ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Mashed potato (ukb-b-15710)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Mashed potato (👉 📊) Osteoarthritis (self-reported) (ebi-a-GCST005811) MR Egger 11 1.088321577 0.375401446 0.017621541
Mashed potato (👉 📊) Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) Inverse variance weighted 11 -2.665627289 1.295618937 0.039646216
Mashed potato (👉 📊) Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) Inverse variance weighted 11 -2.665094989 1.29529513 0.039636281
Mashed potato (👉 📊) Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) Inverse variance weighted 11 -1.616436908 0.69437109 0.019916615
Mashed potato (👉 📊) Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) Inverse variance weighted 11 -2.941622053 1.17487819 0.012287869
Mashed potato (👉 📊) Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) Inverse variance weighted 11 -5.857901928 2.094719561 0.005165799
Mashed potato (👉 📊) Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) Inverse variance weighted 11 1.080272278 0.548607365 0.048939617
Mashed potato (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) Weighted median 11 2.603911705 1.180105909 0.027348535
Mashed potato (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) Inverse variance weighted 11 2.106339958 0.84350946 0.012520841
Mashed potato (👉 📊) Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) Weighted median 11 -3.599515833 1.700659489 0.034298807
Mashed potato (👉 📊) Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) Inverse variance weighted 11 -2.459630497 1.024188839 0.016326223
Mashed potato (👉 📊) Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) Inverse variance weighted 11 0.61956151 0.302206426 0.040352053
Mashed potato (👉 📊) Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) Inverse variance weighted 11 -0.625935862 0.299123382 0.036387782
Mashed potato (👉 📊) Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) MR Egger 11 -0.975473763 0.40372626 0.038853515
Mashed potato (👉 📊) Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) Weighted median 11 -4.341838523 1.76664235 0.013983839
Mashed potato (👉 📊) Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) Inverse variance weighted 11 -4.262715538 1.314404755 0.001182463
Mashed potato (👉 📊) Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) MR Egger 11 -6.438409847 2.837570289 0.049444893
Mashed potato (👉 📊) Rheumatoid arthritis (ieu-a-832) Weighted median 4 1.47451878 0.637935983 0.020811329
Mashed potato (👉 📊) Rheumatoid arthritis (ieu-a-833) Weighted median 4 1.058558503 0.50522311 0.036150572
Mashed potato (👉 📊) Fracture resulting from simple fall (ukb-a-332) Inverse variance weighted 11 -0.109731673 0.050006009 0.028208841
Mashed potato (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis (ukb-b-14753) Inverse variance weighted 2 -0.007282604 0.00333533 0.02900096
Mashed potato (👉 📊) Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) Inverse variance weighted 2 0.007533228 0.003286581 0.021898916
Mashed potato (👉 📊) Diagnoses - main ICD10: S82.80 Fractures of other parts of lower leg (closed) (ukb-b-5946) Inverse variance weighted 2 -0.007475709 0.003735302 0.045352902
Mashed potato (👉 📊) Ankle spacing width (ukb-e-3143_AFR) Weighted median 5 1.252013483 0.623361506 0.044591566
Mashed potato (👉 📊) Ankle spacing width (ukb-e-3143_AFR) Inverse variance weighted 5 1.635014332 0.649549646 0.011830822

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Mashed potato Osteoarthritis (self-reported) (ebi-a-GCST005811) rs264633 1.325777975588 0.644015486478545 0.0395314272000412
Mashed potato Osteoarthritis (self-reported) (ebi-a-GCST005811) rs4756830 -1.34784284024927 0.631424863696558 0.0327932668017106
Mashed potato Osteoarthritis (self-reported) (ebi-a-GCST005811) All - MR Egger 1.08832157683668 0.375401445841401 0.0176215409627539
Mashed potato Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) rs264633 -7.18474997723082 2.98662890706223 0.0161442238345114
Mashed potato Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) All - Inverse variance weighted -2.66562728879109 1.29561893684766 0.039646215647784
Mashed potato Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) rs264633 -7.1400708336269 2.98147362126177 0.0166288582387832
Mashed potato Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) All - Inverse variance weighted -2.66509498901888 1.29529512985423 0.0396362810745518
Mashed potato Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) rs4756830 -5.01809259333076 2.143651204918 0.0192368505599281
Mashed potato Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) All - Inverse variance weighted -1.61643690815683 0.694371089773933 0.0199166150899221
Mashed potato Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) rs264633 -7.91851898949525 2.70824347383778 0.0034572256668406
Mashed potato Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) All - Inverse variance weighted -2.94162205291814 1.17487819038691 0.0122878686611235
Mashed potato Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) rs57664184 -18.5285971723329 6.86658684372846 0.0069679787573132
Mashed potato Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) All - Inverse variance weighted -5.85790192816334 2.09471956102957 0.0051657985672253
Mashed potato Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) All - Inverse variance weighted 1.08027227820453 0.548607364725975 0.0489396173467148
Mashed potato Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs55768233 5.71232839518034 2.18258982558079 0.008864791748922
Mashed potato Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) All - Inverse variance weighted 2.10633995754711 0.843509459966752 0.0125208414277545
Mashed potato Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs4756830 -7.26361152079652 3.48121869228418 0.0369320888436549
Mashed potato Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs55768233 7.42498261238249 2.90733496383584 0.0106530175019687
Mashed potato Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) All - Inverse variance weighted -2.45963049732892 1.02418883900873 0.0163262225989932
Mashed potato Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) rs79733344 3.04822482117149 1.29424124083331 0.0185116665955291
Mashed potato Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) All - Inverse variance weighted 0.619561509940249 0.302206426010194 0.0403520533258209
Mashed potato Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) rs115597995 -3.26030580513359 1.54578583675143 0.0349309882156078
Mashed potato Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) rs55768233 -1.88600824162627 0.741453959886296 0.0109697184903318
Mashed potato Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) All - Inverse variance weighted -0.625935862450019 0.29912338220986 0.0363877819914597
Mashed potato Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) All - MR Egger -0.975473762714602 0.403726259673204 0.0388535149500367
Mashed potato Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) All - Inverse variance weighted -4.26271553834336 1.31440475484706 0.0011824634141661
Mashed potato Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) All - MR Egger -6.43840984715185 2.83757028875025 0.049444893286269
Mashed potato Rheumatoid arthritis (ieu-a-833) rs264633 1.24707566412969 0.516331086201534 0.0157238268329056
Mashed potato Rheumatoid arthritis (ieu-a-833) rs58215605 1.65057087185789 0.826234434115117 0.0457488866260935
Mashed potato Fracture resulting from simple fall (ukb-a-332) rs55768233 -0.34049863300953 0.1685723773938 0.0433941995558898
Mashed potato Fracture resulting from simple fall (ukb-a-332) rs58215605 -0.35442704497536 0.168779432621129 0.035733930148549
Mashed potato Fracture resulting from simple fall (ukb-a-332) All - Inverse variance weighted -0.109731672659014 0.0500060093047882 0.0282088408944103
Mashed potato Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis (ukb-b-14753) All - Inverse variance weighted -0.0072826040173549 0.0033353297314922 0.0290009598436288
Mashed potato Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) All - Inverse variance weighted 0.0075332277145112 0.0032865813875193 0.0218989164750142
Mashed potato Diagnoses - main ICD10: S82.80 Fractures of other parts of lower leg (closed) (ukb-b-5946) All - Inverse variance weighted -0.0074757091691953 0.0037353023351763 0.0453529020818451
Mashed potato Ankle spacing width (ukb-e-3143_AFR) rs264633 1.51943456825341 0.581344395431042 0.0089579042831002
Mashed potato Ankle spacing width (ukb-e-3143_AFR) rs57664184 4.8317066386077 1.27444577482675 0.0001499079863696
Mashed potato Ankle spacing width (ukb-e-3143_AFR) All - Inverse variance weighted 1.63501433163665 0.649549645795127 0.0118308221252686