ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Fruit smoothie | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs148801832 | 3.86494573001878 | 1.587088882725 | 0.0148818272323753 |
| Fruit smoothie | Osteoarthritis (self-reported) (ebi-a-GCST005811) | All - MR Egger | 1.91387296714078 | 0.570320414343928 | 0.0029927953510928 |
| Fruit smoothie | Heel bone mineral density (ebi-a-GCST006288) | All - Inverse variance weighted | -0.178711138306795 | 0.0765447735502733 | 0.0195576945009408 |
| Fruit smoothie | Heel bone mineral density (ebi-a-GCST006288) | All - MR Egger | -0.319901315411664 | 0.136657548400023 | 0.0282728001399088 |
| Fruit smoothie | Frozen shoulder (ebi-a-GCST90000512) | rs115361090 | 3.67266341153406 | 1.6386774439738 | 0.0250107710865543 |
| Fruit smoothie | Bone disorder (ebi-a-GCST90038652) | rs148801832 | -0.0675214510797157 | 0.0342553394658943 | 0.0487099301011825 |
| Fruit smoothie | Bone disorder (ebi-a-GCST90038652) | rs149304310 | -0.0819870145833516 | 0.0316863042924748 | 0.0096686689252605 |
| Fruit smoothie | Bone disorder (ebi-a-GCST90038652) | rs67791558 | 0.0903528850739151 | 0.0323263392147512 | 0.0051895906407372 |
| Fruit smoothie | Bone disorder (ebi-a-GCST90038652) | rs685117 | -0.0486830905664383 | 0.024559144264219 | 0.0474479564000297 |
| Fruit smoothie | Bone disorder (ebi-a-GCST90038652) | All - MR Egger | -0.0626822529595582 | 0.0134442370831917 | 0.0001697434268734 |
| Fruit smoothie | Osteoporosis (ebi-a-GCST90038656) | rs1379657 | 0.0641079452763511 | 0.0299072293127835 | 0.0320681457999938 |
| Fruit smoothie | Osteoporosis (ebi-a-GCST90038656) | rs149304310 | -0.0595641237258224 | 0.0270246362941956 | 0.0275195943213644 |
| Fruit smoothie | Osteoporosis (ebi-a-GCST90038656) | rs183426795 | -0.0670824467556227 | 0.030323194861495 | 0.0269494893420174 |
| Fruit smoothie | Osteoporosis (ebi-a-GCST90038656) | rs3111807 | 0.060189221672035 | 0.0286125667035239 | 0.0354138838006482 |
| Fruit smoothie | Osteoporosis (ebi-a-GCST90038656) | rs67791558 | 0.058862660944206 | 0.0275703385789223 | 0.0327610454426515 |
| Fruit smoothie | Osteoporosis (ebi-a-GCST90038656) | All - MR Egger | -0.0455836749347459 | 0.0114664210707757 | 0.0008104696775094 |
| Fruit smoothie | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs77343107 | -0.0406600610022803 | 0.0200236777493308 | 0.0422956842481822 |
| Fruit smoothie | Spine arthritis or spondylitis (ebi-a-GCST90038657) | All - MR Egger | 0.0205133158595959 | 0.0084728236805469 | 0.0256539711501641 |
| Fruit smoothie | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | rs143438158 | -28.6695382846684 | 13.5689623223045 | 0.034611360786777 |
| Fruit smoothie | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | rs6429985 | 53.4686247337729 | 24.1208694115568 | 0.0266439006876879 |
| Fruit smoothie | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | rs685117 | 17.7383725238478 | 4.92676938112967 | 0.0003177200629179 |
| Fruit smoothie | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | All - MR Egger | 10.3676594441441 | 4.40433061647948 | 0.0279175112570047 |
| Fruit smoothie | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | rs143438158 | -28.5749942328128 | 13.5803076085271 | 0.0353654288267699 |
| Fruit smoothie | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | rs6429985 | 54.0871085648385 | 24.2324755164107 | 0.0256143541444792 |
| Fruit smoothie | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | rs685117 | 17.5721441260292 | 4.90874461510115 | 0.0003439054958029 |
| Fruit smoothie | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | All - MR Egger | 10.3980310915241 | 4.40654349956215 | 0.0275792202705248 |
| Fruit smoothie | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | rs67791558 | -38.5868701319345 | 16.1043554283898 | 0.0165727471314065 |
| Fruit smoothie | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | rs77236912 | -25.57986470236 | 12.3470231055114 | 0.038289369494972 |
| Fruit smoothie | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | All - Inverse variance weighted | -7.20608372024848 | 2.5628123140656 | 0.0049267034399217 |
| Fruit smoothie | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | rs67791558 | -38.6067397869973 | 16.1043554283898 | 0.0165170428125848 |
| Fruit smoothie | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | rs77236912 | -25.6540953021928 | 12.371766638789 | 0.0381164752109646 |
| Fruit smoothie | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | All - Inverse variance weighted | -7.21757139442589 | 2.57150642767185 | 0.0050044321496951 |
| Fruit smoothie | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | rs113156836 | 2.99843704951366 | 1.00757196400662 | 0.0029212665999687 |
| Fruit smoothie | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | rs141577316 | -1.17437044514139 | 0.48113839307632 | 0.0146541057939031 |
| Fruit smoothie | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | rs115361090 | 50.7902822659581 | 23.9056484400047 | 0.0336188105665903 |
| Fruit smoothie | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | All - MR Egger | -11.6916372828329 | 4.21127813666487 | 0.011012553525054 |
| Fruit smoothie | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs142521944 | -10.0434973852695 | 3.84529453245547 | 0.0090042464046195 |
| Fruit smoothie | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs685117 | -3.64100273776168 | 1.33783818967261 | 0.0064975201060596 |
| Fruit smoothie | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | All - MR Egger | -2.72233935847496 | 1.04749077702337 | 0.0163848718960472 |
| Fruit smoothie | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | rs3111807 | 18.1722032594587 | 8.46113167636171 | 0.0317354274773531 |
| Fruit smoothie | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | rs77343107 | 23.5086225498487 | 9.54691518583534 | 0.013799861644879 |
| Fruit smoothie | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | All - MR Egger | -5.16634099603205 | 2.15026426475119 | 0.0251520870465162 |
| Fruit smoothie | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | rs7930618 | 13.2255124919495 | 6.63547131087303 | 0.0462446473477412 |
| Fruit smoothie | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | rs141348882 | 8.75081920450052 | 4.2138254638548 | 0.0378299609391701 |
| Fruit smoothie | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | All - MR Egger | 3.56865134548594 | 1.6364992066733 | 0.0401850183044371 |
| Fruit smoothie | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs115361090 | -25.8973129551819 | 12.6564321968741 | 0.0407388623039396 |
| Fruit smoothie | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | All - Inverse variance weighted | -3.57840808339562 | 1.34839090441051 | 0.0079582537282984 |
| Fruit smoothie | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | rs142521944 | -10.0853889280652 | 4.58537845517954 | 0.0278447279568005 |
| Fruit smoothie | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | rs62438192 | -12.0569460090448 | 5.50195098855529 | 0.0284232452961669 |
| Fruit smoothie | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | All - Inverse variance weighted | -1.65441579832086 | 0.762161517494222 | 0.0299546717873767 |
| Fruit smoothie | Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) | rs685117 | -2.55951677605029 | 0.965326358416464 | 0.0080146437142563 |
| Fruit smoothie | Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) | All - MR Egger | -1.7094575794428 | 0.75228708809638 | 0.0331889800612044 |
| Fruit smoothie | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs6429985 | 9.37026255336167 | 3.58999637280159 | 0.0090514799006815 |
| Fruit smoothie | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | All - MR Egger | -1.18231851739285 | 0.543078596791995 | 0.0404847913320426 |
| Fruit smoothie | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | All - Inverse variance weighted | 0.818519541432124 | 0.405263428059701 | 0.0434122112981566 |
| Fruit smoothie | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs6051417 | -6.91368865811444 | 2.24623294644675 | 0.0020846228056686 |
| Fruit smoothie | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs6429985 | 5.20828489318366 | 2.53438863105812 | 0.0398745742924445 |
| Fruit smoothie | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | 0.538265496604794 | 0.232000781588632 | 0.02033535569291 |
| Fruit smoothie | Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) | rs1379657 | -41.6498036941384 | 18.1389953979731 | 0.0216674656772056 |
| Fruit smoothie | Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) | rs141348882 | 22.9467530615229 | 10.7764885148883 | 0.0332265625581102 |
| Fruit smoothie | Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) | rs685117 | 13.0939911438316 | 5.53360317075662 | 0.0179684054104961 |
| Fruit smoothie | Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | 5.92474109590473 | 2.90976394656583 | 0.0417344246350952 |
| Fruit smoothie | Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) | All - MR Egger | 16.5409000177286 | 4.34998699640357 | 0.0009751124883383 |
| Fruit smoothie | Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) | rs685117 | -7.96294108104536 | 3.2284358708866 | 0.0136440255775082 |
| Fruit smoothie | Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) | rs77236912 | 21.1012851791184 | 7.92287935548044 | 0.0077370250183408 |
| Fruit smoothie | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | rs143438158 | 7.99086326282868 | 4.06539422978743 | 0.0493469849293246 |
| Fruit smoothie | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | rs149304310 | 5.65423145473542 | 2.66468827098168 | 0.0338452093623699 |
| Fruit smoothie | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | rs7930618 | 12.5013027757809 | 4.5777536671468 | 0.0063165180041829 |
| Fruit smoothie | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | All - Inverse variance weighted | 1.57175636923017 | 0.665079527078083 | 0.0181149170000022 |
| Fruit smoothie | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | All - MR Egger | 2.78725216472465 | 1.10905084420171 | 0.0197884111961552 |
| Fruit smoothie | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | rs77343107 | -7.66319276370656 | 3.59248610536015 | 0.0329151391434686 |
| Fruit smoothie | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | All - MR Egger | -1.83554196754019 | 0.803220006968242 | 0.0323005421236268 |
| Fruit smoothie | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | rs72686604 | -0.0413672342765046 | 0.018971373485265 | 0.0292198162507751 |
| Fruit smoothie | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | All - Inverse variance weighted | -0.0093134864339384 | 0.0041673667473817 | 0.0254264596039369 |
| Fruit smoothie | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | rs77236912 | 0.0505149129275064 | 0.0167187600520604 | 0.0025156642023418 |
| Fruit smoothie | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | rs149304310 | -0.0807407131004328 | 0.0316625986637049 | 0.0107712316600587 |
| Fruit smoothie | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | All - MR Egger | -0.0358173554449953 | 0.012747511222005 | 0.0104974638790663 |
| Fruit smoothie | Operation code: elbow surgery (ukb-b-10324) | All - Inverse variance weighted | -0.0181918459991164 | 0.0091542302382532 | 0.0468934658653189 |
| Fruit smoothie | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | rs67791558 | 0.0611368423144174 | 0.028290812271499 | 0.0306942554546966 |
| Fruit smoothie | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | All - Inverse variance weighted | 0.0362583238330625 | 0.0137938152889405 | 0.0085738953249679 |
| Fruit smoothie | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | All - Inverse variance weighted | -0.0224750521062785 | 0.0103895143624442 | 0.0305224362176692 |
| Fruit smoothie | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | rs62438192 | -0.0408430882761098 | 0.0193568268273171 | 0.034857538578781 |
| Fruit smoothie | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | All - Inverse variance weighted | -0.0216708650579053 | 0.0093465675435949 | 0.0204172370993113 |
| Fruit smoothie | Fractured heel (right) (ukb-b-3499) | rs3111807 | 0.0932109033219557 | 0.0471635979039469 | 0.0481172462734243 |
| Fruit smoothie | Fractured heel (right) (ukb-b-3499) | rs72686604 | 0.121472898575829 | 0.0448670346967517 | 0.0067813003180952 |
| Fruit smoothie | Fractured heel (right) (ukb-b-3499) | All - Inverse variance weighted | 0.0251194156856875 | 0.0102163206485028 | 0.0139420249920905 |
| Fruit smoothie | Operative procedures - main OPCS: W91.9 Unspecified other manipulation of joint (ukb-b-4663) | rs67791558 | -0.0255405539659832 | 0.0103580511842314 | 0.0136719751510798 |
| Fruit smoothie | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | rs67791558 | 0.0295492568749007 | 0.0150635828962009 | 0.0498049522916108 |
| Fruit smoothie | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | All - MR Egger | -0.0178895538129693 | 0.0073476954020783 | 0.0269849974964241 |
| Fruit smoothie | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs72686604 | -0.0402175795871335 | 0.0179311864074891 | 0.0249042652380427 |
| Fruit smoothie | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | All - Inverse variance weighted | -0.008767062581358 | 0.00401273108973 | 0.028902642170591 |
| Fruit smoothie | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | All - MR Egger | -0.015267087223282 | 0.0073130628152524 | 0.0498324287871268 |
| Fruit smoothie | Ankle spacing width (ukb-e-3143_AFR) | rs6051417 | -2.39163357768275 | 1.04930258603136 | 0.0226516049369384 |
| Fruit smoothie | Ankle spacing width (ukb-e-3143_AFR) | All - Inverse variance weighted | -1.04474967452876 | 0.495618243468295 | 0.0350333600535324 |
| Fruit smoothie | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | rs117735178 | -7.52827493619114 | 2.95355027045591 | 0.0108066360718503 |
| Fruit smoothie | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | All - Inverse variance weighted | -1.29801864676446 | 0.653661125989443 | 0.0470592094699711 |