ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Other dessert (ukb-b-17441)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Other dessert (👉 📊) Heel bone mineral density (ebi-a-GCST006979) Weighted median 15 -0.102238126 0.046517871 0.027961601
Other dessert (👉 📊) Ultradistal forearm bone mineral density (ebi-a-GCST90013422) Inverse variance weighted 12 -0.55221946 0.260466888 0.033996444
Other dessert (👉 📊) Bone mineral density (ebi-a-GCST90014022) Inverse variance weighted 14 -0.09181045 0.037984965 0.015648125
Other dessert (👉 📊) Rheumatoid arthritis (ebi-a-GCST90018690) Weighted median 9 1.455611024 0.742388137 0.049912362
Other dessert (👉 📊) Spine arthritis or spondylitis (ebi-a-GCST90038657) Weighted median 16 0.00901168 0.00456206 0.04822806
Other dessert (👉 📊) Fracture of lower leg or ankle (ebi-a-GCST90038707) Inverse variance weighted 16 -0.005692116 0.002563868 0.026410043
Other dessert (👉 📊) Cervical root disorders (finn-b-G6_CERVROOT) Inverse variance weighted 16 -4.591451535 2.168269238 0.034211906
Other dessert (👉 📊) Achilles tendinitis (finn-b-M13_ACHILLESTEND) Inverse variance weighted 16 1.414374883 0.625036539 0.023643857
Other dessert (👉 📊) Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) Inverse variance weighted 16 1.094047272 0.46913972 0.019699183
Other dessert (👉 📊) Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) Weighted median 16 2.626407932 1.228649239 0.032546093
Other dessert (👉 📊) Cervicalgia (finn-b-M13_CERVICALGIA) Inverse variance weighted 16 -0.927252846 0.44364874 0.036612337
Other dessert (👉 📊) Contracture of joint (finn-b-M13_CONTRACTUREJOINT) MR Egger 16 10.82938119 4.325574596 0.025291573
Other dessert (👉 📊) Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) MR Egger 16 -5.942804215 2.300784023 0.0216848
Other dessert (👉 📊) Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) MR Egger 16 5.516812173 2.3409934 0.03353798
Other dessert (👉 📊) Peroneal tendinitis (finn-b-M13_PERONEALTEND) Inverse variance weighted 16 6.057577286 2.591239575 0.019402084
Other dessert (👉 📊) Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) MR Egger 16 4.713170111 2.061339388 0.038320879
Other dessert (👉 📊) Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) Weighted median 16 -1.127206623 0.558282501 0.043480843
Other dessert (👉 📊) Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) MR Egger 16 -5.301653802 2.461148514 0.049136718
Other dessert (👉 📊) Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) MR Egger 16 4.627219866 1.940560546 0.031799836
Other dessert (👉 📊) Shoulder region (finn-b-Z21_SHOUL_REGION) MR Egger 16 -11.32278982 5.15316464 0.045333352
Other dessert (👉 📊) Shoulder region (finn-b-Z21_SHOUL_REGION) Weighted median 16 -6.20294355 3.008437783 0.039222142
Other dessert (👉 📊) Osteomyelitis (ieu-b-4975) Weighted median 16 1.088253288 0.513326172 0.034005749
Other dessert (👉 📊) Osteomodulin (prot-a-2147) MR Egger 15 3.205271626 1.234519836 0.022158011
Other dessert (👉 📊) Osteomodulin (prot-a-2147) Weighted median 15 1.2616061 0.629383745 0.045015442
Other dessert (👉 📊) Bone morphogenetic protein 10 (prot-a-254) Inverse variance weighted 15 -0.863365823 0.436595568 0.047985636
Other dessert (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) Inverse variance weighted 16 0.010194618 0.005068186 0.044273473
Other dessert (👉 📊) Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) Weighted median 6 0.014476368 0.006690069 0.03047514
Other dessert (👉 📊) Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) Inverse variance weighted 6 0.012778647 0.005807801 0.027788767
Other dessert (👉 📊) Non-cancer illness code, self-reported: joint pain (ukb-b-4122) Inverse variance weighted 3 0.0101732 0.004748041 0.032144421
Other dessert (👉 📊) Non-cancer illness code, self-reported: joint disorder (ukb-b-8201) Weighted median 5 0.012128798 0.006092507 0.046505848
Other dessert (👉 📊) Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) Inverse variance weighted 15 -0.005038239 0.0023052 0.028845072
Other dessert (👉 📊) Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) MR Egger 16 -0.01324901 0.005320667 0.025958079
Other dessert (👉 📊) Knee pain for 3+ months (ukb-e-3773_CSA) Weighted median 12 -3.794273088 1.833568298 0.038514353
Other dessert (👉 📊) Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) MR Egger 10 -3.197116668 1.275681193 0.036586691
Other dessert (👉 📊) Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) Inverse variance weighted 13 0.708549666 0.339756999 0.037027556
Other dessert (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) MR Egger 10 -3.288862563 1.270537991 0.03218513
Other dessert (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) Inverse variance weighted 13 0.672531178 0.341552881 0.048948534

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Other dessert Heel bone mineral density (ebi-a-GCST006979) rs72763755 0.288151654445296 0.12846256977126 0.0248917397253282
Other dessert Ultradistal forearm bone mineral density (ebi-a-GCST90013422) rs142984618 -2.60869403967615 0.902345039368327 0.0038399844341388
Other dessert Ultradistal forearm bone mineral density (ebi-a-GCST90013422) All - Inverse variance weighted -0.552219459506527 0.260466887717135 0.033996444133662
Other dessert Bone mineral density (ebi-a-GCST90014022) All - Inverse variance weighted -0.091810449713474 0.0379849652943438 0.0156481245956909
Other dessert Spine arthritis or spondylitis (ebi-a-GCST90038657) rs76915123 0.0284181744024798 0.0135616934497104 0.0361288879455731
Other dessert Fracture of lower leg or ankle (ebi-a-GCST90038707) rs142984618 -0.0212998161698803 0.009125873563943 0.0195955654419652
Other dessert Fracture of lower leg or ankle (ebi-a-GCST90038707) All - Inverse variance weighted -0.0056921160886034 0.0025638677930269 0.0264100426131456
Other dessert Cervical root disorders (finn-b-G6_CERVROOT) All - Inverse variance weighted -4.59145153452369 2.16826923819404 0.0342119060050013
Other dessert Achilles tendinitis (finn-b-M13_ACHILLESTEND) rs116587920 4.52717251699414 2.05498463071478 0.027593329569692
Other dessert Achilles tendinitis (finn-b-M13_ACHILLESTEND) rs191624694 4.95515210053174 2.19334651353486 0.0238725440670282
Other dessert Achilles tendinitis (finn-b-M13_ACHILLESTEND) All - Inverse variance weighted 1.41437488329227 0.625036539449511 0.0236438572005552
Other dessert Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) rs7296465 4.00538018378327 1.83307146598105 0.0288840858037754
Other dessert Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) All - Inverse variance weighted 1.09404727185938 0.46913971950055 0.0196991834396088
Other dessert Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) rs34432311 6.24440366206081 2.99950660857352 0.0373598033293548
Other dessert Cervicalgia (finn-b-M13_CERVICALGIA) All - Inverse variance weighted -0.927252845806105 0.443648739926344 0.0366123372971362
Other dessert Contracture of joint (finn-b-M13_CONTRACTUREJOINT) rs4923342 -23.7395471522208 8.30543064880137 0.0042589573157535
Other dessert Contracture of joint (finn-b-M13_CONTRACTUREJOINT) All - MR Egger 10.8293811861953 4.32557459577045 0.0252915734533262
Other dessert Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) All - MR Egger -5.94280421549234 2.30078402337853 0.0216847998463397
Other dessert Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) rs116587920 6.80972255983505 3.29625051503914 0.0388379623897198
Other dessert Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) All - MR Egger 5.51681217250952 2.34099339961363 0.0335379798625609
Other dessert Peroneal tendinitis (finn-b-M13_PERONEALTEND) rs2275336 24.3364654324988 8.70434338497361 0.0051755563294766
Other dessert Peroneal tendinitis (finn-b-M13_PERONEALTEND) rs4923342 23.409831219551 9.24910038713198 0.0113725293065758
Other dessert Peroneal tendinitis (finn-b-M13_PERONEALTEND) rs7296465 16.4143217635576 7.94529352949579 0.0388362604309904
Other dessert Peroneal tendinitis (finn-b-M13_PERONEALTEND) All - Inverse variance weighted 6.05757728644775 2.59123957477519 0.0194020843174457
Other dessert Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) All - MR Egger 4.71317011069731 2.06133938841423 0.0383208786310483
Other dessert Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) All - MR Egger -5.30165380209759 2.46114851396852 0.0491367179642063
Other dessert Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) rs142984618 10.7059101321673 3.57646628318245 0.0027585859117615
Other dessert Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) rs890665 -6.02860366990482 2.56353645373369 0.0186891141517245
Other dessert Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) All - MR Egger 4.62721986577986 1.94056054573225 0.0317998356603942
Other dessert Shoulder region (finn-b-Z21_SHOUL_REGION) All - MR Egger -11.3227898184235 5.15316464007786 0.0453333517826309
Other dessert Osteomodulin (prot-a-2147) rs11776091 -4.80220697171466 1.80508489007714 0.0078053147234176
Other dessert Osteomodulin (prot-a-2147) rs34432311 3.10914914779031 1.54804823227511 0.0445974367933887
Other dessert Osteomodulin (prot-a-2147) All - MR Egger 3.20527162553286 1.23451983638772 0.0221580112721366
Other dessert Bone morphogenetic protein 10 (prot-a-254) All - Inverse variance weighted -0.863365822650829 0.436595568481242 0.0479856355690314
Other dessert Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) rs7296465 0.0496458244060372 0.0213736132933391 0.0201919222861695
Other dessert Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) rs9939787 0.0533142756891196 0.0206961888151581 0.0099938170094179
Other dessert Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) All - Inverse variance weighted 0.0101946180850941 0.0050681862396228 0.0442734726462772
Other dessert Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) rs7296465 0.0292503451887826 0.0127491310765129 0.0217732106313332
Other dessert Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) All - Inverse variance weighted 0.0127786470054987 0.005807801205393 0.0277887669825461
Other dessert Non-cancer illness code, self-reported: joint pain (ukb-b-4122) All - Inverse variance weighted 0.0101732001147827 0.0047480408165557 0.0321444210674462
Other dessert Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) rs13200945 -0.0233234062717436 0.0088135811799707 0.008137689007267
Other dessert Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) All - Inverse variance weighted -0.0050382389633491 0.0023051999065652 0.028845071707262
Other dessert Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) rs191624694 -0.0198026658885988 0.009280572282338 0.0328610906264192
Other dessert Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) All - MR Egger -0.013249009891406 0.0053206672308679 0.0259580786518279
Other dessert Knee pain for 3+ months (ukb-e-3773_CSA) rs72763755 12.093685016964 5.13023968479807 0.0184067159103031
Other dessert Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) rs4923342 4.18909777214355 1.85493635914024 0.0239237719277618
Other dessert Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) rs76915123 -5.8601843543519 2.88963210702341 0.0425598792213184
Other dessert Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) All - MR Egger -3.19711666812209 1.27568119266809 0.0365866909442022
Other dessert Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) rs72763755 3.00518040202838 1.38904089599066 0.0305032734256679
Other dessert Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) All - Inverse variance weighted 0.708549666119185 0.339756998663979 0.0370275558839828
Other dessert Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) rs4923342 4.15783160611452 1.82423866885719 0.0226543051716332
Other dessert Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) rs76915123 -6.08858797618076 2.83807814666775 0.03192720949551
Other dessert Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) All - MR Egger -3.28886256253862 1.27053799122206 0.0321851303730094
Other dessert Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) rs72763755 3.07495166174164 1.39588121557039 0.0276035687602754
Other dessert Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) All - Inverse variance weighted 0.672531178040825 0.341552881464086 0.0489485341211973