ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Ice-cream | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs112107763 | 4.3444263439609 | 1.6111838824429 | 0.007008950545635 |
| Ice-cream | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs113438694 | -4.08187781417176 | 2.0601033627462 | 0.0475470314862923 |
| Ice-cream | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs7251800 | 4.05644083107498 | 1.99977115326709 | 0.0425140847039448 |
| Ice-cream | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | All - MR Egger | 3.63989060800701 | 1.43215734817109 | 0.0234995168651301 |
| Ice-cream | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | rs112107763 | 2.50270288240965 | 0.992509059476711 | 0.0116825129116625 |
| Ice-cream | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | rs113438694 | -2.82710074410806 | 1.25117320173884 | 0.0238485812385171 |
| Ice-cream | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | rs2389921 | -2.3506957749584 | 1.19704787750581 | 0.0495597690275703 |
| Ice-cream | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | All - MR Egger | 2.32163571690506 | 0.763235088410077 | 0.0087910647632845 |
| Ice-cream | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | All - MR Egger | 0.0168857097532311 | 0.0063972440363645 | 0.0194220600899791 |
| Ice-cream | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs1582047 | -5.86574193777345 | 2.99117350327255 | 0.0498770457606166 |
| Ice-cream | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs28607628 | 8.37440613805544 | 2.53105866212749 | 0.0009374445197955 |
| Ice-cream | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs7251800 | 6.29930743751882 | 2.9930743751882 | 0.035323722664177 |
| Ice-cream | Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) | All - MR Egger | -8.18950687524749 | 3.81073248375241 | 0.0496034294543909 |
| Ice-cream | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | All - Inverse variance weighted | -0.384726611160288 | 0.17363805254108 | 0.0267133265469362 |
| Ice-cream | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | rs7251800 | 10.9545317675399 | 3.51701294790726 | 0.001841158342361 |
| Ice-cream | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | All - Inverse variance weighted | 2.45313871541577 | 0.94855995411787 | 0.0097048630483574 |
| Ice-cream | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | rs496092 | 19.9961752683288 | 8.96819894979243 | 0.0257689802612642 |
| Ice-cream | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | All - MR Egger | 8.7873748253535 | 3.72552602569294 | 0.0334050451534286 |
| Ice-cream | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs6444192 | 3.07372586596315 | 1.00176085914993 | 0.0021526382120837 |
| Ice-cream | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs7250190 | 1.96459813705271 | 0.899219047805221 | 0.0289047897941838 |
| Ice-cream | Spondylosis (finn-b-M13_SPONDYLOSIS) | All - Inverse variance weighted | 0.581288275511389 | 0.279109679900491 | 0.0372829744776009 |
| Ice-cream | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs113738028 | 8.22237261249456 | 3.39886804977822 | 0.0155568114465339 |
| Ice-cream | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs191306100 | 4.33773553627673 | 1.81122715244393 | 0.0166242071207979 |
| Ice-cream | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | All - MR Egger | 3.62556131685921 | 1.16676086191528 | 0.0077185156850569 |
| Ice-cream | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs10467770 | 8.55163340442011 | 3.95221270861848 | 0.030482897181474 |
| Ice-cream | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs113738028 | -15.7615231756678 | 6.72445676303618 | 0.0190827624187179 |
| Ice-cream | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | 2.08809291085552 | 1.05223198455465 | 0.0472066336668317 |
| Ice-cream | Lumbar spine bone mineral density (ieu-a-982) | rs112107763 | -1.98263240134313 | 0.559513281691546 | 0.0003948611051471 |
| Ice-cream | Lumbar spine bone mineral density (ieu-a-982) | rs191306100 | -1.20116593910593 | 0.516721617456546 | 0.0200938904636316 |
| Ice-cream | Lumbar spine bone mineral density (ieu-a-982) | All - MR Egger | -1.01268332315522 | 0.38737490273025 | 0.0214199546678436 |
| Ice-cream | Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) | All - MR Egger | 0.0186595673357543 | 0.0076310266701329 | 0.0283026597816509 |
| Ice-cream | Fractured bone site(s): Ankle (ukb-a-438) | rs2389921 | 0.0377640191698993 | 0.0175572026224758 | 0.0314830501388599 |
| Ice-cream | Fractured bone site(s): Ankle (ukb-a-438) | All - Inverse variance weighted | 0.0095011954050931 | 0.0043994621250304 | 0.0308015879621909 |
| Ice-cream | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs145248784 | -0.432573928492858 | 0.179007343419745 | 0.0156698810611886 |
| Ice-cream | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | All - MR Egger | -0.271888237855325 | 0.111559488826068 | 0.0287448639740275 |
| Ice-cream | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | rs10467770 | -0.0264641223965793 | 0.009844776182746 | 0.0071851576513313 |
| Ice-cream | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | rs6444192 | -0.0224597895679984 | 0.0102460847327912 | 0.0283768863349827 |
| Ice-cream | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | All - MR Egger | 0.0642860172692532 | 0.0251007817832999 | 0.0374905133468796 |
| Ice-cream | Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) | All - Inverse variance weighted | -0.0105038045392467 | 0.0044578047580846 | 0.0184593509743935 |
| Ice-cream | Neck/shoulder pain for 3+ months (ukb-b-16118) | rs13243784 | 0.313292094617244 | 0.134600962329245 | 0.0199353694460662 |
| Ice-cream | Neck/shoulder pain for 3+ months (ukb-b-16118) | rs145248784 | 0.273747761746826 | 0.113916295597011 | 0.0162584928554183 |
| Ice-cream | Neck/shoulder pain for 3+ months (ukb-b-16118) | All - Inverse variance weighted | 0.0856012694093897 | 0.0335739764457462 | 0.0107836820618733 |
| Ice-cream | Non-cancer illness code, self-reported: ankylosing spondylitis (ukb-b-18194) | rs7251800 | -0.0139382716049383 | 0.0067512195121951 | 0.0389650181290423 |
| Ice-cream | Non-cancer illness code, self-reported: ankylosing spondylitis (ukb-b-18194) | All - Inverse variance weighted | -0.008074241482742 | 0.0039930970972273 | 0.0431711996893967 |
| Ice-cream | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs10467770 | 0.353974493639325 | 0.154535230395433 | 0.0219880218573295 |
| Ice-cream | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs113738028 | -0.399146080202079 | 0.162697369271819 | 0.0141550720350285 |
| Ice-cream | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs145248784 | -0.420300086049173 | 0.146168027023339 | 0.0040344126156338 |
| Ice-cream | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | All - MR Egger | -0.325030519665859 | 0.108634361151748 | 0.00970477638074 |
| Ice-cream | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | All - Inverse variance weighted | -0.0064673201204478 | 0.0032266728032956 | 0.0450346220752795 |
| Ice-cream | Non-cancer illness code, self-reported: fracture wrist / colles fracture (ukb-b-7831) | All - Inverse variance weighted | 0.0074630705553609 | 0.003612665117741 | 0.0388466633084846 |
| Ice-cream | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | All - MR Egger | 0.0738799579853177 | 0.0252219919189155 | 0.0220497402756656 |
| Ice-cream | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | All - Inverse variance weighted | -0.0063151821252152 | 0.0031667538526065 | 0.0461287674185069 |
| Ice-cream | Heel bone mineral density (BMD) (ukb-b-8875) | rs10467770 | 0.348908764893741 | 0.154502869996074 | 0.023929005386631 |
| Ice-cream | Heel bone mineral density (BMD) (ukb-b-8875) | rs113738028 | -0.395471337003048 | 0.162669135174513 | 0.0150514241016566 |
| Ice-cream | Heel bone mineral density (BMD) (ukb-b-8875) | rs145248784 | -0.42502165153148 | 0.146126255579969 | 0.0036306038606527 |
| Ice-cream | Heel bone mineral density (BMD) (ukb-b-8875) | All - MR Egger | -0.329324977414657 | 0.107848687853109 | 0.008588504749916 |
| Ice-cream | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | All - Inverse variance weighted | -0.0045894271179836 | 0.0023084153774216 | 0.0467974457791992 |
| Ice-cream | Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) | rs6495888 | -0.0219280443992325 | 0.0106804105126257 | 0.0400620304239512 |
| Ice-cream | Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) | rs7251800 | 0.0217460403492924 | 0.0101358024691358 | 0.0319154433757056 |
| Ice-cream | Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) | All - Inverse variance weighted | -0.0059592157384602 | 0.0029107985865667 | 0.0406307350300225 |
| Ice-cream | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | rs28607628 | -4.23960265237164 | 1.92735194735906 | 0.0278279446572673 |
| Ice-cream | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | All - Inverse variance weighted | -1.53426909520036 | 0.673670943948753 | 0.0227578438053393 |
| Ice-cream | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | rs28607628 | -3.96648967251848 | 1.91274357866924 | 0.0381055627377425 |
| Ice-cream | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | All - Inverse variance weighted | -1.41618802683093 | 0.692635378141775 | 0.0408906439206467 |
| Ice-cream | Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) | All - Inverse variance weighted | -1.48470053949949 | 0.650600444496141 | 0.0224865885231121 |
| Ice-cream | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) | All - Inverse variance weighted | -1.3932998811333 | 0.652711929516443 | 0.0327910677152837 |
| Ice-cream | Osteoarthrosis (ukb-e-740_CSA) | rs113438694 | 9.14362754841888 | 4.03685106603635 | 0.0235102491689634 |
| Ice-cream | Osteoarthrosis (ukb-e-740_CSA) | All - Inverse variance weighted | 2.32363168242252 | 1.15963672433016 | 0.0450959604328864 |
| Ice-cream | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | rs496092 | 8.98413533175563 | 4.05580920963514 | 0.0267513005495827 |
| Ice-cream | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | All - Inverse variance weighted | 4.01789906827868 | 1.46744775071031 | 0.0061810601441562 |
| Ice-cream | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | rs2389921 | 9.47471746445012 | 3.38885185321274 | 0.0051763607621819 |
| Ice-cream | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | All - Inverse variance weighted | 2.16527623983299 | 1.07362570057303 | 0.0437175629587446 |