ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Low fat hard cheese | Rheumatoid Arthritis (bbj-a-73) | rs72759807 | 6.2222256933326 | 3.07264860474379 | 0.0428636125076898 |
| Low fat hard cheese | Rheumatoid Arthritis (bbj-a-73) | All - MR Egger | 3.40736978405738 | 1.1277060513656 | 0.0128623567017218 |
| Low fat hard cheese | Rheumatoid Arthritis (bbj-a-74) | rs72759807 | 6.2222256933326 | 3.07089135511282 | 0.0427447729995995 |
| Low fat hard cheese | Rheumatoid Arthritis (bbj-a-74) | All - MR Egger | 2.46714552395194 | 1.03924201214411 | 0.0390109348324261 |
| Low fat hard cheese | Rheumatoid arthritis (ebi-a-GCST002318) | rs72759807 | 6.28868877937536 | 3.02692106434658 | 0.0377475081750197 |
| Low fat hard cheese | Rheumatoid arthritis (ebi-a-GCST002318) | All - Inverse variance weighted | 1.2241170390178 | 0.488976888979357 | 0.0122997695799254 |
| Low fat hard cheese | Total body bone mineral density (ebi-a-GCST005348) | rs113861725 | -1.02266437784639 | 0.493070325033082 | 0.0380724319553096 |
| Low fat hard cheese | Total body bone mineral density (ebi-a-GCST005348) | All - Inverse variance weighted | -0.275755477661276 | 0.138733102051335 | 0.0468483164167302 |
| Low fat hard cheese | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | rs113861725 | -2.26447112237415 | 1.0605928643874 | 0.0327528967318767 |
| Low fat hard cheese | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | rs27779 | -2.63091032775733 | 1.00810582652384 | 0.0090606797853478 |
| Low fat hard cheese | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | All - Inverse variance weighted | -0.672737441995059 | 0.266952777153307 | 0.0117334299238406 |
| Low fat hard cheese | Heel bone mineral density (ebi-a-GCST006288) | rs113861725 | -0.617880331410687 | 0.261679866716489 | 0.0182155601051662 |
| Low fat hard cheese | Heel bone mineral density (ebi-a-GCST006288) | All - MR Egger | -0.318342111475939 | 0.139289474363034 | 0.0383926701033707 |
| Low fat hard cheese | Osteopontin levels (ebi-a-GCST90010244) | rs113861725 | 2.77359784004293 | 1.27255550904243 | 0.0292908648383219 |
| Low fat hard cheese | Osteopontin levels (ebi-a-GCST90010244) | All - Inverse variance weighted | 1.52432569801078 | 0.757380958104041 | 0.0441538381096302 |
| Low fat hard cheese | Rheumatoid arthritis (ebi-a-GCST90013534) | rs72759807 | 6.2226161932506 | 3.11228434642029 | 0.0455680491517043 |
| Low fat hard cheese | Rheumatoid arthritis (ebi-a-GCST90013534) | All - MR Egger | 2.57047682096314 | 0.950897739570538 | 0.0205385758401317 |
| Low fat hard cheese | Neck circumference (ebi-a-GCST90017135) | rs10473702 | 7.92506470480344 | 3.29892600216022 | 0.0162916014067273 |
| Low fat hard cheese | Neck circumference (ebi-a-GCST90017135) | rs27779 | -7.8271631246363 | 3.81932776552934 | 0.0404272946214825 |
| Low fat hard cheese | Neck circumference (ebi-a-GCST90017135) | All - MR Egger | 8.17016098122848 | 3.13156002382065 | 0.02831833056388 |
| Low fat hard cheese | Compression fracture (ebi-a-GCST90018828) | rs117864679 | -5.96629480180394 | 2.92618086873962 | 0.0414564397491536 |
| Low fat hard cheese | Compression fracture (ebi-a-GCST90018828) | All - Inverse variance weighted | -1.08581328355055 | 0.532844719713297 | 0.0415732593056766 |
| Low fat hard cheese | Heel bone mineral density T score (ebi-a-GCST90025982) | rs117864679 | -0.464267742701163 | 0.160224258248279 | 0.0037601538388015 |
| Low fat hard cheese | Heel bone mineral density T score (ebi-a-GCST90025982) | rs142165664 | -0.364728394345859 | 0.149922280810375 | 0.0149832724881062 |
| Low fat hard cheese | Heel bone mineral density T score (ebi-a-GCST90025982) | rs27779 | 0.452923097097803 | 0.179912466908721 | 0.0118203163066697 |
| Low fat hard cheese | Heel bone mineral density T score (ebi-a-GCST90025982) | All - MR Egger | -0.618328949719249 | 0.133429173514079 | 0.0189305102618016 |
| Low fat hard cheese | Sciatica (ebi-a-GCST90038692) | All - Inverse variance weighted | -0.0087993803959309 | 0.0043405400192709 | 0.0426363659878428 |
| Low fat hard cheese | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | rs117864679 | 20.8516496558272 | 5.48587704723475 | 0.0001441312226369 |
| Low fat hard cheese | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | rs9895448 | 18.8792328438717 | 7.09790658846697 | 0.0078179840489345 |
| Low fat hard cheese | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | All - Inverse variance weighted | 5.70669214090508 | 1.79570548616093 | 0.0014831181142026 |
| Low fat hard cheese | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | rs7915755 | 33.0448585863211 | 11.7755696994673 | 0.0050126199653841 |
| Low fat hard cheese | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | All - Inverse variance weighted | 6.7789390234305 | 3.00232103363095 | 0.023951928659094 |
| Low fat hard cheese | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs113861725 | 12.5304481461399 | 5.18355982727086 | 0.0156342264939586 |
| Low fat hard cheese | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs117864679 | 5.81248516496558 | 2.38309992879183 | 0.0147261822322328 |
| Low fat hard cheese | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs41280272 | 12.513271845778 | 4.9812595141545 | 0.0120025328783478 |
| Low fat hard cheese | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | All - Inverse variance weighted | 2.21629898154305 | 0.91781222902274 | 0.0157454525469155 |
| Low fat hard cheese | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | All - MR Egger | 3.72885535082032 | 1.68743709310334 | 0.04428103628785 |
| Low fat hard cheese | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | rs113861725 | 16.3808919094324 | 7.75005408321229 | 0.0345452811863674 |
| Low fat hard cheese | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | rs117864679 | 7.93733681462141 | 3.6629480180394 | 0.030240507126869 |
| Low fat hard cheese | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | All - Inverse variance weighted | 2.74744793309666 | 1.1616790665282 | 0.0180268467235956 |
| Low fat hard cheese | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | rs117864679 | 19.3971042012817 | 6.66508426299549 | 0.0036113234886943 |
| Low fat hard cheese | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | rs9895448 | 19.9837321803159 | 8.90449077443384 | 0.0248175572814151 |
| Low fat hard cheese | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | All - Inverse variance weighted | 4.11722095314472 | 2.09088970047144 | 0.0489388610081657 |
| Low fat hard cheese | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | rs117864679 | 9.78685022549252 | 3.9686684073107 | 0.0136620384004329 |
| Low fat hard cheese | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | All - MR Egger | 6.91546450784643 | 2.26765579552301 | 0.0086565051194112 |
| Low fat hard cheese | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs113101192 | -4.49453922228732 | 2.18168781315309 | 0.0393870473545321 |
| Low fat hard cheese | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs142296911 | -5.89101895022229 | 2.46097083245419 | 0.0166758181216249 |
| Low fat hard cheese | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | All - MR Egger | -2.56107859848356 | 1.18167027074332 | 0.0479417634316779 |
| Low fat hard cheese | Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) | All - MR Egger | 5.47611140192797 | 2.51561912382778 | 0.0470979612224462 |
| Low fat hard cheese | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | All - Inverse variance weighted | 2.72075329538983 | 1.32859094283731 | 0.0405748223416689 |
| Low fat hard cheese | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | rs2708032 | 102.447109227348 | 38.8209591253165 | 0.0083159838783521 |
| Low fat hard cheese | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | rs9895448 | -13.0485037886896 | 5.3170084335802 | 0.0141235232091325 |
| Low fat hard cheese | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | All - MR Egger | 4.84365897576932 | 2.17095835901082 | 0.0425404441996645 |
| Low fat hard cheese | Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) | rs10473702 | 3.03908781511749 | 1.45203692759176 | 0.0363507206838644 |
| Low fat hard cheese | Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) | rs142165664 | 2.96099824734343 | 1.03625586167294 | 0.0042712622637759 |
| Low fat hard cheese | Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) | rs9895448 | -4.81184982233829 | 1.95213836208742 | 0.013704679800123 |
| Low fat hard cheese | Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) | All - MR Egger | 2.63425120252789 | 0.945685678309677 | 0.0145893794802204 |
| Low fat hard cheese | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs118109475 | 1.82884469360389 | 0.756094802656025 | 0.0155716529016384 |
| Low fat hard cheese | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs27779 | 1.74574423617543 | 0.868774126922982 | 0.0444911315083297 |
| Low fat hard cheese | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs7915755 | -2.37342979684662 | 0.786055527572996 | 0.002532612791795 |
| Low fat hard cheese | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | All - MR Egger | 0.897993717025858 | 0.418660369523923 | 0.0499874353759044 |
| Low fat hard cheese | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | rs10473702 | 17.1365831787891 | 8.21037722390919 | 0.0368713379008139 |
| Low fat hard cheese | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | rs117864679 | 20.8307619273677 | 8.11962971754094 | 0.0103032638746698 |
| Low fat hard cheese | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | rs27779 | -26.5795706944456 | 11.3678274909639 | 0.019379993526602 |
| Low fat hard cheese | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | All - MR Egger | 11.4492739526203 | 5.04945388994889 | 0.0397253958559453 |
| Low fat hard cheese | Osteocrin (prot-a-2157) | rs113101192 | 5.5788249490648 | 2.1029896555644 | 0.0079825581597942 |
| Low fat hard cheese | Osteocrin (prot-a-2157) | All - Inverse variance weighted | 1.13664253277522 | 0.518629129317412 | 0.0284063211376143 |
| Low fat hard cheese | Bone morphogenetic protein 10 (prot-a-254) | All - MR Egger | -2.08097066683192 | 0.926177253663879 | 0.0401309410516051 |
| Low fat hard cheese | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | rs142296911 | 0.0549548977614128 | 0.0223235074996126 | 0.0138260947784811 |
| Low fat hard cheese | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | rs9895448 | -0.0533950939680637 | 0.0238199409221285 | 0.0249863821836813 |
| Low fat hard cheese | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | All - MR Egger | 0.0231071289002451 | 0.010736605321187 | 0.0480755844176791 |
| Low fat hard cheese | Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) | All - Inverse variance weighted | 0.0128385616713002 | 0.0061439869962565 | 0.0366524816327416 |
| Low fat hard cheese | Operation code: shoulder surgery (ukb-b-5935) | rs27779 | -0.0518949930743949 | 0.0235970527247543 | 0.0278626359443769 |
| Low fat hard cheese | Operation code: shoulder surgery (ukb-b-5935) | rs7915755 | -0.0459335744921166 | 0.0213681181983302 | 0.0315843950239695 |
| Low fat hard cheese | Operation code: shoulder surgery (ukb-b-5935) | rs9895448 | -0.0757814118755084 | 0.0235814889336016 | 0.001310833237875 |
| Low fat hard cheese | Operation code: shoulder surgery (ukb-b-5935) | All - Inverse variance weighted | -0.0386397620927658 | 0.0085124566971015 | 5.64674705902417e-06 |
| Low fat hard cheese | Non-cancer illness code, self-reported: joint disorder (ukb-b-8201) | rs7915755 | -0.0240195674405116 | 0.0121335683868309 | 0.0477489057841998 |
| Low fat hard cheese | Non-cancer illness code, self-reported: joint disorder (ukb-b-8201) | All - Inverse variance weighted | -0.0137685681352212 | 0.0057138162306222 | 0.0159657562965057 |
| Low fat hard cheese | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | rs140259232 | 0.048202154200451 | 0.0192080074845272 | 0.0120908285564048 |
| Low fat hard cheese | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | All - MR Egger | 0.0211023747070922 | 0.0093918972543556 | 0.0391118291717219 |
| Low fat hard cheese | Shoulder lesions (ukb-d-M13_SHOULDER) | rs140259232 | 0.0716215276111884 | 0.0277933838698844 | 0.0099682934936889 |
| Low fat hard cheese | Shoulder lesions (ukb-d-M13_SHOULDER) | rs2708032 | 0.0589232195323273 | 0.0283256414203781 | 0.0375064793596519 |
| Low fat hard cheese | Shoulder lesions (ukb-d-M13_SHOULDER) | rs27779 | -0.0656408848382523 | 0.0308973781052528 | 0.0336299645152634 |
| Low fat hard cheese | Shoulder lesions (ukb-d-M13_SHOULDER) | All - MR Egger | 0.0414870574499535 | 0.0126768067226002 | 0.0047870113979442 |
| Low fat hard cheese | Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) | rs140259232 | 0.0715844648083289 | 0.0277953029794176 | 0.0100119622335474 |
| Low fat hard cheese | Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) | rs2708032 | 0.0588082502726835 | 0.028327541197318 | 0.0378930539701805 |
| Low fat hard cheese | Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) | rs27779 | -0.0659234823089721 | 0.0308994271008352 | 0.0328849129039747 |
| Low fat hard cheese | Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) | All - MR Egger | 0.0416177222082391 | 0.0126651422438271 | 0.004654503848968 |
| Low fat hard cheese | Ankle spacing width (ukb-e-3143_EAS) | rs72891041 | -3.45805876967993 | 1.55336362811642 | 0.0260024836009103 |
| Low fat hard cheese | Ankle spacing width (ukb-e-3143_EAS) | All - MR Egger | -10.358426947243 | 3.58739481469409 | 0.0446771640658221 |
| Low fat hard cheese | Heel bone mineral density (BMD) (ukb-e-3148_CSA) | All - Inverse variance weighted | 1.48415389200858 | 0.682288603888236 | 0.0296107717360019 |
| Low fat hard cheese | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | rs113861725 | 4.61322777039499 | 2.15068566275114 | 0.031952585873582 |
| Low fat hard cheese | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | All - MR Egger | 6.34688674996151 | 2.42579847028665 | 0.0473021694632408 |
| Low fat hard cheese | Osteoarthrosis (ukb-e-740_AFR) | rs10473702 | -5.37253663208951 | 2.63659336852188 | 0.0415818295787725 |
| Low fat hard cheese | Osteoarthrosis (ukb-e-740_AFR) | All - Inverse variance weighted | -3.08400769653918 | 1.48563554380272 | 0.0379046409264839 |
| Low fat hard cheese | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) | rs7915755 | 4.79875452172719 | 2.37877192179129 | 0.0436616760979333 |
| Low fat hard cheese | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) | All - Inverse variance weighted | 1.40554944109283 | 0.679966470002945 | 0.0387260135772615 |