538321209 | 0.0050139553179397 | 0.0394079630243915 |
| Shellfish | Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) | rs12487739 | 0.062588695574854 | 0.0259517669956628 | 0.0158769661918745 |
| Shellfish | Operation code: knee surgery (not replacement) (ukb-b-1508) | rs12487739 | 0.233379768220753 | 0.0818896035250995 | 0.0043728632928096 |
| Shellfish | Operation code: knee surgery (not replacement) (ukb-b-1508) | All - MR Egger | -0.217997974280177 | 0.0638479493737951 | 0.0051320330611302 |
| Shellfish | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs112496522 | -0.422968161830296 | 0.151150082270186 | 0.0051367231128911 |
| Shellfish | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs117089761 | -0.514940504229217 | 0.1865699305712 | 0.0057794253407751 |
| Shellfish | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs12487739 | 0.529077131311934 | 0.193775551537785 | 0.0063265082482203 |
| Shellfish | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs4556085 | -0.446093957970841 | 0.195620387267024 | 0.0225836040046662 |
| Shellfish | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | All - Inverse variance weighted | -0.0684726581433379 | 0.0332518851385951 | 0.0394739996483829 |
| Shellfish | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | All - MR Egger | -0.184985582154016 | 0.0609674921490171 | 0.0042250843039808 |
| Shellfish | Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint (ukb-b-19054) | rs12487739 | 0.0589205370639319 | 0.0289401977928609 | 0.0417562737886611 |
| Shellfish | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs116445357 | -1.34378677017541 | 0.674045496963713 | 0.0461942167598612 |
| Shellfish | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs1458476 | -1.51717733522051 | 0.624457601552273 | 0.0151158185804937 |
| Shellfish | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs146789604 | 1.68764786587013 | 0.73925913122387 | 0.0224368018345811 |
| Shellfish | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs182535176 | -1.34273322944633 | 0.675538366220453 | 0.0468505113337952 |
| Shellfish | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs62580288 | -1.4792383733732 | 0.683891728184744 | 0.0305433653906337 |
| Shellfish | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs67500360 | -1.4712266669937 | 0.744225767287022 | 0.0480579865226564 |
| Shellfish | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs75694103 | -1.72892740177457 | 0.767044275837207 | 0.0241953802997836 |
| Shellfish | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | All - MR Egger | -0.656082716720867 | 0.225161376061795 | 0.0058194281977075 |
| Shellfish | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs116445357 | -1.40808639554227 | 0.673957586659273 | 0.0366824870947697 |
| Shellfish | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs1458476 | -1.46595099974084 | 0.624743336722285 | 0.0189514183284026 |
| Shellfish | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs146789604 | 1.74024220294489 | 0.739404971534132 | 0.0185940494545974 |
| Shellfish | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs182535176 | -1.4277866436363 | 0.675440737472542 | 0.0345272914960305 |
| Shellfish | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs62580288 | -1.36771778558101 | 0.684196904201772 | 0.0456070612415074 |
| Shellfish | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs75694103 | -1.80844298282904 | 0.766915043037923 | 0.0183699944983371 |
| Shellfish | Heel bone mineral density (BMD) (right) (ukb-b-4657) | All - MR Egger | -0.643514948962379 | 0.225331702783506 | 0.0067744458976337 |
| Shellfish | Operation code: shoulder surgery (ukb-b-5935) | rs12487739 | 0.12350415444046 | 0.055872630091783 | 0.0270733274501483 |
| Shellfish | Operation code: shoulder surgery (ukb-b-5935) | All - MR Egger | -0.317971003563044 | 0.111721104148113 | 0.046578494717865 |
| Shellfish | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs12487739 | 0.194252546508986 | 0.0925399883418793 | 0.0358063179302921 |
| Shellfish | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs191200892 | -0.219116144191044 | 0.0940176613938701 | 0.0197752572301835 |
| Shellfish | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs77497974 | -0.197105076343685 | 0.0911876887535946 | 0.0306542939664074 |
| Shellfish | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | All - MR Egger | -0.0574999477106362 | 0.0264698365175704 | 0.0358189634630663 |
| Shellfish | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | rs141410118 | -0.112020677375299 | 0.0523647256260994 | 0.0324162953572605 |
| Shellfish | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | rs146163137 | -0.13544937009928 | 0.0555125903420338 | 0.0146882509083436 |
| Shellfish | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | rs62580288 | -0.116031784661622 | 0.054760166417504 | 0.0340981964903383 |
| Shellfish | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | All - Inverse variance weighted | -0.0178966821834955 | 0.0089773402037151 | 0.0462024041375897 |
| Shellfish | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | All - MR Egger | -0.0364962685455238 | 0.0173073985254076 | 0.041279588806277 |
| Shellfish | Ankle spacing width (ukb-e-3143_EAS) | rs2272317 | 3.76721181518948 | 1.32214314026229 | 0.0043812484896499 |
| Shellfish | Ankle spacing width (ukb-e-3143_EAS) | All - Inverse variance weighted | 2.12205334475535 | 0.918502246889909 | 0.0208692860311331 |
| Shellfish | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | rs12487739 | -22.0318721163441 | 6.65698449865141 | 0.0009343358551168 |
| Shellfish | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | rs1458476 | 2.34867664746261 | 1.18347520416775 | 0.0471935314138857 |
| Shellfish | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | rs8021398 | -43.4767950508095 | 19.1887890272717 | 0.0234673445924457 |
| Shellfish | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | All - MR Egger | 3.8688314595507 | 1.61662191118259 | 0.0403479670333586 |
| Shellfish | Spondylosis and allied disorders (ukb-e-721_CSA) | rs17139905 | 48.1797475195923 | 19.5247654711809 | 0.0136013733414112 |
| Shellfish | M51 Other intervertebral disk disorders (ukb-e-M51_CSA) | rs2272317 | 19.029072673066 | 7.43791683181967 | 0.0105158871028759 |
| Shellfish | M51 Other intervertebral disk disorders (ukb-e-M51_CSA) | All - Inverse variance weighted | 10.328272667192 | 3.55661175351742 | 0.0036847046857244 |