ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Broccoli (ukb-b-15601)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Broccoli (👉 📊) Osteoporosis (bbj-a-137) Inverse variance weighted 4 1.30484087 0.631639232 0.038847287
Broccoli (👉 📊) Frozen shoulder (ebi-a-GCST90000513) MR Egger 6 1.528803052 0.499219016 0.037570775
Broccoli (👉 📊) Ultradistal forearm bone mineral density (ebi-a-GCST90013422) Weighted median 6 -0.428107212 0.210129863 0.041615392
Broccoli (👉 📊) Ultradistal forearm bone mineral density (ebi-a-GCST90013422) Inverse variance weighted 6 -0.375237603 0.157821592 0.017425422
Broccoli (👉 📊) Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) Inverse variance weighted 8 -2.299313147 1.17224328 0.049824905
Broccoli (👉 📊) Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) Weighted median 8 2.836871317 1.367818791 0.038078283
Broccoli (👉 📊) Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) Inverse variance weighted 8 2.601017318 1.058016787 0.013956173
Broccoli (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) MR Egger 8 -5.222627374 1.891591219 0.032811874
Broccoli (👉 📊) Otherdisorders of bone (finn-b-M13_OTHERBONE) Weighted median 8 0.949679908 0.463659724 0.040537859
Broccoli (👉 📊) Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) Inverse variance weighted 8 1.193968677 0.505619967 0.018206306
Broccoli (👉 📊) Recurrent dislocation and subluxation of joint (finn-b-M13_RECUDISLOCATIO) Inverse variance weighted 8 1.247465407 0.591280362 0.034878195
Broccoli (👉 📊) Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) Inverse variance weighted 8 1.044143806 0.407986085 0.010489427
Broccoli (👉 📊) Bone sialoprotein 2 (prot-a-1396) Inverse variance weighted 8 0.652600148 0.321235739 0.042201226
Broccoli (👉 📊) Knee pain for 3+ months (ukb-a-353) MR Egger 8 -0.269931765 0.09562893 0.030246584
Broccoli (👉 📊) Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) Inverse variance weighted 8 0.009950743 0.004374652 0.022927747
Broccoli (👉 📊) Ankle spacing width (left) (ukb-b-2122) Inverse variance weighted 8 -0.096718142 0.040049934 0.015737851
Broccoli (👉 📊) Ankle spacing width (ukb-b-4080) MR Egger 8 0.312767228 0.106688741 0.02623292
Broccoli (👉 📊) Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) Inverse variance weighted 2 0.007292811 0.00283995 0.010230596
Broccoli (👉 📊) Ankle spacing width (right) (ukb-b-8607) Inverse variance weighted 8 -0.082810001 0.040536562 0.041067569
Broccoli (👉 📊) Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) MR Egger 7 -5.80214328 2.020356149 0.034919347

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Broccoli Osteoporosis (bbj-a-137) rs10982277 2.20310521389638 0.862131516646045 0.0106060765243534
Broccoli Osteoporosis (bbj-a-137) All - Inverse variance weighted 1.30484086985251 0.631639232097151 0.038847286728789
Broccoli Frozen shoulder (ebi-a-GCST90000513) rs113230204 1.07301500286191 0.437751424909104 0.0142381983114136
Broccoli Frozen shoulder (ebi-a-GCST90000513) rs2382312 -1.32556738300864 0.463765999014041 0.0042596084521077
Broccoli Frozen shoulder (ebi-a-GCST90000513) All - MR Egger 1.52880305238174 0.499219016426239 0.0375707746767796
Broccoli Ultradistal forearm bone mineral density (ebi-a-GCST90013422) rs7540542 -0.791382256528899 0.366558019668105 0.0308536609662672
Broccoli Ultradistal forearm bone mineral density (ebi-a-GCST90013422) All - Inverse variance weighted -0.375237603434876 0.157821592190941 0.0174254221656068
Broccoli Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) All - Inverse variance weighted -2.29931314691038 1.17224327963633 0.0498249051632185
Broccoli Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) rs56120169 7.99248700547019 2.96490909503598 0.0070242207826063
Broccoli Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) All - Inverse variance weighted 2.60101731768464 1.05801678698258 0.0139561733363929
Broccoli Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs113230204 -3.53022742113622 1.48174423385439 0.0171964213437132
Broccoli Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) All - MR Egger -5.22262737416381 1.89159121866638 0.0328118743695595
Broccoli Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) rs113230204 2.73050474432253 0.985142249058794 0.0055766842878969
Broccoli Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) All - Inverse variance weighted 1.19396867688882 0.505619966580223 0.018206305873456
Broccoli Recurrent dislocation and subluxation of joint (finn-b-M13_RECUDISLOCATIO) rs113230204 3.12794756656966 1.07220883080867 0.0035308366006811
Broccoli Recurrent dislocation and subluxation of joint (finn-b-M13_RECUDISLOCATIO) All - Inverse variance weighted 1.24746540708465 0.591280361556345 0.0348781952064403
Broccoli Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) rs10982277 3.35268055068575 1.55028875939229 0.0305706633015232
Broccoli Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) All - Inverse variance weighted 1.04414380611148 0.40798608490565 0.0104894266846816
Broccoli Bone sialoprotein 2 (prot-a-1396) All - Inverse variance weighted 0.65260014769125 0.32123573881896 0.042201225655595
Broccoli Knee pain for 3+ months (ukb-a-353) rs2382312 0.194133542697511 0.0797195493801238 0.0148833046979514
Broccoli Knee pain for 3+ months (ukb-a-353) All - MR Egger -0.269931765141969 0.095628930422526 0.0302465839095918
Broccoli Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) rs113230204 0.0267996581830494 0.0127687979168514 0.0358310463610585
Broccoli Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) All - Inverse variance weighted 0.0099507434097172 0.0043746522114974 0.0229277471825338
Broccoli Ankle spacing width (left) (ukb-b-2122) rs2382312 -0.262540123062316 0.11364421479304 0.0208774453413037
Broccoli Ankle spacing width (left) (ukb-b-2122) All - Inverse variance weighted -0.0967181422783048 0.0400499339231819 0.0157378506144861
Broccoli Ankle spacing width (ukb-b-4080) rs11613757 0.218637477617529 0.0761328768995154 0.0040815675869898
Broccoli Ankle spacing width (ukb-b-4080) All - MR Egger 0.312767228342622 0.106688741304648 0.0262329203856717
Broccoli Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) rs7540542 0.0090071359679455 0.0039258678062713 0.0217730172984928
Broccoli Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) All - Inverse variance weighted 0.0072928112872368 0.0028399502710045 0.0102305964813274
Broccoli Ankle spacing width (right) (ukb-b-8607) rs2382312 -0.228094359948146 0.115041355511329 0.0473991383210455
Broccoli Ankle spacing width (right) (ukb-b-8607) All - Inverse variance weighted -0.0828100012101198 0.0405365619883575 0.0410675687731812
Broccoli Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) rs11613757 -2.26264820345733 0.902042417111654 0.012129260883465
Broccoli Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) All - MR Egger -5.80214327994485 2.02035614908785 0.0349193472560586