ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Salted nuts | Rheumatoid arthritis (ebi-a-GCST000679) | rs1381597 | -8.77113445921528 | 3.18369650741315 | 0.0058689285528572 |
| Salted nuts | Rheumatoid arthritis (ebi-a-GCST000679) | rs906822 | -6.94027442016718 | 3.47974125722115 | 0.0460996210782817 |
| Salted nuts | Rheumatoid arthritis (ebi-a-GCST000679) | All - Inverse variance weighted | -4.61372097842694 | 1.43591985594759 | 0.0013132110488179 |
| Salted nuts | Menstruation quality of life impact (joint pain) (ebi-a-GCST006647) | rs4972701 | 27.7224171290425 | 11.6590459655622 | 0.017418142422665 |
| Salted nuts | Menstruation quality of life impact (joint pain) (ebi-a-GCST006647) | rs906822 | 14.8730987873079 | 6.5534118081035 | 0.0232367259124185 |
| Salted nuts | Menstruation quality of life impact (joint pain) (ebi-a-GCST006647) | All - Inverse variance weighted | 10.9212462371854 | 4.96541584220645 | 0.0278450485436894 |
| Salted nuts | Heel bone mineral density (ebi-a-GCST006979) | rs4972701 | 0.719063487174153 | 0.244846525880381 | 0.0033162571353995 |
| Salted nuts | Heel bone mineral density (ebi-a-GCST006979) | All - MR Egger | -0.20559810764849 | 0.0957426521407723 | 0.0435903010877289 |
| Salted nuts | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | rs1381597 | -3.80719402548524 | 1.0152517401294 | 0.0001768345704016 |
| Salted nuts | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | All - Inverse variance weighted | -0.400016654857611 | 0.203230779909534 | 0.0490349384366558 |
| Salted nuts | Osteoprotegerin levels (ebi-a-GCST90000490) | All - Inverse variance weighted | 3.7671394657047 | 1.53254990388405 | 0.0139679720034944 |
| Salted nuts | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | rs147958200 | 9.65784352858996 | 3.82010278415328 | 0.011466101808423 |
| Salted nuts | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | rs150856188 | 7.91679759961886 | 3.74299297523593 | 0.0344215810036948 |
| Salted nuts | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | rs506454 | 4.83527586331325 | 2.43706785762861 | 0.0472497457400546 |
| Salted nuts | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | All - MR Egger | 3.59138083111934 | 1.44118067309108 | 0.0226832549849001 |
| Salted nuts | Osteoporosis (ebi-a-GCST90038656) | rs150856188 | 0.0650779008829105 | 0.032695563146851 | 0.0465446950025486 |
| Salted nuts | Osteoporosis (ebi-a-GCST90038656) | rs9613266 | -0.0737129041616969 | 0.0326725766416299 | 0.024063786569674 |
| Salted nuts | Osteoporosis (ebi-a-GCST90038656) | All - MR Egger | 0.0403838167657027 | 0.0141763094376925 | 0.0106619046998519 |
| Salted nuts | Rheumatoid arthritis (ebi-a-GCST90038685) | rs506454 | -0.0515298290999226 | 0.0244465940727623 | 0.0350436980942058 |
| Salted nuts | Rheumatoid arthritis (ebi-a-GCST90038685) | All - MR Egger | -0.0272775435589135 | 0.0119825028782107 | 0.0352669713333013 |
| Salted nuts | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | rs10845793 | 17.9592086915215 | 9.15582525015706 | 0.0498199935917314 |
| Salted nuts | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | rs1381597 | -35.8238828302801 | 12.8356827144931 | 0.005255189297045 |
| Salted nuts | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | rs55768166 | -27.6186547491513 | 12.448137091604 | 0.0265072887836151 |
| Salted nuts | Chondromalacia (finn-b-M13_CHONDROMALACIA) | rs144425541 | -20.1911940995997 | 7.26121055732775 | 0.0054243081451504 |
| Salted nuts | Chondromalacia (finn-b-M13_CHONDROMALACIA) | rs73085383 | -22.1104421014185 | 9.79165211973423 | 0.0239399829728218 |
| Salted nuts | Chondromalacia (finn-b-M13_CHONDROMALACIA) | All - MR Egger | -5.47420110812255 | 2.49923121033321 | 0.0399239434153987 |
| Salted nuts | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs10845793 | 24.5636617171578 | 12.4810370983313 | 0.0490589974925776 |
| Salted nuts | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs146665115 | 15.1422409092022 | 7.06474682431395 | 0.0320848252711846 |
| Salted nuts | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs75342409 | 36.3688746155085 | 11.8574507328289 | 0.0021609241729825 |
| Salted nuts | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | All - Inverse variance weighted | 5.35827511148784 | 2.66649165421565 | 0.0444857187280644 |
| Salted nuts | Other juvenile arthritis (finn-b-M13_JUVEARTH) | rs147958200 | 34.0628430296378 | 14.9748029138809 | 0.0229253001334726 |
| Salted nuts | Other juvenile arthritis (finn-b-M13_JUVEARTH) | All - Inverse variance weighted | 2.25668506488232 | 1.09162653516973 | 0.0387088680437085 |
| Salted nuts | Other juvenile arthritis (finn-b-M13_JUVEARTH) | All - MR Egger | 3.80185709889136 | 1.80932523307737 | 0.0478668801469935 |
| Salted nuts | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs10996983 | 4.30212024603861 | 2.14908486119835 | 0.0453021322433963 |
| Salted nuts | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs144425541 | -3.40329560924071 | 1.57465916248451 | 0.0306729200049368 |
| Salted nuts | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs79900875 | -5.61597619496658 | 2.8603759351229 | 0.0496032013348541 |
| Salted nuts | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | All - Inverse variance weighted | -0.609515203882645 | 0.308172816507064 | 0.0479472426078411 |
| Salted nuts | Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) | All - Inverse variance weighted | -1.44586766164593 | 0.707794716276917 | 0.0410743932094603 |
| Salted nuts | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | rs150856188 | 153.515929894274 | 52.8200423715928 | 0.0036561907857002 |
| Salted nuts | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | rs506454 | 15.3329872956041 | 6.76438994196004 | 0.0234072515774035 |
| Salted nuts | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | rs9613266 | 41.2881596337965 | 19.4577866606492 | 0.0338431920790804 |
| Salted nuts | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | All - Inverse variance weighted | 7.14351996617686 | 3.47104956880698 | 0.0395873692154951 |
| Salted nuts | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | All - Inverse variance weighted | -3.8640922112169 | 1.70481411668661 | 0.0234160875818091 |
| Salted nuts | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -4.4468355988656 | 1.81701113993854 | 0.0143916862936232 |
| Salted nuts | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | rs10996983 | 5.96134017564028 | 2.44537413434151 | 0.0147768282414557 |
| Salted nuts | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | rs80265037 | 7.51958651024682 | 2.64848120686738 | 0.0045225801053985 |
| Salted nuts | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | All - MR Egger | 1.47806546527834 | 0.62883544803857 | 0.0285989947250733 |
| Salted nuts | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs146665115 | 10.6794755082099 | 3.76831013659846 | 0.0045966103334613 |
| Salted nuts | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs75342409 | 15.1367504709933 | 5.7027615601671 | 0.0079476834053825 |
| Salted nuts | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs9613266 | 18.3359659585442 | 8.40720802037329 | 0.0291847778169388 |
| Salted nuts | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | 3.44423517979611 | 1.25874274179882 | 0.0062143741441436 |
| Salted nuts | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | rs906822 | -16.8103760597058 | 7.48298871623268 | 0.0246733512805342 |
| Salted nuts | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | All - Inverse variance weighted | -3.04110405018171 | 1.35846152021076 | 0.0251794571216544 |
| Salted nuts | Shoulder region (finn-b-Z21_SHOUL_REGION) | rs506454 | -15.1775478878283 | 5.66243556897762 | 0.007353595501025 |
| Salted nuts | Shoulder region (finn-b-Z21_SHOUL_REGION) | All - MR Egger | -8.64060874678078 | 4.05667483043079 | 0.0451632744783041 |
| Salted nuts | Rheumatoid arthritis (ieu-a-834) | rs1381597 | -8.77113445921528 | 3.31851952123629 | 0.0082154021310112 |
| Salted nuts | Rheumatoid arthritis (ieu-a-834) | rs906822 | -6.94027442016718 | 3.54094235595576 | 0.0499948857827189 |
| Salted nuts | Rheumatoid arthritis (ieu-a-834) | All - Inverse variance weighted | -4.54229973049274 | 1.43629655469675 | 0.0015641629346871 |
| Salted nuts | Bone sialoprotein 2 (prot-a-1396) | rs80265037 | -7.18123428558094 | 3.23184711146372 | 0.0262818417944997 |
| Salted nuts | Bone sialoprotein 2 (prot-a-1396) | All - MR Egger | 2.53475579914036 | 1.16981533057048 | 0.0418983436113173 |
| Salted nuts | Bone morphogenetic protein 6 (prot-a-256) | rs138188349 | 6.39529500413475 | 3.11303675937663 | 0.0399409607002047 |
| Salted nuts | Bone morphogenetic protein 6 (prot-a-256) | rs73085383 | -8.55896744530801 | 2.94608951600342 | 0.003670232011192 |
| Salted nuts | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | All - Inverse variance weighted | -0.0144089617012201 | 0.0068551181403757 | 0.0355596224865428 |
| Salted nuts | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | All - MR Egger | -0.0295052347800927 | 0.0126059802392221 | 0.0292031071796854 |
| Salted nuts | Knee pain for 3+ months (ukb-a-353) | rs117345122 | -0.629491126630122 | 0.277310705614378 | 0.0232084965494215 |
| Salted nuts | Knee pain for 3+ months (ukb-a-353) | rs146665115 | 0.629608278262882 | 0.300496580030405 | 0.0361508979272067 |
| Salted nuts | Knee pain for 3+ months (ukb-a-353) | All - Inverse variance weighted | -0.120682998885054 | 0.0585836821340069 | 0.0393975393877845 |
| Salted nuts | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs80265037 | 1.19526423558649 | 0.559702833408199 | 0.0327174444497754 |
| Salted nuts | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs9613266 | 1.11485380871023 | 0.531984139776281 | 0.0361130423626804 |
| Salted nuts | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - Inverse variance weighted | 0.243501418249676 | 0.121572921627332 | 0.0451853620273514 |
| Salted nuts | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | rs13284665 | -0.0687071537859749 | 0.034432813397858 | 0.0459995306889369 |
| Salted nuts | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | rs1381597 | -0.112080407937818 | 0.0450213384160381 | 0.0127924629511145 |
| Salted nuts | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | All - Inverse variance weighted | -0.020795155223119 | 0.0090543447491315 | 0.0216356269423814 |
| Salted nuts | Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) | rs1381597 | -0.0364284410688667 | 0.0155963214045283 | 0.0195065040781718 |
| Salted nuts | Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) | All - Inverse variance weighted | -0.0229198775911766 | 0.0092977325541008 | 0.0136973493147369 |
| Salted nuts | Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) | All - Inverse variance weighted | 0.0247870127098543 | 0.0093291700942463 | 0.0078854290112437 |
| Salted nuts | Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) | rs9613266 | -0.0438762128880436 | 0.0180311401953515 | 0.0149595164258808 |
| Salted nuts | Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) | All - Inverse variance weighted | -0.0210696718107675 | 0.0093156530063411 | 0.0237128959399072 |
| Salted nuts | Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) | rs4972701 | -0.033711368112533 | 0.0149839118532238 | 0.0244592569528461 |
| Salted nuts | Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) | rs9613266 | -0.0382975403758744 | 0.0144317720254021 | 0.0079615441506277 |
| Salted nuts | Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) | All - Inverse variance weighted | -0.0293997081196231 | 0.0085472840824489 | 0.000582456229663 |
| Salted nuts | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs1381597 | -0.120253547035767 | 0.0559649061315162 | 0.031655703856133 |
| Salted nuts | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs4972701 | -0.11803872622948 | 0.055953681071992 | 0.0348946106115584 |
| Salted nuts | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs80261113 | -0.125043046721282 | 0.0507296070229911 | 0.0137054221662728 |
| Salted nuts | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | All - Inverse variance weighted | -0.0273328694297705 | 0.0112523589136283 | 0.0151372310294124 |
| Salted nuts | Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) | rs147958200 | 0.0423317283704221 | 0.0193425057379503 | 0.0286307390315673 |
| Salted nuts | Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) | rs73085383 | 0.055510288485812 | 0.0170563543686452 | 0.0011358317588143 |
| Salted nuts | Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) | All - Inverse variance weighted | 0.013384307197854 | 0.0043345335831622 | 0.0020162309142292 |
| Salted nuts | Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) | All - MR Egger | 0.0204919440995722 | 0.0085372799933972 | 0.0274105715363165 |
| Salted nuts | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs906822 | -0.0469608921619646 | 0.0221438499186488 | 0.0339454227604157 |
| Salted nuts | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | All - MR Egger | 0.0183676065755625 | 0.0086957103594411 | 0.0474384280453156 |
| Salted nuts | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | rs13284665 | 0.0427369652660948 | 0.0172430265644796 | 0.0131933453101049 |
| Salted nuts | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | rs4972701 | 0.0640445587660732 | 0.0225795439847133 | 0.0045625642128847 |
| Salted nuts | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | All - Inverse variance weighted | 0.0106478671827312 | 0.0047042517641627 | 0.0236075900752091 |
| Salted nuts | Ankle spacing width (left) (ukb-e-4100_CSA) | rs4972701 | 5.508506782624 | 2.39355354025904 | 0.0213694409168641 |
| Salted nuts | Ankle spacing width (left) (ukb-e-4100_CSA) | All - Inverse variance weighted | 1.05036774470566 | 0.515886292273709 | 0.0417458292402391 |
| Salted nuts | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | rs146665115 | -4.13779595034645 | 1.96183612191251 | 0.0349321070750758 |
| Salted nuts | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | rs906822 | -6.24526549459525 | 3.10517683171839 | 0.0442997847458559 |
| Salted nuts | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | rs146665115 | -4.27579667596317 | 1.97430070358112 | 0.0303320415302825 |
| Salted nuts | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | rs4972701 | -5.12580490738481 | 2.57223664577141 | 0.0462896670329606 |
| Salted nuts | Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) | rs1381597 | -40.4287746515813 | 15.7847472929642 | 0.0104294550578503 |
| Salted nuts | Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) | rs506454 | 6.86431527553023 | 3.18373215569477 | 0.0310790361847662 |
| Salted nuts | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | rs55830729 | 17.0350297093703 | 8.08989881411133 | 0.0352290255263917 |
| Salted nuts | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | All - Inverse variance weighted | 7.35786112716906 | 2.82788623021845 | 0.0092710415499582 |
| Salted nuts | Pain in joint (ukb-e-745_CSA) | rs506454 | 10.8835342480202 | 5.42650075360356 | 0.0448961018672474 |
| Salted nuts | Pain in joint (ukb-e-745_CSA) | All - Inverse variance weighted | 6.389293546077 | 2.52946630687476 | 0.0115387443422099 |
| Salted nuts | Pain in joint (ukb-e-745_CSA) | All - MR Egger | 13.2616323038234 | 4.94978341172139 | 0.020065298496551 |