ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Grapefruit juice | Rheumatoid arthritis (bbj-a-151) | rs4715882 | 1.90808975790966 | 0.959431985040348 | 0.0467265714681958 |
| Grapefruit juice | Rheumatoid arthritis (bbj-a-151) | All - Inverse variance weighted | 2.14153014944447 | 0.770844872928032 | 0.0054667744918231 |
| Grapefruit juice | Rheumatoid Arthritis (bbj-a-74) | rs1610378 | 4.00508341157614 | 1.98025436025834 | 0.0431237350601789 |
| Grapefruit juice | Rheumatoid Arthritis (bbj-a-74) | rs79766916 | 5.26232927933247 | 1.93166362725933 | 0.0064448243046103 |
| Grapefruit juice | Rheumatoid Arthritis (bbj-a-74) | All - Inverse variance weighted | 1.16096399312226 | 0.512397832946164 | 0.0234668613062611 |
| Grapefruit juice | Rheumatoid Arthritis (bbj-a-74) | All - MR Egger | 2.15655669797991 | 0.975521975104283 | 0.0430101713279433 |
| Grapefruit juice | Rheumatoid arthritis (ebi-a-GCST002318) | rs2745952 | -4.30300656520442 | 2.19541576702301 | 0.0499962342139947 |
| Grapefruit juice | Rheumatoid arthritis (ebi-a-GCST002318) | All - MR Egger | 2.58735667840946 | 1.09747292270306 | 0.0379772228871462 |
| Grapefruit juice | Osteopontin levels (ebi-a-GCST90010244) | rs12141930 | 11.8905531954058 | 5.03020433946833 | 0.01808705897122 |
| Grapefruit juice | Osteopontin levels (ebi-a-GCST90010244) | rs145263654 | 21.3289080607218 | 10.6561158774955 | 0.0453315416449137 |
| Grapefruit juice | Osteopontin levels (ebi-a-GCST90010244) | All - Inverse variance weighted | 3.01798722600292 | 1.30066206377432 | 0.02032211732098 |
| Grapefruit juice | Rheumatoid arthritis (ebi-a-GCST90013534) | rs4715882 | 1.36795471944378 | 0.693389892195128 | 0.0485125772747687 |
| Grapefruit juice | Rheumatoid arthritis (ebi-a-GCST90013534) | rs79766916 | 5.26101730494221 | 1.95921508945479 | 0.0072471699825718 |
| Grapefruit juice | Rheumatoid arthritis (ebi-a-GCST90013534) | All - Inverse variance weighted | 1.21363709900373 | 0.440912056255856 | 0.0059131224062301 |
| Grapefruit juice | Rheumatoid arthritis (ebi-a-GCST90013534) | All - MR Egger | 2.25814432309058 | 0.845512778264917 | 0.0182734743398469 |
| Grapefruit juice | Rheumatoid arthritis (ebi-a-GCST90018690) | rs12141930 | 7.04737939704273 | 2.94126259995775 | 0.0165733345048183 |
| Grapefruit juice | Rheumatoid arthritis (ebi-a-GCST90018690) | All - Inverse variance weighted | 1.4676322709981 | 0.663096355967541 | 0.0268768546761613 |
| Grapefruit juice | Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) | All - Inverse variance weighted | -2.1548586920974 | 1.0360915379048 | 0.0375442786317432 |
| Grapefruit juice | Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) | All - Inverse variance weighted | -2.21236434801913 | 1.03731904547183 | 0.0329434870232381 |
| Grapefruit juice | Gluteal tendinitis (finn-b-M13_GLUTEALTEND) | rs118070183 | 22.9306920477701 | 8.02187314607031 | 0.0042562106957887 |
| Grapefruit juice | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | rs117071613 | 3.778318588064 | 1.87111000141386 | 0.0434568161004962 |
| Grapefruit juice | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | All - Inverse variance weighted | 0.617375311087014 | 0.312127644664558 | 0.047933466895841 |
| Grapefruit juice | Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) | rs4715882 | 1.59699300962588 | 0.787515216927498 | 0.0425716345975565 |
| Grapefruit juice | Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) | rs80254797 | 3.31537505180273 | 1.33684477895272 | 0.0131382382710935 |
| Grapefruit juice | Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) | All - MR Egger | 1.27010025651149 | 0.6028798444763 | 0.0494347050091387 |
| Grapefruit juice | Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) | rs145263654 | 12.4865741606404 | 5.86823326825153 | 0.0333515857801685 |
| Grapefruit juice | Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) | All - Inverse variance weighted | 3.63524646557835 | 1.41097674171029 | 0.0099833853232972 |
| Grapefruit juice | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs145311903 | 6.07514583449567 | 2.60983305747212 | 0.0199232056002341 |
| Grapefruit juice | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs1610378 | 5.42483474170389 | 2.29512239072088 | 0.0180965654136911 |
| Grapefruit juice | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs74448388 | 4.08099708685581 | 1.98534993414607 | 0.0398253754995507 |
| Grapefruit juice | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs80254797 | 4.6254829351764 | 2.22361848232468 | 0.0375108303671586 |
| Grapefruit juice | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | All - Inverse variance weighted | 1.76090701072297 | 0.550898584681481 | 0.0013914111732898 |
| Grapefruit juice | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | rs11074030 | 5.20563955480027 | 2.35093399249045 | 0.0268091307155959 |
| Grapefruit juice | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | rs145311903 | 5.39944083861809 | 2.54164264504411 | 0.0336375251212249 |
| Grapefruit juice | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | rs1610378 | 4.68508454965336 | 2.23821852979391 | 0.0363294899419843 |
| Grapefruit juice | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | All - Inverse variance weighted | 1.57765132897318 | 0.51950243774064 | 0.0023906385271289 |
| Grapefruit juice | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs2745952 | 33.6708094159777 | 13.9554478908842 | 0.0158332898988203 |
| Grapefruit juice | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs74448388 | 33.6276755185591 | 12.771769102505 | 0.0084642006197685 |
| Grapefruit juice | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs79766916 | 53.2093080209741 | 21.0265762278987 | 0.0113876046961977 |
| Grapefruit juice | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | All - Inverse variance weighted | 7.76848875363044 | 3.33811580451878 | 0.0199542142048708 |
| Grapefruit juice | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | rs12141930 | 38.1946841199221 | 19.1496348914505 | 0.0460932365226372 |
| Grapefruit juice | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | rs141538567 | 40.3480869018959 | 19.2181298590005 | 0.0357745741056932 |
| Grapefruit juice | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | rs1610378 | 34.2087043939265 | 16.6538632979581 | 0.0399659920269987 |
| Grapefruit juice | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | rs76621665 | 44.621300187785 | 14.6651166949835 | 0.0023447925437146 |
| Grapefruit juice | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | All - Inverse variance weighted | 8.4753197894141 | 4.10519190043332 | 0.0389668475587639 |
| Grapefruit juice | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs11074030 | 11.2397034688591 | 4.1085370249714 | 0.0062248725914808 |
| Grapefruit juice | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs117066529 | 13.0741380534324 | 5.41107614157142 | 0.0156842730554419 |
| Grapefruit juice | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs1610378 | 9.69262431122618 | 3.89791447349703 | 0.0128963791289764 |
| Grapefruit juice | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs4715882 | 4.92589199432738 | 2.21822015285953 | 0.0263746333011884 |
| Grapefruit juice | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | All - Inverse variance weighted | 3.23212285287061 | 0.948989513189847 | 0.0006595664643441 |
| Grapefruit juice | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs11074030 | 10.2881349480891 | 3.30250251326039 | 0.0018378642828056 |
| Grapefruit juice | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs145311903 | 7.11040027772095 | 3.5644988314643 | 0.0460665949641679 |
| Grapefruit juice | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs79766916 | -11.5759873700599 | 4.50007215859146 | 0.0100996014671243 |
| Grapefruit juice | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | All - Inverse variance weighted | 2.21604253932599 | 0.784687676856885 | 0.0047412444640935 |
| Grapefruit juice | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | All - Inverse variance weighted | 1.36030880898409 | 0.559384729748534 | 0.0150242214162487 |
| Grapefruit juice | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | rs145263654 | 4.65936416964173 | 2.27858779737962 | 0.04086991208623 |
| Grapefruit juice | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | All - Inverse variance weighted | 1.43666915995074 | 0.558377438088871 | 0.0100839984569089 |
| Grapefruit juice | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | rs145263654 | 4.58326629472924 | 2.26336822239713 | 0.0428698302704587 |
| Grapefruit juice | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | All - Inverse variance weighted | 1.30811520066201 | 0.555753492942438 | 0.0185841687780669 |
| Grapefruit juice | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | rs115791397 | 19.4632620427184 | 8.1913728740937 | 0.0174982199297686 |
| Grapefruit juice | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | rs117066529 | 32.9160652168769 | 13.5395221530719 | 0.0150526514458655 |
| Grapefruit juice | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | rs76621665 | 21.9728357526802 | 7.57349945850348 | 0.0037164269506977 |
| Grapefruit juice | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | 5.80114970329514 | 2.36320414974949 | 0.014097026466096 |
| Grapefruit juice | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs117066529 | 13.5355782200241 | 6.54298492628789 | 0.0385727360543018 |
| Grapefruit juice | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | All - Inverse variance weighted | 2.0226321606354 | 0.989984728286595 | 0.0410431035505893 |
| Grapefruit juice | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | rs12153371 | -20.8951789207226 | 8.1463583016914 | 0.0103184205261648 |
| Grapefruit juice | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | All - MR Egger | 7.30666400349673 | 3.32077955435069 | 0.04108518327282 |
| Grapefruit juice | Knee and hip osteoarthritis (ieu-a-1170) | rs2745952 | -5.35290167991995 | 2.667531202275 | 0.044782941419622 |
| Grapefruit juice | Knee and hip osteoarthritis (ieu-a-1170) | rs4715882 | -6.22642160615454 | 2.33069991591471 | 0.007551724483974 |
| Grapefruit juice | Knee and hip osteoarthritis (ieu-a-1170) | All - Inverse variance weighted | -4.04654949332769 | 1.92617937792573 | 0.0356570740799018 |
| Grapefruit juice | Knee osteoarthritis (ieu-a-1171) | rs2745952 | -6.39283488686432 | 3.17183632629417 | 0.0438523266124737 |
| Grapefruit juice | Knee osteoarthritis (ieu-a-1171) | rs4715882 | -10.7456608225298 | 3.15275912701899 | 0.0006536048249818 |
| Grapefruit juice | Knee osteoarthritis (ieu-a-1171) | All - Inverse variance weighted | -6.72311106120005 | 2.40865788047097 | 0.0052508622003668 |
| Grapefruit juice | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | rs117066529 | 0.0260436830024373 | 0.0122505659543924 | 0.0335101943696902 |
| Grapefruit juice | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | rs117071613 | 0.0319298002845772 | 0.0114213216293698 | 0.0051798511755603 |
| Grapefruit juice | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | All - MR Egger | 0.0162604849095456 | 0.0049560796612054 | 0.0041525332097374 |
| Grapefruit juice | Diagnoses - main ICD10: M51.2 Other specified intervertebral disk displacement (ukb-b-12872) | All - Inverse variance weighted | -0.0150691730631133 | 0.0069205999339014 | 0.0294479484313946 |
| Grapefruit juice | Non-cancer illness code, self-reported: bone disorder (ukb-b-14356) | rs12153371 | -0.0268109538603153 | 0.0118718214244621 | 0.0239226617440507 |
| Grapefruit juice | Operative procedures - secondary OPCS: Z84.3 Hip joint (ukb-b-17133) | All - Inverse variance weighted | -0.0173561631333555 | 0.0083286390185635 | 0.0371680378231156 |
| Grapefruit juice | Diagnoses - secondary ICD10: M47.82 Other spondylosis (Cervical region) (ukb-b-2625) | rs12153371 | 0.0258221148314348 | 0.01169543205615 | 0.0272526137176136 |
| Grapefruit juice | Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) | All - Inverse variance weighted | 0.0165931868262991 | 0.0074033257231522 | 0.0250056619806554 |
| Grapefruit juice | Operation code: reduction or fixation of bone fracture (ukb-b-847) | rs147861907 | -0.131626727105772 | 0.0506466185733546 | 0.0093516396768829 |
| Grapefruit juice | Operation code: reduction or fixation of bone fracture (ukb-b-847) | rs2745952 | 0.137609273790089 | 0.0508711183667738 | 0.0068292674172862 |
| Grapefruit juice | Operation code: reduction or fixation of bone fracture (ukb-b-847) | rs35133449 | 0.119245218869528 | 0.0522317042073948 | 0.0224300997710727 |
| Grapefruit juice | Operation code: reduction or fixation of bone fracture (ukb-b-847) | All - MR Egger | -0.0673668324102215 | 0.0307258006543725 | 0.0457370668499969 |
| Grapefruit juice | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | rs11665478 | 6.89971550234738 | 3.47723463842161 | 0.0472275710740154 |
| Grapefruit juice | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | All - MR Egger | 3.26325779803962 | 1.22052159109656 | 0.0202732084824943 |
| Grapefruit juice | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | All - MR Egger | 3.16278644604877 | 1.22775874378022 | 0.0242730076152316 |
| Grapefruit juice | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | All - MR Egger | 2.96787756007332 | 1.24393797194612 | 0.0343929480493141 |
| Grapefruit juice | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | All - MR Egger | 3.18683711404818 | 1.24953310480274 | 0.0254459351503667 |
| Grapefruit juice | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | rs4715882 | -15.210652476751 | 5.55025664838544 | 0.0061339925505594 |
| Grapefruit juice | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | rs74448388 | -37.4037332364448 | 15.8471150789274 | 0.0182608216046345 |
| Grapefruit juice | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | All - Inverse variance weighted | -6.85650852382292 | 3.34572836969491 | 0.0404296524696283 |
| Grapefruit juice | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | All - MR Egger | -18.0473312509344 | 6.28453721797862 | 0.0140452950388176 |
| Grapefruit juice | Osteoarthrosis (ukb-e-740_AFR) | rs12141930 | 21.6492322366481 | 10.1678181548161 | 0.0332384178519603 |
| Grapefruit juice | Osteoarthrosis (ukb-e-740_AFR) | All - Inverse variance weighted | 6.29329810839159 | 2.65570120672612 | 0.0178010198276607 |
| Grapefruit juice | Osteoarthrosis (ukb-e-740_CSA) | rs1610378 | -14.700164072799 | 7.38801794368414 | 0.0466206394090152 |
| Grapefruit juice | Osteoarthrosis (ukb-e-740_CSA) | rs4715882 | -8.01634015637354 | 3.63951255631832 | 0.0276239269640892 |
| Grapefruit juice | Osteoarthrosis (ukb-e-740_CSA) | All - Inverse variance weighted | -4.53869166429757 | 2.05247447938102 | 0.0270132201158013 |
| Grapefruit juice | M51 Other intervertebral disk disorders (ukb-e-M51_CSA) | rs11074030 | 23.5429246962257 | 11.9225938190587 | 0.0483081206440467 |
| Grapefruit juice | M51 Other intervertebral disk disorders (ukb-e-M51_CSA) | All - MR Egger | -15.5091409415171 | 6.15931178587466 | 0.0270082607604076 |