ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Pea | Osteoarthritis (hip) (ebi-a-GCST007091) | rs148417417 | 0.991453365579278 | 0.481500530744903 | 0.0394855305533455 |
| Pea | Osteoarthritis (hip) (ebi-a-GCST007091) | rs7608988 | 1.24555391971649 | 0.515940744987167 | 0.0157723394800413 |
| Pea | Osteoarthritis (hip) (ebi-a-GCST007091) | All - Inverse variance weighted | 0.341426044682203 | 0.161159732975498 | 0.0341279417190879 |
| Pea | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | All - Inverse variance weighted | 0.187724476173772 | 0.0950700346926322 | 0.0483145318926075 |
| Pea | Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) | All - Inverse variance weighted | -1.05506189211176 | 0.44700342480638 | 0.0182601936280733 |
| Pea | Bone mineral density (ebi-a-GCST90014022) | rs5752467 | 0.16801818205465 | 0.0848855709746084 | 0.0477767103463341 |
| Pea | Bone mineral density (ebi-a-GCST90014022) | All - Inverse variance weighted | 0.0571219586594608 | 0.0272257625923699 | 0.035897655052021 |
| Pea | Achilles tendon injury (ebi-a-GCST90018567) | rs148417417 | -4.79213403223865 | 2.03425219684617 | 0.0184867132699691 |
| Pea | Achilles tendon injury (ebi-a-GCST90018567) | All - Inverse variance weighted | -2.08451813105135 | 1.05699318371036 | 0.048595830127015 |
| Pea | Achilles tendon injury (ebi-a-GCST90018787) | rs61995486 | -1.48854070829271 | 0.683849882592038 | 0.0295024485806903 |
| Pea | Achilles tendon injury (ebi-a-GCST90018787) | All - Inverse variance weighted | -0.486759502779937 | 0.220773193339237 | 0.027468524421792 |
| Pea | Compression fracture (ebi-a-GCST90018828) | rs1108523 | -2.09016738161326 | 0.912608293380436 | 0.0220026237732584 |
| Pea | Compression fracture (ebi-a-GCST90018828) | rs7608988 | 3.18163459408753 | 1.30288066915951 | 0.0146061466241616 |
| Pea | Compression fracture (ebi-a-GCST90018828) | All - MR Egger | 1.81311202126367 | 0.746412702057998 | 0.0454804944623346 |
| Pea | Joint disorder (ebi-a-GCST90038654) | All - Inverse variance weighted | -0.0160600915439133 | 0.0081585258167523 | 0.0490100644991583 |
| Pea | Rheumatoid arthritis (ebi-a-GCST90038685) | rs17769165 | 0.0230339188677614 | 0.0094163981435389 | 0.0144391060639866 |
| Pea | Rheumatoid arthritis (ebi-a-GCST90038685) | All - MR Egger | 0.0166147409250074 | 0.0070743534801795 | 0.0434053763877491 |
| Pea | Osteoarthritis (ebi-a-GCST90038686) | rs61995486 | -0.0456292654793129 | 0.0232053334798072 | 0.0492608911127873 |
| Pea | Osteoarthritis (ebi-a-GCST90038686) | All - Inverse variance weighted | -0.0176570505772556 | 0.0067466990172834 | 0.0088670168978647 |
| Pea | Fractures (ebi-a-GCST90038703) | All - Inverse variance weighted | -0.0073584260856653 | 0.0033132008657784 | 0.0263549078608436 |
| Pea | Fracture of pelvis or lower limb (ebi-a-GCST90038706) | rs663060 | -0.0176200611234168 | 0.0072073633580664 | 0.0144960412040356 |
| Pea | Fracture of pelvis or lower limb (ebi-a-GCST90038706) | All - Inverse variance weighted | -0.0062002858265002 | 0.002283034454312 | 0.006611402098527 |
| Pea | Fracture of lower leg or ankle (ebi-a-GCST90038707) | All - MR Egger | -0.0099257579303334 | 0.0043223854848933 | 0.0472800572188335 |
| Pea | Achilles tendinitis (finn-b-M13_ACHILLESTEND) | rs663060 | -3.31616202038637 | 1.34838563319323 | 0.0139186026701861 |
| Pea | Achilles tendinitis (finn-b-M13_ACHILLESTEND) | All - Inverse variance weighted | -0.9077831286037 | 0.455636273476984 | 0.0463335838987477 |
| Pea | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs663060 | -9.29341024314273 | 4.02731436757145 | 0.0210216763984959 |
| Pea | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | All - Inverse variance weighted | -1.45765567430466 | 0.736054873403318 | 0.047662779236269 |
| Pea | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | All - Inverse variance weighted | -2.12614721676982 | 0.985322662776366 | 0.0309419659583138 |
| Pea | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs115234215 | 5.8639368735338 | 2.25719769673704 | 0.0093800285292368 |
| Pea | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | All - Inverse variance weighted | 1.46763474681939 | 0.509234993300151 | 0.003951117228453 |
| Pea | Injuries to the neck (finn-b-ST19_INJURI_NECK) | All - Inverse variance weighted | 0.780886984747698 | 0.316769304182487 | 0.0136952121485427 |
| Pea | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | All - Inverse variance weighted | 3.50146351151759 | 1.57532496629359 | 0.0262365195416604 |
| Pea | Shoulder region (finn-b-Z21_SHOUL_REGION) | rs113111621 | -8.13333710047331 | 3.44816149237707 | 0.0183368021558555 |
| Pea | Shoulder region (finn-b-Z21_SHOUL_REGION) | rs17769165 | 15.8237375438555 | 6.55037454132474 | 0.0157050096267748 |
| Pea | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | All - Inverse variance weighted | -0.0223407322553023 | 0.0088811595911926 | 0.0118857021490181 |
| Pea | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | rs61995486 | -0.0210309654916716 | 0.0104158026996965 | 0.0434726541579506 |
| Pea | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | All - Inverse variance weighted | -0.0089575519361705 | 0.0041497585597576 | 0.0308834000319061 |
| Pea | Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint (ukb-b-19054) | All - Inverse variance weighted | -0.0074433671934791 | 0.0036946427950269 | 0.0439426092341385 |
| Pea | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | rs1108523 | 0.0130722937168812 | 0.0057830767936748 | 0.0237940033838892 |
| Pea | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | All - Inverse variance weighted | 0.0088339717826651 | 0.0038791917863192 | 0.022770034904621 |
| Pea | Operative procedures - main OPCS: W91.9 Unspecified other manipulation of joint (ukb-b-4663) | rs1108523 | 0.0095698544873412 | 0.0041567457313483 | 0.0213212590664881 |
| Pea | Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) | All - Inverse variance weighted | -0.0079869967322843 | 0.003951825063472 | 0.0432703808590536 |
| Pea | Operative procedures - main OPCS: W15.1 Osteotomy of neck of first metatarsal bone (ukb-b-6551) | rs1108523 | 0.0088256791992598 | 0.0043530153923795 | 0.0426127011298247 |
| Pea | Operative procedures - main OPCS: W15.1 Osteotomy of neck of first metatarsal bone (ukb-b-6551) | All - Inverse variance weighted | 0.0067009815398253 | 0.0029199265084239 | 0.021738027479173 |
| Pea | Operative procedures - main OPCS: W90.1 Aspiration of joint (ukb-b-9333) | All - Inverse variance weighted | 0.0061473105243731 | 0.0029725779889374 | 0.0386394143671556 |
| Pea | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | All - Inverse variance weighted | 0.0040699899173805 | 0.0019346008256191 | 0.0353969478403333 |
| Pea | Heel bone mineral density (BMD) (ukb-e-3148_EAS) | rs5752467 | 2.40606588718802 | 1.07492619230319 | 0.0251979462239747 |
| Pea | Heel bone mineral density (BMD) (ukb-e-3148_EAS) | All - Inverse variance weighted | 1.08420600496618 | 0.426765596398334 | 0.0110688154459465 |
| Pea | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | rs5752467 | 2.53395587578631 | 1.09205044501381 | 0.0203211284596778 |
| Pea | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | All - Inverse variance weighted | 1.14566893106597 | 0.433549474548405 | 0.0082288368945631 |