ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Savoury biscuits | Total body bone mineral density (age 30-45) (ebi-a-GCST005346) | rs201426 | 7.68714285486451 | 3.09399525693717 | 0.0129720361265495 |
| Savoury biscuits | Total body bone mineral density (age 30-45) (ebi-a-GCST005346) | rs9477316 | -8.00916193877474 | 2.38843305229689 | 0.0007985055213495 |
| Savoury biscuits | Total body bone mineral density (age 30-45) (ebi-a-GCST005346) | All - MR Egger | -3.05130487442071 | 1.37379961017815 | 0.0337851852836073 |
| Savoury biscuits | Menstruation quality of life impact (joint pain) (ebi-a-GCST006647) | rs9477316 | -7.02278429511087 | 3.306175267286 | 0.0336583080540177 |
| Savoury biscuits | Shoulder impingement (ebi-a-GCST90014054) | rs144420440 | 10.2824503660772 | 5.21580800859778 | 0.0486779995522093 |
| Savoury biscuits | Shoulder impingement (ebi-a-GCST90014054) | All - Inverse variance weighted | 2.36623587048346 | 0.905998749984413 | 0.0090081950426994 |
| Savoury biscuits | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | rs72703933 | -44.2580655134567 | 19.3140255684892 | 0.0219345838885025 |
| Savoury biscuits | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | All - Inverse variance weighted | -11.143017505054 | 5.37971825293376 | 0.0383306462449795 |
| Savoury biscuits | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | rs118185638 | 71.1948110253896 | 30.3871646128945 | 0.0191332906214406 |
| Savoury biscuits | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | All - Inverse variance weighted | -7.09300585679164 | 2.86870369240373 | 0.0134153921891033 |
| Savoury biscuits | Rheumatoid arthritis (ebi-a-GCST90018910) | rs115256662 | -6.00238701602669 | 2.96199069005671 | 0.0427165837571007 |
| Savoury biscuits | Rheumatoid arthritis (ebi-a-GCST90018910) | rs1582441 | -7.93354489453052 | 3.70598117910595 | 0.032294951128895 |
| Savoury biscuits | Rheumatoid arthritis (ebi-a-GCST90018910) | rs9477316 | -1.99287237328873 | 0.922974917685706 | 0.0308359201754218 |
| Savoury biscuits | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs147754441 | -0.0929971769441301 | 0.0369433078697087 | 0.0118260013947543 |
| Savoury biscuits | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs148264590 | -0.103593470081427 | 0.0379857032102075 | 0.0063880119298727 |
| Savoury biscuits | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs17274931 | 0.0805538312925413 | 0.0393679060490327 | 0.0407386411073478 |
| Savoury biscuits | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs184316814 | 0.0913403146512303 | 0.0387259345820194 | 0.0183423251949308 |
| Savoury biscuits | Spine arthritis or spondylitis (ebi-a-GCST90038657) | All - MR Egger | -0.0471156021925849 | 0.0210872246616869 | 0.033937517272184 |
| Savoury biscuits | Other joint disorder (ebi-a-GCST90038688) | All - Inverse variance weighted | 0.0156684645652314 | 0.0074136005422734 | 0.0345600730790184 |
| Savoury biscuits | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | All - MR Egger | -0.0511514884770684 | 0.0176297889346502 | 0.0073058354549836 |
| Savoury biscuits | Fracture of forearm or wrist (ebi-a-GCST90038705) | rs12830907 | 0.0546469126607839 | 0.0266968340836398 | 0.0406636262334045 |
| Savoury biscuits | Fracture of forearm or wrist (ebi-a-GCST90038705) | All - MR Egger | -0.0365783827521575 | 0.0129024625838619 | 0.0085751632689509 |
| Savoury biscuits | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | rs201426 | 89.1357705722775 | 35.7085328880532 | 0.0125530505790986 |
| Savoury biscuits | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | rs201426 | 88.8965441348854 | 35.6606876005748 | 0.0126724379236396 |
| Savoury biscuits | Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) | rs201426 | -62.310512726049 | 22.2321102483011 | 0.0050672704465192 |
| Savoury biscuits | Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) | All - Inverse variance weighted | -5.76741144636168 | 2.70120293828132 | 0.0327506340909877 |
| Savoury biscuits | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | rs114398359 | -37.3367573831073 | 18.3395446431368 | 0.0417643495699292 |
| Savoury biscuits | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | rs148469143 | 99.7111670475241 | 44.8019734985133 | 0.0260411435806702 |
| Savoury biscuits | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | All - Inverse variance weighted | -6.76559131841795 | 2.62381769422386 | 0.0099221828297853 |
| Savoury biscuits | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | rs138234447 | 28.9037990174406 | 10.9361902302896 | 0.0082187280974359 |
| Savoury biscuits | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | rs148469143 | 117.555398314948 | 59.8274735429789 | 0.0494250473753016 |
| Savoury biscuits | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | All - MR Egger | 22.7646802090998 | 9.10998108300225 | 0.0181631945263684 |
| Savoury biscuits | Cervicalgia (finn-b-M13_CERVICALGIA) | rs1582441 | -17.3934050006039 | 6.64880475244046 | 0.0088961393919144 |
| Savoury biscuits | Cervicalgia (finn-b-M13_CERVICALGIA) | All - Inverse variance weighted | -1.95057439889723 | 0.872276132524775 | 0.025339385473989 |
| Savoury biscuits | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs113939496 | 16.6319999679383 | 7.15777155246695 | 0.0201454286293075 |
| Savoury biscuits | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs115256662 | 6.45539735685889 | 3.07524327526476 | 0.0358036675214228 |
| Savoury biscuits | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs1582441 | -9.53123455841176 | 4.6228683745292 | 0.0392308082498375 |
| Savoury biscuits | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs77615488 | -3.98343096021652 | 1.94724336412498 | 0.0407881602507697 |
| Savoury biscuits | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | rs72703933 | -25.7230750204826 | 10.1485569416748 | 0.0112558612029761 |
| Savoury biscuits | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | All - MR Egger | 8.1410026680996 | 3.97355034093144 | 0.0493176074152985 |
| Savoury biscuits | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | All - Inverse variance weighted | 1.77785264835753 | 0.666296512142061 | 0.0076245121890359 |
| Savoury biscuits | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs113939496 | 54.3806283289048 | 23.429077545197 | 0.0202828374673502 |
| Savoury biscuits | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs138234447 | 13.0972549879568 | 5.86069444100576 | 0.0254330029496568 |
| Savoury biscuits | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs9477316 | 23.1007436540765 | 8.09580856370034 | 0.0043251389756351 |
| Savoury biscuits | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | All - MR Egger | 16.4435317483067 | 5.09840178146595 | 0.0030344230066236 |
| Savoury biscuits | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | rs1582441 | 66.2739241673896 | 30.2957098463802 | 0.0287010878728506 |
| Savoury biscuits | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | rs76239392 | 161.049309724116 | 61.7557786598179 | 0.0091115015872573 |
| Savoury biscuits | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | All - Inverse variance weighted | -11.2991724075786 | 4.42691367940107 | 0.0106989308986395 |
| Savoury biscuits | Rheumatoid arthritis (ieu-a-831) | rs9477316 | -2.54886492921347 | 1.25922409831001 | 0.0429541917976696 |
| Savoury biscuits | Rheumatoid arthritis (ieu-a-831) | All - Inverse variance weighted | -2.56688901564521 | 1.23181774865829 | 0.0371763546859594 |
| Savoury biscuits | Rheumatoid arthritis (ieu-a-833) | rs9477316 | -2.54886492921347 | 1.25922409831001 | 0.0429541917976696 |
| Savoury biscuits | Rheumatoid arthritis (ieu-a-833) | All - Inverse variance weighted | -2.3672181225332 | 1.05297662731298 | 0.0245685204986832 |
| Savoury biscuits | Four-jointed box protein 1 (prot-a-1112) | rs10445634 | -10.8268957575044 | 5.02677303026992 | 0.0312522388569388 |
| Savoury biscuits | Four-jointed box protein 1 (prot-a-1112) | rs117809572 | -10.780104836223 | 5.40191171936149 | 0.045976475090731 |
| Savoury biscuits | Four-jointed box protein 1 (prot-a-1112) | rs144420440 | -13.1989291163291 | 4.845844568336 | 0.0064542925915137 |
| Savoury biscuits | Four-jointed box protein 1 (prot-a-1112) | rs148289362 | -9.12513659221204 | 4.4330970050701 | 0.0395506760801582 |
| Savoury biscuits | Bone sialoprotein 2 (prot-a-1396) | rs114398359 | 10.5164260436566 | 4.77279133130813 | 0.0275657179977704 |
| Savoury biscuits | Bone sialoprotein 2 (prot-a-1396) | rs118185638 | 10.1723750900864 | 4.7967297172765 | 0.0339479276486975 |
| Savoury biscuits | Bone sialoprotein 2 (prot-a-1396) | rs71489617 | 10.3060378904055 | 4.75296941526094 | 0.0301330800730229 |
| Savoury biscuits | Bone sialoprotein 2 (prot-a-1396) | rs73682371 | 8.66492424510513 | 4.4082928481515 | 0.049345258351382 |
| Savoury biscuits | Bone sialoprotein 2 (prot-a-1396) | rs78373761 | 10.3552356628744 | 4.95317699868431 | 0.0365616928942959 |
| Savoury biscuits | Bone sialoprotein 2 (prot-a-1396) | All - Inverse variance weighted | 2.27733004056282 | 0.914085853844183 | 0.0127249970863058 |
| Savoury biscuits | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | rs201426 | 0.523732060010749 | 0.209756929991181 | 0.01253011565207 |
| Savoury biscuits | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | All - Inverse variance weighted | 0.0883512652349181 | 0.0370186913426111 | 0.0170019132250718 |
| Savoury biscuits | Operation code: knee surgery (not replacement) (ukb-b-1508) | All - Inverse variance weighted | -0.0497298820619583 | 0.0221831845969537 | 0.0249754122881553 |
| Savoury biscuits | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs12830907 | -0.0968078173729743 | 0.0412020197318403 | 0.0187941442925281 |
| Savoury biscuits | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - Inverse variance weighted | -0.0552910907355477 | 0.0243647329801259 | 0.023249584264026 |
| Savoury biscuits | Diagnoses - secondary ICD10: M81.99 Osteoporosis, unspecified (Site unspecified) (ukb-b-17796) | rs201426 | -0.0575902561477207 | 0.0279054449531993 | 0.0390400861919471 |
| Savoury biscuits | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs148469143 | 0.375605408561364 | 0.176979201707478 | 0.0338113923213385 |
| Savoury biscuits | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs201426 | 0.357558997226568 | 0.180319319448631 | 0.0473762347372073 |
| Savoury biscuits | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | All - Inverse variance weighted | 0.0609263752259522 | 0.0301750095566121 | 0.0434767806208173 |
| Savoury biscuits | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs114398359 | -1.21029720334471 | 0.492463123610285 | 0.0139853183812392 |
| Savoury biscuits | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs71489617 | -2.00299084648576 | 0.474885462009582 | 2.46653850606822e-05 |
| Savoury biscuits | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs78714534 | 1.18813732792481 | 0.530257905143635 | 0.0250469272599451 |
| Savoury biscuits | Ankle spacing width (ukb-b-4080) | rs114398359 | -0.855588612946666 | 0.434686668128151 | 0.0490348939248895 |
| Savoury biscuits | Ankle spacing width (ukb-b-4080) | rs12830907 | -0.862956584188372 | 0.424665686945998 | 0.0421450965248738 |
| Savoury biscuits | Ankle spacing width (ukb-b-4080) | rs138234447 | -0.977791611107378 | 0.449982492192225 | 0.0297837202488494 |
| Savoury biscuits | Ankle spacing width (ukb-b-4080) | rs189773247 | -1.14771107603182 | 0.461053042958513 | 0.0127985745690656 |
| Savoury biscuits | Ankle spacing width (ukb-b-4080) | All - Inverse variance weighted | -0.169185694705408 | 0.0855341887063996 | 0.0479299339915672 |
| Savoury biscuits | Fractured heel (left) (ukb-b-8221) | rs113939496 | -0.204648944569351 | 0.070390230804067 | 0.0036450665040136 |
| Savoury biscuits | Fractured heel (left) (ukb-b-8221) | rs12830907 | -0.162523911169037 | 0.0667837011718967 | 0.0149500643484413 |
| Savoury biscuits | Fractured heel (left) (ukb-b-8221) | All - Inverse variance weighted | -0.0254988113873716 | 0.0122476217088654 | 0.0373479665967027 |
| Savoury biscuits | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | All - Inverse variance weighted | -0.0541896295898281 | 0.0251694391306068 | 0.031319218288964 |
| Savoury biscuits | Heel bone mineral density (BMD) (ukb-b-8875) | rs114398359 | -1.18285678494253 | 0.492395477748896 | 0.0162945909037411 |
| Savoury biscuits | Heel bone mineral density (BMD) (ukb-b-8875) | rs71489617 | -1.99096078562108 | 0.47481211959576 | 2.75101404569411e-05 |
| Savoury biscuits | Heel bone mineral density (BMD) (ukb-b-8875) | rs78714534 | 1.15888521533177 | 0.530118048001543 | 0.0288090971084211 |
| Savoury biscuits | Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) | rs71489617 | 0.0602222179888939 | 0.0240732662139122 | 0.0123625758556239 |
| Savoury biscuits | Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) | All - Inverse variance weighted | 0.0135647545464907 | 0.0054340532803639 | 0.0125514169709895 |
| Savoury biscuits | Fractured/broken bones in last 5 years (ukb-e-2463_AFR) | All - Inverse variance weighted | -4.56160305700811 | 2.31744364812257 | 0.0490246623039447 |
| Savoury biscuits | Ankle spacing width (ukb-e-3143_EAS) | All - MR Egger | 9.02771724896821 | 3.75961483313884 | 0.0430936216604837 |
| Savoury biscuits | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | rs12830907 | 16.3582319810085 | 6.76494905230866 | 0.0156023673266652 |
| Savoury biscuits | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | rs201426 | 12.1941689353307 | 4.89616775195727 | 0.0127544203625164 |
| Savoury biscuits | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | All - MR Egger | -3.74982548504916 | 1.70613755749461 | 0.0430258259076051 |