ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Broad bean | Osteoporosis (bbj-a-137) | All - Inverse variance weighted | 0.483228353580326 | 0.227530448357237 | 0.033687169792856 |
| Broad bean | Rheumatoid arthritis (bbj-a-151) | rs905491 | 2.66018943639059 | 1.18256751382813 | 0.0244804978567788 |
| Broad bean | Rheumatoid arthritis (bbj-a-151) | All - Inverse variance weighted | 0.608920139188102 | 0.291883141463376 | 0.0369625175244413 |
| Broad bean | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | rs11014050 | 3.73067981073314 | 1.82634092101526 | 0.0410814283110818 |
| Broad bean | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | All - Inverse variance weighted | 1.11221676884128 | 0.372839741422656 | 0.0028534840744428 |
| Broad bean | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | rs11014050 | 5.05687151322028 | 2.18791907542275 | 0.0208179512510448 |
| Broad bean | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | All - Inverse variance weighted | 1.54300655861235 | 0.450787958601507 | 0.0006195461328878 |
| Broad bean | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | rs976088 | 3.14758790745294 | 1.4660158474949 | 0.0317904642374546 |
| Broad bean | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | All - Inverse variance weighted | 0.750802785424063 | 0.301751564622475 | 0.0128410003555216 |
| Broad bean | Knee osteoarthritis (ebi-a-GCST007090) | rs182604899 | 1.48448545278667 | 0.74782349877223 | 0.0471361692807617 |
| Broad bean | Knee osteoarthritis (ebi-a-GCST007090) | rs185311646 | 1.85795173200715 | 0.899911731145988 | 0.0389614976035544 |
| Broad bean | Knee osteoarthritis (ebi-a-GCST007090) | rs77934214 | 1.813679117383 | 0.873699242593139 | 0.0379067097478819 |
| Broad bean | Knee osteoarthritis (ebi-a-GCST007090) | All - Inverse variance weighted | 0.405801426489686 | 0.1992810965995 | 0.0417175560862604 |
| Broad bean | Rheumatoid arthritis (ebi-a-GCST90013534) | All - Inverse variance weighted | 0.457288556141489 | 0.195035319732463 | 0.0190452116173553 |
| Broad bean | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs147717277 | -6.98183428821242 | 2.981121005039 | 0.0191798720425294 |
| Broad bean | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | All - Inverse variance weighted | -5.65716481448164 | 1.85643972507353 | 0.0023089221524143 |
| Broad bean | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | All - MR Egger | -7.02890047810951 | 3.14200852399995 | 0.0374641392152385 |
| Broad bean | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs905491 | -1.8075991468132 | 0.863128592603304 | 0.0362385315994562 |
| Broad bean | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs147717277 | 1.44238512689538 | 0.726225811647224 | 0.0470179347254351 |
| Broad bean | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | All - Inverse variance weighted | 0.999674281220267 | 0.450667649531154 | 0.0265406995488618 |
| Broad bean | Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) | rs118103685 | 24.2972360523388 | 7.76065821427701 | 0.001743180434006 |
| Broad bean | Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) | rs147717277 | 2.08232668369343 | 1.0109638526495 | 0.0394230250089946 |
| Broad bean | Burn and corrosion of head and neck (finn-b-ST19_BURN_CORROSION_HEAD_NECK) | All - Inverse variance weighted | -2.78213125008845 | 1.40969950784408 | 0.0484314172292318 |
| Broad bean | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs147717277 | -1.21948413520167 | 0.543590805549803 | 0.0248719182169918 |
| Broad bean | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs185311646 | 10.7580356950634 | 5.0722297573683 | 0.0339245171487671 |
| Broad bean | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs547613760 | 4.60571884905922 | 1.68680785873188 | 0.0063250846435116 |
| Broad bean | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | All - Inverse variance weighted | 2.22510951466576 | 1.03703119572218 | 0.0319006413628334 |
| Broad bean | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs138763370 | 2.60950391507699 | 0.94099795049661 | 0.005552097566101 |
| Broad bean | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs72662025 | 4.22840351619892 | 1.69833403889733 | 0.0127837988761003 |
| Broad bean | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs976088 | -3.83209442165296 | 1.80609530126823 | 0.0338581923864045 |
| Broad bean | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | All - Inverse variance weighted | 0.474840465130376 | 0.237422212513642 | 0.0455020649260511 |
| Broad bean | Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) | rs547613760 | 3.13241034249533 | 1.25980915439589 | 0.0129036825723931 |
| Broad bean | Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) | All - Inverse variance weighted | 0.600723325303778 | 0.252876058602453 | 0.0175221414183572 |
| Broad bean | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs72662025 | 2.45038224967005 | 1.18534751101925 | 0.0387127794642274 |
| Broad bean | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs7844716 | 1.65268768334504 | 0.818080403255795 | 0.0433624368300393 |
| Broad bean | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | All - Inverse variance weighted | 0.470364244779185 | 0.163971114137304 | 0.0041231902156845 |
| Broad bean | Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) | All - Inverse variance weighted | 0.431480992950399 | 0.18965300226461 | 0.0228994739287932 |
| Broad bean | Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) | rs186366228 | 17.2736176653904 | 6.40174153536403 | 0.0069701193299498 |
| Broad bean | Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) | All - Inverse variance weighted | 3.01115705123929 | 1.46820999671135 | 0.0402763432391814 |
| Broad bean | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | rs35650677 | 12.730612814829 | 4.11044979316845 | 0.001954016833732 |
| Broad bean | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | rs56181616 | 7.10352643825724 | 3.23457434004654 | 0.0280830669846708 |
| Broad bean | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | All - Inverse variance weighted | 1.7415122748334 | 0.698838388269805 | 0.012702244938595 |
| Broad bean | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs147717277 | 2.26496168979085 | 0.780872506385035 | 0.0037250544835749 |
| Broad bean | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs60801456 | 5.01636920477347 | 2.43652218517569 | 0.0395111467775621 |
| Broad bean | Rheumatoid arthritis (ieu-a-831) | All - Inverse variance weighted | 1.87190632278813 | 0.791031360788267 | 0.0179614303405535 |
| Broad bean | Rheumatoid arthritis (ieu-a-833) | All - Inverse variance weighted | 1.04043522798075 | 0.483057268082378 | 0.0312515585676008 |
| Broad bean | Bone sialoprotein 2 (prot-a-1396) | rs147717277 | -4.39762085547963 | 2.22181956236626 | 0.0477835869773477 |
| Broad bean | Bone sialoprotein 2 (prot-a-1396) | rs184217006 | -4.7363634192984 | 2.18801756491878 | 0.0304120051156653 |
| Broad bean | Bone sialoprotein 2 (prot-a-1396) | All - MR Egger | -2.54667341861713 | 1.02251069589827 | 0.0227475522869681 |
| Broad bean | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | rs7844716 | -0.0585328265091104 | 0.0236347560219807 | 0.0132656346028008 |
| Broad bean | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | All - Inverse variance weighted | -0.0187439071295328 | 0.0090949219689986 | 0.0393106671835862 |
| Broad bean | Fracture resulting from simple fall (ukb-b-15251) | rs184217006 | 0.789954655072489 | 0.297566047524262 | 0.0079374169869001 |
| Broad bean | Fracture resulting from simple fall (ukb-b-15251) | rs186366228 | 0.603251932061223 | 0.304984926924202 | 0.0479317596167638 |
| Broad bean | Fracture resulting from simple fall (ukb-b-15251) | rs7844716 | -0.723923480560261 | 0.306494236251704 | 0.0181791867869652 |
| Broad bean | Fracture resulting from simple fall (ukb-b-15251) | All - MR Egger | 0.65698237493454 | 0.219453282290585 | 0.0122161268211879 |
| Broad bean | Operative procedures - main OPCS: T67.6 Primary simple repair of tendon (ukb-b-16193) | rs7844716 | -0.0238891872908317 | 0.0109087303226873 | 0.0285304343208692 |
| Broad bean | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs147717277 | -1.48830273118428 | 0.331281206138837 | 7.03700516237432e-06 |
| Broad bean | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs185311646 | 1.32435359211178 | 0.329464574048957 | 5.82686596682604e-05 |
| Broad bean | Ankle spacing width (right) (ukb-b-8607) | rs185311646 | -0.801496264720446 | 0.299418717302848 | 0.0074319919997108 |
| Broad bean | Ankle spacing width (right) (ukb-b-8607) | rs976088 | -0.624865714471113 | 0.301067434767875 | 0.0379401408731574 |
| Broad bean | Ankle spacing width (right) (ukb-b-8607) | All - Inverse variance weighted | -0.12591632327918 | 0.061327708629703 | 0.0400559162174503 |
| Broad bean | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | rs35650677 | 0.0286383153264797 | 0.0130107081144293 | 0.0277265208223946 |
| Broad bean | Other joint disorders (ukb-d-M13_OTHERJOINT) | rs72796907 | 0.19040129695975 | 0.0541540740147709 | 0.000438235904784 |
| Broad bean | Other joint disorders (ukb-d-M13_OTHERJOINT) | All - MR Egger | 0.0598020182276535 | 0.0257406444886514 | 0.031416498446698 |
| Broad bean | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | rs184217006 | 0.0756350786101747 | 0.0310396773542353 | 0.0148210503834976 |
| Broad bean | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | rs72796907 | 0.0930644677061025 | 0.0294293777395273 | 0.0015652919371882 |
| Broad bean | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | All - Inverse variance weighted | 0.0172235917374608 | 0.007743338973032 | 0.0261275472465124 |
| Broad bean | Heel bone mineral density (BMD) (ukb-e-3148_EAS) | rs147717277 | 1.90688203216677 | 0.620096178182738 | 0.0021040436604703 |
| Broad bean | Heel bone mineral density (BMD) (ukb-e-3148_EAS) | All - MR Egger | 3.57834841760973 | 0.921418586117099 | 0.0046515897545913 |
| Broad bean | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | rs147717277 | 0.796403672257886 | 0.394462851752146 | 0.0434916530222616 |
| Broad bean | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | rs7844716 | -4.77130934181713 | 1.90389621121349 | 0.0122079242167742 |
| Broad bean | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | rs976088 | -4.30074190501597 | 2.17668731118914 | 0.0481751891885925 |
| Broad bean | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | All - MR Egger | 1.7595070196559 | 0.499214262366803 | 0.0047601992635868 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | rs147717277 | 0.902820919905202 | 0.39647615103196 | 0.0227794902985825 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | rs7844716 | -5.0729248440276 | 1.91298599347188 | 0.0080055450717563 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | rs976088 | -4.6035602788813 | 2.1903862376259 | 0.0355785422278604 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | All - MR Egger | 1.92920734127237 | 0.501857700064965 | 0.0027269918151617 |
| Broad bean | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | rs138763370 | 4.31906563665984 | 2.19073519365179 | 0.0486650855063699 |
| Broad bean | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | rs77934214 | 2.15311629439045 | 0.887758770634868 | 0.0152940823807343 |
| Broad bean | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | rs7844716 | -5.13159525678635 | 1.9394289964054 | 0.0081466437774887 |
| Broad bean | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | All - MR Egger | 1.46610358251025 | 0.557250692556783 | 0.0233672195668305 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | rs138763370 | 4.40774607178517 | 2.20058857533239 | 0.0451788905239585 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | rs72662025 | -3.74330751799188 | 1.82483751276241 | 0.0402367630063539 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | rs77934214 | 2.16315881442026 | 0.89077152664381 | 0.0151651729497096 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | rs7844716 | -5.35966615708796 | 1.9485187786638 | 0.0059479671666099 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | All - MR Egger | 1.46859537200238 | 0.59989404302564 | 0.0323551396950008 |
| Broad bean | Pain in joint (ukb-e-745_CSA) | rs118103685 | -9.07643700099902 | 4.3128304675888 | 0.035333131562481 |
| Broad bean | Pain in joint (ukb-e-745_CSA) | rs77934214 | -11.9907689155886 | 4.04512706800594 | 0.0030342142881176 |
| Broad bean | Pain in joint (ukb-e-745_CSA) | All - Inverse variance weighted | -3.54132637848385 | 1.38507491973654 | 0.0105647209552247 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | rs147717277 | 1.77745564989301 | 0.629731253307563 | 0.0047641575267923 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | rs60801456 | -6.34476411749619 | 3.18860039527481 | 0.0466099629470425 |
| Broad bean | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | All - MR Egger | 3.60463433334613 | 0.935648751687209 | 0.0048599312104573 |
| Broad bean | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | rs60801456 | 39.1503100342471 | 18.5266207021408 | 0.0345843221475655 |
| Broad bean | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | rs77934214 | 3.66150280286734 | 1.60599980316661 | 0.0226142165683929 |
| Broad bean | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | All - Inverse variance weighted | 3.127111848888 | 1.4484044468558 | 0.0308498108416063 |