ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Side salad (ukb-b-1604)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Side salad (👉 📊) Heel bone mineral density T score (ebi-a-GCST90025982) Inverse variance weighted 5 -0.070911345 0.024771887 0.004202159
Side salad (👉 📊) Arthritis (not osteoarthritis) (ebi-a-GCST90038699) MR Egger 15 -0.006184981 0.002862428 0.049965457
Side salad (👉 📊) Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) Inverse variance weighted 17 1.199680058 0.502183109 0.016897543
Side salad (👉 📊) Achilles tendinitis (finn-b-M13_ACHILLESTEND) Weighted median 17 -0.722175623 0.323221211 0.025462838
Side salad (👉 📊) Contracture of joint (finn-b-M13_CONTRACTUREJOINT) Inverse variance weighted 17 -1.778102673 0.680783304 0.009005422
Side salad (👉 📊) Infective bursitis (finn-b-M13_INFBURSA) MR Egger 17 1.9890644 0.812578362 0.027156175
Side salad (👉 📊) Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) Inverse variance weighted 17 -0.838472859 0.355052236 0.018198821
Side salad (👉 📊) Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) Inverse variance weighted 17 -0.983668989 0.455022634 0.030633416
Side salad (👉 📊) Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) Weighted median 17 -3.355049288 1.321491894 0.01112224
Side salad (👉 📊) Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) Inverse variance weighted 17 -2.439031479 0.936204602 0.00918117
Side salad (👉 📊) Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) Weighted median 17 -0.504803483 0.237203771 0.033325251
Side salad (👉 📊) Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) Inverse variance weighted 17 -0.435637404 0.169067124 0.009974482
Side salad (👉 📊) Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) MR Egger 17 0.637934237 0.291679951 0.044988397
Side salad (👉 📊) Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) MR Egger 17 1.143642507 0.50693814 0.039432224
Side salad (👉 📊) Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) Inverse variance weighted 17 0.575816328 0.293106012 0.049468355
Side salad (👉 📊) Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) Inverse variance weighted 17 2.01418188 0.968057279 0.037466569
Side salad (👉 📊) Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) Inverse variance weighted 17 -1.197651953 0.585284442 0.040729485
Side salad (👉 📊) Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) Weighted median 17 -1.356697388 0.626806978 0.030429215
Side salad (👉 📊) Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) Inverse variance weighted 17 -1.169084089 0.469475272 0.01276737
Side salad (👉 📊) Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) MR Egger 17 -0.852099208 0.318501426 0.017292429
Side salad (👉 📊) Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) Inverse variance weighted 17 -0.384654778 0.187985555 0.040737359
Side salad (👉 📊) Hip osteoarthritis (ieu-a-1169) Inverse variance weighted 3 0.97686468 0.46897445 0.037252992
Side salad (👉 📊) Bone sialoprotein 2 (prot-a-1396) Weighted median 16 0.532890105 0.246757984 0.030806297
Side salad (👉 📊) Fractured bone site(s): Arm (ukb-a-440) MR Egger 17 -0.008081508 0.003444456 0.03311954
Side salad (👉 📊) Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) Inverse variance weighted 5 -0.003798139 0.001775807 0.03244989
Side salad (👉 📊) Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) Weighted median 5 0.004595943 0.002305671 0.046226259
Side salad (👉 📊) Diagnoses - main ICD10: M51.3 Other specified intervertebral disk degeneration (ukb-b-19807) Inverse variance weighted 4 -0.003171975 0.001475609 0.031586508
Side salad (👉 📊) Ankle spacing width (ukb-b-4080) Weighted median 18 0.047692125 0.023801907 0.045101107
Side salad (👉 📊) Operative procedures - main OPCS: W91.9 Unspecified other manipulation of joint (ukb-b-4663) Weighted median 4 -0.004388505 0.001807439 0.015181324
Side salad (👉 📊) Operative procedures - main OPCS: W91.9 Unspecified other manipulation of joint (ukb-b-4663) Inverse variance weighted 4 -0.003812763 0.001475677 0.009773618
Side salad (👉 📊) Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) Weighted median 5 -0.005247256 0.002637139 0.046618104
Side salad (👉 📊) Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) Inverse variance weighted 5 -0.005096132 0.002473629 0.039380882
Side salad (👉 📊) Fractured/broken bones in last 5 years (ukb-e-2463_CSA) MR Egger 12 -2.360948036 0.813534788 0.015777123
Side salad (👉 📊) Fractured/broken bones in last 5 years (ukb-e-2463_CSA) Weighted median 12 -1.479692175 0.658624874 0.024663122
Side salad (👉 📊) Fractured/broken bones in last 5 years (ukb-e-2463_CSA) Inverse variance weighted 12 -1.359079914 0.545770883 0.01276704
Side salad (👉 📊) Fractured/broken bones in last 5 years (ukb-e-2463_CSA) Weighted mode 12 -1.786183513 0.67213054 0.022286163
Side salad (👉 📊) Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) Inverse variance weighted 12 -0.842291999 0.428482385 0.049326754
Side salad (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) Inverse variance weighted 12 0.254319809 0.122106138 0.03727159

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Side salad Heel bone mineral density T score (ebi-a-GCST90025982) rs114485796 -0.124627650112392 0.0549241554409172 0.0232630767080731
Side salad Heel bone mineral density T score (ebi-a-GCST90025982) rs6777760 -0.104464759972774 0.049807150769395 0.0359595272781841
Side salad Heel bone mineral density T score (ebi-a-GCST90025982) All - Inverse variance weighted -0.0709113451782711 0.0247718872067781 0.0042021592830729
Side salad Arthritis (not osteoarthritis) (ebi-a-GCST90038699) All - MR Egger -0.0061849808186642 0.0028624275992172 0.049965457003802
Side salad Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) rs114485796 5.55492666203082 2.72490580073419 0.0414923957375968
Side salad Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) rs62193132 5.81200779846794 2.52068589674706 0.021126018600376
Side salad Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) All - Inverse variance weighted 1.19968005836698 0.502183109280975 0.0168975432386316
Side salad Contracture of joint (finn-b-M13_CONTRACTUREJOINT) rs7007359 -7.77176664554966 3.17285289042392 0.0143071801353064
Side salad Contracture of joint (finn-b-M13_CONTRACTUREJOINT) All - Inverse variance weighted -1.77810267251682 0.680783304048929 0.0090054220549942
Side salad Infective bursitis (finn-b-M13_INFBURSA) rs117937572 3.29585976371414 1.37821787705599 0.0167846028118368
Side salad Infective bursitis (finn-b-M13_INFBURSA) All - MR Egger 1.98906439971419 0.812578362384871 0.0271561754676297
Side salad Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) rs4886903 -3.71670407293352 1.56040677140421 0.0172244376004266
Side salad Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) All - Inverse variance weighted -0.838472859129047 0.355052235718796 0.0181988210659967
Side salad Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) rs150619835 -7.23881214327074 3.36669699727025 0.0315454986104813
Side salad Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) rs2684857 -5.59956760095745 2.24847502123388 0.0127604921992326
Side salad Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) rs8104604 -3.91794418436439 1.78453681497623 0.0281280075935701
Side salad Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) All - Inverse variance weighted -0.983668988939663 0.455022633863881 0.0306334160177011
Side salad Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) All - Inverse variance weighted -2.43903147914576 0.936204601959408 0.0091811698861069
Side salad Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) rs5769096 -1.23584735215 0.544525635363552 0.0232327591905571
Side salad Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) All - Inverse variance weighted -0.435637403501241 0.169067123757792 0.0099744819215862
Side salad Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) rs114485796 1.73844138622508 0.775425715995278 0.0249666294651899
Side salad Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) rs5769096 1.03635524149837 0.460462922070101 0.0244057364025108
Side salad Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) rs7007359 -1.35979409589597 0.6812223833241 0.0459220651187594
Side salad Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) rs72838032 1.88693536323269 0.760265477509207 0.0130668280019046
Side salad Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) All - MR Egger 0.637934236757054 0.291679950751468 0.0449883966557546
Side salad Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) rs117937572 1.97416626541336 0.861822318057794 0.0219814501638752
Side salad Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) rs4886903 3.34699097030116 1.23418932790508 0.006689992729836
Side salad Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) All - Inverse variance weighted 0.575816328351724 0.293106012376325 0.0494683548898183
Side salad Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) All - MR Egger 1.14364250652059 0.506938139950335 0.0394322242090695
Side salad Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) rs116799944 6.34552510287721 2.98605558509191 0.0335822263847507
Side salad Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) All - Inverse variance weighted 2.01418188043004 0.968057279073304 0.0374665685400367
Side salad Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) rs116799944 3.58510865424465 1.81264835040628 0.0479479895514532
Side salad Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) rs62193132 -6.47825486252898 2.81543114167728 0.0213926789821435
Side salad Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) rs9458781 -6.19363217192324 2.83458569158584 0.0288872316225169
Side salad Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) All - Inverse variance weighted -1.19765195307141 0.585284441973664 0.0407294846365438
Side salad Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) rs62193132 -5.65849465006678 2.35796195944183 0.0164067393126248
Side salad Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) All - Inverse variance weighted -1.16908408894093 0.469475271819552 0.0127673702542299
Side salad Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) rs117114624 -1.51421598894475 0.628473141042604 0.0159806693549103
Side salad Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) rs150619835 -3.58342294648027 1.43353461824799 0.0124294487261551
Side salad Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) All - Inverse variance weighted -0.384654777579513 0.187985554608295 0.0407373587685495
Side salad Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) All - MR Egger -0.852099208355844 0.318501425779471 0.0172924294087923
Side salad Hip osteoarthritis (ieu-a-1169) All - Inverse variance weighted 0.976864679830315 0.468974450038354 0.0372529922186986
Side salad Fractured bone site(s): Arm (ukb-a-440) rs116799944 -0.0147842613562628 0.0069054785517232 0.0322783384207496
Side salad Fractured bone site(s): Arm (ukb-a-440) rs8104604 -0.0206204416226317 0.0076477722514571 0.0070121279054724
Side salad Fractured bone site(s): Arm (ukb-a-440) All - MR Egger -0.0080815077180626 0.0034444555575113 0.0331195401421231
Side salad Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) rs9458781 -0.0090089876345881 0.0041745517889419 0.0309221541358426
Side salad Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) All - Inverse variance weighted -0.0037981386019051 0.0017758066267005 0.0324498898776102
Side salad Diagnoses - main ICD10: M51.3 Other specified intervertebral disk degeneration (ukb-b-19807) All - Inverse variance weighted -0.0031719747720412 0.0014756085066601 0.0315865075610012
Side salad Ankle spacing width (ukb-b-4080) rs112562181 -0.166339453222872 0.070939249928195 0.0190364967148497
Side salad Ankle spacing width (ukb-b-4080) rs6777760 0.133083051955852 0.0603704840582418 0.0274934826117778
Side salad Ankle spacing width (ukb-b-4080) rs76123066 -0.138152536595867 0.0695774433122847 0.0470784509821788
Side salad Operative procedures - main OPCS: W91.9 Unspecified other manipulation of joint (ukb-b-4663) All - Inverse variance weighted -0.0038127630177312 0.0014756774498912 0.0097736178042164
Side salad Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) rs9458781 -0.0128118278395025 0.0044481142825033 0.0039731838699304
Side salad Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) All - Inverse variance weighted -0.0050961324410016 0.0024736288514643 0.0393808820797975
Side salad Fractured/broken bones in last 5 years (ukb-e-2463_CSA) rs150619835 -3.00603854743982 1.33261642815783 0.024086807672564
Side salad Fractured/broken bones in last 5 years (ukb-e-2463_CSA) rs2684857 -3.93174272256969 2.00046328468844 0.0493660989915455
Side salad Fractured/broken bones in last 5 years (ukb-e-2463_CSA) rs76123066 -1.79212112514351 0.572707376578645 0.0017527753901836
Side salad Fractured/broken bones in last 5 years (ukb-e-2463_CSA) All - Inverse variance weighted -1.35907991384156 0.545770883064864 0.0127670398745635
Side salad Fractured/broken bones in last 5 years (ukb-e-2463_CSA) All - MR Egger -2.36094803574474 0.813534788062546 0.0157771232597575
Side salad Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) All - Inverse variance weighted -0.842291998888013 0.428482384756708 0.0493267540329519
Side salad Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) All - Inverse variance weighted 0.254319808908559 0.12210613810936 0.0372715901731473