ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Vegetarian alternatives | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | All - Inverse variance weighted | -4.70024360436196 | 1.90494095667283 | 0.0136099768832284 |
| Vegetarian alternatives | Osteoprotegerin levels (ebi-a-GCST90010243) | rs551343 | -18.7693079411205 | 7.24733191496722 | 0.0096025250307559 |
| Vegetarian alternatives | Osteoprotegerin levels (ebi-a-GCST90010243) | All - Inverse variance weighted | -6.93424742038036 | 3.26898825871511 | 0.0339031862699487 |
| Vegetarian alternatives | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | All - Inverse variance weighted | 25.7835898056851 | 12.4018337962659 | 0.0376160361487559 |
| Vegetarian alternatives | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | All - Inverse variance weighted | 3.41631734514694 | 1.71875236934688 | 0.0468478883586612 |
| Vegetarian alternatives | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | rs72733403 | 6.50632236924376 | 3.04474138727842 | 0.0326057386220767 |
| Vegetarian alternatives | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | All - Inverse variance weighted | 2.07251269768144 | 1.04854487601921 | 0.0480912969609506 |
| Vegetarian alternatives | Bone disorder (ebi-a-GCST90038652) | All - Inverse variance weighted | 0.049820660172892 | 0.0245526505546598 | 0.04244446891643 |
| Vegetarian alternatives | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | All - Inverse variance weighted | 14.4174710070089 | 6.48661032949356 | 0.0262393416505505 |
| Vegetarian alternatives | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | rs9993067 | -12.3961116719519 | 5.13668941177614 | 0.0158110046703545 |
| Vegetarian alternatives | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | All - Inverse variance weighted | -6.33977877987033 | 3.07324931000868 | 0.0391229718769593 |
| Vegetarian alternatives | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs4440163 | 9.55137580819334 | 4.57919269516246 | 0.036994849903591 |
| Vegetarian alternatives | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | All - Inverse variance weighted | 3.78908390259306 | 1.90823303916844 | 0.0470721440792811 |
| Vegetarian alternatives | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | rs551343 | -24.2851953712833 | 10.4993686541089 | 0.0207218239579473 |
| Vegetarian alternatives | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | All - Inverse variance weighted | -11.060684117666 | 4.61384604288579 | 0.0165172644407973 |
| Vegetarian alternatives | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs9993067 | 9.98170560774166 | 4.95844466878076 | 0.0441070663808428 |
| Vegetarian alternatives | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | All - MR Egger | 109.736910309265 | 37.4581578201441 | 0.0428314839885648 |
| Vegetarian alternatives | Pyogenic arthritis (finn-b-M13_PYOGARTH) | rs551343 | 17.6603878020514 | 8.00857938525937 | 0.0274412145648073 |
| Vegetarian alternatives | Pyogenic arthritis (finn-b-M13_PYOGARTH) | All - Inverse variance weighted | 8.22166550653332 | 3.61007229104008 | 0.022760914481902 |
| Vegetarian alternatives | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | All - Inverse variance weighted | 9.99454208084054 | 4.87595721366009 | 0.0403878562905131 |
| Vegetarian alternatives | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | All - Inverse variance weighted | -3.98938387832018 | 1.85121846461627 | 0.0311614923695284 |
| Vegetarian alternatives | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -1.9899309299098 | 0.97402496663359 | 0.0410526492012229 |
| Vegetarian alternatives | Ankle and foot (finn-b-Z21_ANKLE_FOOT) | rs4440163 | 62.7930341594106 | 26.3303579971841 | 0.0170877094258504 |
| Vegetarian alternatives | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | All - Inverse variance weighted | -0.0230818278218498 | 0.0081374844732938 | 0.0045613556671168 |
| Vegetarian alternatives | Operative procedures - main OPCS: W20.5 Primary open reduction of fracture of ankle and extramedullary fixation NEC (ukb-b-13151) | All - Inverse variance weighted | -0.0275672383020514 | 0.0125394334000179 | 0.0279175027722699 |
| Vegetarian alternatives | Operative procedures - secondary OPCS: Z85.6 Ankle joint (ukb-b-15453) | All - Inverse variance weighted | 0.0258631926250111 | 0.0117439439429115 | 0.0276471004263802 |
| Vegetarian alternatives | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | rs12873398 | 0.068295289437956 | 0.0333872696524839 | 0.0408007830697288 |
| Vegetarian alternatives | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | rs551343 | 0.0873756767509038 | 0.02979796931486 | 0.0033649459882 |
| Vegetarian alternatives | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | All - Inverse variance weighted | 0.0392318384858234 | 0.0165293775835572 | 0.0176222382631946 |
| Vegetarian alternatives | Operative procedures - secondary OPCS: Z66.5 Lumbar vertebra (ukb-b-17671) | rs10767356 | 0.0455021874970724 | 0.022624247023224 | 0.0443029269683331 |
| Vegetarian alternatives | Operative procedures - secondary OPCS: Z66.5 Lumbar vertebra (ukb-b-17671) | All - Inverse variance weighted | 0.0246919078048395 | 0.0125015133762072 | 0.0482552694704498 |
| Vegetarian alternatives | Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) | rs10767356 | 0.091217784772772 | 0.0381497615768716 | 0.0168005078236522 |
| Vegetarian alternatives | Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) | rs9993067 | 0.0807268820619352 | 0.0386040843972654 | 0.0365147336014313 |
| Vegetarian alternatives | Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) | rs10767356 | 0.0680091434567138 | 0.0278837956587317 | 0.0147271412167691 |
| Vegetarian alternatives | Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) | rs4440163 | 0.0637931093401862 | 0.0282893297975587 | 0.024131840790789 |
| Vegetarian alternatives | Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) | All - Inverse variance weighted | 0.0295947301282273 | 0.01404486168532 | 0.0351039635006717 |
| Vegetarian alternatives | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | All - Inverse variance weighted | 0.08687976898942 | 0.0345211180558894 | 0.0118455057907218 |
| Vegetarian alternatives | Heel bone mineral density (BMD) (ukb-e-3148_CSA) | All - Inverse variance weighted | -4.70931056545929 | 2.38174149730476 | 0.0480128001406787 |
| Vegetarian alternatives | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | rs4440163 | -32.4473392840056 | 11.2617384529163 | 0.0039616210982022 |
| Vegetarian alternatives | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | All - Inverse variance weighted | -15.283632217223 | 5.0617274961357 | 0.002532342323159 |
| Vegetarian alternatives | Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) | rs9993067 | -35.940621814888 | 17.970310907444 | 0.0455002638963584 |
| Vegetarian alternatives | Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) | All - Inverse variance weighted | -21.8752800571498 | 9.68271102259991 | 0.0238703091058591 |
| Vegetarian alternatives | Pain in joint (ukb-e-745_AFR) | rs9993067 | -47.3806935016828 | 18.5860654741553 | 0.0107952114538683 |
| Vegetarian alternatives | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) | All - Inverse variance weighted | -4.98317791055254 | 2.37327357824748 | 0.0357546692335272 |
| Vegetarian alternatives | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | rs10767356 | 29.6974977281883 | 12.0925962358187 | 0.0140555198235886 |
| Vegetarian alternatives | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | All - MR Egger | -296.960092578665 | 98.6217800643229 | 0.0395075389549249 |