ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Low calorie hot chocolate | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs76910833 | -0.0665792339807588 | 0.03118583227446 | 0.0327676057624303 |
| Low calorie hot chocolate | Spine arthritis or spondylitis (ebi-a-GCST90038657) | All - Inverse variance weighted | -0.0143472137887339 | 0.0063925977463138 | 0.0248100212321338 |
| Low calorie hot chocolate | Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) | rs115441677 | 14.7747080875857 | 6.20239260727334 | 0.0172143076179301 |
| Low calorie hot chocolate | Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) | rs116707297 | 14.9298143476292 | 7.19322077754059 | 0.0379365556269824 |
| Low calorie hot chocolate | Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) | All - Inverse variance weighted | 2.45124401047335 | 1.16325134512389 | 0.0350972098483411 |
| Low calorie hot chocolate | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs116707297 | -23.1644996442202 | 8.46755935054014 | 0.0062252269577338 |
| Low calorie hot chocolate | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | All - Inverse variance weighted | -3.31751383388296 | 1.32987246449996 | 0.0126095453214132 |
| Low calorie hot chocolate | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs146704655 | 170.668208081707 | 82.5371815878595 | 0.0386613138921646 |
| Low calorie hot chocolate | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | All - Inverse variance weighted | -6.9173293229192 | 3.39413204950915 | 0.0415473339743511 |
| Low calorie hot chocolate | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs4969076 | 9.09158182952227 | 4.09649762667428 | 0.0264625935221249 |
| Low calorie hot chocolate | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs62342194 | 8.92237587625599 | 4.15248356763904 | 0.0316594411649076 |
| Low calorie hot chocolate | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs72785604 | 9.83178925697174 | 3.29285981658244 | 0.0028284642907337 |
| Low calorie hot chocolate | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | All - MR Egger | -4.34413969747183 | 1.52715721621084 | 0.0094282627019627 |
| Low calorie hot chocolate | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs150202527 | 8.76163727848057 | 4.1312192812005 | 0.0339356324405044 |
| Low calorie hot chocolate | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs62342194 | 34.2306704621823 | 14.4845183392251 | 0.0181149973417155 |
| Low calorie hot chocolate | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs72785604 | 33.782519183979 | 11.5162361968931 | 0.0033519737880165 |
| Low calorie hot chocolate | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs74632403 | 41.7723073145278 | 19.0859142392339 | 0.0286225893523614 |
| Low calorie hot chocolate | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | All - Inverse variance weighted | 6.60324236024351 | 2.48767409950052 | 0.0079453349162986 |
| Low calorie hot chocolate | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | All - MR Egger | 11.573777787291 | 5.06168899014519 | 0.032211069395164 |
| Low calorie hot chocolate | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | rs2446482 | -22.6173655197118 | 11.4828155784195 | 0.0488761218668382 |
| Low calorie hot chocolate | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | rs78503161 | -22.3366626673107 | 9.82439191610702 | 0.0229905056216742 |
| Low calorie hot chocolate | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | All - Inverse variance weighted | -5.17612020617059 | 1.83805252157768 | 0.0048612138697524 |
| Low calorie hot chocolate | Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) | rs150202527 | 1.29231817153308 | 0.65082449432803 | 0.0470707468371006 |
| Low calorie hot chocolate | Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) | rs4969076 | -4.67793599949256 | 2.29932447432685 | 0.0419029452259953 |
| Low calorie hot chocolate | Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) | All - MR Egger | 1.69005128909789 | 0.803217001866898 | 0.0470232383025538 |
| Low calorie hot chocolate | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs149683155 | -16.9045134278957 | 8.15739259844756 | 0.0382380580231463 |
| Low calorie hot chocolate | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs150202527 | -6.24464935955604 | 2.89721871668607 | 0.0311309744466376 |
| Low calorie hot chocolate | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs4969076 | -24.605414776992 | 10.1619570158468 | 0.0154639853206918 |
| Low calorie hot chocolate | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs79434743 | -19.0741160955942 | 7.74146022224634 | 0.0137437804765452 |
| Low calorie hot chocolate | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | -4.5067009372094 | 1.90377658313216 | 0.0179211835142531 |
| Low calorie hot chocolate | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | rs150202527 | 7.33635496294499 | 2.57530552594317 | 0.0043893853719629 |
| Low calorie hot chocolate | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | rs62342194 | -19.8882107713238 | 9.35947940969168 | 0.0335927022460078 |
| Low calorie hot chocolate | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | All - MR Egger | 12.477825588422 | 3.18317338077982 | 0.0007330220516248 |
| Low calorie hot chocolate | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs150202527 | -2.47033383330962 | 1.24566408591816 | 0.0473511161272351 |
| Low calorie hot chocolate | Bone sialoprotein 2 (prot-a-1396) | rs4969076 | 8.37799837197256 | 3.91149450805028 | 0.0322021824766406 |
| Low calorie hot chocolate | Bone sialoprotein 2 (prot-a-1396) | All - Inverse variance weighted | 1.70075998992042 | 0.804559557157111 | 0.0345236455111477 |
| Low calorie hot chocolate | Osteocrin (prot-a-2157) | rs58812776 | 8.03538133979158 | 4.02571001255027 | 0.0459321881891259 |
| Low calorie hot chocolate | Osteocrin (prot-a-2157) | All - Inverse variance weighted | 2.56967023947528 | 0.804512062298639 | 0.0014028064985024 |
| Low calorie hot chocolate | Osteocrin (prot-a-2157) | All - MR Egger | 4.87464056828758 | 1.83905414232901 | 0.0146060677026065 |
| Low calorie hot chocolate | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs58812776 | 0.0484921630973909 | 0.0200220932890131 | 0.0154382080075514 |
| Low calorie hot chocolate | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs79434743 | 0.0430765891534052 | 0.0215505283201294 | 0.0456230009285897 |
| Low calorie hot chocolate | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs8046371 | 0.0408858368351782 | 0.0195864862023081 | 0.0368473554218702 |
| Low calorie hot chocolate | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | All - MR Egger | 0.0203069360295932 | 0.0090380351345566 | 0.0350150648082895 |
| Low calorie hot chocolate | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs149683155 | 0.0171478149179629 | 0.0086372955248581 | 0.0471086309544922 |
| Low calorie hot chocolate | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs2446482 | 0.0164753029911043 | 0.0081655853847837 | 0.0436276025662966 |
| Low calorie hot chocolate | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs74632403 | 0.0231721968138985 | 0.0081297461554989 | 0.0043678325235258 |
| Low calorie hot chocolate | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | All - MR Egger | 0.0083179601307234 | 0.0039912312638584 | 0.0489786528871298 |
| Low calorie hot chocolate | Fractured bone site(s): Leg (ukb-b-3798) | rs4969076 | 0.0668865560876598 | 0.0264949573435667 | 0.0115862553636735 |
| Low calorie hot chocolate | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs192654283 | 0.10483325037332 | 0.0399246723079476 | 0.0086451663410909 |
| Low calorie hot chocolate | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs62342194 | -0.108691803762369 | 0.0437343940379078 | 0.0129452990321989 |
| Low calorie hot chocolate | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | All - Inverse variance weighted | 0.0267747971848637 | 0.0091695779238875 | 0.0035007675354633 |
| Low calorie hot chocolate | Pain in joint (ukb-e-745_AFR) | rs116707297 | -23.9278090432758 | 11.6501714211786 | 0.0399893437327183 |
| Low calorie hot chocolate | Pain in joint (ukb-e-745_AFR) | All - Inverse variance weighted | -7.79042801852684 | 2.79499053860063 | 0.0053152132568131 |