ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Poultry (ukb-b-16010)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Poultry (👉 📊) Osteoporosis (bbj-a-137) Inverse variance weighted 4 -1.169076071 0.480491829 0.014970906
Poultry (👉 📊) Total body bone mineral density (age 0-15) (ebi-a-GCST005345) Weighted median 9 0.55552567 0.26572858 0.03656613
Poultry (👉 📊) Total body bone mineral density (age 0-15) (ebi-a-GCST005345) Inverse variance weighted 9 0.441806425 0.206660071 0.032529629
Poultry (👉 📊) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (ebi-a-GCST005528) Wald ratio 1 -4.920762804 2.167618518 0.023200061
Poultry (👉 📊) Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) Weighted median 9 0.854075479 0.382673826 0.025624032
Poultry (👉 📊) Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) Inverse variance weighted 9 0.678087753 0.333396763 0.041964075
Poultry (👉 📊) Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) Inverse variance weighted 9 1.89125339 0.936930429 0.043532627
Poultry (👉 📊) Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) Weighted median 9 0.616423101 0.314226389 0.049795496
Poultry (👉 📊) Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) Inverse variance weighted 9 0.554797867 0.241459472 0.02157971
Poultry (👉 📊) Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) MR Egger 9 3.360873599 1.408543163 0.048448311
Poultry (👉 📊) Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) Weighted median 9 2.024961297 0.940086397 0.031238904
Poultry (👉 📊) Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) Inverse variance weighted 9 2.298073944 0.674840429 0.000660771
Poultry (👉 📊) Otherdisorders of bone (finn-b-M13_OTHERBONE) Inverse variance weighted 9 1.023612924 0.368036572 0.005414494
Poultry (👉 📊) Other shoulder lesions (finn-b-M13_SHOULDERNAS) Inverse variance weighted 9 1.364307746 0.684506124 0.046247525
Poultry (👉 📊) Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) MR Egger 9 11.45195948 4.750342922 0.046721484
Poultry (👉 📊) Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) Inverse variance weighted 9 5.580426614 2.159273718 0.009754864
Poultry (👉 📊) Neck/shoulder pain for 3+ months (ukb-a-341) Inverse variance weighted 9 -0.082026075 0.036418736 0.024303052
Poultry (👉 📊) Fractured bone site(s): Arm (ukb-a-440) Inverse variance weighted 9 0.008960715 0.003681347 0.014929451
Poultry (👉 📊) Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) MR Egger 9 -0.027075797 0.011071306 0.044393905
Poultry (👉 📊) Operation code: knee replacement/revision (ukb-b-11120) Inverse variance weighted 5 0.011261584 0.005702241 0.048274949
Poultry (👉 📊) Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) Weighted median 4 0.011135187 0.005647988 0.048663114
Poultry (👉 📊) Neck/shoulder pain for 3+ months (ukb-b-16118) Weighted median 9 -0.097224778 0.042286103 0.021492821
Poultry (👉 📊) Neck/shoulder pain for 3+ months (ukb-b-16118) Inverse variance weighted 9 -0.084016997 0.030023241 0.005135668
Poultry (👉 📊) Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) Wald ratio 1 0.00934352 0.004132796 0.023770232
Poultry (👉 📊) Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) Inverse variance weighted 4 -0.007610523 0.003497601 0.029560769
Poultry (👉 📊) Ankle spacing width (right) (ukb-b-8607) Inverse variance weighted 9 0.121924115 0.062188415 0.049930379
Poultry (👉 📊) Ankle spacing width (ukb-e-3143_AFR) Inverse variance weighted 7 -1.047155261 0.432272691 0.015416612

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Poultry Osteoporosis (bbj-a-137) All - Inverse variance weighted -1.16907607116014 0.480491829218167 0.0149709056994336
Poultry Total body bone mineral density (age 0-15) (ebi-a-GCST005345) All - Inverse variance weighted 0.44180642484431 0.206660070708096 0.0325296294455844
Poultry Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (ebi-a-GCST005528) rs34010017 -4.92076280435775 2.16761851844502 0.0232000610182596
Poultry Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs2869444 1.74177930522489 0.710426106545836 0.0142167787824899
Poultry Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs34010017 1.36335999047487 0.654725854781418 0.0373116820558514
Poultry Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs62157712 1.81806180936738 0.700034519776798 0.0094013705311708
Poultry Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) All - Inverse variance weighted 0.678087753182992 0.333396762598666 0.0419640753495433
Poultry Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) All - Inverse variance weighted 1.89125338969569 0.936930428757898 0.0435326274568662
Poultry Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) rs75615794 1.08762045654286 0.422677144248885 0.0100771482958953
Poultry Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) All - Inverse variance weighted 0.554797866828563 0.241459471582906 0.0215797095392747
Poultry Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) rs34010017 4.74272220348064 1.85343202428909 0.0105008016408293
Poultry Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) rs62128640 4.59881115340621 1.57231525061411 0.0034460476349954
Poultry Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) rs75615794 2.27060100050773 1.15076429821419 0.0484814023473989
Poultry Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) All - Inverse variance weighted 2.29807394420475 0.674840428631584 0.0006607711993056
Poultry Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) All - MR Egger 3.36087359924851 1.40854316274997 0.0484483106933548
Poultry Otherdisorders of bone (finn-b-M13_OTHERBONE) rs74922770 3.77593637323642 1.76667015497607 0.0325721150525759
Poultry Otherdisorders of bone (finn-b-M13_OTHERBONE) rs75615794 1.58632794076334 0.675252510934194 0.0188119467191277
Poultry Otherdisorders of bone (finn-b-M13_OTHERBONE) All - Inverse variance weighted 1.02361292411183 0.36803657155044 0.0054144938920287
Poultry Other shoulder lesions (finn-b-M13_SHOULDERNAS) rs35856977 6.40920369749638 2.72655488991422 0.0187401454993674
Poultry Other shoulder lesions (finn-b-M13_SHOULDERNAS) rs75615794 2.52446501702306 1.15205294804422 0.028431885922647
Poultry Other shoulder lesions (finn-b-M13_SHOULDERNAS) All - Inverse variance weighted 1.36430774577315 0.684506124061558 0.0462475248245931
Poultry Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) All - MR Egger 11.4519594792117 4.75034292166327 0.046721484172972
Poultry Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) All - Inverse variance weighted 5.58042661404733 2.15927371838305 0.0097548638131767
Poultry Neck/shoulder pain for 3+ months (ukb-a-341) All - Inverse variance weighted -0.0820260748508606 0.0364187364582117 0.0243030518706861
Poultry Fractured bone site(s): Arm (ukb-a-440) All - Inverse variance weighted 0.0089607149027791 0.0036813470153541 0.0149294511613796
Poultry Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) All - MR Egger -0.0270757974320472 0.0110713058118444 0.0443939050095993
Poultry Operation code: knee replacement/revision (ukb-b-11120) rs34010017 0.0271839739646379 0.0093982497569106 0.0038224918321712
Poultry Operation code: knee replacement/revision (ukb-b-11120) All - Inverse variance weighted 0.0112615842006173 0.005702240961829 0.0482749487145024
Poultry Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) rs34010017 0.016140654455976 0.0075526759669001 0.0325916823905942
Poultry Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) rs62157712 -0.0296921670453726 0.0081954122837298 0.0002911799405799
Poultry Neck/shoulder pain for 3+ months (ukb-b-16118) rs10810867 -0.22859365513054 0.0914233792079876 0.0124058368640165
Poultry Neck/shoulder pain for 3+ months (ukb-b-16118) All - Inverse variance weighted -0.0840169972929392 0.0300232405198902 0.0051356675627532
Poultry Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) rs34010017 0.009343519933324 0.0041327962216974 0.0237702320319749
Poultry Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) rs10810867 -0.0142148181879512 0.0072322151386359 0.049358005132464
Poultry Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) All - Inverse variance weighted -0.0076105229695159 0.0034976013838169 0.0295607690624432
Poultry Ankle spacing width (right) (ukb-b-8607) rs10810867 0.288302806449437 0.142353099912298 0.0428401203489796
Poultry Ankle spacing width (right) (ukb-b-8607) rs2869444 0.454656580395771 0.141570027903643 0.0013202957202047
Poultry Ankle spacing width (right) (ukb-b-8607) rs34010017 0.291344035877999 0.128223364356161 0.0230768311497416
Poultry Ankle spacing width (right) (ukb-b-8607) All - Inverse variance weighted 0.121924115240983 0.0621884150612206 0.0499303794682694
Poultry Ankle spacing width (ukb-e-3143_AFR) All - Inverse variance weighted -1.04715526149119 0.432272690884185 0.0154166120776984