ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Hot chocolate | Frozen shoulder (ebi-a-GCST90000513) | rs142532384 | -3.34890605485915 | 1.0476895323558 | 0.001391212614715 |
| Hot chocolate | Frozen shoulder (ebi-a-GCST90000513) | All - Inverse variance weighted | -0.684951714218218 | 0.335826635364722 | 0.0413902685169945 |
| Hot chocolate | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | rs1789571 | 4.08520216896506 | 2.00371535680814 | 0.0414686320231659 |
| Hot chocolate | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | All - Inverse variance weighted | 1.21816604582585 | 0.487329027835128 | 0.0124305948986385 |
| Hot chocolate | Heel bone mineral density T score (ebi-a-GCST90025982) | rs112847589 | -0.374636543190326 | 0.150009017687865 | 0.0125098284616964 |
| Hot chocolate | Heel bone mineral density (ebi-a-GCST90029004) | rs1042953 | -0.369568308863019 | 0.17322864426139 | 0.0328908297585495 |
| Hot chocolate | Heel bone mineral density (ebi-a-GCST90029004) | rs112847589 | -0.394985725659941 | 0.165062398001153 | 0.0167136122912751 |
| Hot chocolate | Heel bone mineral density (ebi-a-GCST90029004) | rs116341761 | 0.37126031506539 | 0.176230629435233 | 0.0351459310770574 |
| Hot chocolate | Heel bone mineral density (ebi-a-GCST90029004) | rs1512376 | -0.325940219353393 | 0.163595885152771 | 0.0463326976964821 |
| Hot chocolate | Heel bone mineral density (ebi-a-GCST90029004) | rs1591287 | 0.359448062297919 | 0.179599253153604 | 0.045350429641581 |
| Hot chocolate | Heel bone mineral density (ebi-a-GCST90029004) | rs4926877 | -0.417328582160768 | 0.164213416986457 | 0.011041605595527 |
| Hot chocolate | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs9509220 | -10.955149278465 | 3.40388939150998 | 0.0012889844890812 |
| Hot chocolate | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | All - Inverse variance weighted | -1.76817205550064 | 0.843305446512082 | 0.0360187198298186 |
| Hot chocolate | Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) | rs114421178 | 10.1103945786425 | 4.89407170936337 | 0.0388430980554763 |
| Hot chocolate | Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) | All - Inverse variance weighted | -2.4728775278525 | 0.975333078645584 | 0.0112313060523876 |
| Hot chocolate | Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) | rs59246261 | -4.83982097143721 | 1.92136411250343 | 0.0117705223725184 |
| Hot chocolate | Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) | All - Inverse variance weighted | -0.998127066632037 | 0.468605915132459 | 0.0331722357462256 |
| Hot chocolate | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | rs116341761 | 47.2740762142216 | 23.9839203579754 | 0.048715438973253 |
| Hot chocolate | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | rs142532384 | 8.43702298903742 | 4.07280632776724 | 0.0383074030988668 |
| Hot chocolate | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | rs59246261 | -14.8219517250265 | 5.8481170071533 | 0.0112613468657887 |
| Hot chocolate | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | rs9509220 | -16.1416017986868 | 5.7507815509195 | 0.0050027975128074 |
| Hot chocolate | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | All - MR Egger | 8.85502099838827 | 3.0976271444128 | 0.0113755473681966 |
| Hot chocolate | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | All - Inverse variance weighted | 2.07561096146103 | 0.96829032282037 | 0.032066290396517 |
| Hot chocolate | Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) | rs149887645 | 49.4923210367876 | 19.877107432595 | 0.0127773412824573 |
| Hot chocolate | Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) | All - MR Egger | 19.9310079488367 | 7.20216754933672 | 0.0137346743121551 |
| Hot chocolate | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | rs1789571 | -25.1456018208596 | 12.0247021020217 | 0.0365135315970614 |
| Hot chocolate | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs1789571 | -1.74052751372339 | 0.594122372472888 | 0.0033942319872543 |
| Hot chocolate | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | All - Inverse variance weighted | -0.402983497872252 | 0.158259910512088 | 0.0108859186585663 |
| Hot chocolate | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs1042953 | 8.54759041157026 | 4.25110248787831 | 0.0443596741038242 |
| Hot chocolate | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs1512376 | 7.23293537664795 | 3.66418929293181 | 0.0483871516908965 |
| Hot chocolate | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs6796609 | 16.2497202183158 | 7.76157435305866 | 0.0362946149904648 |
| Hot chocolate | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | All - MR Egger | 7.86899751737783 | 3.10068870704465 | 0.0219364396482277 |
| Hot chocolate | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | rs9509220 | -11.6448847604289 | 5.46413823373971 | 0.03307698917238 |
| Hot chocolate | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | All - Inverse variance weighted | -3.30070111739713 | 1.35451444639048 | 0.0148172578874555 |
| Hot chocolate | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | rs112847589 | 24.5237121202124 | 7.64304032446081 | 0.001333675661618 |
| Hot chocolate | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | All - Inverse variance weighted | 4.58176485545846 | 2.00609463562142 | 0.0223760807677485 |
| Hot chocolate | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | rs112847589 | 23.1930533011336 | 9.97444255292943 | 0.0200586992853744 |
| Hot chocolate | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | rs17847219 | 24.9967136426891 | 9.07941199135121 | 0.0059030197063924 |
| Hot chocolate | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | rs6796609 | 49.1933678827844 | 23.3535923968251 | 0.0351645641341295 |
| Hot chocolate | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | rs9509220 | -26.8548957782814 | 11.3403262359254 | 0.0178802598560281 |
| Hot chocolate | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | All - MR Egger | 22.8625351913439 | 5.6807951078512 | 0.0009801632284217 |
| Hot chocolate | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs78254142 | 6.30272830430707 | 2.98177019093196 | 0.0345362941286517 |
| Hot chocolate | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | All - Inverse variance weighted | -1.26909245932324 | 0.633041549019427 | 0.0449893724156319 |
| Hot chocolate | Hip osteoarthritis (ieu-a-1169) | rs4926877 | 5.29735436843922 | 2.5749375647195 | 0.0396597923028801 |
| Hot chocolate | Hip osteoarthritis (ieu-a-1169) | All - Inverse variance weighted | 1.97704318914035 | 0.966721910069155 | 0.0408449787953078 |
| Hot chocolate | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | rs112847589 | 0.0643456017877016 | 0.0223425313749555 | 0.0039772533810105 |
| Hot chocolate | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | rs76187757 | -0.0471879115547238 | 0.0234561585915298 | 0.0442463666816987 |
| Hot chocolate | Fractured/broken bones in last 5 years (ukb-a-308) | rs112847589 | 0.144458520835258 | 0.0630549727049984 | 0.021963800403083 |
| Hot chocolate | Fractured/broken bones in last 5 years (ukb-a-308) | rs78254142 | 0.13924034239479 | 0.0699991366125611 | 0.0466821900947934 |
| Hot chocolate | Fractured/broken bones in last 5 years (ukb-a-308) | All - MR Egger | 0.0665302855728565 | 0.0313099531542955 | 0.0495243284669402 |
| Hot chocolate | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | All - Inverse variance weighted | 0.055073309929617 | 0.0221760632490423 | 0.0130113870606503 |
| Hot chocolate | Diagnoses - secondary ICD10: M06.99 Rheumatoid arthritis, unspecified (Site unspecified) (ukb-b-11874) | rs9509220 | 0.0229068319643129 | 0.0107569175094279 | 0.0332130982977929 |
| Hot chocolate | Diagnoses - secondary ICD10: M06.99 Rheumatoid arthritis, unspecified (Site unspecified) (ukb-b-11874) | All - Inverse variance weighted | 0.0126496415209351 | 0.0063340761798816 | 0.0458167561649503 |
| Hot chocolate | Fractured/broken bones in last 5 years (ukb-b-13346) | rs112847589 | 0.133915304116025 | 0.0545026855114349 | 0.014008690385218 |
| Hot chocolate | Fractured bone site(s): Ankle (ukb-b-15582) | rs4926877 | 0.0493818399626404 | 0.0217694564577369 | 0.0233048239782012 |
| Hot chocolate | Fractured bone site(s): Ankle (ukb-b-15582) | rs76187757 | 0.0469591737714008 | 0.0227495667845013 | 0.0390007655195005 |
| Hot chocolate | Fractured bone site(s): Ankle (ukb-b-15582) | All - MR Egger | 0.0929087077865725 | 0.0268593110627487 | 0.0085792957692273 |
| Hot chocolate | Fractured heel (ukb-b-18389) | rs1591287 | -0.0292221868026777 | 0.0143247871032379 | 0.0413529602091423 |
| Hot chocolate | Fractured heel (ukb-b-18389) | rs78254142 | 0.032101670037989 | 0.0145222692288717 | 0.0270695548740914 |
| Hot chocolate | Fractured heel (ukb-b-18389) | All - MR Egger | 0.0163442898392946 | 0.0068120779833057 | 0.0281657424496241 |
| Hot chocolate | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs4926877 | 0.156699863962153 | 0.0776024852287263 | 0.0434598420690776 |
| Hot chocolate | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | All - Inverse variance weighted | 0.0575951853925975 | 0.0185776795686242 | 0.001933667020685 |
| Hot chocolate | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | rs1591287 | -0.0286096816794936 | 0.0099961746891935 | 0.0042089324051853 |
| Hot chocolate | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | All - Inverse variance weighted | -0.0151652725119626 | 0.0076087537061309 | 0.0462466779493099 |
| Hot chocolate | Non-cancer illness code, self-reported: other joint disorder (ukb-b-5316) | rs1591287 | -0.0396896033517009 | 0.0158378796848673 | 0.0122108304851915 |
| Hot chocolate | Non-cancer illness code, self-reported: other joint disorder (ukb-b-5316) | All - Inverse variance weighted | -0.0144305739363558 | 0.0071226123018863 | 0.0427624623910068 |
| Hot chocolate | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | All - Inverse variance weighted | -0.0080985232143836 | 0.0039898988487858 | 0.0423812943056728 |
| Hot chocolate | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs116341761 | 0.0642561471280111 | 0.0249421714293867 | 0.0099891398663911 |
| Hot chocolate | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | All - Inverse variance weighted | 0.0121431881427674 | 0.0057327182680779 | 0.0341560022817666 |
| Hot chocolate | Osteoarthrosis (ukb-e-740_AFR) | rs1789571 | 25.831771321462 | 9.94108983799705 | 0.0093636177247744 |
| Hot chocolate | Osteoarthrosis (ukb-e-740_AFR) | rs6796609 | -5.48888621063687 | 2.57915669496049 | 0.0333229170608632 |