ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Fruitcake | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | All - MR Egger | 4.35496484477446 | 1.8096085490497 | 0.0348247517399219 |
| Fruitcake | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | rs595711 | -5.3404342208824 | 1.68632590326557 | 0.0015407055146442 |
| Fruitcake | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | All - Inverse variance weighted | -1.4837817687255 | 0.501809657372329 | 0.0031078745676909 |
| Fruitcake | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | rs595711 | -8.10481296128544 | 2.06219278575565 | 8.487816430343e-05 |
| Fruitcake | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | All - Inverse variance weighted | -2.00842448356233 | 0.710098771280786 | 0.0046785200071902 |
| Fruitcake | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | rs595711 | -2.92533301652831 | 1.35635367320572 | 0.0310241584396953 |
| Fruitcake | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | All - Inverse variance weighted | -0.786185381238518 | 0.377634373136918 | 0.0373544161302541 |
| Fruitcake | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | rs2058736 | -17.3584688940258 | 6.56147252652587 | 0.0081566857867511 |
| Fruitcake | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | rs595711 | -17.0926209180416 | 7.24691486360059 | 0.0183436925533183 |
| Fruitcake | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | All - Inverse variance weighted | -5.20474157211628 | 2.54363983477653 | 0.0407387952061712 |
| Fruitcake | Cervical root disorders (finn-b-G6_CERVROOT) | rs2058736 | 20.9335381699665 | 9.30858064485252 | 0.0245224745859883 |
| Fruitcake | Cervical root disorders (finn-b-G6_CERVROOT) | rs73148292 | 21.7045550937314 | 10.1789804054627 | 0.0329828766950099 |
| Fruitcake | Cervical root disorders (finn-b-G6_CERVROOT) | All - Inverse variance weighted | 7.28618912211806 | 3.21449047428309 | 0.0234103924037893 |
| Fruitcake | Cervical root disorders (finn-b-G6_CERVROOT) | All - MR Egger | 21.3518187610503 | 9.60782049935725 | 0.0481680113129419 |
| Fruitcake | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | rs73148292 | 2.23195351598948 | 0.95427941301213 | 0.0193411846925008 |
| Fruitcake | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | All - Inverse variance weighted | 0.70735109798249 | 0.294400852323803 | 0.0162754137294155 |
| Fruitcake | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | rs595711 | -5.55398803071029 | 2.24238554181084 | 0.0132558293081849 |
| Fruitcake | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | rs7137088 | -5.00266414066663 | 2.4495293351489 | 0.0411221714612608 |
| Fruitcake | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | All - Inverse variance weighted | -1.63335852606779 | 0.727178224419732 | 0.0246937713995609 |
| Fruitcake | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs595711 | 4.09123984615156 | 1.85627942202884 | 0.027524344086882 |
| Fruitcake | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs73148292 | 3.72168971074731 | 1.86084485537365 | 0.0455002638963584 |
| Fruitcake | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | All - Inverse variance weighted | 1.51513179931986 | 0.590999296899927 | 0.010356962786606 |
| Fruitcake | Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) | rs7137088 | 3.27467290272926 | 1.53928127405127 | 0.0333865428611683 |
| Fruitcake | Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) | rs73148292 | 3.38239036389855 | 1.42081601492917 | 0.0172846090328266 |
| Fruitcake | Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) | All - Inverse variance weighted | 1.16412009268788 | 0.456129662713943 | 0.0107054504475532 |
| Fruitcake | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | rs3779787 | 19.6782607578347 | 7.60661467100107 | 0.0096817490665523 |
| Fruitcake | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | rs17075938 | 19.6797473475407 | 8.21294495847852 | 0.0165666612154225 |
| Fruitcake | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | rs3779787 | 26.077068369589 | 12.6241535713827 | 0.0388616478249053 |
| Fruitcake | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | rs7137088 | 42.4153395299272 | 12.3253507785211 | 0.000578907196825 |
| Fruitcake | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | All - Inverse variance weighted | 10.2425049535063 | 3.99621570697277 | 0.0103756784632346 |
| Fruitcake | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs139464753 | 4.01670842266255 | 1.87506636153539 | 0.0321799112647124 |
| Fruitcake | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs7137088 | 4.7103487064117 | 1.63178615830916 | 0.003894025942261 |
| Fruitcake | Cervical disc disorders (finn-b-M13_CERVICDISC) | All - MR Egger | 3.30349229695918 | 1.40827287081675 | 0.038775227986365 |
| Fruitcake | Infective bursitis (finn-b-M13_INFBURSA) | rs139464753 | 20.2439393562875 | 7.56577981299037 | 0.0074568003107563 |
| Fruitcake | Infective bursitis (finn-b-M13_INFBURSA) | All - MR Egger | 12.7922522056987 | 5.4119368539966 | 0.0375669115810274 |
| Fruitcake | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | rs17075938 | 1.96188462726367 | 0.817814434424768 | 0.0164427806559393 |
| Fruitcake | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | All - Inverse variance weighted | 0.735662041307636 | 0.320077360582347 | 0.0215397022619298 |
| Fruitcake | Loose body in joint (finn-b-M13_LOOSEJOINT) | rs2058736 | 12.4959918065347 | 5.64257921865353 | 0.0267883128424638 |
| Fruitcake | Loose body in joint (finn-b-M13_LOOSEJOINT) | All - Inverse variance weighted | 3.85378435043217 | 1.92738439512988 | 0.0455554454288158 |
| Fruitcake | Other joint disorders (finn-b-M13_OTHERJOINT) | rs139464753 | 2.00157686303657 | 0.905905555392397 | 0.0271415284545216 |
| Fruitcake | Other joint disorders (finn-b-M13_OTHERJOINT) | rs73148292 | 1.90855882602426 | 0.715709559759097 | 0.0076607611351794 |
| Fruitcake | Other joint disorders (finn-b-M13_OTHERJOINT) | All - Inverse variance weighted | 0.727436546042263 | 0.220026919128645 | 0.0009459580352528 |
| Fruitcake | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | rs139464753 | 23.675536709507 | 10.7420970471093 | 0.0275246398906057 |
| Fruitcake | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | All - MR Egger | 22.6322703329981 | 7.90840128701854 | 0.0154667308357903 |
| Fruitcake | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | 1.37668872721797 | 0.524141187777074 | 0.0086252567559129 |
| Fruitcake | Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) | All - Inverse variance weighted | 2.65508902326183 | 1.26387705169346 | 0.0356629658296256 |
| Fruitcake | Injuries to the neck (finn-b-ST19_INJURI_NECK) | rs11596121 | -5.92895884292247 | 2.5311070934808 | 0.0191582694169308 |
| Fruitcake | Injuries to the neck (finn-b-ST19_INJURI_NECK) | rs2058736 | -4.72847181342637 | 1.87128793426084 | 0.0115089263879467 |
| Fruitcake | Injuries to the neck (finn-b-ST19_INJURI_NECK) | All - Inverse variance weighted | -1.38230500019811 | 0.681742989044614 | 0.0426006521801854 |
| Fruitcake | Four-jointed box protein 1 (prot-a-1112) | All - Inverse variance weighted | 1.17165759511142 | 0.581424424855809 | 0.0438889048397111 |
| Fruitcake | Bone sialoprotein 2 (prot-a-1395) | rs74641672 | -6.05458313905802 | 2.26323653033928 | 0.0074687361666056 |
| Fruitcake | Fractured bone site(s): Ankle (ukb-a-438) | rs595711 | -0.0504994134157026 | 0.0244248503838786 | 0.0386830746405841 |
| Fruitcake | Fractured bone site(s): Ankle (ukb-a-438) | rs79458768 | -0.0580796480459174 | 0.0252678019809873 | 0.0215297366406679 |
| Fruitcake | Fractured bone site(s): Ankle (ukb-a-438) | All - Inverse variance weighted | -0.017317332047811 | 0.0069246206078446 | 0.0123900966544686 |
| Fruitcake | Fractured bone site(s): Other bones (ukb-a-441) | rs2058736 | -0.138786390807238 | 0.051228780504147 | 0.0067456072639074 |
| Fruitcake | Fractured bone site(s): Other bones (ukb-a-441) | rs79458768 | -0.135935289076669 | 0.0477018853259462 | 0.0043762714273575 |
| Fruitcake | Fractured bone site(s): Other bones (ukb-a-441) | All - Inverse variance weighted | -0.0296309217798943 | 0.0133068257080338 | 0.0259642498855064 |
| Fruitcake | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | rs2905563 | 0.0407609701091505 | 0.0154095125668426 | 0.0081646913473081 |
| Fruitcake | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | All - Inverse variance weighted | 0.0178597032638892 | 0.0073677032185395 | 0.0153483643268072 |
| Fruitcake | Operative procedures - secondary OPCS: Z84.3 Hip joint (ukb-b-17133) | All - Inverse variance weighted | -0.0151068471281944 | 0.0070075681999081 | 0.0311000479727209 |
| Fruitcake | Ankle spacing width (ukb-b-4080) | rs17075938 | 0.434533084508942 | 0.210856921624667 | 0.0393225135688397 |
| Fruitcake | Ankle spacing width (ukb-b-4080) | rs2058736 | 0.513627857782117 | 0.212902793531374 | 0.0158435643099194 |
| Fruitcake | Ankle spacing width (ukb-b-4080) | rs2959061 | 0.458452660002022 | 0.200713072106198 | 0.022364503558956 |
| Fruitcake | Ankle spacing width (ukb-b-4080) | rs3779787 | 0.406090431341308 | 0.204373803435826 | 0.046922568236188 |
| Fruitcake | Ankle spacing width (ukb-b-4080) | rs7137088 | 0.480333461606773 | 0.209735954058374 | 0.0220107808992348 |
| Fruitcake | Ankle spacing width (ukb-b-4080) | rs73148292 | 0.426477012469251 | 0.192269806599372 | 0.0265468255461999 |
| Fruitcake | Ankle spacing width (ukb-b-4080) | rs920655 | -0.888179642083666 | 0.208332383449219 | 2.01446278576538e-05 |
| Fruitcake | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs595711 | -0.0985766049391883 | 0.0356321745199661 | 0.005666063810851 |
| Fruitcake | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs73148292 | -0.107663393841717 | 0.0355048668250064 | 0.0024265288921683 |
| Fruitcake | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs74641672 | -0.0814121915276676 | 0.038110520816671 | 0.0326620530534675 |
| Fruitcake | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | All - Inverse variance weighted | -0.0302934486582382 | 0.012610412348584 | 0.0162942657842774 |
| Fruitcake | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | rs920655 | -0.0535699019719594 | 0.0251985495269577 | 0.0335105771120522 |
| Fruitcake | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | All - Inverse variance weighted | -0.0170311152582395 | 0.0078788634204408 | 0.0306474148170859 |
| Fruitcake | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | rs17075938 | -11.6930063815626 | 5.08958983126052 | 0.0215939159379788 |
| Fruitcake | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | rs920655 | -14.2055169269349 | 5.50410349937308 | 0.0098544355921225 |
| Fruitcake | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | All - Inverse variance weighted | -5.55421440765403 | 2.30836315758988 | 0.0161226685661113 |