ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Dark chocolate | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | rs112868306 | 4.65152838427948 | 1.23144104803493 | 0.0001585345644671 |
| Dark chocolate | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | rs145537395 | 5.4621891509482 | 2.05620985555635 | 0.0078971522665663 |
| Dark chocolate | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | All - Inverse variance weighted | 1.26894305240282 | 0.564872345032503 | 0.0246768330893036 |
| Dark chocolate | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | All - MR Egger | 2.02426166364861 | 0.943350793152833 | 0.0466188673653536 |
| Dark chocolate | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs145537395 | -8.38611956554932 | 3.40492065269394 | 0.0137802489602439 |
| Dark chocolate | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs259386 | -6.3634626339097 | 3.12426269271054 | 0.0416712312686156 |
| Dark chocolate | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs7008560 | -8.22304465303368 | 3.28389892425696 | 0.0122780940252476 |
| Dark chocolate | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | All - Inverse variance weighted | -1.80265674631101 | 0.705231874943412 | 0.0105846848581096 |
| Dark chocolate | Menstruation quality of life impact (stiff neck) (ebi-a-GCST006652) | All - Inverse variance weighted | 3.65441757706822 | 1.61060690671697 | 0.0232701946923206 |
| Dark chocolate | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | rs145537395 | -1.4719205203636 | 0.690153604983764 | 0.0329457846341003 |
| Dark chocolate | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | All - Inverse variance weighted | -0.334822689514302 | 0.149393302387031 | 0.0250120739791885 |
| Dark chocolate | Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) | rs259386 | -1.92940225280682 | 0.817699049999081 | 0.0182970872732547 |
| Dark chocolate | Achilles tendon injury (ebi-a-GCST90018567) | rs75633229 | -3.82037677650861 | 1.51225045929622 | 0.0115275678824914 |
| Dark chocolate | Achilles tendon injury (ebi-a-GCST90018567) | All - Inverse variance weighted | -2.41648110320893 | 0.979657551607483 | 0.0136380170252965 |
| Dark chocolate | Achilles tendon injury (ebi-a-GCST90018787) | rs10806742 | -3.60295765180372 | 1.49675106430652 | 0.0160759962640544 |
| Dark chocolate | Achilles tendon injury (ebi-a-GCST90018787) | rs61788541 | -3.07420469319006 | 1.51555418285772 | 0.0425157670883377 |
| Dark chocolate | Achilles tendon injury (ebi-a-GCST90018787) | All - Inverse variance weighted | -0.844584815018367 | 0.314834880646204 | 0.0073046228023284 |
| Dark chocolate | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | rs17143632 | -5.76577310074837 | 2.75058180165143 | 0.0360643392220845 |
| Dark chocolate | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | All - Inverse variance weighted | -2.01417326269422 | 1.01741331557808 | 0.0477372351166159 |
| Dark chocolate | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | All - MR Egger | -3.54545567180966 | 1.59759567492336 | 0.0388418525652386 |
| Dark chocolate | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | rs17143632 | -5.75084641114888 | 2.76279454768738 | 0.0373852001535104 |
| Dark chocolate | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | All - MR Egger | -3.50911027426614 | 1.60249010577908 | 0.0412205561000118 |
| Dark chocolate | Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) | rs75633229 | -3.13519591518227 | 1.39785805135515 | 0.0249060281857056 |
| Dark chocolate | Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) | All - MR Egger | -2.52169924384931 | 1.10570653216187 | 0.0342853858433208 |
| Dark chocolate | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs10273549 | 4.20836769721151 | 2.04622963243653 | 0.039720397802209 |
| Dark chocolate | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs150993006 | 3.80125387331556 | 1.85738992577646 | 0.0407016259340675 |
| Dark chocolate | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs17143632 | 1.84683859499142 | 0.902386234878246 | 0.040695749434295 |
| Dark chocolate | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs5760827 | 4.02784757737902 | 1.92154196352026 | 0.0360685456805003 |
| Dark chocolate | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | All - Inverse variance weighted | 1.00276440073417 | 0.41049139171518 | 0.0145722345650135 |
| Dark chocolate | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs75633229 | -1.7987821737768 | 0.533029388813449 | 0.0007391237200965 |
| Dark chocolate | Cervical disc disorders (finn-b-M13_CERVICDISC) | All - Inverse variance weighted | -0.679665909983908 | 0.288212269805182 | 0.0183631550237121 |
| Dark chocolate | Cervical disc disorders (finn-b-M13_CERVICDISC) | All - MR Egger | -1.22051527837781 | 0.434930770350425 | 0.0112696659284893 |
| Dark chocolate | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | rs6916329 | 25.2252529223039 | 11.2170794748088 | 0.0245236084833097 |
| Dark chocolate | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | All - Inverse variance weighted | 3.27109099303229 | 1.58334856668489 | 0.0388348696780935 |
| Dark chocolate | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | All - Inverse variance weighted | 0.436943283136653 | 0.187213935272998 | 0.0195996496411231 |
| Dark chocolate | Otherdisorders of bone (finn-b-M13_OTHERBONE) | rs75633229 | 2.03227055158557 | 0.734259503898642 | 0.0056439120181371 |
| Dark chocolate | Otherdisorders of bone (finn-b-M13_OTHERBONE) | All - Inverse variance weighted | 0.778566074081242 | 0.369141352831231 | 0.0349336021728762 |
| Dark chocolate | Other joint disorders (finn-b-M13_OTHERJOINT) | rs10273549 | 1.64946615250875 | 0.784610926598756 | 0.035529392197537 |
| Dark chocolate | Other joint disorders (finn-b-M13_OTHERJOINT) | rs6951020 | 2.1613078292662 | 0.88546972740862 | 0.0146523250774769 |
| Dark chocolate | Other joint disorders (finn-b-M13_OTHERJOINT) | All - Inverse variance weighted | 0.260592355248266 | 0.128886501507149 | 0.0431892991434611 |
| Dark chocolate | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | All - Inverse variance weighted | 2.55574865722883 | 1.18608403476828 | 0.03117915299263 |
| Dark chocolate | Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) | rs115832742 | 13.2634676504146 | 5.28886890395916 | 0.0121482663160216 |
| Dark chocolate | Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) | rs75633229 | 8.2980540587039 | 3.43320081843821 | 0.0156489209457969 |
| Dark chocolate | Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) | All - Inverse variance weighted | 4.20546500955244 | 1.7072635802311 | 0.0137673080101065 |
| Dark chocolate | Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) | rs115832742 | -6.79232701055021 | 3.23021721375412 | 0.0354879601135028 |
| Dark chocolate | Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) | All - Inverse variance weighted | -2.5476590905102 | 1.04254265240519 | 0.0145376017549142 |
| Dark chocolate | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs150993006 | 3.3454637169417 | 1.69344959285148 | 0.0482078165078216 |
| Dark chocolate | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs17143632 | 1.78441789302991 | 0.826395815099025 | 0.0308286443178148 |
| Dark chocolate | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs259386 | 3.80367872696202 | 1.89265173370574 | 0.0444620246183357 |
| Dark chocolate | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs5760827 | 4.71516835663819 | 1.7589499512224 | 0.0073474435339602 |
| Dark chocolate | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | 0.892017184718795 | 0.369927374883029 | 0.0158944352559393 |
| Dark chocolate | Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) | rs78920357 | -4.54728554046254 | 2.08884440808462 | 0.0294851660939031 |
| Dark chocolate | Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) | All - MR Egger | -1.4893053541363 | 0.631233485391158 | 0.0291623251671384 |
| Dark chocolate | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | All - Inverse variance weighted | -1.81736511501102 | 0.896641462822825 | 0.0426769148448917 |
| Dark chocolate | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs10273549 | 3.47725297015358 | 1.24824465595257 | 0.0053409925250672 |
| Dark chocolate | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs10806742 | 3.3968182836657 | 1.27268653372171 | 0.0076074260096976 |
| Dark chocolate | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs112868306 | 5.00087336244541 | 2.37030567685589 | 0.034875497576109 |
| Dark chocolate | Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) | rs112868306 | -11.5545851528384 | 5.29606986899563 | 0.0291295960075203 |
| Dark chocolate | Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) | rs146635941 | -6.50885864945825 | 2.7458925079014 | 0.0177689365906659 |
| Dark chocolate | Psoriatic arthritis (ieu-b-5116) | rs10462943 | -7.3214234827722 | 2.32732392949637 | 0.001656021181561 |
| Dark chocolate | Psoriatic arthritis (ieu-b-5116) | rs10799451 | 3.52337855278257 | 1.73569865837047 | 0.0423617940549088 |
| Dark chocolate | Psoriatic arthritis (ieu-b-5116) | All - MR Egger | 3.30531435693686 | 1.18634558328073 | 0.0164622096092941 |
| Dark chocolate | Osteocalcin (prot-a-246) | All - Inverse variance weighted | 0.98111149761616 | 0.483957372811347 | 0.0426349694862609 |
| Dark chocolate | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - MR Egger | 0.324180595110609 | 0.1456175940717 | 0.039009458220779 |
| Dark chocolate | Operation code: elbow surgery (ukb-b-10324) | rs5760827 | 0.0326648091761019 | 0.0151750820350607 | 0.0313556877390391 |
| Dark chocolate | Operation code: elbow surgery (ukb-b-10324) | All - Inverse variance weighted | 0.0166907559409903 | 0.0066841027573922 | 0.0125219824781759 |
| Dark chocolate | Operative procedures - secondary OPCS: Z66.5 Lumbar vertebra (ukb-b-17671) | All - Inverse variance weighted | 0.011666199855432 | 0.0058389782267359 | 0.0457181203098292 |
| Dark chocolate | Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) | All - Inverse variance weighted | -0.0168205199167347 | 0.0085090682599199 | 0.0480669822954642 |
| Dark chocolate | Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) | rs10462943 | -0.0245520605466295 | 0.0124273130337851 | 0.0481940708027467 |
| Dark chocolate | Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) | All - Inverse variance weighted | -0.0134599367678663 | 0.0059060897670069 | 0.0226674861313693 |
| Dark chocolate | Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement (ukb-b-8136) | All - Inverse variance weighted | -0.0147428760235553 | 0.0065003299351848 | 0.0233280090466705 |
| Dark chocolate | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | rs10806742 | -0.0326874299798342 | 0.0126275599372619 | 0.0096372982196159 |
| Dark chocolate | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | All - Inverse variance weighted | -0.0155325704862066 | 0.0062352786430965 | 0.0127355867864666 |
| Dark chocolate | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | All - Inverse variance weighted | 0.0069971192030371 | 0.0033272377953708 | 0.035467395271882 |
| Dark chocolate | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs5760827 | 0.0298212965973926 | 0.0147933603334614 | 0.04381494800378 |
| Dark chocolate | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | All - Inverse variance weighted | 0.0085493073405944 | 0.0036759676288155 | 0.0200329713969114 |
| Dark chocolate | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | rs150993006 | 0.0311110110254378 | 0.013001080925272 | 0.0167132577975775 |
| Dark chocolate | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | All - Inverse variance weighted | 0.0093014151443359 | 0.0031839834187419 | 0.0034855840112323 |
| Dark chocolate | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | All - MR Egger | 0.0162113155795795 | 0.0059808887841284 | 0.0169046942225561 |
| Dark chocolate | Ankle spacing width (left) (ukb-e-4100_AFR) | rs10273549 | -3.15315516126875 | 1.5357867284845 | 0.0400608956717692 |
| Dark chocolate | Ankle spacing width (left) (ukb-e-4100_AFR) | rs112868306 | -1.21048034934498 | 0.417467248908297 | 0.003736610822589 |
| Dark chocolate | Ankle spacing width (left) (ukb-e-4100_AFR) | All - Inverse variance weighted | -0.540983462490049 | 0.269946410031406 | 0.0450657523840063 |