ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Rose wine | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | rs12456862 | 3.61618412972776 | 1.7360716262215 | 0.0372540099287419 |
| Rose wine | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | rs13224220 | 1.23078696271415 | 0.520717561148295 | 0.0180965654136911 |
| Rose wine | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | All - Inverse variance weighted | 0.887021270070393 | 0.410714515924221 | 0.030795688076005 |
| Rose wine | Osteoarthritis (hip) (ebi-a-GCST007091) | rs73187524 | -1.98494748159788 | 0.897361673972376 | 0.0269679386127906 |
| Rose wine | Osteoarthritis (hip) (ebi-a-GCST007091) | All - Inverse variance weighted | -0.509863839754089 | 0.239002325067606 | 0.0329000625917543 |
| Rose wine | Osteoarthritis (hip) (ebi-a-GCST007091) | All - MR Egger | -1.17368503335827 | 0.442847747441594 | 0.0211668133389976 |
| Rose wine | Osteoprotegerin levels (ebi-a-GCST90010243) | rs13224220 | -3.00126783406193 | 0.985314941506747 | 0.0023190899194795 |
| Rose wine | Osteoprotegerin levels (ebi-a-GCST90010243) | All - MR Egger | -3.59699678273226 | 1.2856904669646 | 0.017345488032587 |
| Rose wine | Heel bone mineral density T score (ebi-a-GCST90025982) | rs13224220 | 0.313488437188701 | 0.0414470596952259 | 3.9210369088862e-14 |
| Rose wine | Heel bone mineral density T score (ebi-a-GCST90025982) | All - Inverse variance weighted | 0.277413476060024 | 0.0678466741798072 | 4.335555564606e-05 |
| Rose wine | Osteoarthritis (ebi-a-GCST90038686) | rs591596 | 0.0846470680392781 | 0.0431696408265992 | 0.0499022599197413 |
| Rose wine | Sciatica (ebi-a-GCST90038692) | rs117158232 | 0.0347911417491256 | 0.015316102942332 | 0.0231143033566604 |
| Rose wine | Sciatica (ebi-a-GCST90038692) | rs71641030 | 0.0384080783073538 | 0.0152243620994442 | 0.0116423343039989 |
| Rose wine | Sciatica (ebi-a-GCST90038692) | All - Inverse variance weighted | 0.0102843248824664 | 0.0049302266359429 | 0.0369809726638904 |
| Rose wine | Fracture of forearm or wrist (ebi-a-GCST90038705) | rs9327014 | -0.0235694435030163 | 0.0105925574459432 | 0.0260748810288403 |
| Rose wine | Fracture of forearm or wrist (ebi-a-GCST90038705) | All - MR Egger | 0.0141518170615374 | 0.0056561112551564 | 0.0293995714921065 |
| Rose wine | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | rs12456862 | -13.9188974049899 | 6.62588035509867 | 0.0356684952629283 |
| Rose wine | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | All - MR Egger | 9.23744314163515 | 3.78103174798162 | 0.0309816588524863 |
| Rose wine | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | rs117606955 | -3.56398172417625 | 1.65698187451385 | 0.0314850745619914 |
| Rose wine | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | rs71641030 | 2.3485423352311 | 1.14035719887575 | 0.0394483217015911 |
| Rose wine | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | All - MR Egger | -0.887759077052129 | 0.379023540180508 | 0.0372347616758084 |
| Rose wine | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | rs13224220 | 8.8789547778409 | 3.28690096898746 | 0.0069065898674871 |
| Rose wine | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | rs79763018 | 167.868999368623 | 73.0591933304819 | 0.0215781750966566 |
| Rose wine | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | All - Inverse variance weighted | 5.96037133761539 | 2.60246810921742 | 0.0220052979895073 |
| Rose wine | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | All - MR Egger | 11.2058442803742 | 5.10789791233335 | 0.0486727730788037 |
| Rose wine | Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) | rs12456862 | 2.63822238395233 | 1.30394899436724 | 0.0430467799220495 |
| Rose wine | Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) | rs71641030 | 3.62455540906605 | 1.71689466745234 | 0.0347627626222285 |
| Rose wine | Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) | All - MR Egger | -2.02711547259886 | 0.565899459740203 | 0.0037676246117481 |
| Rose wine | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | rs12456862 | 17.1332832980812 | 8.07387022675067 | 0.0338322189291909 |
| Rose wine | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | rs13224220 | -6.11894588653708 | 2.31750187293668 | 0.0082827847973629 |
| Rose wine | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | rs591596 | 20.1343299422351 | 9.48092444067094 | 0.0336979671130651 |
| Rose wine | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | All - MR Egger | -11.0906490680093 | 3.48577605768216 | 0.007896425597045 |
| Rose wine | Gluteal tendinitis (finn-b-M13_GLUTEALTEND) | rs77066209 | 28.3126080869637 | 12.4022070328584 | 0.0224381139542929 |
| Rose wine | Gluteal tendinitis (finn-b-M13_GLUTEALTEND) | All - Inverse variance weighted | 2.87324748345624 | 1.26842001215875 | 0.0234993224813144 |
| Rose wine | Infective bursitis (finn-b-M13_INFBURSA) | rs35815255 | 14.5038128402164 | 6.46551352060591 | 0.0248802028975639 |
| Rose wine | Infective bursitis (finn-b-M13_INFBURSA) | All - MR Egger | 6.10779251315399 | 2.35442446817002 | 0.0234765374609409 |
| Rose wine | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs73187524 | -22.2479530229096 | 8.63452154495079 | 0.0099769156821157 |
| Rose wine | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | All - Inverse variance weighted | -5.62418302712202 | 2.14462199284135 | 0.0087297797099747 |
| Rose wine | Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) | All - Inverse variance weighted | 1.33414753980417 | 0.597941771971704 | 0.025665685159698 |
| Rose wine | Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) | rs13224220 | 5.439749067648 | 2.45539940889295 | 0.0267310233473148 |
| Rose wine | Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) | rs9327014 | 20.9245577170745 | 7.88314241171287 | 0.0079463192044181 |
| Rose wine | Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) | All - Inverse variance weighted | 4.23223531211979 | 1.85982199246577 | 0.0228691758548765 |
| Rose wine | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | rs12456862 | -10.4694974489603 | 3.45698105483409 | 0.0024576394220013 |
| Rose wine | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | All - Inverse variance weighted | -1.90673109034742 | 0.748606217536615 | 0.010864051786082 |
| Rose wine | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs41273040 | -8.81282935459543 | 2.52574361212167 | 0.0004844651192133 |
| Rose wine | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | All - Inverse variance weighted | -1.57696271630685 | 0.765811003757746 | 0.0394744958299896 |
| Rose wine | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | rs591596 | 12.0735226485943 | 5.98875024637264 | 0.043796446194597 |
| Rose wine | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | All - Inverse variance weighted | 2.47740719555064 | 1.09204952356227 | 0.0232935731277316 |
| Rose wine | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs13224220 | 0.961166407336972 | 0.417808952225707 | 0.0214203274371259 |
| Rose wine | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs41273040 | 3.33208429580371 | 1.15970763035446 | 0.0040632311237132 |
| Rose wine | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs71641030 | -4.8836114985311 | 1.90342149552124 | 0.0102967378492668 |
| Rose wine | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | All - MR Egger | 1.90808226865268 | 0.766932777270225 | 0.0285397250450433 |
| Rose wine | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs41273040 | -12.4769362848564 | 5.02065655104374 | 0.0129507605662231 |
| Rose wine | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs73187524 | -12.49689851956 | 5.76461831114052 | 0.0301691675371625 |
| Rose wine | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | All - Inverse variance weighted | -3.66550308491217 | 1.3572952159139 | 0.0069215810062868 |
| Rose wine | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | rs9327014 | 10.1064190334169 | 4.96848098691791 | 0.0419408676274063 |
| Rose wine | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | All - Inverse variance weighted | 2.4531554669641 | 1.17166941323486 | 0.0362843381558657 |
| Rose wine | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs13224220 | 0.887072208912709 | 0.298434965875505 | 0.0029546817187945 |
| Rose wine | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs35815255 | -3.31994192259684 | 1.28447050983466 | 0.0097470142380336 |
| Rose wine | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs41273040 | 1.67434271376329 | 0.822941815404902 | 0.0418929366986857 |
| Rose wine | Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) | rs145013270 | 10.2328067466445 | 4.76303599002257 | 0.0316836554987718 |
| Rose wine | Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) | All - MR Egger | 2.43217966162724 | 1.10619063668457 | 0.0482493493303254 |
| Rose wine | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs13224220 | 4.26864909810895 | 2.03553228448879 | 0.0359875787779459 |
| Rose wine | Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) | rs13224220 | 3.9763886487688 | 1.94908905299382 | 0.0413377064329261 |
| Rose wine | Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) | All - MR Egger | 6.83295798984354 | 2.93615061746992 | 0.0382655251771217 |
| Rose wine | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs13224220 | 0.344216947812986 | 0.0708871545357998 | 1.19875188378814e-06 |
| Rose wine | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs150686554 | -0.512891675806977 | 0.218347375010875 | 0.0188253674049372 |
| Rose wine | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs71641030 | 0.501761406751423 | 0.242665468373105 | 0.0386674595428372 |
| Rose wine | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | All - Inverse variance weighted | -0.0306401719505697 | 0.0133637021400191 | 0.0218600578465364 |
| Rose wine | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | All - MR Egger | -0.0690209142494338 | 0.0243444382037803 | 0.016221080725553 |
| Rose wine | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs13224220 | -0.0116101080952028 | 0.0049875892217639 | 0.0199227484038699 |
| Rose wine | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - Inverse variance weighted | -0.0104573158790194 | 0.0041696399159463 | 0.0121428289712975 |
| Rose wine | Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) | rs12456862 | 0.0160868642301015 | 0.0077853336062528 | 0.0387998050842611 |
| Rose wine | Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) | rs12456862 | -0.0228208510541518 | 0.0105041430704966 | 0.0298136644662684 |
| Rose wine | Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) | All - Inverse variance weighted | -0.0066158165606515 | 0.0033256344682953 | 0.0466637243109486 |
| Rose wine | Ankle spacing width (right) (ukb-b-8607) | rs71514907 | 0.622151148209957 | 0.246907712837597 | 0.011743086259642 |
| Rose wine | Ankle spacing width (right) (ukb-b-8607) | All - Inverse variance weighted | 0.128038559901991 | 0.0621871495252763 | 0.03950160391979 |
| Rose wine | Fractured bone site(s): Wrist (ukb-b-9571) | rs71514907 | -0.051026840588146 | 0.023065164823937 | 0.0269466123633917 |
| Rose wine | Fractured bone site(s): Wrist (ukb-b-9571) | All - Inverse variance weighted | -0.0131052292307382 | 0.005373275073602 | 0.014729399399101 |
| Rose wine | Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) | rs13224220 | -0.0097563947409584 | 0.0037556085191862 | 0.0093817672247019 |
| Rose wine | Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) | All - MR Egger | -0.0118243067548462 | 0.0051045928843789 | 0.0390206461559953 |
| Rose wine | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs12456862 | -0.0514826354931884 | 0.0204263609967629 | 0.0117220966132975 |
| Rose wine | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs145013270 | -0.0461871956289345 | 0.020277942748545 | 0.0227440889564251 |
| Rose wine | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | All - MR Egger | 0.0173803123719536 | 0.0078754799593134 | 0.0459126952872264 |
| Rose wine | Osteoarthrosis (ukb-e-740_AFR) | rs71514907 | 12.7499760047805 | 3.48317702898932 | 0.000251778142275 |
| Rose wine | Osteoarthrosis (ukb-e-740_AFR) | All - Inverse variance weighted | 2.88277817249887 | 1.42363427017687 | 0.0428732231128764 |
| Rose wine | Internal derangement of knee (ukb-e-835_CSA) | All - MR Egger | 5.99070425438174 | 2.27088045099575 | 0.0335181103801224 |