ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Dried fruit (ukb-b-15321)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Dried fruit (👉 📊) Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) Inverse variance weighted 7 0.732311901 0.331430864 0.027136653
Dried fruit (👉 📊) Achilles tendon injury (ebi-a-GCST90018787) Weighted median 6 0.915889979 0.447237061 0.040571289
Dried fruit (👉 📊) Arthritis (not osteoarthritis) (ebi-a-GCST90038699) Weighted median 7 0.015543137 0.006166475 0.011715927
Dried fruit (👉 📊) Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) Weighted median 7 3.067314005 1.557937371 0.048972603
Dried fruit (👉 📊) Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) Inverse variance weighted 7 2.451656274 1.247773005 0.049434433
Dried fruit (👉 📊) Cervical root disorders (finn-b-G6_CERVROOT) Inverse variance weighted 7 -5.308026679 2.566527363 0.038623609
Dried fruit (👉 📊) Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) Weighted median 7 -5.906596945 2.928838305 0.043726519
Dried fruit (👉 📊) Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) Inverse variance weighted 7 -7.131766119 2.989274389 0.017042709
Dried fruit (👉 📊) Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) Inverse variance weighted 7 1.599381583 0.753746322 0.033845327
Dried fruit (👉 📊) Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) Inverse variance weighted 7 -3.954975132 1.996312806 0.047575577
Dried fruit (👉 📊) Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) Weighted median 7 -5.109712503 2.073760174 0.013740213
Dried fruit (👉 📊) Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) Inverse variance weighted 7 -4.213950191 1.6141574 0.009037849
Dried fruit (👉 📊) Fracture of femur (finn-b-ST19_FRACT_FEMUR) Inverse variance weighted 7 -1.187654284 0.593181637 0.045265761
Dried fruit (👉 📊) Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) Inverse variance weighted 7 -4.226139217 1.859656022 0.023054028
Dried fruit (👉 📊) Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) Inverse variance weighted 7 1.96099717 0.831383211 0.018338267
Dried fruit (👉 📊) Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) Inverse variance weighted 7 4.763950166 1.940515265 0.014088758
Dried fruit (👉 📊) Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) Inverse variance weighted 7 0.871793808 0.366086107 0.017247439
Dried fruit (👉 📊) Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) Inverse variance weighted 6 0.006152107 0.002221806 0.005623438
Dried fruit (👉 📊) Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) Weighted median 6 -0.003120525 0.001537904 0.042450445
Dried fruit (👉 📊) Diagnoses - secondary ICD10: M06.99 Rheumatoid arthritis, unspecified (Site unspecified) (ukb-b-11874) Wald ratio 1 0.017882953 0.00769383 0.020108142
Dried fruit (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-b-16254) Weighted median 7 0.057034605 0.028399564 0.044612317
Dried fruit (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-b-16254) Inverse variance weighted 7 0.046919075 0.020706724 0.02345837
Dried fruit (👉 📊) Non-cancer illness code, self-reported: joint disorder (ukb-b-8201) Weighted median 3 -0.016938234 0.007785057 0.029574963
Dried fruit (👉 📊) Fractured heel (left) (ukb-b-8221) MR Egger 7 0.048230648 0.016694915 0.034229004

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Dried fruit Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) All - Inverse variance weighted 0.732311901387701 0.331430863993204 0.027136652688594
Dried fruit Arthritis (not osteoarthritis) (ebi-a-GCST90038699) rs6674704 -0.0223959426541243 0.0113065058106508 0.0476135486158569
Dried fruit Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) All - Inverse variance weighted 2.45165627445661 1.24777300505872 0.0494344325541121
Dried fruit Cervical root disorders (finn-b-G6_CERVROOT) All - Inverse variance weighted -5.30802667942373 2.56652736251223 0.0386236086022244
Dried fruit Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) rs6674704 -25.5870827355793 6.79754672109839 0.0001671069865553
Dried fruit Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) All - Inverse variance weighted -7.13176611913545 2.98927438885271 0.0170427094604447
Dried fruit Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) rs73185262 5.37560499258129 2.28012874905785 0.018394077299231
Dried fruit Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) All - Inverse variance weighted 1.59938158317604 0.753746321587124 0.0338453270754034
Dried fruit Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) rs6674704 -12.6707811401777 5.11260242054284 0.0131994279817445
Dried fruit Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) rs73185262 -10.3008727062426 5.09118144800027 0.0430445486544261
Dried fruit Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) All - Inverse variance weighted -3.95497513154824 1.99631280604249 0.0475755767895611
Dried fruit Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) rs190615711 -6.65847059743729 2.94015599272382 0.0235331983348072
Dried fruit Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) All - Inverse variance weighted -4.21395019133684 1.6141574001681 0.0090378486767572
Dried fruit Fracture of femur (finn-b-ST19_FRACT_FEMUR) rs73185262 -4.7024692704062 1.48848321664067 0.0015818352070314
Dried fruit Fracture of femur (finn-b-ST19_FRACT_FEMUR) All - Inverse variance weighted -1.18765428391982 0.593181636737459 0.0452657611408672
Dried fruit Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) All - Inverse variance weighted -4.22613921688014 1.85965602173751 0.0230540277388234
Dried fruit Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) rs190615711 3.78650376143422 1.51420039188709 0.0123961335693855
Dried fruit Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) All - Inverse variance weighted 1.96099717032568 0.831383210698735 0.0183382668928611
Dried fruit Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) All - Inverse variance weighted 4.76395016588322 1.94051526541488 0.0140887579612229
Dried fruit Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) rs190615711 1.83910166802711 0.667852623176692 0.0058916078005891
Dried fruit Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) All - Inverse variance weighted 0.87179380751581 0.366086107442482 0.0172474394851527
Dried fruit Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) rs190615711 0.0098021912786068 0.0036130225244829 0.0066673700044958
Dried fruit Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) All - Inverse variance weighted 0.0061521071741601 0.0022218061054148 0.0056234378219642
Dried fruit Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) rs190615711 -0.00436328374912 0.0019079045271583 0.0221986960839569
Dried fruit Diagnoses - secondary ICD10: M06.99 Rheumatoid arthritis, unspecified (Site unspecified) (ukb-b-11874) rs7093348 0.0178829532237024 0.0076938302069878 0.0201081422575261
Dried fruit Pain type(s) experienced in last month: Knee pain (ukb-b-16254) All - Inverse variance weighted 0.0469190749259134 0.020706724416954 0.0234583700327969
Dried fruit Non-cancer illness code, self-reported: joint disorder (ukb-b-8201) rs6674704 -0.0201187645025563 0.009153098853275 0.0279471345174521
Dried fruit Non-cancer illness code, self-reported: joint disorder (ukb-b-8201) rs7093348 -0.0254009626445091 0.0092633648859671 0.0061049964349204
Dried fruit Fractured heel (left) (ukb-b-8221) rs190615711 0.0522046156036846 0.0235751975981372 0.0268021552283638
Dried fruit Fractured heel (left) (ukb-b-8221) All - MR Egger 0.048230647753974 0.0166949153333727 0.0342290039037167