ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Sprouts | Total body bone mineral density (ebi-a-GCST005348) | rs1475680 | 1.20191613167916 | 0.49116764996504 | 0.0144027330613773 |
| Sprouts | Total body bone mineral density (ebi-a-GCST005348) | rs2148815 | 1.40461698396197 | 0.492012728845437 | 0.004305869022087 |
| Sprouts | Total body bone mineral density (ebi-a-GCST005348) | All - Inverse variance weighted | 0.31136942960838 | 0.146502211694256 | 0.0335568761211386 |
| Sprouts | Total body bone mineral density (age over 60) (ebi-a-GCST005349) | All - Inverse variance weighted | 0.533120177926465 | 0.250259692614579 | 0.0331495060325024 |
| Sprouts | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | rs1430633 | 48.7390048629568 | 17.8437600283055 | 0.0063059884356899 |
| Sprouts | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | rs1475680 | 18.0104820954945 | 7.92449886453596 | 0.0230406615220959 |
| Sprouts | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | All - Inverse variance weighted | 9.19818612081712 | 4.1996838639775 | 0.028509070318206 |
| Sprouts | Achilles tendon injury (ebi-a-GCST90018787) | rs995059 | 2.79595634813152 | 1.41545290124158 | 0.0482331331225098 |
| Sprouts | Achilles tendon injury (ebi-a-GCST90018787) | All - Inverse variance weighted | 1.23582708899774 | 0.372148976013587 | 0.0008976435406298 |
| Sprouts | Compression fracture (ebi-a-GCST90018828) | rs12025892 | -2.00016239478171 | 0.839039705524129 | 0.0171316079977105 |
| Sprouts | Compression fracture (ebi-a-GCST90018828) | rs143750890 | 6.8643964481289 | 2.77412179763092 | 0.0133445434726593 |
| Sprouts | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | rs115979407 | -26.9427409547969 | 11.3138590687396 | 0.0172473164252156 |
| Sprouts | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | rs12025892 | -14.7210869624056 | 7.04793352640269 | 0.0367338651918844 |
| Sprouts | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | All - Inverse variance weighted | -7.02235941169549 | 3.50093775469202 | 0.0448721500530366 |
| Sprouts | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | All - MR Egger | -16.2146774307357 | 6.02749750462374 | 0.0210247243564332 |
| Sprouts | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | rs115979407 | -26.7694862507682 | 11.3105901120598 | 0.0179444194032702 |
| Sprouts | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | rs12025892 | -14.7779251360056 | 7.02086772945029 | 0.0353037260764767 |
| Sprouts | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | All - Inverse variance weighted | -6.97791032817485 | 3.50650443836015 | 0.0465919880529222 |
| Sprouts | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | All - MR Egger | -16.2543606795391 | 6.02597603680522 | 0.0207535943274447 |
| Sprouts | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | rs4682860 | -16.9188031327398 | 6.43450030122498 | 0.0085538497779564 |
| Sprouts | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | All - MR Egger | 8.80218702597396 | 3.50255071139821 | 0.0288281852429382 |
| Sprouts | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | All - Inverse variance weighted | -2.77397909582982 | 1.24815221703156 | 0.0262516545696572 |
| Sprouts | Other juvenile arthritis (finn-b-M13_JUVEARTH) | rs995059 | -10.0479681260976 | 4.90166097281806 | 0.0403731289355028 |
| Sprouts | Other juvenile arthritis (finn-b-M13_JUVEARTH) | All - Inverse variance weighted | -2.87516709621749 | 1.35284500997671 | 0.0335637089570752 |
| Sprouts | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | All - MR Egger | 1.59712147944617 | 0.694413292947351 | 0.0420350249339215 |
| Sprouts | Peroneal tendinitis (finn-b-M13_PERONEALTEND) | All - MR Egger | -12.0823071999551 | 5.2204825815082 | 0.040979694346587 |
| Sprouts | Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) | rs114208675 | 19.1144693614079 | 6.46291220900733 | 0.003100814800821 |
| Sprouts | Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) | All - Inverse variance weighted | 3.66769917225248 | 1.38230554669269 | 0.0079704231199555 |
| Sprouts | Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) | All - MR Egger | 6.53547027498585 | 2.55777518146334 | 0.0267492000706356 |
| Sprouts | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs2148815 | -18.0140144270829 | 7.80078245895265 | 0.0209293034315718 |
| Sprouts | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | All - MR Egger | 10.0614304211184 | 3.71888793548498 | 0.0204549252903415 |
| Sprouts | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | All - MR Egger | 2.9066355901169 | 1.26316370176414 | 0.0419524387512764 |
| Sprouts | Bone sialoprotein 2 (prot-a-1395) | rs143750890 | -4.70232304710533 | 1.77394514951646 | 0.0080308179230039 |
| Sprouts | Bone sialoprotein 2 (prot-a-1395) | All - Inverse variance weighted | -1.34429013106246 | 0.571200076297203 | 0.0186001694712866 |
| Sprouts | Osteocalcin (prot-a-246) | rs995059 | -4.4560554298346 | 2.15812880621401 | 0.038944074002047 |
| Sprouts | Alkaline phosphatase, bone (prot-c-2795_23_3) | All - Inverse variance weighted | -4.71709661985798 | 2.23669649416141 | 0.0349482976034208 |
| Sprouts | Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) | rs2148815 | 0.0691982573226572 | 0.0266616936347837 | 0.0094475760301724 |
| Sprouts | Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) | All - Inverse variance weighted | 0.0255880763337043 | 0.0098551996195315 | 0.0094205320542872 |
| Sprouts | Non-cancer illness code, self-reported: bone disorder (ukb-b-14356) | rs4682860 | -0.0187566938884798 | 0.0084851730370172 | 0.0270686922039233 |
| Sprouts | Non-cancer illness code, self-reported: bone disorder (ukb-b-14356) | rs995059 | -0.0178936837598623 | 0.0086839870337524 | 0.039347153625126 |
| Sprouts | Non-cancer illness code, self-reported: bone disorder (ukb-b-14356) | All - Inverse variance weighted | -0.0161438028079352 | 0.0049652874071453 | 0.0011486523395124 |
| Sprouts | Fracture resulting from simple fall (ukb-b-15251) | rs1430633 | 0.74978482856226 | 0.280219038763772 | 0.0074571183473738 |
| Sprouts | Fracture resulting from simple fall (ukb-b-15251) | rs2148815 | 0.591149325863205 | 0.277174577226159 | 0.0329436863827661 |
| Sprouts | Fracture resulting from simple fall (ukb-b-15251) | All - Inverse variance weighted | 0.174748105988873 | 0.0889747801861 | 0.0495279573934426 |
| Sprouts | Operative procedures - secondary OPCS: Z85.6 Ankle joint (ukb-b-15453) | rs4682860 | -0.0247690608474463 | 0.0122331648704733 | 0.042893375209757 |
| Sprouts | Operative procedures - secondary OPCS: Z85.6 Ankle joint (ukb-b-15453) | All - Inverse variance weighted | -0.0126751086402546 | 0.0061931726051733 | 0.0406948110626156 |
| Sprouts | Fractured bone site(s): Ankle (ukb-b-15582) | rs4682860 | -0.0577244962848919 | 0.0210725282816788 | 0.0061565545174038 |
| Sprouts | Fractured bone site(s): Ankle (ukb-b-15582) | All - Inverse variance weighted | -0.026782335381517 | 0.0116336402411013 | 0.0213269544115517 |
| Sprouts | Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) | All - Inverse variance weighted | 0.0121815513827673 | 0.0059337737841492 | 0.0400805248678212 |
| Sprouts | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | rs2148815 | 0.0257388523406315 | 0.0118944077198384 | 0.0304685176547841 |
| Sprouts | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | All - Inverse variance weighted | 0.0135984832803498 | 0.0059648543803643 | 0.0226214604063744 |
| Sprouts | Non-cancer illness code, self-reported: joint pain (ukb-b-4122) | All - Inverse variance weighted | -0.0136708435751837 | 0.0052277370474987 | 0.008921190568592 |